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| 1 | Therapeutic potential of targeting the renin angiotensin system in portal hypertension显示文摘Portal hypertension is responsible for the bulk of the morbidity and mortality in patients with cirrhosis.Drug therapy to reduce portal pressure involves targeting two vascular beds.The first approach is to reduce intra hepatic vascular tone induced by the activity of powerful vasocontrictors such as angiotensin Ⅱ,endothelin-1 and the sympathetic system and mediated via contraction of perisinusoidal myofibroblasts and pervascular smooth muscle cells.The second approach is to reduce mesenteric and portal blood flow.Non-selective b-blockers are widely used and have been shown to prolong patient survival and reduce oesophageal variceal bleeding in advanced cirrhosis.However many patients are unable to tolerate these drugs and they are ineffective in a significant proportion of patients.Unfortunately there are no other drug therapies that have proven efficacy in the treatment of portal hypertension and prevention of variceal bleeding.This review briefly outlines current therapeutic approaches to themanagement of portal hypertension,and the evidence supporting the role of the renin angiotensin system(RAS) and the use of RAS blockers in this condition.It will also outline recent advances in RAS research that could lead to the development of new treatments focusing in particular on the recently discovered 'alternate axis' of the RAS. | Chandana B Herath Josephine A Grace Peter W Angus | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 9 |
| 2 | Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases显示文摘BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2 is extensively expressed during development and is upregulated at sites of tissue damage,inflammation,and in stromal cells of metastatic tumors.MMP-7 is expressed in the epithelial cells and in a variety of cancers including colon tumors.Plasma MMP-2 and MMP-7 levels were assessed before and after minimally invasive colorectal resection for cancer pathology.AIM To determine plasma MMP-2 and MMP-7 levels before and after minimally invasive colorectal resection for cancer pathology.METHODS Patients enrolled in a plasma bank for whom plasma was available were eligible.Plasma obtained from preoperative(Preop)and postoperative blood samples was used.Only colorectal cancer(CRC)patients who underwent elective minimally invasive cancer resection with preop,post-operative day(POD)1,3 and at least 1 late postop sample(POD 7-34)were included.Late samples were bundled into 7 d blocks(POD 7-13,14-20,etc.)and treated as single time points.Plasma MMP-2 and MMP-7 levels were determined via enzyme-linked immunosorbent assay in duplicate.RESULTS Total 88 minimally invasive CRC resection CRC patients were studied(right colectomy,37%;sigmoid,24%;and LAR/AR 18%).Cancer stages were:1,31%;2,30%;3,34%;and 4,5%.Mean Preop MMP-2 plasma level(ng/mL)was 179.3±40.9(n=88).Elevated mean levels were noted on POD1(214.3±51.2,n=87,P<0.001),POD3(258.0±63.9,n=80,P<0.001),POD7-13(229.9±62.3,n=65,P<0.001),POD 14-20(234.9±47.5,n=25,P<0.001),POD 21-27(237.0±63.5,n=17,P<0.001,)and POD 28-34(255.4±59.7,n=15,P<0.001).Mean Preop MMP-7 level was 3.9±1.9(n=88).No significant differences were noted on POD 1 or 3,however,significantly elevated levels were noted on POD 7-13(5.7±2.5,n=65,P<0.001),POD 14-20(5.9±2.5,n=25,P<0.001),POD 21-27(6.1±3.6,n=17,P=0.002)and on POD 28-34(6.8±3.3,n=15 P<0.001,)vs preop levels.CONCLUSION MMP-2 levels are elevated for 5 wk and MMP-7 levels elevated for weeks 2-6.The etiology of these changes in unclear,trauma and wound healing likely play a role.These changes may promote residual tumor growth and metastasis. | HMC Shantha Kumara Hiromichi Miyagaki Sajith A Herath Erica Pettke Xiaohong Yan Vesna Cekic Richard L Whelan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 3 | Antifungal constituent from Gordonia dassanayakei显示文摘 | Athukoralage P S Herath H M T B Deraniyagala S A | 2001 | Fitoterapia2001，72，5： | 1 |
