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| 1 | Characterization and Use of Male Sterility in Hybrid Rice Breeding显示文摘引起那的杂交稻(Oryza sativa L.) 在导致的 the1970s 在中国被开始在米饭生产率的大改进。一般来说,它在超过 20% 增加谷物收益到生来的米饭变化,和现在杂交稻广泛地被介绍了进非洲,南部的亚洲和美洲。这些杂种品种通过也被产生三线的混合 andtwo 线混血儿系统;前者从细胞质雄性不育(厘米) 被导出,后者源于遗传因子的雄性不育性(公克) 。有厘米(HL, BT 和 WA ) 的三种主要类型和公克的二种类型(光周期敏感(PGMS ) 并且温度敏感(TGMS )) 。BT-typeCMS 和 HL-typeCMS 基因作为 orf79 和 orfH79 被描绘,它是妄想的有毒的基因导出的 frommitochondrial 重新整理。,为 CMS-WA 的 Rf3 位于染色体 1 Rf1, Rf4, Rf5 和 Rf6correspond 到 CMS-BT, CMS-WA 和 CMS-HL,在染色体 10 上定位了。为 BT 厘米的 Rf1 基因最近被克隆,并且编码指向线粒体的 PPR 蛋白质。PGMS 被认为被二后退的 loci 在染色体上控制 7 和 12,而九后退的等位基因为 TGMS 被识别了并且在不同染色体上印射。注意仍然着急地被需要解决雄性不育性的分子的复杂性帮助米饭繁殖…… | Shaoqing Li Daichang Yang Yingguo Zhu | 2007 | Journal of Integrative Plant Biology2007，49，6： | 33 |
| 2 | Fluorination vs. chlorination: a case study on high performance organic photovoltaic materials显示文摘Halogenation is a very efficient chemical modification method to tune the molecular energy levels, absorption spectra and molecular packing of organic semiconductors. Recently, in the field of organic solar cells(OSCs), both fluorine-and chlorinesubstituted photovoltaic materials, including donors and acceptors, demonstrated their great potentials in achieving high power conversion efficiencies(PCEs), raising a question that how to make a decision between fluorination and chlorination when designing materials. Herein, we systemically studied the impact of fluorination and chlorination on the properties of resulting donors(PBDB-T-2 F and PBDB-T-2 Cl) and acceptors(IT-4 F and IT-4 Cl). The results suggest that all the OSCs based on different donor and acceptor combinations can deliver good PCEs around 13%–14%. Chlorination is more effective than fluorination in downshifting the molecular energy levels and broadening the absorption spectra. The influence of chlorination and fluorination on the crystallinity of the resulting materials is dependent on their introduction positions. As chlorination has the advantage of easy synthesis, it is more attractive in designing low-cost photovoltaic materials and therefore may have more potential in largescale applications. | Yun Zhang Huifeng Yao Shaoqing Zhang Yunpeng Qin Jianqi Zhang Liyan Yang Wanning Li Zhixiang Wei Feng Gao Jianhui Hou | 2018 | Science China Chemistry2018，61，10： | 11 |
| 3 | Convergence of Y Chromosome STR Haplotypes from Different SNP Haplogroups Compromises Accuracy of Haplogroup Prediction显示文摘The paternally inherited Y chromosome has been widely used in forensics for personal identification,in anthropology and population genetics to understand origin and migration of human populations,and also in medical and clinical studies(Wang and Li,2013;Wang et al.,2014).There are two kinds of extremely useful markers in Y chromosome,single nucleotide polymorphism(SNP)and short tandem repeats(STRs). | Chuan-Chao Wang Ling-Xiang Wang Rukesh Shrestha Shaoqing Wen Manfei Zhang Xinzhu Tong Li Jin Hui Li | 2015 | Journal of Genetics and Genomics2015，42，7： | 8 |
| 4 | Y chromosomal clue successfully facilitated the arrest of Baiyin serial killer显示文摘The Baiyin serial murders,or called Gan-Meng 8.05 serial murders,has been considered to be the most infamous among the major criminal cases since 1949.Between May26,1988 and February 9,2002,11 women including an8-year-old girl were found gagged,raped,and murdered,often by slitting their throats,and some of their bodies were mutilated brutally,resembling the infamous‘‘Jack the Ripper’’killings that occurred in London more than one hundred years ago.Nine of these 11 murders took place | Hongbing Yao Shaoqing Wen Xinzhu Tong Boyan Zhou Panxin Du Meisen Shi Li Jin Hui Li | 2016 | Science Bulletin2016，61，22： | 8 |
