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| 1 | PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma(PDAC),and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC显示文摘High expression of PD-L1 marks the poor prognosis of pancreatic ductal adenocarcinomas(PDAC).However,the regulatory mechanism of PD-L1 remains elusive.We recently reported that cancer Forkhead box protein 3(Cancer-FOXP3 or C-FOXP3)promoted immune evasion of PDAC by recruiting Treg cells into PDAC via upregulation of CCL5.In this study,we confirmed that PD-L1 was overexpressed in PDAC samples from two independent cohorts of patients with radical resection.Moreover,C-FOXP3 was colocalized and correlated with the expression of PD-L1 in tumor cells at the mRNA and protein levels,and this finding was confirmed by the The Cancer Genome Atlas(TCGA)database.Chromatin immunoprecipitation(ChIP)revealed that C-FOXP3 directly bound to the promoter region of PD-L1 in pancreatic cancer cells.Furthermore,overexpression of C-FOXP3 activated the luciferase reporter gene under the control of the PD-L1 promoter.However,mutation of the binding motif-a completely reversed the luciferase activity.In addition,C-FOXP3-induced upregulation of PD-L1 effectively inhibited the activity of CD8+T cells.Based on our recent finding that the CCL-5 antibody achieved a better response to PDAC models with high C-FOXP3 levels,we further demonstrated that the PD-L1 antibody strengthened the antitumor effect of CCL-5 blockade in xenograft and orthotopic mouse models with high C-FOXP3 levels.In conclusion,C-FOXP3 directly activates PD-L1 and represents a core transcription factor that mediates the immune escape of PDAC.Combined blockade of PD-L1 and CCL-5 may provide an effective therapy for patients with PDAC that have high C-FOXP3 levels. | Xiuchao Wang Xin Li Xunbin Wei Haiping Jiang Chungen Lan Shengyu Yang Han Wang Yanhui Yang Caijuan Tian Zanmei Xu Jiangyan Zhang Jihui Hao He Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 11 |
| 2 | A new combined criterion to better predict malignant lesions in patients with pancreatic cystic neoplasms显示文摘Objective:Cystic lesions of the pancreas have been increasingly recognized.Some lesions exhibit benign behavior,while others have unequivocal malignant potential.Thus,accurate identification of malignancy in patients diagnosed with pancreatic cystic neoplasms(PCNs)remains a major challenge.The aim of this study was to define a combined criterion to better predict malignant lesions in patients with PCNs.Methods:We retrospectively analyzed 165 patients who underwent resection of PCNs from October 2011 to May 2017.The relationship among malignancy and serum carbohydrate antigen 19-9(CA19-9),preoperative neutrophil-to-lymphocyte ratio(NLR),and the presence of enhanced solid component on imaging was analyzed.Results:NLR before surgery in patients with malignant PCNs(2.81±2.14)was significantly higher than that in patients diagnosed with pancreatic neuroendocrine tumor(1.90±0.69,P=0.013)or healthy volunteers(1.40±0.48;P<0.001).Serum CA19-9≥39U/m L,NLR>1.976 and presence of enhanced solid component were independent predictors of PCN malignancy.A combined criterion meeting any two or more of the three elements including CA19-9≥39 U/m L,NLR>1.976,and presence of enhanced solid component on computed tomography imaging is an indicator with a high positive predictive value of 80.5%and a high negative predictive value of 87.9%,and thus,represents a highly accurate test(86.1%).Conclusions:The new combined criterion is an effective predictor of tumor malignancy in patients with PCNs. | Chungen Lan Xin Li Xiuchao Wang Jihui Hao He Ren | 2018 | Cancer Biology & Medicine2018，15，1： | 6 |
| 3 | Outburst Risk of Barrier Lakes in Sichuan,China显示文摘34 barrier lakes induced by earthquake have been formed by wedged debris on the river channels after a massive earthquake happening on May 12 in Sichuan, China. Among them, the Tangjiashan Barrier Lake is the largest one. It faces very urgent risk of dam breaking when water level reaches the top and begins overflow in case of storm rainfalls and continually aftershocks, threatening already devastated cities and villages with about 1.5 million people downstream. The outburst of a similar barrier lake occurred in the Minjiang River in 1933, causing a catastrophic flood. Risk analysis indicates that not all barrier lakes are highly dangerous. Only those lakes with very high dams and water to be filled up in short period need to be dealt with immediately. | CHENG Genwei WANG Xiaodan HE Xiubin FAN Jihui FAN Jianrong | 2008 | Journal of Mountain Science2008，5，3： | 4 |
| 4 | Long-period Gratings in-situ Sensing for Flow Monitoring in Liquid Composite Molding显示文摘Liquid composite moulding (LCM) processes are used to manufacture high quality and complex-shaped composite parts in the automotive, marine, aerospace and civil industries. On-line sensing plays an important role in controlling the quality of the final product in the LCM manufacturing environment. The long-period fiber grating (LPG)technology, a new real-time fiber optic sensor system, was developed to monitor the flow front progression. The sensor operation and characterization under various process conditions were discussed in detail. The experimental results showed that LPG sensors were robust and reliable to detect the arrival of resin at pre-selected locations in structures with low-medium fiber volume fraction; however were limited at different depths in structures with high fiber volume fraction. | Yingdan ZHU, Chang WANG, Jihui WANG, Wei HE and Guoqiang GAO State Key Laboratory of Advanced Technology for Materials Synthesis and Proceeding, Wuhan University of Technology, Wuhan 430070, China | 2005 | Journal of Materials Science & Technology2005，21，2： | 3 |
