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| 1 | Reprogramming of ovine adult fibroblasts to pluripotency via drug-inducible expression of defined factors显示文摘在 enucleated 鸡蛋的体的房间的 Reprogramming 做了多丽,绵羊,在 1996 的第一个成功地克隆的哺乳动物。然而,绵羊的机制体的房间 reprogramming 还没被探讨了。而且,绵羊胚胎的茎(ES ) 细胞仍然不是可得到的,它限制精确修改基因的绵羊的产生。在这研究,我们报导体的房间能是的那只绵羊直接 reprogrammed 到导致的 pluripotent 用定义因素(Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, SV40 大 T 和 hTERT ) 的茎(iPS ) 房间。我们的观察显示从绵羊的体的细胞比从另外的种,在 iPS,细胞被报导了的体的细胞对改编更困难。我们证明绵羊 iPS 房间表示 ES 房间标记,包括碱的磷酸酶, Oct4, Nanog, Sox2, Rex1,阶段特定的胚胎的 antigen-1, TRA-1-60, TRA-1-81 和 E-cadherin。绵羊 iPS 房间展出了正常 karyotypes 并且能在 vitro 并且在 teratomas 区分进所有三细菌层。我们的学习可以帮助在绵羊揭示体的房间 reprogramming 的机制并且提供一个平台为绵羊 ES 房间探索文化条件。而且,绵羊 iPS 房间可以直接被用来产生精确修改基因的绵羊。 | Lei Bao Lixiazi He Jijun Chen Zhao Wu Jing Liao Lmgdun Rao Jiangtao Ren Hui Li Hui Zhu Lei Qian Yijun Gu Huimin Dai Xun Xu Jinqiu Zhou Wen Wang Chun Cui Lei Xiao | 2011 | Cell Research2011，21，4： | 32 |
| 2 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 3 | Endothelial Nitric Oxide Synthase Gene Intron 4, 27 bp Repeat Polymorphism and Essential Hypertension in the Kazakh Chinese Population显示文摘为了调查在 27 bp 之间的关系,在内含子 4in 重复多型性 endothelial 在 KazakhChinese 人口的氮的氧化物合酶( eNOS4 )基因和必要高血压,有必要高血压和 138 个健康的人的 151 个病人在 Xinjiang uygur 从 Shawan 区域的 Boertonggu 农村被选择中国 in2006 的自治区域。在二个组的 eNOS 的多型性与聚合酶链反应试金被检测,在每个组的遗传型频率是计算的跟随 Hardy-Weinberg 法律。Fourand 27 bp 重复的五辆双人脚踏车是被指明一 and “ b' 分别地。b/b, b/a 和 eNOS4 基因的 a/a 遗传型的频率在控制组是 84.06% , 15.22% 和 0.72% ,这被发现,并且 81.46% , 15.89% 和 2.65% 分别地在高血压组织。基因的频率一 and “ b' 在控制组是 91.67% 和 8.33% , 89.40% 和 10.60% 分别地在高血压组织。血浆 eNOS 活动没与 eNOS 基因的遗传型和等位基因被联系,这被发现。在高血压组的血浆 eNOS 活动显著地与控制组(P<0.01 ) 相比被减少。结果建议 eNOS4 基因多型性是不大可能的是为在 Xinjiang 哈萨克人口的必要高血压的主要基因危险性因素。然而,在血浆 eNOS 活动之间的一个积极协会和必要高血压被揭示了。 | Fengmei DENG Qinghua HU Bin TANG Fang HE Shuxia GUO Jiang CHEN Feng LI Xuehua WU Jun ZHANG Huimin ZHANG Juan ZHAO Hua ZHONG Ling HE Jun LI Le ZHANG Shuren WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，5： | 18 |
| 4 | Timing of the formation of the Tianhuashan Basin in northern Wuyi as constrained by geochronology of volcanic and plutonic rocks显示文摘The Tianhuashan Basin is one of the most important volcanic basins in the northern Wuyi,southeastern China,comprising two successive volcanic units,the Daguding Formation and the overlying Ehuling Formation,along with several small associated igneous intrusions.The Lengshuikeng super-large-scale Ag-Pb-Zn deposit,which is closely related to these volcanic-intrusive rocks,is located in the northwestern part of the basin.In order to understand the basin evolution and magmatism,we determined LA-ICP-MS U-Pb zircon ages for the volcanic successions and associated intrusive rocks.U-Pb zircon dating of volcanic units yielded precise ages of 144±1 Ma for crystal tuff in the lower member of the Daguding Formation,142±1 Ma for andesite within the upper member of the Daguding Formation,140±1 Ma for tuffite of the first(i.e.,lowermost) member of the Ehuling Formation,and 137±1 Ma for rhyolitic ignimbrite within the third volcano-stratigraphic member of the Ehuling Formation.Three types of intrusive igneous rocks(quartz syenite porphyry,K-feldspar granite porphyry,and rhyolite porphyry) yielded precise weighted mean 206 Pb/238 U ages of 144±1,140±1,and 140±1 Ma,respectively,suggesting that these intrusions along with the aforementioned volcanics were all emplaced during the Early Cretaceous.In addition,the weighted mean 206 Pb/238 U ages determined on zircon from two samples of a granite porphyry intrusion,which hosts ore mineralization of the Lengshuikeng Ag-Pb-Zn deposit,are 158±1 and 157±1 Ma,indicating emplacement in the Late Jurassic.These new geochronological results for igneous rocks of the Tianhuashan Basin constrain the timing of volcanic and plutonic activity in the basin,and have important implications for our understanding the tectonic history of the region,and for identifying metallogenic types and the timing of ore deposition of the Lengshuikeng deposit. | SU HuiMin MAO JingWen HE XiRong LU Ran | 2013 | Science China Earth Sciences2013，56，6： | 16 |
