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| 1 | Enhanced antitumor efficacy on hepatoma-bearing rats with adriamycin-loaded nanoparticles administered into hepatic artery显示文摘AIM: To investigate the antitumor activity of adriamycin (ADR) encapsulated in nanoparticles (NADR) and injected into the hepatic artery of hepatoma-bearing rats.METHODS: NADR was prepared by the interfacial polymerization method. Walker-256 carcinosarcomas were surgically implanted into the left liver lobes of 60 male Wistar rats, which were divided into 4 groups at random (15 rats per group). On the 7th day after implantation, normal saline (NS), free ADR (FADR), NADR, or ADR mixed with unloaded nanoparticles (ADR+NP) was respectively injected via the hepatic artery (i.a.) of rats in different groups. The dose of ADR in each formulation was 2.0 mg/kg body weight and the concentration was 1.0 mg/mL. Survival time, tumor enlargement ratio, and tumor necrosis degree were compared between each group.RESULTS: Compared with the rats that received NS i.a.,the rats that received FADR or ADR+NP acquired apparent inhibition on tumor growth, as well as prolonged their life span. Further significant anticancer efficacy was observed in rats that received i.a. administration of NADR. Statistics indicated that NADR brought on a more significant tumor inhibition and more extensive tumor necrosis, as compared to FADR or ADR+NP. The mean tumor enlargement ratio on the 7th day after NADR i.a. was 1.106. The mean tumorbearing survival time was 39.50 days. Prolonged life span ratio was 109.22% as compared with rats that accepted NS.CONCLUSION: Therapeutic effect of ADR on liver malignancy can be significantly enhanced by its nanopaticle formulation and administration via hepatic artery. | Jiang-HaoChen RuiLing QingYao LingWang ZhongMa YuLi ZheWang HuXu | 2004 | World Journal of Gastroenterology2004，10，13： | 8 |
| 2 | Synthesis of Dual-Band Bandpass Filters Using Successive Frequency Transformations and Circuit Conversions 显示文摘 | Guan Xuehui Ma Zhewang Cai Peng | 2006 | IEEE Microwave And Wireless Components Letters2006，16，： | 1 |
| 3 | A novel compact interdigital bandpass filter using muhilayer cross-coupled folded quarter- wavelength resonators显示文摘 | MU Yani MA Zhewang Xu Deming | 2005 | IEEE Microwave and Wireless Components Letters2005，15，12： | 1 |
| 4 | Lower low‐density lipoprotein cholesterol levels are associated with Parkinson’s disease显示文摘 | XuemeiHuang HongleiChen William C.Miller Richard B.Mailman Jennifer L.Woodard Peter C.Chen DongXiang Richard W.Murrow Yi‐ZheWang CharlesPoole | 2007 | Mov Disord2007，，3： | 1 |
| 5 | Design of microstrip dual-band bandpass filter with controllable bandwidth显示文摘 | GUAN XUEHUI MA ZHEWANG CAI PENG ANADA TETSUO GEN HAGIWARA | 2007 | Microwave and Optical Technology Letters2007，49，3： | 1 |
| 6 | Design and implementation of microwave dual-band bandpass filters using microstrip composite resonators显示文摘 | MA ZHEWANG SHIMIZU TAICHI KOBAYASHI YOSHIO ANADA TETSUO GEN HAGIWARA | 2008 | Microwave and Optical Technology Letters2008，50，6： | 1 |
| 7 | Seismic analysis of inelastic moment‐resisting frames Part I: Modified force analogy method for end offsets显示文摘 | Kevin K. F.Wong ZheWang | 2007 | Struct Design Tall Spec Build2007，，3： | 1 |
| 8 | Antimicrobial activity of clove and rosemary essential oils alone and in combination显示文摘 | YuJieFu YuanGangZu LiYanChen XiaoGuangShi ZheWang SuSun ThomasEfferth | 2007 | Phytother Res2007，，10： | 1 |
| 9 | Precise modification of poly(aryl ether ketone sulfone)proton exchangemembranes with positively charged bismuth oxide clusters for high proton conduction performance显示文摘In the field of proton exchange membranes(PEMs),it is still a great challenge to explore new Nafion alternatives,maintaining the high proton conductivity and lowering the cost of practical application.In this work,a series of low sulfonated poly(aryl ether ketone sulfone)(SPAEKS)membranes hybridized by[Bi_(6)O_(5)(OH)_(3)]_(2)(NO_(3))10⋅6H_(2)O(H_(6)Bi_(12)O_(16))have been successfully fabricated.When the doping amount of H6Bi12O16 reaches 5 wt%,the DS15-Bi12-5 showing the best proton conductive ability and mechanical properties.The proton conductivity can achieve 72.8 mS⋅cm−1 at 80℃ and the tensile strength can reach 43.57 MPa.Confirmed by experimental data and activation energy(Ea)calculations,the existence of Bi cluster makes more hydrogen bonds,providing additional proton hopping sites and offers more proton transport vehicles,leading to a high proton conduction performance.This work proved that polyoxometalates(POMs)can replace the role of sulfonate groups in SPAEKS to a certain extent and work out the defects of high sulfonation,making a remarkable contribution to the practical application of low sulfonated SPAEKS. | Yi-Zhuo Yin Zhen-Guo Zhang Wen-Wen He Jing-Mei Xu Feng-Yu Jiang Xu Han Wan-Ting Di ZheWang Shengqian Ma | 2022 | SusMat2022，2，1： | 0 |
| 10 | Sequence evolution of putative cytotoxic T cell epitopes in NS3 region of hepatitis C virus显示文摘AIM:Quasispecies of hepatitis C virus (HCV) are the foundation for rapid sequence evolution of HCV to evade immune surveillance of hosts. The consensus sequence evolution of a segment of HCV NS3 region, which encompasses putative cytotoxic T cell epitopes,was evaluated.METHODS:Three male patients, infected with HCV through multiple transfusions,were identified from clinical symptoms and monitored by aminotransferase for 60 months.Blood samples taken at months 0, 32, and 60 were used for viral RNA extraction. A segment of HCV NS3 region was amplified from the RNA extraction by RT-PCR and subjected to subcloning and sequencing.HLA types of these three patients were determined using complement-dependent microlymphocytotoxic assay. CTL epitopes were predicted using MHC binding motifs.RESULTS:No patient had clinical symptoms or elevation of aspartate/alanine arninotransferase. Two patients showed positive HCV PCR results at all 3 time points. The other one showed a positive HCV PCR result only at month 0.A reported HLA-A2-restricted CTL epitope had no alteration in the HLA-A2-negative carrier over 60 months.In the HLA-A2-positive individuals, all the sequences from 0 month 0 showed an amber mutation on the initial codon of the epitope. Most changes of consensus sequences in the same patient occurred on predicted cytotoxic T cell epitopes.CONCLUSION:Amber mutation and changes of consensus sequence in HCV NS3 region may be related to viral immune escape. | Hua-ZhangGuo YingYin Wen-LiangWang Chuan-ShanZhang TaoWang ZheWang JingZhang HongCheng Hai-TaoWang | 2004 | World Journal of Gastroenterology2004，10，6： | 0 |
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