| 5 | Geochemistry and genesis of authigenic pyrite from gas hydrate accumulation system in the Qilian Mountain permafrost, Qinghai, northwest China显示文摘A type of authigenic pyrites that fully fill or semi-fill the rock fractures of drillholes with gas hydrate anomalies are found in the Qilian Mountain permafrost; this type of pyrite is known as 'fracture-filling' pyrite. The occurrence of 'fracture-filling' pyrite has a certain similarity with that of the hydrate found in this region, and the pyrite is generally concentrated in the lower part of the hydrate layer or the hydrate anomaly layer. The morphology, trace elements, rare earth elements, and sulfur isotope analyses of samples from drillhole DK-6 indicate that the 'fracture-filling' pyrites are dominated by cubic ones mainly aligned in a step-like fashion along the surfaces of rock fractures and are associated with a circular structure, lower Co/Ni and Sr/Ba, lower ?REE, higher LREE, significant Eu negative anomalies, and ? 34 SCDT positive bias. In terms of the pyrites' unique crystal morphology and geochemical characteristics and their relationship with the hydrate layers or abnormal layers, they are closely related with the accumulation system of the gas hydrate in the Qilian Mountain permafrost. As climate change is an important factor in affecting the stability of the gas hydrate, formation of fracture-filling pyrites is most likely closely related to the secondary change of the metastable gas hydrate under the regional climate warming. The distribution intensity of these pyrites indicates that when the gas hydrate stability zone(GHSZ) is narrowing, the hydrate decomposition at the bottom of the GHSZ is stronger than that at the top of the GHSZ, whereas the hydrate decomposition within the GHSZ is relatively weak. Thus, the zone between the shallowest and the deepest distribution of the fracture-filling pyrite recorded the largest possible original GHSZ. | WANG PingKang ZHU YouHai LU ZhenQuan HUANG Xia PANG ShouJi ZHANG Shuai JIANG ShaoQing LI QingHai YANG KaiLi LI Bing | 2014 | Science China Earth Sciences2014，57，9： | 6 |
| 6 | In vitro differentiation of human adipose-derived mesenchymal stem cells into endothelial-like cells显示文摘The neovascularization of ischemic tis- sue is a crucial initial step for the functional rehabili- tation and wound healing. However, the short of seed cell candidate for the foundation of vascular network is still a big issue. Human adipose tissue derived mesenchymal stem cells (hADSCs), which possess multilineage potential, are capable of adipogenic, osteogenic, and chondrogenic differentiation. We examined whether this kind of stem cells could dif- ferentiate into endothelial-like cells and participate in blood vessel formation, and whether they could be used as an ideal cell source for therapeutic angio- genesis in ischemic diseases or vascularization of tissue constructs. The results showed that hADSCs, grown under appropriately induced conditions, dis- played characteristics similar to those of vessel en- dothelium. The differentiated cells expressed endo- thelial cell markers CD34 and vWF, and had high metabolism of acetylated low-density lipoprotein and prostacyclin. In addition, the induced cells were able to form tube-like structures when cultured on matrigel. Our data indicated that induced hADSCs could ex- hibit characteristics of endothelial cells. Therefore, these cells, as a source of human endothelial cells, may find many applications in such realms as engi- neering blood vessels, endothelial cell transplantation for myocardial regeneration, and induction of angio- genesis for treatment of regional ischemia. | GUAN Lidong LI Shaoqing WANG Yunfang YUE Huimin LIU Daqing HE Lijuan BAI Cixian YAN Fang NAN Xue SHI Shuangshuang PEI Xuetao | 2006 | Chinese Science Bulletin2006，51，15： | 6 |