| 5 | Road Centrality and Landscape Spatial Patterns in Wuhan Metropolitan Area,China显示文摘Road network is a corridor system that interacts with surrounding landscapes,and understanding their interaction helps to develop an optimal plan for sustainable transportation and land use.This study investigates the relationships between road centrality and landscape patterns in the Wuhan Metropolitan Area,China.The densities of centrality measures,including closeness,betweenness,and straightness,are calculated by kernel density estimation(KDE).The landscape patterns are characterized by four landscape metrics,including percentage of landscape(PLAND),Shannon′s diversity index(SHDI),mean patch size(MPS),and mean shape index(MSI).Spearman rank correlation analysis is then used to quantify their relationships at both landscape and class levels.The results show that the centrality measures can reflect the hierarchy of road network as they associate with road grade.Further analysis exhibit that as centrality densities increase,the whole landscape becomes more fragmented and regular.At the class level,the forest gradually decreases and becomes fragmented,while the construction land increases and turns to more compact.Therefore,these findings indicate that the ability and potential applications of centrality densities estimated by KDE in quantifying the relationships between roads and landscapes,can provide detailed information and valuable guidance for transportation and land-use planning as well as a new insight into ecological effects of roads. | LIU Yaolin WANG Huimin JIAO Limin LIU Yanfang HE Jianhua AI Tinghua | 2015 | Chinese Geographical Science2015，25，4： | 9 |
| 6 | Treatment of mine water high in Fe and Mn by modified manganese sand显示文摘The iron and manganese absorption properties of several filter media were studied. Four plain filter media and six surface-modified media were examined. The surface modification was performed using potassium permanganate as a surface treatment. The surface-modified manganese sand was found to be most efficient at removing iron and manganese from water. The metal concentrations in filtered effluent were between 0.01 and 0.04 mg/L, which is far lower than the standard for recycle water. A concen-tration of 5% KMnO4 was found to be most effective as surface modifier. The surface of the manganese sand modified by 5% KMnO4 was examined and found to be covered with a dense membrane of some compound. The membrane had the advantages of uniform texture, large surface area and physical and chemical stability. It was effective at removing iron and manganese from mine water. | HE Xuwen YANG Huimin HE Yong | 2010 | Mining Science and Technology2010，20，4： | 7 |
| 7 | S-scheme photocatalyst Bi2O3/TiO2 nanofiber with improved photocatalytic performance显示文摘In this study,a hierarchical Bi2O3/TiO2 fibrous composite was in-situ fabricated on an electrospun TiO2 nanofiber at ambient temperature.In the Bi2O3/TiO2 composite,S-scheme electron migration occurred between Bi2O3 and TiO2.In the photocatalytic degradation of phenol under simulated sunlight,the asprepared Bi2O3/TiO2 nanofibers considerably outperformed Bi2O3 nanoparticles and TiO2 nanofibers.This improvement is contributed by maintaining and effectively utilizing the useful carriers and consuming the useless holes and electrons,realized by the S-scheme heterojunction and hierarchical structure.This study also provides an alternative design fashion for photocatalysts. | Rongan He Haijuan Liu Huimin Liu Difa Xu Liuyang Zhang | 2020 | Journal of Materials Science & Technology2020，52，17： | 6 |
