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| 1 | Ethnicity association of Helicobacter pylori virulence genotype and metronidazole susceptibility显示文摘AIM:To characterise the cag pathogenicity island in Helicobacter pylori(H.pylori) isolates by analysing the strains' vacA alleles and metronidazole susceptibilities in light of patient ethnicity and clinical outcome.METHODS:Ninety-five H.pylori clinical isolates obtained from patients with dyspepsia living in Malaysia were analysed in this study.Six genes in the cagPAI region(cagE,cagM,cagT,cag13,cag10 and cag67) andvacA alleles of theH.pylori isolates were identified by polymerase chain reaction.The isolates' metronidazole susceptibility was also determined using the E-test method,and the resistant gene was characterised by sequencing.RESULTS:More than 90% of the tested isolates had at least one gene in the cagPAI region,and cag67 was predominantly detected in the strains isolated from the Chinese patients,compared with the Malay and Indian patients(P < 0.0001).The majority of the isolates(88%) exhibited partial deletion(rearrangement) in the cagPAI region,with nineteen different patterns observed.Strains with intact or deleted cagPAI regions were detected in 3.2% and 8.4% of isolates,respectively.The prevalence of vacA s1m1 was significantly higher in the Malay and Indian isolates,whereas the isolates from the Chinese patients were predominantly genotyped as vacA s1m2(P = 0.018).Additionally,the isolates from the Chinese patients were more sensitive to metronidazole than the isolates from the Malay and Indian patients(P = 0.047).Although we attempted to relate the cagPAI genotypes,vacA alleles and metronidazole susceptibilities to disease outcome,no association was observed.The vacA alleles were distributed evenly among the strains with intact,partially deleted or deleted cagPAI regions.Interestingly,the strains exhibiting an intact cagPAI region were sensitive to metronidazole,whereas the strains with a deleted cagPAI were more resistant.CONCLUSION:Successful colonisation by different H.pylori genotypes is dependent on the host's genetic makeup and may play an important role in the clinical outcome. | Hanafiah Alfizah Awang Hamat Rukman Ahmad Norazah Razlan Hamizah Mohamed Ramelah | 2013 | World Journal of Gastroenterology2013，19，8： | 2 |
| 2 | The effects of short-term,rapid glycemic control on the peroneal nerve function and serum VCAM-1 and AGE in type 2 diabetic patients in Malaysia显示文摘 | Norlinah MI Hamizah R Md Isa SH | 2009 | Indian J Med Sci2009，63，4： | 1 |
| 3 | Resistotype of Helico- bacter pylori isolates:the impact on eradication outcome显示文摘 | Alfizah H Norazah A Hamizah R | 2014 | J Med Microbiol2014，63，5： | 1 |
| 4 | Stock prices and demand for money in China: New evidence显示文摘 | Ahmad Zubaidi Baharumshah Siti Hamizah Mohd Marial Awou Yol | 2007 | Journal of International Financial Markets Institutions & Money2007，，1： | 1 |
| 5 | 查看详情显示文摘 | Ng M H Aminuddin B S Hamizah S Lynette C Mazlyzam A L Ruszymah B H I | | 0，，04： | 1 |
| 6 | Diagnostic Value of the <sup>13</sup>C Methacetin Breath Test in Various Stages of Chronic Liver Disease显示文摘 | Hamizah Razlan Nurhayaty Muhamad Marzuki Mei-Ling Sharon Tai Azhar-Shah Shamsul Tze-Zen Ong Sanjiv Mahadeva Edoardo G. Giannini | 2011 | Gastroenterology Research and Practice2011，，： | 1 |
| 7 | The effects of short-term,rapid glycemic control on the peroneal nerve function and serum VCAM-1 and AGE in type 2 diabetic patients in Malaysia显示文摘 | Norlinah MI Hamizah R Md Isa SH | 2009 | Indian J Med Sci2009，63，： | 1 |
| 8 | Resistotype of Helicobacter pylori isolates: the impact on eradication outcome显示文摘 | Alfizah H Norazah A Hamizah R | 2014 | J Med MicroN- ol2014，63，5： | 1 |
| 9 | Tin stearate organometallic precursor prepared SnO_2 quantum dots nanopowder for aqueous- and non-aqueous medium photocatalytic hydrogen gas evolution显示文摘Current study reports a rapid one-pot non-hydrolytic condition in the synthesis of Sn O_2 QDs nanopowder using tin(II) stearate(Sn(St)_2) as environmentally-benign organometallic precursor,which is an unprecedentedly employed-compound in preceding Sn O_2 nanopowder productions.The as-synthesized Sn O_2 QDs that are hydrophobic can be easily transferred from organic solvent to aqueous solution through a robust ligand exchange method.The stearate-capping ligands on the surface of QDs can be replaced by beta-cyclodextrin(β-CD) and eventually render the QDs highly water soluble,which ultimately make it exhibit bi-functionality for different liquid medium applications.Structural characterizations reveal that the bi-functional QDs are indeed well-matched with the standard rutile Sn O_2 cassiterite phase without the presence of any impurities.The QDs can be interchangeably used as photocatalyst for both aqueous and non-aqueous phase,where it shows significant enhancement of hydrogen gas production as compared to that of commercial Sn O_2 nanopowder. | Choonyian Haw Weesiong Chiu Noor Hamizah Khanis Saadah Abdul Rahman Poisim Khiew Shahidan Radiman Roslan Abd-Shukor Muhammad Azmi Abdul Hamid | 2016 | Journal of Energy Chemistry2016，25，4： | 0 |
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