| 7 | Effect of preoperative nutrition therapy type and duration on short-time outcomes in gastric cancer patient with gastric outlet obstruction显示文摘Objective:To avoid perioperative complications caused malnutrition,nutrition therapy is necessary in gastric outlet obstruction(GOO)patients.Compared to parenteral nutrition(PN),enteral nutrition(EN)is associated with many advantages.This study aimed to investigate whether preoperative EN has beneficial clinical effects compared to preoperative PN in gastric cancer patients with GOO undergoing surgery.Methods:According to the methods of preoperative nutrition therapy,143 patients were divided into EN group(n=42)and PN group(n=101)between January 2013 and December 2017 at the Chinese People’s Liberation Army General Hospital.Multiple logistic regression models were used to assess the association between the methods of preoperative nutrition therapy and postoperative day of flatus passage.The generalized additive model and twopiecewise linear regression model were used to calculate the inflection point of the preoperative nutritional therapy time on the postoperative day of flatus passage in the PN group.Results:EN shortened the postoperative day of flatus passage in gastric cancer patients with GOO,which is a protective factor,especially in patients who underwent non-radical operations and the postoperative day of flatus passage reduced when the preoperative PN therapy was up to 3 d and a longer PN therapy(>3 d)did not accelerate the postoperative recovery of gastrointestinal functions.Conclusions:Preoperative EN therapy would benefit gastric cancer patients with GOO by accelerating postoperative recovery.For patients with absolute obstruction,no more than 3-day PN therapy is recommended if patients can tolerate general anesthesia and surgery. | Jiyang Li Shaoqing Li Hongqing Xi Peifa Liu Wenquan Liang Yunhe Gao Chuang Wang Bo Wei Lin Chen Yun Tang Zhi Qiao | 2021 | Chinese Journal of Cancer Research2021，33，2： | 4 |
| 8 | An Examination of the Predictability of Tropical Cyclone Genesis in High-Resolution Coupled Models with Dynamically Downscaled Coupled Data Assimilation Initialization显示文摘Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically challenging.It requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses to local warm sea surface temperatures and feedbacks,with aid from coherent coupled initialization.This study uses three sets of highresolution regional coupled models(RCMs)covering the Asia−Pacific(AP)region initialized with local observations and dynamically downscaled coupled data assimilation to evaluate the predictability of TC genesis in the West Pacific.The APRCMs consist of three sets of high-resolution configurations of the Weather Research and Forecasting−Regional Ocean Model System(WRF-ROMS):27-km WRF with 9-km ROMS,and 9-km WRF with 3-km ROMS.In this study,a 9-km WRF with 9-km ROMS coupled model system is also used in a case test for the predictability of TC genesis.Since the local sea surface temperatures and wind shear conditions that favor TC formation are better resolved,the enhanced-resolution coupled model tends to improve the predictability of TC genesis,which could be further improved by improving planetary boundary layer physics,thus resolving better air−sea and air−land interactions. | Mingkui LI Shaoqing ZHANG Lixin WU Xiaopei LIN Ping CHANG Gohkan DANABASOGLU Zhiqiang WEI Xiaolin YU Huiqin HU Xiaohui MA Weiwei MA Haoran ZHAO Dongning JIA Xin LIU Kai MAO Youwei MA Yingjing JIANG Xue WANG Guangliang LIU Yuhu CHEN | 2020 | Advances in Atmospheric Sciences2020，37，9： | 4 |
| 9 | Characterization of a Novel Gain-of-Function Spotted-Leaf Mutant with Enhanced Disease Resistance in Rice显示文摘We here reported the identification and characterization of a novel gain-of-function spotted-leaf 26 (Spl26) mutant from an ethylmethylsulfone (EMS)-induced rice cultivar IR64. Spl26 displayed reddish- brown lesions that firstly appeared on the leaf tips at the early tillering stage and spread gradually downward to cover the whole leaf blades that wilted subsequently. The lesion development was light- dependent under natural conditions. Spl26 exhibited impaired photosynthetic capacity with decreased chlorophyll content and lowered photosynthetic parameters which ultimately led to the poor performance of agronomic traits. Severe cell death occurred in Spl26 in accompany with increased malonaldehyde level and membrane ion leakage rate, elevated