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| 1 | Severe acute pancreatitis: Clinical course and management显示文摘Severe acute pancreatitis (SAP) develops in about 25% of patients with acute pancreatitis (AP). Severity of AP is linked to the presence of systemic organ dysfunctions and/or necrotizing pancreatitis pathomorphologically. Risk factors determining independently the outcome of SAP are early multi-organ failure, infection of necrosis and extended necrosis (> 50%). Up to one third of patients with necrotizing pancreatitis develop in the late course infection of necroses. Morbidity of SAP is biphasic, in the first week strongly related to early and persistence of organ or multi-organ dysfunction. Clinical sepsis caused by infected necrosis leading to multi-organ failure syndrome (MOFS) occurs in the later course after the first week. To predict sepsis, MOFS or deaths in the first 48-72 h, the highest predictive accuracy has been objectified for procalcitonin and IL-8; the Sepsis- Related Organ Failure Assessment (SOFA)-score predicts the outcome in the first 48 h, and provides a daily assessment of treatment response with a high positive predictive value. Contrast-enhanced CT provides the highest diagnostic accuracy for necrotizing pancreatitis when performed after the first week of disease. Patients who suffer early organ dysfunctions or at risk of developing a severe disease require early intensive care treatment. Early vigorous intravenous fluid replacement is of foremost importance. The goal is to decrease the hematocrit or restore normal cardiocirculatory functions. Antibiotic prophylaxis has not been shown as an effective preventive treatment. Early enteral feeding is based on a high level of evidence, resulting in a reduction of local and systemic infection. Patients suffering infected necrosis causing clinical sepsis, pancreatic abscess or surgical acute abdomen are candidates for early intervention. Hospital mortality of SAP after interventional or surgical debridement has decreased in high volume centers to below 20%. | Hans G Beger Bettina M Rau | 2007 | World Journal of Gastroenterology2007，13，38： | 122 |
| 2 | Clostridium difficile causing acute renal failure: Case presentation and review显示文摘AIM: Clostridium difficile infection is primarily a nosocomial infection but asymptomatic carriers of Clostridium difficile can be found in up to 5% of the general population.Ampicillin, cephalosporins and clindamycin are the antibiotics that are most frequently associated with Clostridium difficile-associated diarrhea or colitis. Little is known about acute renal failure as a consequence of Clostridium difficile-associated diarrhea.METHODS: In this case report, we describe the course of Clostridium difficile-associated diarrhea in an 82-yearold patient developing acute renal failure. Stopping the offending agent and symptomatic therapy brought a rapid improvement of diarrhea and acute renal failure, full recovery was gained 18 d after admission. In a systematic review we looked for links between the two conditions.RESULTS: The link between Clostridium difficilr-associated diarrhea and acute renal failure in our patient was most likely volume depletion. However, in experimental studies a direct influence of Clostridium difficile toxins on renal duct cells could be shown.CONCLUSION: Rapid diagnosis, nonspecific supportive treatment and specific antibiotic treatment, especially in the elderly, may lower excess mortality Clostridium difficile-associated diarrhea and renal failure being possible complications. | Jasmin Arrich Gottfried H.Sodeck Gürkan Seng(o|¨)lge Christoforos Konnaris Marcus Müllner Anton N.Laggner Hans Domanovits | 2005 | World Journal of Gastroenterology2005，11，8： | 15 |
