4篇
您的检索式：作者名="Haisong Lin"
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| 1 | Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells显示文摘 | Haisong Liu Huan Yang Dicong Zhu Xin Sui Juan Li Zhen Liang Lei Xu Zeyu Chen Anzhi Yao Long Zhang Xi Zhang Xing Yi Meng Liu Shiqing Xu Wenjian Zhang Hua Lin Lan Xie Jinning LOU Yong Zhang Jianzhong Xi Hongkui Deng | 2014 | Cell Research2014，24，10： | 3 |
| 2 | Identification of a new target region by loss of heterozygosity at 5p15.33 in sporadic gastric carcinomas: genotype and phenotype related显示文摘 | Yun Lu Yingyan Yu Zhenggang Zhu Heng Xu Jun Ji Lei Bu Bingya Liu Haisong Jiang Yanzhen Lin Xiangyin Kong Landian Hu | 2004 | Cancer Letters2004，，2： | 1 |
| 3 | Association between the polymorphisms of the VDR gene and kidney stone formation in Guangxi population显示文摘Objective:To investigate the relationship between the rs9729,rs11574129,BsmI(rs1544410),TaqI(rs731236)and DdeI(rs3782905)polymorphisms of the vitamin D receptor(VDR)gene and kidney stone formation in a study group from Guangxi.Methods:A hospital-based casecontrol study including 890patients with kidney stone formation and 822age-and sex-matched controls without stone formation was conducted.Five single-nucleotide polymorphisms(SNPs)of the VDR gene were studied using SNPscanTMhighthroughput SNP classification assays.Results:The T allele variant of rs9729significantly increased the risk of kidney stone formation(P=0.021).In particular,a significantly increased risk of kidney stone formation was found in the combined genotypes TG/TT of rs9729compared with the wild GG genotype after covariate adjustment.However,after gender stratification analysis,compared with the wild GG genotype,the GT,TT and GT/TT genotypes of rs9729increased the risk of kidney stone formation in males.Moreover,the GA and GA/GG genotypes of rs11574129 were associated with increased risk of kidney stone formation in males.By contrast,the GC and GC/CC genotypes of DdeI(rs3782905)significantly decreased the risk of kidney stone formation in males.Haplotype analysis suggested that the five-locus polymorphism of VDR was significantly related to kidney stone formation in male participants(P=0.0025).Conclusion:TheT allele variant of the rs9729polymorphism of the VDR gene was significantly related to the risk of kidney stone formation.Gender may affect the association between the rs9729,rs11574129and DdeI polymorphisms of the VDR gene and the risk of kidney stone formation in the Chinese population. | Xiujuan Zhu Haisong Lin Yuanliang Xie Shengzhu Huang Jiarong Tian Xiaoying Xian Lulin Chen Zengnan Mo | 2018 | 广西医科大学学报2018，35，6： | 0 |
| 4 | Lanthanum promoting bone formation by regulating osteogenesis,osteoclastogenesis and angiogenesis显示文摘With lanthanum(La) in agriculture, medicine, and the chemical industry, La shows accumulation in the body, especially in the bone, because of its similar structure to calcium. Moreover, La has a direct role in bone formation regulating osteoblasts and osteoclasts. Nevertheless, bone formation is complex under the regulation of osteogenesis, osteoclastogenesis, and angiogenesis in the bone microenvironment. It is difficult to comprehensively understand the regulation of bone homeostasis from a single kind of cell.Herein, some bone microenvironment-related cells and mouse calvaria culture models were used to study the regulatory effect of La-based compound-lanthanum nitrate(La(NO_(3))_(3)) on bone formation.La(NO_(3))_(3) has good biological safety, and the osteogenic differentiation is significantly increased under La(NO_(3))_(3) treatment for bone marrow mesenchymal stem cells(BMMSC). In contrast, the differentiation,maturation, and bone erosion ability of osteoclasts are significantly decreased. Meanwhile, the angiogenesis ability of human umbilical vein endothelial cells(HUVEC) is significantly promoted when treated with La(NO_(3))_(3). Furthermore, bone metabolism and angiogenesis are improved under La(NO_(3))_(3) treatment in the calvaria ex vivo culture model and BMMSC-HUVEC co-culture system. These results suggest that La has the beneficial effect of promoting bone metabolism and improving bone formation in the bone microenvironment. | Dandan Zou Runlian Lin Yu Han Juan Jia Guoqiang Zhou Haisong Zhang Kun Ge | 2024 | Journal of Rare Earths2024，42，3： | 0 |
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