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| 1 | CD4^(+) T cell-released exosomes inhibit CD8^(+) cytotoxic T-lymphocyte responses and antitumor immunity显示文摘T cells secrete bioactive exosomes(EXO),but the potential immunoregulatory effect of T-cell EXO is largely unknown.In this study,we generated activated ovalbumin(OVA)-specific CD4^(+) T cells in vitro via coculture of OVA-pulsed dendritic cells(DC_(OVA))with naive CD4^(+) T cells derived from OVA-specific T-cell receptor(TCR)transgenic OTII mice.CD4^(+) T-cell EXO were then purified from the CD4^(+) T-cell culture supernatants by differential ultracentrifugation.CD4^(+) T-cell EXO exhibited the‘saucer’shape that is characteristic of EXO with a diameter between 50 and 100 nm,as assessed by electron microscopy,and contained the EXO-associated proteins LAMP-1,TCR and lymphocyte function associated antigen-1(LFA-1),as determined by western blot.Flow cytometric analysis showed that CD4^(+) T-cell EXO expressed CD4^(+) T-cell markers(CD4,TCR,LFA-1,CD25 and Fas ligand),but to a lesser extent than CD4^(+) T cells.We demonstrated that DC_(OVA) took up CD4^(+) T-cell EXO via peptide/major histocompatibility complex(pMHC)II/TCR and CD54/LFA-1 interactions.OVA-specific CD4^(+) T-cell EXO from OTII mice,but not ConA-stimulated polyclonal CD4^(+) T-cell EXO from wild-type C57BL/6 mice inhibited DC_(OVA)-stimulated in vitro CD4^(+) T-cell proliferation and in vivo CD81 cytotoxic T lymphocyte(CTL)responses and antitumor immunity against OVA-expressing B16 melanoma BL6-10OVA cells.In addition,EXO derived from a T-cell hybridoma cell line,MF72.2D9,expressing an OVA-specific CD4^(+) TCR,had a similar inhibitory effect as OTII CD4^(+) T-cell EXO on CTL-mediated antitumor immunity.Taken together,our data indicate that antigen-specific T-cell EXO may serve as a new type of immunosuppressive reagent for use in transplant rejection and treatment of autoimmune diseases. | Haifeng Zhang Yufeng Xie Wei Li Rajni Chibbar Sidong Xiong Jim Xiang | 2011 | Cellular & Molecular Immunology2011，8，1： | 10 |
| 2 | A novel oncolytic virus engineered with PD-L1 scFv effectively inhibits tumor growth in a mouse model显示文摘The adoptive transfer of engineered chimeric antigen receptor(CAR)T cells has yielded impressive clinical results for targeting hematological cancers.1 However,the advancement of CAR T-cell therapy in solid tumors remains limited,due to the scarcity of tumor antigens that are deemed safe for targeting.Moreover,the requirement of patient-specific autologous T cells for the current standard treatment has also hampered its application.Oncolytic virus(OV)therapy has been classified as another form of novel immunotherapy. | Chuanjian Wu Manman Wu Minglong Liang Sidong Xiong Chunsheng Dong | 2019 | Cellular & Molecular Immunology2019，16，9： | 3 |
| 3 | mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines显示文摘Although IL-12 plays a critical role in priming Th1 and cytotoxic T lymphocyte(CTL) responses, Toll-like receptor(TLR) signaling only induces low amounts of IL-12 in dendritic cells and macrophages, implying the existence of stringent regulatory mechanisms. In this study, we sought to uncover the mechanisms underlying TLR-induced IL-12 expression and the Th1 response. By systemic screening, we identified a number of protein kinases involved in the regulation of TLRinduced IL-12 expression. In particular, PI3 K, ERK, and m TOR play critical roles in the TLR-induced Th1 response by regulating IL-12 and IL-10 production in innate immune cells. Moreover, we identified c-fos as a key molecule that mediates m TOR-regulated IL-12 and IL-10 expression in TLR signaling. Mechanistically, m TOR plays a crucial role in c-fos expression, thereby modulating NFκB binding to promoters of IL-12 and IL-10. By controlling the expression of a special innate gene program, m TOR can specifically regulate the TLR-induced T cell response in vivo. Furthermore, blockade of m TOR by rapamycin efficiently boosted TLR-induced antigen-specific T and B cell responses to HBV and HCV vaccines. Taken together, these results reveal a novel mechanism through which m TOR regulates TLR-induced IL-12 and IL-10 production, contributing new insights for strategies to improve vaccine efficacy. | Li He Aiping Zang Min Du Dapeng Ma Chuanping Yuan Chun Zhou Jing Mu Huanjing Shi Dapeng Li Xulin Huang Qiang Deng Jianhua Xiao Huimin Yan Lijian Hui Ke Lan Sidong Xiong Xiaoxia Li Zhong Huang Hui Xiao | 2015 | Virologica Sinica2015，30，3： | 2 |
