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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis显示文摘瞄准:门静脉高血压是肝肝硬化的普通复杂并发症。肝内压力能以几个方法被提高。从内脏的内脏影响脉管系统, vasoconstrictors 的增加和增加的循环进门静脉系统的反常建筑学都可以作出贡献。因而内长的血管扩张药也许能减轻高血压。我们因此试图调查内长的血管扩张药的层次,氮的氧化物(没有) 并且通过氮的氧化物 synthase (NOS ) 的表示的一氧化碳(公司) 并且他我氧合酶(惊讶) 。方法:肝脏硬化症(n=20 ) 并且非肝脏硬化症(n=20 ) 肝从经历了外科的病人被获得。NOS 的各种各样的 isoforms 的 mRNA 和蛋白质表情并且惊讶用竞争 PCR,西方的污点和免疫组织化学被检验。结果:当内皮 NOS (eNOS ) 在硬变肝是起来调整的时,在可诱导的 NOS (i NOS ) 或神经元 NOS (nNOS ) 表情没有重要变化。附随地, caveolin-1, eNOS 的一个确定的下面管理者,是起来调整的。可诱导的 HO-1 和组成的 HO-2 被发现在不同本地化在硬变肝虽然显示出增加的表示。结论:NOS 表示力量的差别由于他们在在肝硬化的病理维持肝动态平衡或参与的不同角色。在高血压的肝以内的纯粹的应力可以导致 eNOS 的增加的表示。接着, caveolin-1 也被增加。这是否对进一步的肝硬化用作一个防御机理或是肝硬化的后果,是还未知的。HO-1 和 HO-2 的提高的表示建议公司可以微弱地作为血管扩张药虽然在它的角色补偿。它是可能的那个公司并且不在肝以内有平行或协调的功能并且可以在门静脉高血压的病理生理学反对地工作。 | Beatrice J Goh Bee Tee Tan Wei Min Hon Kang Hoe Lee Hoon Eng Khoo | 2006 | World Journal of Gastroenterology2006，12，4： | 19 |
| 3 | T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis显示文摘AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODS Magnetic resonance(MR) images were acquired from5 subjects scheduled for total knee arthroplasty(TKA)(mean age 70 years) and 20 young healthy control subjects without knee pain(mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained.Following TKA each condyle was divided into 4 parts(distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens(bone and cartilage blocks) were examined. For each joint,the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system.In magnetic resonance imaging(MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTS Eleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis(OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461;medial posterior condyle(MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550],suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage.Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA(P= 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients. CONCLUSION Though cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques. | Benjamin S Kester Philip M Carpenter Hon J Yu Taiki Nozaki Yasuhito Kaneko Hiroshi Yoshioka Ran Schwarzkopf | 2017 | World Journal of Orthopedics2017，8，4： | 12 |
| 4 | Proactive personality, employee creativity, and newcomer outcomes : a longitudinal study显示文摘 | KIM T-Y HON A H CRANT J M | 2009 | Journal of Business and Psychology2009，24，1： | 1 |
| 5 | Experimental investigation into the selective laser sintering of silicon carbide polyamide composites显示文摘 | GILL T J HON K K B | 2004 | Proceedings of Institution of Mechanical Engineering2004，218，： | 1 |
| 6 | Immunolocalization of antifreeze proteins in winter rye leaves,crown,and root by tissue printing显示文摘 | ANTIKAINEN M GRIFFITH M ZHANG J HON W C YANG D PIHAKASKI-MAUNSBACH K | 1996 | Plant Physiol1996，110，： | 1 |
| 7 | Inverse heat conduction problems by meshless local Petrov-Galerkin method显示文摘 | Sladek J Sladek V Hon Y C | 2006 | Engineering Analysis with Boundary Elements2006，30，8： | 1 |
| 8 | Tillage-induced seasonal changes in soil physical properties affecting soil CO2 evolution under intensive cropping 显示文摘 | Franzluebbers A J Hons F M Zuberer D A | 1995 | Soil and Tillage Research1995，34，1： | 1 |
| 9 | Tillage impacts on microbial biomass and soil carbon and nitrogen dynamics of corn and cotton rotations显示文摘 | Wright A L Hons F M Matocha J E Jr | 2005 | Appl Soil Ecol2005，29，1： | 1 |
| 10 | Soil C extracted with water or K2 SO4 : pH effect on determination of microbial biomass 显示文摘 | HANEY R L FRANZLUEBBERS A J HONS F M | 1999 | Canadian Journal of Soil Science1999，79，4： | 1 |
| 11 | The growth and characteristics of CVD SiC-TiC in-situ composites显示文摘 | LIN T T CHANG J F HON M H | 1998 | Ceramics International1998，24，： | 1 |
| 12 | On-line evidence for spontaneous trait inferences at encoding显示文摘 | Uleman James S Hon Alex Roman Robert J Moskowitz Gordon B | 1996 | Personality and Social Psychology Bulletin1996，22，4： | 1 |
| 13 | Soil organic carbon,microbial biomass,and mineralizable carbon and nitrogen in sorghum显示文摘 | FRANZLUEBBERS A J HONS F M ZUBERER D A | 1995 | Soil Science of America Journal1995，，59： | 1 |
| 14 | Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy:a pooled analysis of two randomized ,controlled clinical trials显示文摘 | Major P Lortholary A Hon J | 2001 | J Clin Oncol2001，19，： | 1 |
| 15 | WebLogo: a sequence logo generator 显示文摘 | CROOKS G E HON G CHANDONIA J M | 2004 | Genome Research2004，14，6： | 1 |
| 16 | Determination of Thin Film Hardness for a Film/Substrate System 显示文摘 | Wang H L Chiang M J Hon M H | 2001 | Ceramics International2001，27，4： | 1 |
| 17 | Numerical computation of a cauchy problem for laplace' s equation显示文摘 | CHENG J HON Y C WEI T | 2001 | ZAMM Z Angew Math Mech2001，81，4： | 1 |
| 18 | Circumventing the ill-conditioningproblem with multiquadratic radial basis functions:applications to elliptic partial differential equations显示文摘 | KANSA E J HON Y C | 2000 | Comput Math Appl2000，39，78： | 1 |
| 19 | Reconstruction of high order derivatives from input data 显示文摘 | Wang Y B Hon Y C Cheng J | 2006 | Journal of Inverse and Ill-posed Problems2006，，02： | 1 |
| 20 | Papillary thyroid carcinoma with BRAFV600E mutation: sonographic prediction显示文摘 | Hwang J Shin JH Hon BK et at | 2010 | AJR Am J Roentgenol2010，194，5： | 1 |
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