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| 1 | Enhanced antitumor efficacy on hepatoma-bearing rats with adriamycin-loaded nanoparticles administered into hepatic artery显示文摘AIM: To investigate the antitumor activity of adriamycin (ADR) encapsulated in nanoparticles (NADR) and injected into the hepatic artery of hepatoma-bearing rats.METHODS: NADR was prepared by the interfacial polymerization method. Walker-256 carcinosarcomas were surgically implanted into the left liver lobes of 60 male Wistar rats, which were divided into 4 groups at random (15 rats per group). On the 7th day after implantation, normal saline (NS), free ADR (FADR), NADR, or ADR mixed with unloaded nanoparticles (ADR+NP) was respectively injected via the hepatic artery (i.a.) of rats in different groups. The dose of ADR in each formulation was 2.0 mg/kg body weight and the concentration was 1.0 mg/mL. Survival time, tumor enlargement ratio, and tumor necrosis degree were compared between each group.RESULTS: Compared with the rats that received NS i.a.,the rats that received FADR or ADR+NP acquired apparent inhibition on tumor growth, as well as prolonged their life span. Further significant anticancer efficacy was observed in rats that received i.a. administration of NADR. Statistics indicated that NADR brought on a more significant tumor inhibition and more extensive tumor necrosis, as compared to FADR or ADR+NP. The mean tumor enlargement ratio on the 7th day after NADR i.a. was 1.106. The mean tumorbearing survival time was 39.50 days. Prolonged life span ratio was 109.22% as compared with rats that accepted NS.CONCLUSION: Therapeutic effect of ADR on liver malignancy can be significantly enhanced by its nanopaticle formulation and administration via hepatic artery. | Jiang-HaoChen RuiLing QingYao LingWang ZhongMa YuLi ZheWang HuXu | 2004 | World Journal of Gastroenterology2004，10，13： | 8 |
| 2 | Antioxidative activities of low molecular fucoidans from kelp Laminariajaponica显示文摘 | CHANG Huxue LEI Chen ZHAO Jieli | 2004 | Developments in Food Science2004，42，： | 1 |
| 3 | Effects of NS Series Composite Lactobacillus Prepa-ration on Performance,Plasma Biochemical Indexes and Immunity of Sows显示文摘[Objective] The study was aimed to investigate the effects of NS series composite lactobacillus preparation on production performance and some immune indexes of sows. [Method] The sows were fed on the diets supplemented with the NS series composite lactobacillus preparation, and the changes of production performance, plasma biochemical indexes, levels of IgG, IgA and IgM in serum and colostrum, and T lymphocyte subpopulations were detected. [Result] When the NS series composite lactobacillus preparation was supplemented to the sow diet at a proportion of 0.2%, the average weaning litter weight at 21 days old was significantly increased. The serum contents of total protein and glucose as well as the serum activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP) and superoxide dismutase (SOD) were significantly increased after 30 d post delivery. Moreover, the levels of IgG, IgA and IgM in serum and colostrum of sows were significantly increased at the time of delivery and after 30 d post delivery. The antibodies in colostrum could be maintained at high levels. The percentage of CD3+ and CD4+ lymphocyte subpopulations was also increased after supplementation with the NS series composite lactobacillus preparation at a proportion of 0.2%. [Conclusion] The NS series composite lactobacillus preparation can improve performance, promote growth and metabolism, and enhance humoral and cellular immunity in sows. | WEI Ming-yu LU Jian-ming ZHAO Wu HE Ying JIN Feng HUXu sun zhilyong CHEN Zhongwei LIANG Bao-zhong LIANG Jia-xing SU Qi-lian LAI Sheng-ji HU Ting-jun | 2012 | Animal Husbandry and Feed Science2012，4，1： | 0 |
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