reactive oxygen species (ROS) accumulation, altered ROS scavenging activities, increased DNA fragmentation and decreased soluble protein levels. Defense responses were activated in Spl26 with enhanced resistance to rice bacterial blight, up-regulation of defense response genes and altered endogenous hormone levels. The spotted-leaf phenotype is controlled by a single dominant nuclear gene localized to a 305 kb region between RM5490 and InDel42 on the short arm of chromosome 7. The data suggested that Spl26 is a novel gain-of-function spotted-leaf mutant with enhanced bacterial disease resistance and immunity-associated premature leaf senescence and would provide the basis for cloning of the target gene. | CHEN Ting CHEN Zheng Atul Prakash SATHE ZHANG Zhihong LI Liangjian SHANG Huihui TANG Shaoqing ZHANG Xiaobo WU Jianli | 2019 | Rice science2019，26，6： | 3 |
| 10 | Proliferation and differentiation into endothelial cells of human bone marrow mesenchymal stem cells (MSCs) on poly DL-lactic-co-glycolic acid (PLGA) films显示文摘The functional realization is the most important problem in vascular tissue engineering. The small-caliber blood vessel substitutes are prone to thrombi, which results in functional loss of blood vessels. However, this is probably due to the imper- fection of endothelial layer in the substitutes. In this study, MSCs were seeded on a series of porous PLGA films with various porosity and pore size made by sodium chloride (NaCl) particulate leaching, and cell proliferation on each film was inspected. The film made of the 75% (w/w) particulate proportion and 30―50 μm pore size maximized the proliferation rate and was chosen as the scaffolds for the differentia- tion of MSCs into endothelial cells. The induced cells expressed endothelial cells specific Flk-1, Ⅷ factor and CD34, possessed endothelial cells specific Weible-palade (W-P) body, and had the abilities of ingesting low density lipoprotein and secreting prostacyclin (PGI2). The results show that MSCs not only have the ideal biological compatibility with the porous PLGA films, but also have the potency of dif- ferentiating into functional endothelial cells, whichshould facilitate the endothelialization in vascular tissue engineering. | YUE Huimin ZHANG Lei WANG Yunfang LIANG Feng GUAN Lidong Li Shaoqing YAN Fang NAN Xue BAI Cixian LIN Feng YAN Yongnian PEI Xuetao | 2006 | Chinese Science Bulletin2006，51，11： | 3 |
| 11 | Research progress and prospects of coal petrology and coal quality in China显示文摘Clean utilization of coal depends on the quality of raw coal,which depends on the coal-forming parent materials(petrology and chemical composition of coal),the multiple media of the coal-forming environment,and some epigenetic conditions,such as thermal evolution(coalification),magmatic hydrothermal fluid,groundwater.Based on the research results of predecessors and prediction studies of coal resources since the founding of China,the present status of research on coal petrology,coal quality,coal metamorphism,and coal geochemistry in China is discussed in detail,with emphasis on research progress and the general situation of highly efficient and clean utilization of coal in the technical fields of coking,pyrolysis,combustion,gasification,and liquefaction,and the development prospects of coal petrology and coal quality in China are prospected. | Yuegang Tang Ruiqing Li Shaoqing Wang | 2020 | International Journal of Coal Science & Technology2020，7，2： | 3 |
