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| 1 | APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease显示文摘Current evidence shows that apolipoprotein E(APOE), apolipoprotein CI(APOC1) and low density lipoprotein receptor-related protein(LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. We performed a 30-month longitudinal cohort study to investigate the relationship between Alzheimer's disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer's disease were recruited form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess patients' cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE ε4 carriers compared with non-carriers. In addition, the APOE ε4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive impairment progression group. In conclusion, APOE ε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease. | Qin Zhou Dantao Peng Xinrui Yuan Zeping Lv Shenghang Pang Wenyu Jiang Chuyu Yang Xiaohong Shi Guofang Pang Yige Yang Haiqun Xie Wandong Zhang Caiyou Hu Ze Yang | 2014 | Neural Regeneration Research2014，9，6： | 4 |
| 2 | Monitoring the Effective Sterilization of Low-Temperature Hydrogen Peroxide Gas Plasma Sterilizers in 58 Hospitals——22 PLADs,China,June 2015-December 2019显示文摘Summary What is already known on this topic?Hydrogen peroxide sterilizeation is widely used for luminal devices.However,the low penetrability of the sterilant is of major concern.What is added by this report?This report investigated the effective sterilization of low-temperature hydrogen peroxide gas plasma sterilizers and compared the applicability of different biological monitoring methods based on medical luminal devices. | Jiaqi Wang Baoying Zhang Huihui Sun Jian Zhang Hongyang Duan Haiqun Ban Jin Shen Liubo Zhang | 2021 | China CDC weekly2021，3，29： | 3 |
| 3 | Modulation of Fano resonances in symmetry-broken gold-SiO_2-gold nanotube dimers显示文摘Fano resonances in the symmetry-broken gold-SiO2-gold(BGSG)nanotubes and the associated dimers have been investigated based on the finite element method.In the BGSG nanotube,the symmetry breaking induced the interactions of the inner gold core and outer gold nanoshell plasmons of all multipolar orders and hence the red-shifts of the plasmon resonance modes and the enhanced quadrupole mode peaks were observed.The interference of the quadrupole mode peak with the subradiant dipole mode caused a Fano-dip in the scattering spectrum.By increasing the core offset-value in the BGSG nanotube,the Fano dip with low energy showed a red-shift and became deeper.Unexpectedly the plasmon coupling between a GSG nanotube and a BGSG nanotube can lead to two strong Fano dips in the scattering spectra of the dimer.It was further noted that the thin side of the BGSG nanotube located at two sides of the dimer gap can lead to the strong near-field coupling between two BGSG nanotubes and hence a deeper and broader Fano dip. | WU DaJian YU HaiQun JIANG ShuMin WU XueWei LIU XiaoJun | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，6： | 2 |
| 4 | A Milk-Based Wolfberry Preparation Prevents Prenatal Stress-Induced Cognitive Impairment of Offspring Rats,and Inhibits Oxidative Damage and Mitochondrial Dysfunction In Vitro显示文摘 | Zhihui Feng Haiqun Jia Xuesen Li | | 0，，35： | 1 |
| 5 | Development of insect-resistant transgenic rice with Cry1C-free en-dosperm显示文摘 | Ye Rongjian Haiqun Huang Zhou Yang | 2009 | Pest Manag Sci2009，65，： | 1 |
| 6 | Soil respiration in a mixed urban forest in China in relation to soil temperature and water content显示文摘 | Wenjing Chen Xin Jia Tianshan Zha Bin Wu Yuqing Zhang Chunyi Li Xiaoping Wang Guimei He Haiqun Yu Guopeng Chen | 2013 | European Journal of Soil Biology2013，，： | 1 |
| 7 | Design and Experiment of the High Speed Wire Drawing with Ultrasound显示文摘The previous experiments of wire drawing with ultrasonic vibration were mostly carried out on self-made machine or drawing test machine and the drawing speed didn't conform to practical production. In order to promote the practical application of the technology,the ultrasonic vibration system was designed and manufactured by using the classical dynamics method. The dynamic characteristic of the ultrasonic vibration system was analyzed. The performance parameters of the system were measured on the resistance analyzer. The oxygen-free brass wire drawing with ultrasonic vibration at the approximate speed of practice was carried out on the LH-200/17 drawing machine. By comparing the wire drawing through ultrasonic vibration and the conventional wire drawing,the experimental results show that the drawing process with ultrasound was steady at the high drawing speed of 1 126 mm/s,while the broken wire often occurs at the speed of 980 mm/s during the conventional wire drawing; the ultrasonic vibration reduced the drawing force by 7 %; and the ultrasound also reduced the uneven deformation of the wire and greatly improved the surface quality of the wire. The research results provide theoretical and experimental support for the practice and application of the wire drawing by ultrasonic vibration. | QI Haiqun SHAN Xiaobiao XIE Tao | 2009 | Chinese Journal of Mechanical Engineering2009，22，4： | 1 |
