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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | A prospective,randomized trial comparing conventional transurethral prostate resection with plasmakinetic vaporization of the prostate: physiological changes,early complications and long term followup 显示文摘 | Hon NH Brathwaite D Hussain Z | 2006 | J Urol2006，176，1： | 1 |
| 3 | Immunolocalization of antifreeze proteins in winter rye leaves,crown,and root by tissue printing显示文摘 | ANTIKAINEN M GRIFFITH M ZHANG J HON W C YANG D PIHAKASKI-MAUNSBACH K | 1996 | Plant Physiol1996，110，： | 1 |
| 4 | Tillage-induced seasonal changes in soil physical properties affecting soil CO2 evolution under intensive cropping 显示文摘 | Franzluebbers A J Hons F M Zuberer D A | 1995 | Soil and Tillage Research1995，34，1： | 1 |
| 5 | Soil organic carbon,microbial biomass,and mineralizable carbon and nitrogen in sorghum显示文摘 | FRANZLUEBBERS A J HONS F M ZUBERER D A | 1995 | Soil Science of America Journal1995，，59： | 1 |
| 6 | Tillage-induced seasonal changes in soil physical properties affecting soil CO2 evolution under intensive cropping显示文摘 | Franzluebbers A J Hons F M Zuberer D A | 1995 | Soil & Tillage Research1995，34，： | 1 |
| 7 | PHDD,Depression,and Quality of Life:A population study显示文摘 | Goldney Robert D MD Phillips Pat J MA Fisher Laura J BA HONS | 2004 | Diabetes Care2004，27，5： | 1 |
| 8 | Tillage and crop effects on seasonal dynamics of soil CO2 evolution,water content,temperature,and bulk density显示文摘 | Franzluebbers A J Hons F M Zuberer D A | 1995 | Applied Soil Ecology1995，2，： | 1 |
| 9 | Photodegradation and photoprotection of wood surface显示文摘 | CHANG S T HON D N S FEIST W C | 1982 | Wood and Fiber Science1982，14，2： | 1 |
| 10 | Mechanochemical process in cotton cellulose fiber显示文摘 | HON D N S SRINIVASAN K S V | 1983 | Journal of Applied Polymer Science1983，28，1： | 1 |
| 11 | Chemistry of Weathering and Protection Rowell RM显示文摘 | HON D N S | 1984 | Chemistry of Solid Wood1984，，： | 1 |
| 12 | Proactive personality and employee creativity: the effects of job creativity require- ment and supervisor support for creativity 显示文摘 | KIM T Y HON A H Y LEE D R | 2010 | Creativity Research Journal2010，22，1： | 1 |
| 13 | A prospective,randomized trial comparing conventional transurethral prostate resection with plasma kinetic vaporization of the prostate:physiological changes,early complications and long-term followup显示文摘 | Hon NH Brathwaite D Hussain Z | 2006 | J Urol2006，176，1： | 1 |
| 14 | Evaluation of microcrystalline cellulose I Changes in ultra-structural characteristics during preliminary acid hydrolysis显示文摘 | Tang L G Hon D N S Pan S H | 1998 | Journal of Apply Polymer Science1998，59，3： | 1 |
| 15 | Tillage induced seasonal changes in soil physical properties affecting soil CO2 evolution under intensive cropping 显示文摘 | FRANZLUEBBERS A J HONS F M ZUBERER D A | 1995 | Soil and Tillage Research1995，34，： | 1 |
| 16 | Seasonal changes in soil microbial biomass and mineralizable C and N in wheat management systems显示文摘 | Franzluebbers A J Hons F M Zubere D A | 1994 | Soil Biology and Biochemistry1994，26，11： | 1 |
| 17 | A prospective,randomized trial comparing conventional transurethral prostateresection with plasmagAnetic vaporization of the prostate:physiological chan ges,early complicadom and long-term followup显示文摘 | Hon NH Brathwaite D Hussain Z | 2006 | J Urol2006，176，1： | 1 |
| 18 | Five-year telbivudine treatment with effective viral suppression results in resolution ofliver inflammation and fibrosis regression in patients with chronic hepatitis b显示文摘 | Hon J Xu D Shi G et a! | | J Hepatol0，54，： | 1 |
| 19 | Assembly and characterization of colloid-based antireflective coatings on multicrystalline silicon solar cells显示文摘 | B G Prevo E W Hon O D Velev | 2007 | J Mater Chem2007，17，8： | 1 |
| 20 | 显示文摘 | Tang L G Hon D N S Pan S H | 1996 | J Appl Polymer Sci1996，59，： | 1 |
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