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| 1 | The role of provenance in the diagenesis of siliciclastic reservoirs in the Upper Triassic Yanchang Formation,Ordos Basin,China显示文摘A better understanding of the controls on reservoir quality has become essential in the petroleum exploration in recent years.Determining the original composition of the sediment framework is important not only for paleogeographic reconstructions,but it is also vital for predicting the nature of physical and chemical diagenesis of the potential reservoirs.Depositional setting and diagenesis are important factors in controlling the type and quality of most siliciclastic reservoirs.We studied the Upper Triassic Chang 8 and 6 members,where the relationship between sediment provenance and diagenesis was examined.The study attempts to clarify sediment provenance and post-depositional diagenetic modifications of the sandstones through systematic analytical methods including petrographic macro-and microscopic analysis of grain and heavy mineral types,and measurements of the palaeocurrent direction of the Yanchang Formation sediments in the outcrops in order to determine the provenance of the studied sediments.Furthermore,the relationship between framework grains,pore types and diagenesis of the sediments was analyzed by thin section petrographic characterization using a polarizing microscope.Additionally,a JEOL JSM-T330 scanning electron microscope(SEM) equipped with a digital imaging system was used to investigate the habits and textural relationships of diagenetic minerals.On the basis of our results,we believe that sediment provenance is a significant factor which controls the type and degree of diagenesis which may be expected in sandstones.In the Chang 8 and 6 members,the formation of chlorite rims and laumontite cement was observed where volcanic rock fragments constitute a large part of the framework grains.Furthermore,high biotite content provides abundant iron and magnesium and enables the formation of chlorite rims due to biotite hydrolysis.In addition,ductile deformation of biotite leads to strong mechanical compaction of the sediments.Conversely,high feldspar content diminishes the degree of mechanical compaction,however the dissolution of feldspar minerals in sandstones is commonly observed.Apart from feldspars,quartz and other rigid framework grains highly control the degree of mechanical compaction during the initial stage of burial(0-2 km). | Ding Xiaoqi Han Meimei Zhang Shaonan | 2013 | Petroleum Science2013，10，2： | 16 |
| 2 | Experimental investigation on dilatancy behavior of water-saturated sandstone显示文摘It is important to study the dilatancy property of water-saturated rock for understanding the engineering behavior of loaded rock mass. This study carried out the uniaxial and triaxial compressive experiments on the water-saturated red sandstone, analyzed the influences of confining pressure and pore pressure on dilatancy property of water-saturated rock, and discussed the reasonable basis of the stress of dilatancy onset as a strength design parameter of rock engineering, finally established the prediction model of the stress of dilatancy onset under the impacts of confining pressure and pore pressure. The results show that the strength parameters(the stress of dilatancy onset and peak strength) and deformation parameters(axial strain and circumferential strain) of water-saturated sandstone increase with the confining pressure, and the relations can be fitted with a positive linear function. The cohesion and internal friction angle obtained from the stress of dilatancy onset decrease by 11.57% and 7.33%, respectively, when compared with those obtained from the peak strength. The strength parameters and deformation parameters of water-saturated sandstone decrease basically with the increase of pore pressure, in which the relations between strength parameters or axial strain and pore pressure can be fitted with a negative linear function. However, the relation between the peak circumferential strain and the pore pressure should be characterized by a negative exponential function, and the circumferential strain at dilatancy onset isn't affected by the pore pressure. | Jiangyu Wu Meimei Feng Bangyong Yu Wenli Zhang Xiaoyan Ni Guansheng Han | 2018 | International Journal of Mining Science and Technology2018，28，2： | 4 |
| 3 | A novel microgravimetric DNA sensor with high sensitivity显示文摘 | Tau Liu Ji'an Tang Meimei Han | 2003 | Biochemical and Biophysical Research Communications2003，304，： | 1 |
| 4 | Quantitative study on hydrocarbon expulsion mechanism based on micro-fracture显示文摘The significance of source rocks for oil and gas accumulation has been indisputably acknowledged.Moreover,it has been gradually realized that there is difference between hydrocarbon generation capacity and hydrocarbon expulsion capacity,and this has prompted research on hydrocarbon expulsion efficiency.However,these studies dominantly highlight the results of hydrocarbon expulsion,and investigation into the corresponding process and mechanism is primarily from a macroscopic perspective.Despite its wide acceptance as the most direct hydrocarbon expulsion mode,hydrocarbon expulsion through micro-fractures is still not sufficiently understood.Therefore,this study obtains observations and performs experiments on two types of source rocks(mudstones and shales)of the Chang 7 oil group of the Yanchang Formation in Ordos Basin,China.Microscopy reveals that organic matter is non-uniformly distributed in both types of source rocks.Specifically,mudstones are characterized by a cluster-like organic matter distribution,whereas shales are characterized by a layered organic matter distribution.Thermal evolution simulation experiments demonstrate that the hydrocarbon generation process is accompanied by the emergence of micro-fractures,which are favorable for hydrocarbon expulsion.Moreover,based on the theories of rock