| 8 | In vitro differentiation of human adipose-derived mesenchymal stem cells into endothelial-like cells显示文摘The neovascularization of ischemic tis- sue is a crucial initial step for the functional rehabili- tation and wound healing. However, the short of seed cell candidate for the foundation of vascular network is still a big issue. Human adipose tissue derived mesenchymal stem cells (hADSCs), which possess multilineage potential, are capable of adipogenic, osteogenic, and chondrogenic differentiation. We examined whether this kind of stem cells could dif- ferentiate into endothelial-like cells and participate in blood vessel formation, and whether they could be used as an ideal cell source for therapeutic angio- genesis in ischemic diseases or vascularization of tissue constructs. The results showed that hADSCs, grown under appropriately induced conditions, dis- played characteristics similar to those of vessel en- dothelium. The differentiated cells expressed endo- thelial cell markers CD34 and vWF, and had high metabolism of acetylated low-density lipoprotein and prostacyclin. In addition, the induced cells were able to form tube-like structures when cultured on matrigel. Our data indicated that induced hADSCs could ex- hibit characteristics of endothelial cells. Therefore, these cells, as a source of human endothelial cells, may find many applications in such realms as engi- neering blood vessels, endothelial cell transplantation for myocardial regeneration, and induction of angio- genesis for treatment of regional ischemia. | GUAN Lidong LI Shaoqing WANG Yunfang YUE Huimin LIU Daqing HE Lijuan BAI Cixian YAN Fang NAN Xue SHI Shuangshuang PEI Xuetao | 2006 | Chinese Science Bulletin2006，51，15： | 6 |
| 9 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 10 | Low-overpotential selective reduction of CO2 to ethanol on electrodeposited CuxAuy nanowire arrays显示文摘Direct electrochemical reduction of CO2 to multicarbon products is highly desirable, yet challenging. Here, we present a potentiostatic pulse-electrodeposition of high-aspect-ratio CuxAuy nanowire arrays (NWAs) as high-performance electrocatalysts for the CO2 reduction reaction (CO2RR). The surface electronic structure related to the Cu:Au ratio in the CuxAuy NWAs could be facilely modulated by controlling the electrodeposition potential and the as-fabricated CuxAuy NWAs could be directly used as the catalytic electrode for the CO2RR. The morphology of the high-aspect-ratio nanowire array significantly lowers the onset potential of the alcohol formation due to the diffusion-induced enhancement of the local pH and CO concentration near the nanowire surface. Besides, the properly adjusted surface electronic structure of the CuxAuy NWA enables the adsorption of CO and facilitates the subsequent CO reduction to ethanol via the C-C coupling pathway. Owing to the synergistic effect of morphology and electronic structure, the optimized CuxAuy NWA selectively reduces CO2 to ethanol at low potentials of -0.5——0.7 V vs. RHE with a highest Faradaic efficiency of 48%. This work demonstrates the feasibility to optimize the activity and selectivity of the Cu-based electrocatalysts toward multicarbon alcohols for the CO2RR via simultaneous adjustment of the electronic structure and morphology of the catalysts. | Weiwei Zhu Kuangmin Zhao Suqin Liu Min Liu Feng Peng Pengda An Binhao Qin Huimin Zhou Hongmei Li Zhen He | 2019 | Journal of Energy Chemistry2019，28，10： | 4 |
| 11 | LA-ICP-MS U-Pb Zircon Dating for Felsic Granulite, Huangtuling Area, North Dabieshan: Constraints on Timing of Its Protolith and Granulite-Facies Metamorphism, and Thermal Events in Its Provenance显示文摘 | Chen Nengsong Liu Rong Sun Min Li Huimin He Lei Wang Qinyan Zhang Hongfei | 2005 | Journal of China University of Geosciences2005，16，4： | 4 |