| 12 | Alternate partial root-zone irrigation with high irrigation frequency improves root growth and reduces unproductive water loss by apple trees in arid north-west China显示文摘Alternate partial root-zone irrigation(APRI)can improve water use efficiency in arid areas. However,the effectiveness and outcomes of different frequencies of APRI on water uptake capacity and physiological water use have not been reported. A two-year field experiment was conducted with two irrigation amounts(400 and500 mm) and three irrigation methods(conventional irrigation, APRI with high and low frequencies). Root length density, stomatal conductance, photosynthetic rate,transpiration rate, leaf water use efficiency, midday stem and leaf water potentials were measured. The results show that in comparison with conventional irrigation, APRI with high frequency significantly increased root length density and decreased water potentials and stomatal conductance.No differences in the above indicators between the two APRI frequencies were detected. A significantly positive relationship between stomatal conductance and root length density was found under APRI. Overall, alternate partial root-zone irrigation with high frequency has a great potential to promote root growth, expand water uptake capacity and reduce unproductive water loss in the arid apple production area. | Shaoqing DU Ling TONG Shaozhong KANG Fusheng LI Taisheng DU Sien LI Risheng DING | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 2 |
| 13 | Defining reference genes for quantitative real-time PCR analysis of anther development in rice显示文摘量的即时聚合酶链反应(qPCR ) 是为基因 expressionanalysis 的最精确、广泛地使用的方法之一。然而,为正规化的引用基因的选择为 genomics 的基因 expression.As 开发的精确 quantification 是批评的,采矿大规模数据集象 microarray 和定序 RNA 那样数据成为新引用基因的新 approachfor 利用。在这研究,我们分析了包含不同纸巾和米饭花药和花粉的发展中的阶段的米饭花药和 167 microarraydatasets 的定序 RNA 数据集。我们选择了 5 参考基因,包括的 ACT1, eEF-1, GAPDH, Exp2,和 CCDC72 在以前的研究使用了的 12 候选人基因 andother,并且在八纸巾和花药 inrice 变化 9311 的不同发展阶段和 Yuetai 计算了他们的表达式。UPF3, eIF4A-3, GAPDH,和 PPP6 在米饭为花药开发的 qPCR 分析作为最合适的参考基因被识别。新候选人 referencegenes 比传统地使用的参考基因显示出更多的稳定的表示。这些结果在米饭花药为研究提供一套可靠 referencegenes 发展过程。 | Yanxiao Ji Ping Tu Kun Wang Feng Gao Weilong Yang Yingguo Zhu Shaoqing Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 2 |
| 14 | Identification of Chinese Materia Medicas in Microscopic Powder Images显示文摘This paper describes an identification system for Chinese Materia Medicas (CMMs) in microscopic powder images.The imaging processing of the microscopic powder image is very complex because of the low contrast,blurry boundaries,overlapping objects,and messy background.Therefore,the object detection must segment the significant microscopic structures from the complex image.The objects are detected in these images using an adaptable interactive method.After identifying the significant microscopic structures,the system identifies 14 features belonging to three main characteristics.These features form a 14-dimensional vector that represents the microscopic structures.The multi-dimensional vector is then analyzed using a feature assignment algorithm that picks the most notable features to construct a decision tree with thresholds.The identification system consists of a coarse classifier based on the decision tree and a fine classifier using similarity measurements to rank the possible results.Tests on 528 images from 24 different kinds of microscopic structures show the system effectiveness and applicability. | Shen Yan Yaoli Li Yixu Song Li Lin Peifa Jia Shaoqing Cai | 2012 | Tsinghua Science and Technology2012，17，2： | 2 |
| 15 | The HuaBiao project:whole-exome sequencing of 5000 Han Chinese individuals显示文摘Next-generation sequencing technologies have significantly accelerated the identification of disease-causing mutations and facilitated the emergence of personalized medicine(Genomes Project Consortium et al.,2015;Goodwin et al.,2016;Sirugo et al.,2019).In comparison with whole-genome sequencing,whole-exome sequencing(WES),which covers the coding regions of the genome,offers a cost-efficacy balance.WES provides deeper sequencing depth(>100)and allows the more accurate detection of rare variants that are tailored for clinical applications(Lek et al.,2016). | Meng Hao Weilin Pu Yi Li Shaoqing Wen Chang Sun Yanyun Ma Hongxiang Zheng Xingdong Chen Jingze Tan Guoqing Zhang Menghan Zhang Shuhua Xu Yi Wang Hui Li Jiucun Wang Li Jin | 2021 | Journal of Genetics and Genomics2021，48，11： | 2 |