| 4 | A Vesicular Stomatitis Virus-Based Vaccine Carrying Zika Virus Capsid Protein Protects Mice from Viral Infection显示文摘Dear Editor,Zika virus (ZIKV) is a mosquito-borne virus that belongs to the Flavivirus family along with dengue virus (DENV),yellow fever virus, West Nile virus, and Japanese encephalitis virus (Ming et al. 2016). ZIKV is a singlestranded positive-sense RNA virus encoding three structural proteins, including nucleocapsid protein C, prM/M,envelope glycoprotein E, and seven non-structural proteins.Since 2015. | Xiaodan Shi Jingping Hu Jing Guo Chuanjian Wu Sidong Xiong Chunsheng Dong | 2019 | Virologica Sinica2019，34，1： | 2 |
| 5 | The relationship between human cytomegalovirus infection and atherosclerosis development显示文摘 | Ruizhen Chen Sidong Xiong Yingzhen Yang Weiguo Fu Yuqi Wang Junbo Ge | 2003 | Molecular and Cellular Biochemistry (-)2003，，1： | 1 |
| 6 | Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication显示文摘 | Chunsheng Dong Liang Qu Haoyi Wang Lin Wei Yuansu Dong Sidong Xiong | 2015 | Antiviral Research2015，，： | 1 |
| 7 | Enhanced protection against pulmonary mycobacterial challenge by chitosan-formulated polyepitope gene vaccine is associated with increased pulmonary secretory IgA and gamma-interferon+T cell responses显示文摘 | Wenqing Ai Yan Yue Sidong Xiong | 2013 | Microbiol Immunol2013，57，3： | 1 |
| 8 | The relationship between human cytomegalovirus infection and atherosclerosis development显示文摘 | Ruizhen Chen Sidong Xiong Yingzhen Yang Weiguo Fu Yuqi Wang Junbo Ge | 2003 | Molecular and Cellular Biochemistry (-)2003，，1： | 1 |
| 9 | Modulation of cellular immunity by antibodies against calreticulin显示文摘 | Xiang Qiu Chao Hong Zhaoyan Zhong Yue Li Tengteng Zhang Wanrong Bao Sidong Xiong Xiao‐Ming Gao | 2012 | Eur. J. Immunol2012，，9： | 1 |
| 10 | Differential impairment of regulatory T cells rather than effector T cells by paclitaxel-based chemotherapy显示文摘 | Lei Zhang Kamtai Dermawan Meilin Jin Rongjun Liu Huiru Zheng Lin Xu Yi Zhang Yuchan Cai Yiwei Chu Sidong Xiong | 2008 | Clinical Immunology2008，，： | 1 |
| 11 | In vivo delivery of interleukin-35 relieves coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells显示文摘 | Yadong Hu Chunsheng Dong Yan Yue Sidong Xiong | 2014 | Archives of Virology2014，，9： | 1 |
| 12 | B7-H4 is preferentially expressed in non-dividing brain tumor cells and in a subset of brain tumor stem-like cells显示文摘 | Yu Yao Xiaomei Wang Kunlin Jin Jianhong Zhu Yin Wang Sidong Xiong Ying Mao Liangfu Zhou | 2008 | Journal of Neuro - Oncology2008，，2： | 1 |
| 13 | C-reactive protein functions as a negative regulator of macrophage activation induced by apoptotic DNA显示文摘C-reactive protein(CRP),an acute-phase protein with an ability to bind to nuclear antigen,has been reported to regulate cytokine secretion and modulate immune responses.We previously reported that activated syngeneic lymphocyte-derived apoptotic DNA(apopDNA)could induce macrophage activation and contribute to the initiation and progression of lupus nephritis.It is reasonable to hypothesize that CRP might regulate apopDNA-induced macrophage activation.Herein,CRP was shown to promote macrophage-mediated apopDNA uptake by binding to apopDNA(CRP/apopDNA complex).Notably,CRP/apopDNA treatment inhibited the production of inflammatory cytokines and chemokines by macrophages which could be induced by apopDNA alone.Further coculture and transwell studies revealed that CRP/apopDNA-induced macrophages prohibited apopDNA-induced macrophage activation in an IL-10 dependent manner.These results provide insight into the potential mechanism of CRP regulatory activity in macrophage activation induced by apopDNA in the context of lupus nephritis and other autoimmune diseases. | Weijuan Zhang Yanxing Cai Wei Xu Sidong Xiong | 2011 | Protein & Cell2011，2，8： | 0 |
| 14 | A single dose of recombinant VSV-RABVG vaccine provides full protection against RABV challenge显示文摘Dear Editor,Rabies virus(RABV)is an enveloped,non-segmented,and singlestranded RNA virus that belongs to the genus Lyssavirus within the Rhabdoviridae family(Douglas et al.,2013).RABV causes rabies,and although vaccines are available,rabies continues to be a global public health concern causing more than 60,000 human deaths each year(WHO,2013).There is a high prevalence especially in developing countries in Asia and Africa(Hampson et al.,2015;Singh et al.,2017). | Minglong Liang Zongmei Wang Chuanjian Wu Sidong Xiong Ling Zhao Chunsheng Dong | 2022 | Virologica Sinica2022，37，3： | 0 |
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