| 3 | 金纳米粒在药物及生物大分子递送系统中的应用显示文摘金纳米粒是一种新型纳米载体,在生物医学领域具有广阔的应用前景,具有毒性低、体表面积大、易与生物分子结合的优点,可用于传递小分子药物及生物大分子,其释药作用既能通过生物学方式进行控制,也能通过改变外部环境的方式加以控制。本文主要阐述了这种新型纳米载体的特性及其在药物传递系统中的应用。 | 李欣 徐风华 Ghosh P Han G De M | 2008 | 国际药学研究杂志2008，35，5： | 6 |
| 4 | 参与式管理解决冲突:遥感和GIS用作瑞典北部驯鹿业土地利用需求信息交流的工具显示文摘在解决复杂的土地管理问题时,对短缺或者有争执的资源进行地理评估有助于不同利益相关者之间沟通认识和增进理解。本文中,我们说明如何使用遥感和GIS收集和汇总瑞典北部驯鹿放牧者和其他土地使用者(林业、采矿业、旅游业等等)的土地使用活动及使用模式的信息。该项目主要基于最终的土地使用者,即驯鹿放牧者们所做的工作,体现了面向土地使用者的新的努力。发展驯鹿业的土地利用规划的基础有以下几个方面:收集并数字化传统的驯鹿栖息地生态学和景观信息;将这些信息与来自野外调查及基于人造卫星观测的植被分类结果整合;绘制其他土地使用者的活动情况图。最终的土地利用规划提供的信息有利于驯鹿放牧者与其他利益相关者之间的磋商,并有助于驯鹿管理实施。该项目可作为一种大众参与和计划编制的模式,从而使本土信息和先进的遥感技术融入一个交互式的过程中。 | Per Sandstrm Tina Granqvist Pahlén Lars Edenius Hans Tφmmervik Olle Hagner Leif Hemberg Hkan Olsson Karin Baer Thomas Stenlund Lars Gran Brandt Mikael Egberth 周立志 程利群 | 2003 | AMBIO-人类环境杂志2003，32，8： | 4 |
| 5 | 短期常压低氧步行训练对肥胖成年人运动能力和步态的影响显示文摘为了比较以个人喜好的步行速度(preferred walking speed,PWS)短期低氧与常氧训练对肥胖患者的能量、力学、效率和代谢风险标志物的影响,Fernández Menéndez等纳入肥胖患者23例,在缺氧[海拔3km,n=12;体质量指数(body mass index,BMI)(34.0±0.8)kg/m2]或常氧[海拔360m,n=11;BMI(32.9±0.8)kg/m2]情况下. | 刘青 叶鹏 Fernández Menéndez A Saudan G Sperisen L Hans D Saubade M Millet GP Malatesta D | 2018 | 中华高血压杂志2018，26，6： | 2 |
| 6 | A high efficiency ZVS PWM asymmetrical half bridge converter for plasma display panel sustaining power module显示文摘 | Han S K Moon G W Youn M J | 2004 | 35th Annual Power Electronics Specialists Conference Aachen Germany2004，，： | 1 |
| 7 | Limb regeneration in higher vertebrates: Developing a roadmap 显示文摘 | Han M Yang X Taylor G | 2005 | Anat Rec B New Anat2005，287，1： | 1 |
| 8 | Genetic diversityand recombination of porcine sapoviruses显示文摘 | WANG Q H HAN M G FUNK J A | 2005 | J Clin Microbiol2005，43，12： | 1 |
| 9 | Preparation and characterization of polypyrrole-silica colloidal nanocomposites in water-methanol mixtures显示文摘 | Han M G Armes S P | 2003 | J Colloid Interface Sci2003，262，： | 1 |
| 10 | Applicability of a rapid method based on immunomagnetic capture-fluorescent PCR assay for Campylobaeterjejuni显示文摘 | Liu G M Han Y L Li X | 2006 | Fc c dControl2006，17，7： | 1 |
| 11 | Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti: Sapphire laser显示文摘 | Bindewald-Wittich A Han M Schmitz-Valckenberg S Snyder Sar- ah R Giese G Bille Josef F | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
| 12 | Effect of solution treatment on the strength and fracture toughness of aluminum alloy 7050 显示文摘 | HAN N M ZHANG X M LIU S D HE D G ZHANG R | 2011 | Journal of Alloys and Compounds2011，509，10： | 1 |
| 13 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 14 | Gold nanoparticles in deliveryappliealions显示文摘 | GHOSH P HAN G DE M | 2008 | Adv Drug Deliv Rev2008，60，11： | 1 |
| 15 | Th e I m p act s of En e rgy Pric e son En ergy I nte n sity:Evid e n ce fro m Chin a显示文摘 | HAN G L M TU M Z | 2007 | En ergyPolicy2007，35，5： | 1 |
| 16 | From clusters to phase diagrams: Composition rules of quasicrystals and bulk metallic glasses 显示文摘 | DONG C WANG Q QIANG J B WANG Y M JIANG N HAN G LI Y H WU J XIA J H | 2007 | J Phys D: Appl Phys2007，40，： | 1 |
| 17 | Progress and recent utilization trends in combustion of Chinese oil shale显示文摘 | Jiang X M Han X X Cui Z G | 2007 | Progress in Energy and Combustion Science2007，33，6： | 1 |
| 18 | Sensitivity and stability of porous polycrystalline silicon gas sensor 显示文摘 | Han P G Wong H Cpoon M | 2001 | Colloids and Surfaces2001，179，： | 1 |
| 19 | Preparation and characterization of polypyrrole-silica colloidal nanocomposites in water-methanol mixtures显示文摘 | Han M G Armes S P | 2003 | J Colloid Interface Sci2003，262，： | 1 |
| 20 | Preparation and evaluation of a molecularly imprinted sol-gel material for on-line solid-phase extraction coupled with high performance liquid chroma-tography for the determination of trace pentachloro-phenol in water samples显示文摘 | Han D M Fang G Z Yan X P | 2005 | J Chromatogr A2005，1100，2： | 1 |
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