| 12 | In situ SEM-DIC technique and its application to characterize the high-temperature fatigue crack closure effect显示文摘In situ high-temperature(maximum: 650℃) experiments for fatigue crack growth on single edge-notched GH4169 superalloy specimens have been performed in scanning electron microscopy(SEM). In order to investigate the crack closure behavior,digital image correlation(DIC) method was applied to measure the full-field displacement and strain fields around the crack tip.The deformation carrier(speckle) was fabricated on the polished specimen surface with Zr O2 powders having a good hightemperature resistance, and the speckle patterns were recorded during the fatigue test by SEM. In consideration of the distortion of SEM images, the unabridged model and the bicubic model were used to correct the spatial distortion, and the distortion parameters can be determined by a calibration test. It is shown that the unabridged model makes a better contribution towards improving SEM-DIC measurement accuracy. Based on the deformation field, the mode Ι stress intensity factor range ?K and the crack opening displacement(COD) can be calculated for evaluating the crack closure effect. Additionally, the crack propagation was monitored using SEM and optical microscope. It indicates that the cracks grew initially in trans-granular mode at room temperature and 650°C, then propagated in both trans-granular and inter-granular modes. | YIN YuanJie XIE HuiMin HE Wei | 2020 | Science China(Technological Sciences)2020，63，2： | 4 |
| 13 | Epidemiological and clinical characteristics of 35 children with COVID-19 in Beijing,China显示文摘Importance:Within the coronavirus disease 2019(COVID-19)global pandemic,more attention is warranted for whether this new infectious disease has unique manifestations in children.Objective:To retrospectively determine the epidemiological and clinical characteristics of 35 children with COVID-19 in Beijing,China.Methods:We collected data for 35 children diagnosed with COVID-19 who were admitted to Beijing Ditan Hospital from January 2020 to June 2020,and analyzed their epidemiological characteristics,clinical manifestations,laboratory examinations,chest imaging findings,treatments,and outcomes.Results:The children comprised 18 boys(51.4%)and 17 girls(48.6%)aged 6 months to 15 years.All patients had clear epidemiological history,with family clusters accounting for 28 cases(80.0%)and clear tracing of exposure to high epidemic areas in the remaining 7 cases(20.0%).Four(11.4%)patients were classified as asymptomatic,17(48.6%)as acute upper respiratory infection,and 14(40.0%)as mild pneumonia,with no severe or critical cases.Clinical manifestations were mild,including fever in 18(51.4%),cough in 14(40.0%),and nausea and diarrhea in 7(20.0%)patients.White blood cell count was mostly normal(26 cases,74.3%)or decreased(7 cases,20.0%);lymphocyte percentage was increased in 24(68.7%);neutrophil percentage was decreased in 25(71.4%);alanine aminotransferase was increased in 3(8.6%);and serum potassium was decreased in 4(11.4%).Time to negative viral nucleic acid testing was 2-42 days(mean:14.0±9.4 days).Chest imaging examination revealed that 20 patients(57.1%)had different forms of lung inflammation.Treatment was mainly isolation and nutritional support.Eleven patients were treated with interferon atomization inhalation.No patients required oxygen therapy.All 35 children were cured and discharged.Length of hospital stay was 9-54 days(mean:25.4±13.8 days).During regular follow-up after discharge,5 children showed positivity again in the viral nucleic acid test and were re-hospitalized for observation and treatment.The mean length of