| 16 | Management of extramedullary plasmacytoma: Role of radiotherapy and prognostic factor analysis in 55 patients显示文摘Objective: To investigate potential prognostic factors affecting patient outcomes and to evaluate the optimal methods and effects of radiotherapy(RT) in the management of extramedullary plasmacytoma(EMP).Methods: Data from 55 patients with EMP between November 1999 and August 2015 were collected. The median age was 51(range, 22–77) years. The median tumor size was 3.5(range, 1.0–15.0) cm. The median applied dose was 50.0(range, 30.0–70.0) Gy. Thirty-nine patients(70.9%) presented with disease in the head or neck region. Twelve patients received RT alone, 9 received surgery(S) alone, 3 received chemotherapy(CT) alone, and 3 patients did not receive any treatment. Combination therapies were applied in 28 patients.Results:The median follow-up duration was 56 months.The 5-year local recurrence-free survival(LRFS),multiple myeloma-free survival(MMFS),progression-free survival(PFS)and overall survival(OS)rates were 79.8%,78.6%,65.2% and 76.0%,respectively.Univariate analysis revealed that RT was a favourable factor for all examined endpoints.Furthermore,head and neck EMPs were associated with superior LRFS,MMFS and PFS.Tumor size<4 cm was associated with superior MMFS,PFS and OS;serum M protein negativity was associated with superior MMFS and PFS;age≥50 years and local recurrence were associated with poor MMFS.The dose≥45 Gy group exhibited superior 5-year LRFS,MMFS and PFS rates(94.7%,94.4%,90.0%,respectively),while the corresponding values for the dose<45 Gy group were 62.5%(P=0.008),53.3%(P=0.036)and 41.7%(P<0.001).Conclusions:Involved-site RT of at least 45 Gy should be considered for EMP.Furthermore,patients with head and neck EMP,tumor size<4 cm,age<50 years and serum M protein negativity had better outcomes. | Ge Wen Weihu Wang Yujing Zhang Shaoqing Niu Qiwen Li Yexiong Li | 2017 | Chinese Journal of Cancer Research2017，29，5： | 2 |
| 17 | MoO_(x) and V_(2)O_(x) as hole and electron transport layers through functionalized intercalation in normal and inverted organic optoelectronic devices显示文摘To achieve fabrication and cost competitiveness in organic optoelectronic devices that include organic solar cells(OSCs)and organic light-emitting diodes(OLEDs),it is desirable to have one type of material that can simultaneously function as both the electron and hole transport layers(ETLs and HTLs)of the organic devices in all device architectures(i.e.,normal and inverted architectures).We address this issue by proposing and demonstrating Cs-intercalated metal oxides(with various Cs mole ratios)as both the ETL and HTL of an organic optoelectronic device with normal and inverted device architectures.Our results demonstrate that the new approach works well for widely used transition metal oxides of molybdenum oxide(MoOx)and vanadium oxide(V_(2)O_(x)).Moreover,the Cs-intercalated metaloxide-based ETL and HTL can be easily formed under the conditions of a room temperature,water-free and solution-based process.These conditions favor practical applications of OSCs and OLEDs.Notably,with the analyses of the Kelvin Probe System,our approach of Cs-intercalated metal oxides with a wide mole ratio range of transition metals(Mo or V)/Cs from 1:0 to 1:0.75 can offer significant and continuous work function tuning as large as 1.31 eV for functioning as both an ETL and HTL.Consequently,our method of intercalated metal oxides can contribute to the emerging large-scale and low-cost organic optoelectronic devices. | Xinchen Li Fengxian Xie Shaoqing Zhang Jianhui Hou Wallace CH Choy | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 18 | Printable SnO2 cathode interlayer with up to 500 nm thickness-tolerance for high-performance and large-area organic solar cells显示文摘The printable electrode interlayer with excellent thickness tolerance is crucial for mass production of organic solar cells(OSCs)by solution-based print techniques. Herein, high-quality printable SnO2 films are simply fabricated by spin-coating or bladecoating the chemical precipitated SnO2 colloid precursor with post