| 4 | Physiology of yield determination of rice under elevated carbon dioxide at high temperatures in a subhumid tropical climate显示文摘 | De Costa W A J M Weerakoon W M W Herath H M L K | | 0，，01： | 1 |
| 5 | Prediction of resilient modulus of cohesive subgrade soilsfrom dynamic cone penetrometer test parameters显示文摘 | Mohammad L N Herath A Abu-Farsakh M Y | 2007 | Journal of Materials in Civil Engineering2007，19，11： | 1 |
| 6 | Diterpenoid,steroid,and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources显示文摘 | Jayasuriya H Herath KB Ondeyka JG Guan Z Borris RP Tiwari S de Jong W Chavez F Moss J Stevenson DW Beck HT Slattery M Zamora N Schulman M Ali A Sharma N MacNaul K Hayes N Menke JG Singh SB | | 0，，08： | 1 |
| 7 | Latest trends and issues in the ASP service market显示文摘 | Gupta A Herath S K | 2005 | Industrial management & data systems2005，105，1： | 1 |
| 8 | Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis显示文摘 | Herath C B Warner F J Lubel J S Dean R G Jia Z Lew R A | 2007 | J Hepatol2007，47，： | 1 |
| 9 | Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection显示文摘AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC resection.METHODS: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P < 0.001 for all). CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis. | HMC Shantha Kumara Elizabeth A Myers Sonali AC Herath Joon Ho Jang Linda Njoh Xiaohong Yan Daniel Kirchoff Vesna Cekic Martin Luchtefeld Richard L Whelan | 2014 | World Journal of Gastrointestinal Oncology2014，6，10： | 1 |
| 10 | Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy 显示文摘 | AMACHER D E ADLER R HERATH A | 2005 | Clin Chem2005，51，10： | 1 |
| 11 | Nine bisbenzylisoquinoline alkaloids from Thalictrum cultratum显示文摘 | Wasala H M W Herath S F Hussain A J | 1987 | J Nat Prod1987，50，4： | 1 |
| 12 | Guttiferone I,a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand显示文摘 | Herath K Jayasuriya H Ondeyka JG Guan Z Borris RP Stijfhoorn E Stevenson D Wang J Sharma N Macnaul K Menke JG Ali A Schulman MJ Singh SB | | 0，，04： | 1 |
| 13 | Use of proteomicmethods to identify serum biomarkers associated with rat liver toxici-ty or hypertrophy显示文摘 | AMACHER DE ADLER R HERATH A | 2005 | Clin Chem2005，51，10： | 1 |
| 14 | Evaluation of Resilient Modulus of Subgrade Soil by Cone Penetration Test显示文摘 | Mohammad L N Titi H H Herath A | 1999 | Transportation Research Record1999，1，1652： | 1 |
| 15 | Tobacco use and oral hygiene as risk indieators for Peri- odoniitis 显示文摘 | ALNARASENA N EKANAYAKA A N HERATH L | 2002 | Conununity Dent Oral Epidemiol2002，30，2： | 1 |
| 16 | Use of pro- teomie methods to identify serum biomarkers associated with ratliver toxicity or hypertrophy 显示文摘 | AMACHER DE ADLER R HERATH A | 2005 | Clin Chem2005，51，10： | 1 |
| 17 | Retinal injury by industrial laser burn显示文摘 | Scollo P Herath G Lobo A | 2014 | Occup Med(Lond)2014，64，3： | 1 |
| 18 | Latest trends and issues in the ASP service market显示文摘 | GUPTA A HERATH S K | 2005 | Industrial Management & Data Systems2005，105，1： | 1 |
| 19 | Isoflavonoids and a pterocarpan from Gliricidia sepium显示文摘 | Herath H M T B Dassanyake R S Priyadarshani A M A | 1998 | Phytochemistry1998，47，1： | 1 |
| 20 | Multifractal modelling and simulation of rain fields exhibiting spatial heterogeneity 显示文摘 | Pathirana A Herath S | 2002 | Hydrology and Earth System Sciences2002，6，4： | 1 |
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