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| 1 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 2 | Role of IKur in controlling action potential shape and contractility in the human atrium:influence of chronic atrial fibrillation显示文摘 | Wettwer E Hala O Christ T | 2004 | Circulation2004，110，16： | 1 |
| 3 | Learning and memory disabilities in young adult rats from mildly zinc deficient dams显示文摘 | Halas E S Hunt C D Eberhardt M J | 1986 | Physiol Behav1986，37，3： | 1 |
| 4 | A Hybridization Model for the Plasmon Response of Complex Nanostructures 显示文摘 | Prodan E Radloff C Halas N J | 2003 | Science2003，302，： | 1 |
| 5 | Improving TCP performance over mobile networks 显示文摘 | Hala E | 2002 | ACM Computing Surveys2002，34，3： | 1 |
| 6 | Mild zinc deficiency and undemutrition during the prenatal and postnatal periods in rats: effects on weight, food consumption, and brain catecholamine concentrations显示文摘 | HALAS E S WALLWORK J C SANDSTEAD H H | 1982 | Journal of Nutrition1982，112，： | 1 |
| 7 | Chitosan based nanofibers, review 显示文摘 | MAHER Z E HALA F N RANIA E M | 2012 | Materials Science and Engineering: C2012，32，7： | 1 |
| 8 | The automated windows task: the per- formance of preschool children, children with autism, and children with moderate learning difficulties 显示文摘 | Russell J Hala S Hill E | 2003 | Cogn Develop2003，18，： | 1 |
| 9 | Learning and memory impairment in adult rats due to sever zinc deficiency lactation 显示文摘 | Halas E S Eberhardt M J Diers A | 1983 | Physiol Behav1983，30，3： | 1 |
| 10 | A Cellular Trojan Horse for delivery ofther apeutic nanoparticles into tumors显示文摘 | Choi M R Stanton - Maxey K J Stanley J K Levin C S Bardhan R Akin D Badve S Sturgis J Robinson J P Bashir B Halas H J and Clare S E | 2007 | Nano Letters2007，7，12： | 1 |
| 11 | Phenylpropanoids from leaves of Juniperus phoenicea 显示文摘 | Xing C L Hala N E Charles D H | 1997 | Phytochemistry1997，45，8： | 1 |
| 12 | Natural products inhibiting Candida albicans Secreted aspartic proteases from Lycopodiumcernuum显示文摘 | Zhang Z Z Hala N E Melissa R J etal | 2002 | J Nat Prod2002，65，7： | 1 |
| 13 | Role of IKur in controlling action potential shape and contrac- tility in the human atrium:influence of chronic atrialfibrillation 显示文摘 | WETTWER E HALA O CHRIST T | 2004 | Circulation2004，110，16： | 1 |
| 14 | Toxoplasma gondii infection among chronic hepatitis C patients:A casecontrol study显示文摘Objective:To determine the detection rate of anti-Toxoplasma gondii(T.gondii) IgG and IgM in chronic HCV patients attending the Department of Tropical Medicine Mansoura University hospital in Egypt.Methods:This study included 120 adult chronic HCV patients.81 decompensate cirrhosis(late-stage)and 39 chronic HCV non cirrhotic patients(early-stage) and40 healthy blood donors as controls.Serum samples uere examined for anti-Toxoplasma IgM and anti-Toxoplasma IgG antibodies by ELISA.Real-time RT-polymerase chain reaction assay was done for quantitation of hepatitis C virus.Results:Anti-T.gondii IgG antibodies were detected in 75(92.6%) of 81 late-stage cirrhotic patients.30(76.9%) of the 39 chronic HCV non cirrhotic patients(early-Stage) and in 6(15ft) of 40 controls with statistically significant difference(P<0.001).Anti-T.gondii IgM antibodies were found in 11(13.6%) in late stage patients,5(12.8%)in early stage and in 3(7.5%) of controls with no statistical significant difference(P=0.610).There was no correlation between stage of fibrosis and IgM or IgG antibodies positivity in our studied groups(P=0.526).High IgG levels significantly correlated with high viral load(P=0.026).Conclusions:Our findings suggest that the serious opportunistic T.gondii infection represent a potential significant risk for chronic HCV patients.So.toxoplasmosis should be considered in their investigations and follow-up. | Hala A El-Nahas Nora L El-Tantawy Raghda E Farag Argaya MA Alsalem | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，8： | 1 |
| 15 | Giant peritoneal loose body in the pelvic ('avity : repo,l of a ease显示文摘 | Nomura H Hala F Yasoshima T e! al | 2003 | Surg Today2003，33，10： | 1 |
| 16 | The Effect of Devaluation on Output in the Egyptian Economy: A Vector Autoregression Analysis显示文摘 | Hala E | 2008 | International Research Journal of Finance and Economics2008，，14： | 1 |
| 17 | A hybridization model for the plasmon response of complex nanostructures 显示文摘 | Prodan E Radloff C Halas N J | 2003 | Science2003，302，5644： | 1 |
| 18 | Semimicrodetermination ofvapor-liquid equilibrium显示文摘 | Wichterle I Hala E | 1963 | Ind Eng Chem Fundam1963，2，2： | 1 |
| 19 | Chitosan based nanofibers,review 显示文摘 | Maher Z E Hala F N Rania E M | 2012 | Materials Science and Engineering C2012，32，： | 1 |
| 20 | The Effect of Devaluation on Output in the Egyptian Economy: A Vector Autoregression Analysis显示文摘 | Hala E | 2008 | International Research Journal of Finance and Economics2008，，14： | 1 |
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