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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Investigation of PEG adsorption on the surface of zinc oxide nanoparticles 显示文摘 | Liu F Sheng C Han N X | 2004 | Power Technology2004，145，1： | 1 |
| 3 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 4 | Prospective Study of C-Reactive Protein in Relation to the Development of Diabetes and Metabolic Syndrome in the Mexico City Diabetes Study 显示文摘 | Han TS Sattar N Williams K Gonzalez-Villalpando C | 2002 | Diabetes Care2002，25，11： | 1 |
| 5 | Finite element analysis of Lamb wave propagation in a thin aluminum plate 显示文摘 | Han S J Palazotto A N Leakeas C L | 2009 | Journal of Aerospace Engineering2009，22，2： | 1 |
| 6 | Fabrication, structures and properties of acrylonitrile/vinyl acetate copolymers and copolymers containing microencapsulated phase change materials 显示文摘 | Han N Zhang X X Wang X C | 2010 | Macromolecule Research2010，18，2： | 1 |
| 7 | The Psychology of Appraisal: Specific Emotions and Decision - making 显示文摘 | So J Achar C Han D Agrawal N Duhachek A Maheswaran D | 2015 | Journal of Consumer Psychology2015，，6： | 1 |
| 8 | A high-throughput Agrobacterium mediated transformation system for the grass model species Brachypodium distachyon L显示文摘 | Daniel I P Hans T C Klaus K N | 2008 | Transgenie Re search2008，17，： | 1 |
| 9 | From clusters to phase diagrams: Composition rules of quasicrystals and bulk metallic glasses 显示文摘 | DONG C WANG Q QIANG J B WANG Y M JIANG N HAN G LI Y H WU J XIA J H | 2007 | J Phys D: Appl Phys2007，40，： | 1 |
| 10 | Ho:Tm lasers Ⅱ:experiments,IEEE显示文摘 | LEE C J HAN G BARNES N P | 1996 | Journal of Quantum Electrics1996，32，1： | 1 |
| 11 | Oligonucleotide - Modified Gold Nanoparticles for Intracellular Gene Regulation 显示文摘 | Rosi N L Giljohann D A Thaxton S C Lytton -Jean A K Han M S Mirkin C A | 2006 | Science2006，312，5776： | 1 |
| 12 | Sequence estimation in the pres ence of random parameters via the EM algorithm显示文摘 | Georghiades C N Han J | 1997 | IEEE Transactions on Communications1997，45，： | 1 |
| 13 | Path finding strategies in scale-free networks显示文摘 | Kim B J Yoon C N Han S K | 2002 | Phys Rev E2002，65，02： | 1 |
| 14 | CA2: the most vulnerable sector to bicuculline exposure in rat hippocampal slice cultures显示文摘 | Han C Kasai N Torimitsu K | 2005 | Neuroreport2005，16，： | 1 |
| 15 | Finite-element a- nalysis of lamb wave propagation in a thin aluminum plate显示文摘 | Han S J Palazotto A N Leakeas C L | 2009 | Journal of Aerospace Engineering2009，22，2： | 1 |
| 16 | Hypertension Care and Control in Underserved Urban African American Men: Behavioral and Physiologic Outcomes at 36 Momths显示文摘 | Hill M N Han H R Dennisn C R | 2003 | Am J Hypertens2003，16，11： | 1 |
| 17 | Dissolution and corrosion inhibition of copper,zinc,and their alloys显示文摘 | Jinturkar P Guan Y C Han K N | 1998 | Corrosion1998，54，2： | 1 |
| 18 | Effect of O2 con- centration on metal-insulator transition properties of va- nadium oxide thin films prepared by radio frequency magnetron sputtering显示文摘 | Jang W L Su R M Han N C | 2007 | Thin Solid Films2007，515，2021： | 1 |
| 19 | Comparison of proximal femoral nail antirotation blade and reverse less invasive stabilization system - distal femur systems in the treatment of proximal femoral frac- tures 显示文摘 | HAN N SUN G X LI Z C | 2011 | Orthop Surg2011，3，1： | 1 |
| 20 | Preparation of sorbents loaded on activated carbon to remove H2S from hot coal gas by supercriticalwater impregnation 显示文摘 | Qiu B A Han L N Wang J C | 2011 | Energy & Fuels2011，25，2： | 1 |
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