physics and fracture mechanics,this study establishes micro-fracture development models for both types of source rocks,associated with the calculation of the fracture pressure that is needed for the initiation of fracture development.Furthermore,the relationship between the fluid pressure,fracture pressure,and micro-fracture expansion length during micro-fracture development is quantitatively explored,which helps identify the micro-fracture expansion length.The results indicate that the development of micro-fractures is commonly impacted by the morphology and distribution pattern of the organic matter as well as the mechanical properties of the source rocks.The micro-fractures in turn further affect the hydrocarbon expulsion capacity of the source rocks.The results of this study are expected to provide theoretical and practical guidance for the exploration and exploitation of tight oil and shale oil. | Kaiming Su Jungang Lu Huanxu Zhang Shijia Chen Yong Li Zhenglu Xiao Wen Qiu Meimei Han | 2020 | Geoscience Frontiers2020，11，6： | 1 |
| 5 | Dynamic Changes of ORF1ab and N Gene Ct Values in COVID-19 Omicron Inpatients of Different Age Groups—Beijing Municipality,China,November-December 2022显示文摘Introduction:In November 2021,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant was identified as the variant of concern and has since spread globally,replacing other cocirculating variants.To better understand the dynamic changes in viral load over time and the natural history of the virus infection,we analyzed the expression of the open reading frames 1ab(ORF1ab)and nucleocapsid(N)genes in patients infected with Omicron.Methods:We included patients initially admitted to the hospital for SARS-CoV-2 infection between November 5 and December 25,2022.We collected daily oropharyngeal swabs for quantitative reverse transcriptase-polymerase chain reaction tests using commercial kits.We depicted the cycle threshold(Ct)values for amplification of ORF1ab and N genes from individual patients in age-specific groups in a time series.Results:A total of 480 inpatients were included in the study,with a median age of 59 years(interquartile range,42 to 78;range,16 to 106).In the<45-year-old age group,the Ct values for ORF1ab and N gene amplification remained below 35 for 9.0 and 11.5 days,respectively.In the≥80-year-old age group,the Ct values for ORF1ab and N genes stayed below 35 for 11.5 and 15.0 days,respectively,which was the longest among all age groups.The Ct values for N gene amplification took longer to rise above 35 than those for ORF1ab gene amplification.Conclusion:The time to test negative varied among different age groups,with viral nucleic acid shedding taking longer in older age groups compared to younger age groups.As a result,the time to resolution of Omicron infection increased with increasing age. | Qing Zhang Zhaomin Feng Yiwei Hao Lirong Wei Aibin Wang Zhixing Han Meimei Tian Sheng Sun Xin'gang Li Tianjiao Xue Xiangjing Kong Baoliang Li Cheng Kou Quanyi Wang Da Huo Linghang Wang | 2023 | China CDC weekly2023，5，8： | 0 |
| 6 | Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury显示文摘We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain injury.However,its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains unclear.In this study,we first used an HT22 scratch injury model to mimic traumatic brain injury,then co-cultured the HT22 cells with BV2 microglia expressing high levels of miR-124-3p.We found that exosomes containing high levels of miR-124-3p attenuated apoptosis and endoplasmic reticulum stress.Furthermore,luciferase reporter assay analysis confirmed that miR-124-3p bound specifically to the endoplasmic reticulum stress-related protein IRE1α,while an IRE1αfunctional salvage experiment confirmed that miR-124-3p targeted IRE1αand reduced its expression,thereby inhibiting endoplasmic reticulum stress in injured neurons.Finally,we delivered microglia-derived exosomes containing miR-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly reduced.These findings suggest that,after repetitive mild traumatic brain injury,miR-124-3 can be transferred from microglia-derived exosomes to injured neurons,where it exerts a neuroprotective effect by inhibiting endoplasmic reticulum stress.Therefore,microglia-derived exosomes containing miR-124-3p may represent a novel therapeutic strategy for repetitive mild traumatic brain injury. | Yan Wang Dai Li Lan Zhang Zhenyu Yin Zhaoli Han Xintong Ge Meimei Li Jing Zhao Shishuang Zhang Yan Zuo Xiangyang Xiong Han Gao Qiang Liu Fanglian Chen Ping Lei | 2024 | Neural Regeneration Research2024，19，9： | 0 |
| 7 | Recent Progress of Neutron Computed Tomography Device for Radioactive Sample at CARR显示文摘This neutron computed tomography(CT)system(nCT)will be used as a powerful nondestructive tool to study the radioactive samples,in particular the spent nuclear fuel element,which is able to comprehensively discern some defects inside the fuel elements,analyze the distribution and concentration of the inflammable components,detect the hydrogen concentration distribution and geometry change of zirconium alloy cladding,and also the welding state and welding tightness. | LI Zhengyao HE Linfeng WU Meimei HAN Songbai | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 8 | Set-up for Indirect Neutron Computerized Tomography Applied to Spent Pressurized Water Reactor(PWR)Nuclear Fuel Rod显示文摘Spent PWR nuclear fuel rods have high radioactivity,normal NDT method can’t get meaning detecting data.With indirect neutron imaging method,the detecting of spent fuel rods can be achieved.With traditional indirect neutron imaging method,two dimensions neutron images can be got.In order to get three dimensions data,the CT reconstruction technique is necessary. | WEI Guohai HAN Songbai WU Meimei HE Linfeng WANG Yu WANG Hongli LIU Yuntao SUN Kai CHEN Dongfeng | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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