thermal annealing treatment. The SnO2 films possess outstanding optical and electrical properties, especially extreme thickness-insensitivity. The interfacial electron trap density of SnO2 cathode interlayers(CILs) are very low and show negligible increase as the thicknesses increase from 10 to 160 nm,resulting in slight change of the power conversion efficiencies(PCEs) of the PM6:Y6 based OSCs from 16.10% to 13.07%. For blade-coated SnO2 CIL, the PCE remains high up to 12.08% even the thickness of SnO2 CIL is high up to 530 nm. More strikingly, the large-area OSCs of 100 mm2 with printed SnO2 CILs obtain a high efficiency of 12.74%. To the best of our knowledge, this work presents the first example for the high-performance and large-area OSCs with the thickness-insensitive SnO2 CIL. | Yiming Bai Chunyan Zhao Shuai Zhang Shaoqing Zhang Runnan Yu Jianhui Hou Zhan’ao Tan Yongfang Li | 2020 | Science China Chemistry2020，63，7： | 2 |
| 19 | Road Performance,Thermal Conductivity,and Temperature Distribution of Steel Slag Rubber Asphalt Surface Layer显示文摘The use of steel slag,which is a by-product of the steel manufacture,in the construction of asphalt pavement would contribute to waste reduction and environment protection.Using rubber asphalt at the same time can improve the performance of asphalt mixture.This study investigates the influence of steel slag content on the road performance,thermal conductivity and outdoor temperature distribution of steel slag rubber asphalt mixtures(SSRAM),and calculates the cumulative stress in surface layer.At a certain range of concentration,the steel slag additive improved the deformation resistance and low-temperature cracking resistance of the mixtures.The SSRAM with 40%steel slag content has the best deformation resistance while SSRAM with 60%steel slag content performed well in low-temperature cracking resistance.The thermal conductivity of the SSRAM with different steel slag content(0%,20%,40%,60%,80%,and 100%)was 1.994,2.188,2.239,2.255,2.288,and 2.295 W/(m·K),respectively.Measurements of the outdoor temperature distribution further confirmed that steel slag increased the thermal conductivity of the mixtures,thereby increasing the cumulative temperature difference between the top and bottom layers.The temperature stress and temperature-stress ratio of the SSRAM with 40%steel slag were 0.43 MPa and 0.24,while the SSRAM with 100%steel slag were 0.58 MPa and 0.36.The stress and stress ratio were much higher in the SSRAM with 100%steel slag than in the specimen with 40%steel slag.Accordingly,the maximum accumulated temperature stress aggrandized and caused early temperature cracks in the surface layer.The optimum content of steel slag was 40%. | Zhiqiang Shu Jianmin Wu Shaoqing Li Bingbing Zhang Jianqi Yang | 2021 | Journal of Renewable Materials2021，9，2： | 1 |
| 20 | Effects of CS-1 on A431 cell proliferation, cell cycle, and epidermal growth factor receptor signal transduction显示文摘CS-1,有 C21H20O8N2S 的一个分子的公式的新碱,从繁体中文药被提取。以前的研究证明了 CS-1 能在 vivo 并且在 vitro 禁止几个人的癌房间的增长。这研究的目的是在在人的 A431 细胞线表明小径的表皮的生长因素受体(EGFR ) 调查反肿瘤效果和 CS-1 的机制。通过 sulforhodamine B 试金,我们发现 CS-1 在集中依赖者和时间依赖者礼貌禁止了 A431 房间增长。禁止的率在孵化的 24 h 以后从 14.5% ~ 87.8%。高满意的屏蔽(HCS ) 多参数 cytotoxicity 分析证明在高集中的 CS-1 有从房间 permeabilization 和细微减小导致了全部的 mitochondrial 质量的细微 cytotoxicity,而在原子核尺寸 / 形态学和 lysosomal mass-pH 的变化都没被发现。CS-1 的 cytotoxicity 不是为它的 anti-proliferative 效果的一个主要原因。房间周期分析显示 CS-1 在一个时间依赖者在 A431 房间导致了 G1 阶段拘捕在高集中(2.5 M ) 的举止,和 S 阶段在低集中(0.625 M ) 逮捕。HCS 试金也证明 CS-1 能禁止 EGFR 成为主观,到原子核的 extracellular-signal-regulated kinase (英皇家空军之阶级最低之兵)/mitogen-activated 蛋白质 kinase translocation, phosphorylated 蛋白质 kinase B (Akt ) 的累积,信号变换器和抄写 3 的使活跃之物(STAT3 ) ,并且在原子核的 cyclin D1。这些结果被西方的污点分析证实。CS-1 可能禁止表皮的生长因素绑定到它的受体,导致 phosphorylated 的累积的抑制英皇家空军之阶级最低之兵和 Akt,和在原子核的 STAT3,并且在 G1/S 影响 cyclin D1 和细胞周期拘捕的抄写阶段。 | Haiyan Du Bo Xu Caixia WU Min Li Fuxiang Ran Shaoqing Cai Jingrong Cui | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 1 |
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