| 5 | Novel nanometer scaffolds regulate the biological behaviors of neural stem cells显示文摘Ideal tissue-engineered scaffold materials regulate proliferation, apoptosis and differentiation of cells seeded on them by regulating gene expression. In this study, aligned and randomly oriented collagen nanofiber scaffolds were prepared using electronic spinning technology. Their diameters and appearance reached the standards of tissue-engineered nanometer scaffolds. The nanofiber scaffolds were characterized by a high swelling ratio, high porosity and good mechanical properties. The proliferation of spinal cord-derived neural stem cells on novel nanofiber scaffolds was obviously enhanced. The proportions of cells in the S and G 2 /M phases noticeably increased. Moreover, the proliferation rate of neural stem cells on the aligned collagen nanofiber scaffolds was high. The expression levels of cyclin D1 and cyclin-dependent kinase 2 were increased. Bcl-2 expression was significantly increased, but Bax and caspase-3 gene expressions were obviously decreased. There was no significant difference in the differentiation of neural stem cells into neurons on aligned and randomly oriented collagen nanofiber scaffolds. These results indicate that novel nanofiber scaffolds could promote the proliferation of spinal cord-derived neural stem cells and inhibit apoptosis without inducing differentiation. Nanofiber scaffolds regulate apoptosis and proliferation in neural stem cells by altering gene expression. | Jihui Zhou Fuge Sui Meng Yao Yansong Wang Yugang Liu Feipeng Tian Qiang Li Xiaofeng He Lin Shao Zhiqiang Liu | 2013 | Neural Regeneration Research2013，8，16： | 2 |
| 6 | Study on surface modification of uhrafine inorganic antibacterial particles 显示文摘 | HE Jihui MA Wenshi TAN Shaozao | 2005 | Appl Surf Sci2005，241，34： | 1 |
| 7 | Structure and technology character of robot automation stamping production line 显示文摘 | He Ruilin Liu Jihui Miao Jinzhong | 2012 | Ma- chinist Metal Forming2012，，5： | 1 |
| 8 | Performance evaluation of CCD imaging systems with the square integral method based on MRC显示文摘 | Wang Jihui Jin Weiqi He Yuqing | 2007 | SPIE2007，6621，66： | 1 |
| 9 | Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells显示文摘 | He Ren Lingling Jia Tiansuo Zhao Huan Zhang Jing Chen Shaoguang Yang Jingcheng Liu Ming Yu Jihui Hao | 2014 | Cancer Letters2014，，1： | 1 |
| 10 | Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells显示文摘 | He Ren Tiansuo Zhao Xiuchao Wang Chuntao Gao Jian Wang Ming Yu Jihui Hao | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 1 |
| 11 | Study on flame-retardant mechanism of polycarbonate containing sulfonate-silsesquioxane-fluoro retardants by TGA and FTIR显示文摘 | Shumei Liu Hua Ye Yongsheng Zhou Jihui He Zhijie Jiang Jianqing Zhao Xianbo Huang | 2005 | Polymer Degradation and Stability2005，，8： | 1 |
| 12 | Environment-friendly preparation of exfoliated graphite and functional graphite sheets显示文摘Exfoliated graphite(EG)is promising oil sorbent as well as an intermediate product for the preparation of flexible graphite films(FGFs).It has been a critical challenge to energy conservation and pollution abatement for the traditional EG production technique.Here,we propose a simple and effective preparation method to acquire EG in which flake graphite is intercalated and exfoliated at room temperature,not involving any pollutant emission.The influence factors in the preparation process were explored,such as the amount of H_(2)SO_(4)and H_(2)O_(2),the temperature for the preparation of room temperature exfoliated graphite(RTEG).In contrast to the EG by high temperature exfoliation(HTEG),RTEG exhibits a homogeneous structure and a significantly increased volume and surface area.Moreover,EG blocks with high oil sorption capacity and excellent reuse performance can be obtained by RTEG method.Especially,FGFs fabricated by RTEG has high flexibility,thermal conductivity and electrical conductivity.It suggests that this environment-friendly technology is suitable for large-scale industrial implementation of graphite-based oil sorbents and flexible materials. | Shiyu Hou Shuaijie He Tianle Zhu Jihui Li Liqiang Ma Hongda Du Wanci Shen Feiyu Kang Zheng-Hong Huang | 2021 | Journal of Materiomics2021，7，1： | 0 |
| 13 | Research on the microstructural refinement of sulfur in medium carbon microalloyed steel显示文摘Continuous rolling techniques were used in this study to produce steel with a medium level of carbon but a high level of sulfur.Controlled rolling techniques were used to control the shape of sulfide.The effect of sulfide on the microstructure of steel was also investigated in this study.The size and distribution of sulfide are determined through the use of an image analyzer and the statistics of the products & service solution(SPSS) software.A comparison between the microstructures of normalized and quenched steel reveals that sulfide can pin the boundaries of the austenite grain boundary and refine the microstructure of the austenite grain.It also reveals that the size relationship between sulfide and austenite grain satisfies the Zener equation. | Yang Weining Guo Jihui He Qunxiong | 2008 | Baosteel Technical Research2008，2，4： | 0 |
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