| 8 | Graphene nanoplate-Pt composite as a high performance electrocatalyst for direct methanol fuel cells显示文摘 | Huajie Huang Haiqun Chen Dongping Sun Xin Wang | 2012 | Journal of Power Sources2012，，： | 1 |
| 9 | Graphene nanoplate-Pt composite as a high performance electrocatalyst for direct methanol fuel cells显示文摘 | HUANG Huajie CHEN Haiqun SUN Dongping | 2012 | Journal of Power Sources2012，，204： | 1 |
| 10 | 显示文摘 | Zhu Junwu Chen Haiqun Liu Hongbo | 2004 | Materials Science and Engineering A2004，384，： | 1 |
| 11 | Highly dispersed Cu O nanoparticles prepared by a novel quickprecipitation method显示文摘 | Zhu Junwu Li Dan Chen Haiqun | 2004 | Materials Letters2004，58，26： | 1 |
| 12 | Measuring Cognition in a Geriatric Outpatient Clinic: Rasch Analysis of the Montreal Cognitive Assessment显示文摘 | Lisa Koski Haiqun Xie Lois Finch | 2009 | J Geriatr Psychiatry Neurol2009，22，3： | 1 |
| 13 | Highly dispersed CuO nanopartiele prepared by a novel quiek-preeipita -tion method显示文摘 | JUNWU ZHU DAN LI HAIQUN CHEN | 2004 | Materials Letters2004，58，： | 1 |
| 14 | High photocatalytic activity of magnetically separable manganese ferritefi graphene heteroarchitectures显示文摘 | Fu Yongsheng Xiong Pan Chen Haiqun | | 0，，： | 1 |
| 15 | Gra- phene nanoplate-Pt composite as a high performance electrocatalyst for direct methanol fuel cells 显示文摘 | Huajie Huang Haiqun Chen Dongping Sun | 2012 | Jour-nal of Power Sources2012，，204： | 1 |
| 16 | Mechanically strong, electrically conductive, and biocompatible graphene paper显示文摘 | Chen Haiqun Müller M B Gilmore K J | | 0，，： | 1 |
| 17 | Combination of cobalt ferrite and graphene: High-performance and recyclable visible-light photocatalysis显示文摘 | Yongsheng Fu Haiqun Chen Xiaoqiang Sun Xin Wang | 2011 | Applied Catalysis B, Environmental2011，，： | 1 |
| 18 | Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome显示文摘 | James F. Leckman Liliya Katsovich Ivana Kawikova Haiqun Lin Heping Zhang Holger Kr?nig Syed Morshed Salina Parveen Heidi Grantz Paul J. Lombroso Robert A. King | 2005 | Biological Psychiatry2005，，6： | 1 |
| 19 | Acute-on-Chronic Liver Failure Precipitated by Severe Acute Respiratory Syndrome Coronavirus 2 Infection in a Patient with Hepatitis B Virus-Related Cirrhosis: A Case Report显示文摘We present a case of acute-on-chronic liver failure(ACLF)in a patient with hepatitis B virus(HBV)-related decompensated cirrhosis and coronavirus disease 2019(COVID-19).A 58-year-old woman with HBV-related and decompensated cirrhosis without any anti-viral treatment previously was admitted to the hospital due to a confirmed severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.On admission,she was in stable condition.Thoracic computed tomography(CT)and laboratory findings showed no significant abnormalities.Entecavir was initiated promptly for HBV,while antiviral therapy and supportive treatment were initiated for COVID-19.Her lung infection exacerbated after 10days of recurrent fever despite treatments,and there were signs of HBV reactivation.ACLF and multiple organ dysfunction syndrome developed rapidly from day 10 to day 19.The patient’s clinical deterioration was also consistent with pneumonia progression and elevated interleukin 6 levels.SARS-CoV-2 likely precipitated ACLF in cirrhotic patients,either by inducing HBV flare or serving as an acute insult directly.This study discussed the underlying mechanisms of this process and management details.Monitoring HBV status is necessary,and inflammatory parameters might be valuable.HBV suppression should be initiated early,and variceal hemorrhage primary prevention might be beneficial in COVID-19 patients with cirrhosis. | Wanling Chen Qiran Zhang Shijun Li Ruiting Liang Haiqun Liang Yiqi Yu Chao Qiu Jiannan Lv Wenhong Zhang | 2021 | Infectious Diseases & Immunity2021，1，3： | 1 |
| 20 | Status analysis and comparison of research achievements on open data policy and an estimation of the research trends in China显示文摘The relevant conferences about open data and big data were hosted frequently in recent years,and the day of international open data was set up to support and encourage governments to implement open data policy.China has already accelerated its steps in research and practices.This paper proceeds the literature retrieval based on the databases of CNKI and three foreign database including Web of Science,Emerald and ELSEVIER(SD).The keywords | Haiqun MA Pan PU | 2015 | Journal of Library Science in China2015，，1： | 0 |
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