re-hospitalization stay was 10.8 days.Interpretation:Children with COVID-19 mainly become infected within their family,and children of all ages are generally susceptible.The disease in children is mostly mild and the prognosis is good.Nucleic acid tests in some patients become positive again after discharge,suggesting that it is of great significance to carry out centralized isolation medical observations and active nucleic acid tests in close contacts for early detection of patients and routine epidemic prevention and control. | Ming He Caiying Wang Lin Xu Huimin Zhang Yuhuan Liu Yang Zhao Shuxin He Yanlan Zhang Hongling Yang Yang Liu Min Miao Zhihai Chen Lin Pang | 2020 | Pediatric Investigation2020，4，4： | 3 |
| 14 | Factors affecting potassium fixation in seven soils under 15-year long-term fertilization显示文摘Potassium (K) fixation by seven soils, including black soil, fluvo-aquic soil, grey desert soil, loess soil, paddy soil, red soil and purple soil, was determined by laboratory simulation under a fifteen-year-period of long-term fertilization. Factors affecting soil K fixation were then discussed by factor analysis and stepwise regression. Magnitude of soil K fixation rate was as follows: the black soil > the purple soil > the loess soil > the fluvo-aquic soil > the paddy soil > the grey desert soil > the red soil. Our results showed that soil K fixation capacity was significantly affected by the clay mineral types in the soils. Potassium fixation capacity of soils, whose 2:1 layer silicates were dominant minerals, was af- fected by two components extracted by the method of principal component analysis: the first including soil available K, slow available K and K+ saturation, and the second including cation exchange capacity (CEC), soil organic matter (SOM) and <0.002 mm clay contents. Potassium fixation rate was mainly affected by K+ saturation and CEC with lower added K concentration (from 0.4 to 1.6 g/L), and by K+ saturation and <0.002 mm clay content with higher added K concentration (from 2.4 to 4.0 g/L). | ZHANG HuiMin XU MingGang ZHANG WenJu HE XinHua | 2009 | Chinese Science Bulletin2009，54，10： | 3 |
| 15 | Experimentai Research on Saturated-Gain for Soft X-Ray Laser from Neon-Like Germanium Plasma显示文摘AmpliHcation of spontaneous emissions at 19.6,23.2 and 23.6 nm have been observed by a “ultiple-Target Series Coupling”design in Ge plasma,.The combined length for four targets is up to 56mm.The gain length product(GL)of small signal is up to 18 for both lines at 23.2 and 23.6 nmt and the effective GL is 16.4 and 15.7 for these two lines respectively.This two lines are obviously tending to saturation.The divergence of x-ray laser beam is about 4 mrad. | WANG Shiji GU Yuan ZHOU GuanUn NI Yuanlong YU Songyu FU Sizu MAO Chusheng TAO Zucong CHEN Wannian LIN Zunqi FAN Dianyuan ZHANG Guoping SHENG Jiatian YANG Minglun ZHANG Tanxin SHAO Yunfeng PENG Huimin HE Xiantu YU Min | 1991 | Chinese Physics Letters1991，8，12： | 3 |
| 16 | High-temperature fatigue crack propagation study of superalloy GH4169 by single-lens 3D digital image correlation显示文摘The characterization of fatigue crack propagation behavior is crucial for performance and reliability evaluation of aerospace materials.In this study,high-temperature(maximum:650℃)fatigue crack propagation experiments of Ni-based superalloy GH4169 were conducted.The bi-prism-based single-lens 3D digital image correlation(BSL 3D DIC)technique was used to insitu measure the displacement and strain fields near fatigue crack tip.Based on the deformation information,the modeΙstress intensity factor range△K and the crack opening displacement(COD)were determined for characterizing the crack closure effect.As the major fatigue crack growth model,the parameters of modified Paris’law were obtained based on the effective stress intensity factor range△Keff and the fatigue crack propagation rate(FCPR).Additionally,two kinds of J integrals,JP(path integral method)and JK(stress intensity factor K method),were used to evaluate the small-scale yielding approximation. | YIN YuanJie HE Wei XIE HuiMin WU LiFu | 2020 | Science China(Technological Sciences)2020，63，4： | 3 |
