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| 1 | Towards a better hydraulic cleaning strategy for ultrafiltration membrane fouling by humic acid: Effect of backwash water composition显示文摘As a routine measurement to alleviate membrane fouling, hydraulic cleaning is of great significance for the steady operation of ultrafiltration(UF) systems in water treatment processes. In this work, a comparative study was performed to investigate the effects of the composition of backwash water on the hydraulic cleaning performance of UF membranes fouled by humic acid(HA). Various types of backwash water, including UF permeate, Milli-Q water, Na Cl solution, CaCl_2 solution and HA solution, were compared in terms of hydraulically irreversible fouling index, total surface tension and residual HA. The results indicated that Milli-Q water backwash was superior to UF permeate backwash in cleaning HA-fouled membranes, and the backwash water containing Na+or HA outperformed Milli-Q water in alleviating HA fouling. On the contrary, the presence of Ca^(2+) in backwash water significantly decreased the backwash efficiency. Moreover, Ca^(2+) played an important role in foulant removal, and the residual HA content closely related to the residual Ca^(2+) content.Mechanism analysis suggested that the backwash process may involve fouling layer swelling, ion exchange, electric double layer release and competitive complexation. Ion exchange and competitive complexation played significant roles in the efficient hydraulic cleaning associated with Na+and HA, respectively. | Haiqing Chang Heng Liang Fangshu Qu Jun Ma Nanqi Ren Guibai Li | 2016 | Journal of Environmental Sciences2016，28，5： | 4 |
| 2 | Fouling mechanisms in the early stage of an enhanced coagulation-ultrafiltration process显示文摘我们调查了 ultrafiltration (UF ) 的犯规表演为在提高的 coagulation-UF 混血儿进程对待同轴的凝结的水的膜。然后,我们用数学模型和显微镜学观察方法在 UF 的早阶段分析了犯规机制。最后,我们在膜在这份报纸犯规上讨论了通风的影响。结果显示出那一 trans 膜压力(TMP ) 二阶段侧面在提高的 coagulation-UF 膜的操作期间被观察,并且在渗透之间的关系和操作时间与一条对数的曲线适合很好。膜毛孔堵住和蛋糕过滤作为用数学模型对机制犯规的主要的膜被证实。也就是,对机制犯规的膜的二个阶段进一步被推出变窄的膜毛孔由蛋糕的形成列在后面层。用扫描膜表面的图象从不同过滤取样了的电子显微镜学(SEM ) 的膜尸体分析骑车也证实了毛孔堵住和蛋糕过滤的机制。而且根据渗透和膜犯规抵抗的变化,通风能减轻并且控制仍然犯规到通风条件的某个程度,而是优化的膜需要被学习。 | Haiqing CHANG Baicang LIU Wanshen LUO Guibai LI | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 3 |
| 3 | VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway显示文摘Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases. | Chunsik Lee Rongyuan Chen Guangli Sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li Weiwei Lu Wei Chen Juanxi Liu Jiaxin Hu Qihang Sun Weisi Lu Lekun Fang Shasha Wang Haiqing Kuang Yihan Zhang Geng Tian Jia Mi Bi-Ang Kang Masashi Narazaki Aaron Prodeus Luc Schoonjans David MOrnitz Jean Gariepy Guy Eelen Mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio Mora Jin Yao Chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 4 | Membrane Fouling Alleviation by Chemically Enhanced Backwashing in Treating Algae-Containing Surface Water: From Bench-Scale to Full-Scale Application显示文摘Ultrafiltration(UF)has been increasingly implemented in drinking water treatment plants;however,algae and their secretions can cause severe membrane fouling and pose great challenges to UF in practice.In this study,a simple and practical chemically enhanced backwashing(CEB)process was developed to address such issues using various cleaning reagents,including sodium hypochlorite(NaClO),sodium chloride(NaCl),sodium hydroxide(NaOH),sodium citrate,and their combinations.The results indicate that the type of chemical played a fundamental role in alleviating the hydraulically irreversible membrane fouling(HIMF),with NaClO as the best-performing reagent,followed by NaCl.Furthermore,a CEB process using a combination of NaClO with NaCl,NaOH,or sodium citrate delivered little improvement in the alleviation of membrane fouling compared with NaClO alone.The optimized dosage and dosing frequency of NaClO were 10 mg·L^(-1) two times per day.Long-term pilot-scale and full-scale experiments further verified the feasibility of the CEB process in relieving algae-derived membrane fouling.Compared with the conventional hydraulic backwashing without chemical involvement,the CEB process can effectively remove the organic foulants including biopolymers,humic substances,and proteinlike substances by means of oxidization,thereby weakening the cohesive forces between the organic foulants and the membrane surface.Therefore,the CEB process can efficiently alleviate the algae-related membrane fouling with lower chemical consumption,and is proposed as an alternative to control membrane fouling in treating the algae-containing surface water. | Xiaobin Tang Tiecheng Guo Haiqing Chang Xiao Yue Jinlong Wang Haikuan Yu Binghan Xie Xuewu Zhu Guibai Li Heng Liang | 2022 | Engineering2022，，12： | 0 |
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