| 17 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 18 | mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines显示文摘Although IL-12 plays a critical role in priming Th1 and cytotoxic T lymphocyte(CTL) responses, Toll-like receptor(TLR) signaling only induces low amounts of IL-12 in dendritic cells and macrophages, implying the existence of stringent regulatory mechanisms. In this study, we sought to uncover the mechanisms underlying TLR-induced IL-12 expression and the Th1 response. By systemic screening, we identified a number of protein kinases involved in the regulation of TLRinduced IL-12 expression. In particular, PI3 K, ERK, and m TOR play critical roles in the TLR-induced Th1 response by regulating IL-12 and IL-10 production in innate immune cells. Moreover, we identified c-fos as a key molecule that mediates m TOR-regulated IL-12 and IL-10 expression in TLR signaling. Mechanistically, m TOR plays a crucial role in c-fos expression, thereby modulating NFκB binding to promoters of IL-12 and IL-10. By controlling the expression of a special innate gene program, m TOR can specifically regulate the TLR-induced T cell response in vivo. Furthermore, blockade of m TOR by rapamycin efficiently boosted TLR-induced antigen-specific T and B cell responses to HBV and HCV vaccines. Taken together, these results reveal a novel mechanism through which m TOR regulates TLR-induced IL-12 and IL-10 production, contributing new insights for strategies to improve vaccine efficacy. | Li He Aiping Zang Min Du Dapeng Ma Chuanping Yuan Chun Zhou Jing Mu Huanjing Shi Dapeng Li Xulin Huang Qiang Deng Jianhua Xiao Huimin Yan Lijian Hui Ke Lan Sidong Xiong Xiaoxia Li Zhong Huang Hui Xiao | 2015 | Virologica Sinica2015，30，3： | 2 |
| 19 | Polymer-/Ceramic-based Dielectric Composites for Energy Storage and Conversion显示文摘Dielectric composites boost the family of energy storage and conversion materials as they can take full advantage of both the matrix and filler.This review aims at summarizing the recent progress in developing highperformance polymer-and ceramic-based dielectric composites,and emphases are placed on capacitive energy storage and harvesting,solid-state cooling,temperature stability,electromechanical energy interconversion,and high-power applications.Emerging fabrication techniques of dielectric composites such as 3D printing,electrospinning,and cold sintering are addressed,following by highlighted challenges and future research opportunities.The advantages and limitations of the typical theoretical calculation methods,such as finite-element,phase-field model,and machine learning methods,for designing high-performance dielectric composites are discussed.This review is concluded by providing a brief perspective on the future development of composite dielectrics toward energy and electronic devices. | Honghui Wu Fangping Zhuo Huimin Qiao Lalitha Kodumudi Venkataraman Mupeng Zheng Shuize Wang He Huang Bo Li Xinping Mao Qiaobao Zhang | 2022 | Energy & Environmental Materials2022，5，2： | 2 |
| 20 | Neuroprotective effect of early and short-time applying sophoridine in pMCAO rat brain: Down-regulated TRAF6 and up-regulated p-ERK1/2 expression, ameliorated brain infaction and edema显示文摘 | Zongjie Liu Dan He Xiangjian Zhang Yanhua Li Chunhua Zhu Lipeng Dong Xiaolin Zhang Yinxue Xing Chaohui Wang Huimin Qiao Linyu Chen | 2012 | Brain Research Bulletin2012，，4： | 2 |
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