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| 1 | Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c显示文摘AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA. | Tien S Dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-Huy Han Folasade P May Joseph R Pisegna | 2018 | World Journal of Hepatology2018，10，9： | 4 |
| 2 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 3 | Effect of solution treatment on the strength and fracture toughness of aluminum alloy 7050 显示文摘 | HAN N M ZHANG X M LIU S D HE D G ZHANG R | 2011 | Journal of Alloys and Compounds2011，509，10： | 1 |
| 4 | Neuroprotective effects of ginsen-oside Rd against oxygen - glucose deprivation in cultured hippocampalneurons显示文摘 | Ye R D Li N L Han J L | 2009 | Neuroscience Research2009，64，： | 1 |
| 5 | Population variation in growth and 15-year-old shoot elongation along geographic and climatic gradients in black spruce in Alberta显示文摘 | Wei R P Han S D Dhir N K | 2004 | Canada Journal of Forest Research2004，34，8： | 1 |
| 6 | Phenylacetate synergizes with retinoic acid in inducing the differentiation of human neuroblastoma cells 显示文摘 | Sidell N Wada R Han G | 1995 | Int J Cancer1995，60，4： | 1 |
| 7 | Defective lung vascular development in endothelial nitric oxide synthase-deficient mice 显示文摘 | Han R N Stewart D J | 2006 | Trends Cardiovasc Med2006，16，1： | 1 |
| 8 | Hypertension Care and Control in Underserved Urban African American Men: Behavioral and Physiologic Outcomes at 36 Momths显示文摘 | Hill M N Han H R Dennisn C R | 2003 | Am J Hypertens2003，16，11： | 1 |
| 9 | Effect of O2 con- centration on metal-insulator transition properties of va- nadium oxide thin films prepared by radio frequency magnetron sputtering显示文摘 | Jang W L Su R M Han N C | 2007 | Thin Solid Films2007，515，2021： | 1 |
| 10 | Spl28 encodes a clathrin-associated adaptor protein complex 1, medium subunit μ1 (AP1M1) and is responsible for spotted leaf and early senescence in rice ( Oryza sativa )显示文摘 | Qiao Y Jiang W Lee J Park B Choi M Piao R Woo M Roh J Han L Paek N Seo H Koh H | 2009 | New Phytologist2009，185，1： | 1 |
| 11 | Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hipp-ocampal neurons显示文摘 | Ye R Li N Han J | 2009 | Neurosci Res2009，64，： | 1 |
| 12 | Processing and presentation of endoeytically acquired protein antigens by MHC class I and class II molecules 显示文摘 | Germain R N Castellino F Han R | 1996 | Immunol Rev1996，151，1： | 1 |
| 13 | 查看详情显示文摘 | Schuch R Garibian A Nygaard P Raymond S Araik G Hans H S Patrick J P Per N | | 0，，： | 1 |
| 14 | The draft genome of the fast-growing non-timber forest species moso bamboo (PhyUostachys heterocycla) 显示文摘 | Peng Z H Lu Y Li L Zhao Q Feng Q Gao Z M Lu H Y Hu T YAO N Liu K Y LiY FanDL GuoYL LiW J LuY Q Weng Q J Zhou C C Zhang L Huang T Zhu C R Liu X G Yang X W Wang T Miao K Zhuang C Y Cao X L Tang W L Liu G S Liu Y L Chen J Liu Z J Yuan L C Liu Z H Huang X H LuT T Fei B H Ning Z M Han B Jiang Z H | 2013 | Nature Genetics2013，45，4： | 1 |
| 15 | Effect of chemisorbed water on bed voidage of high temperature fluidized bed 显示文摘 | Yamazaki R Han N Sun Z | 1995 | Powder Technology1995，84，1： | 1 |
| 16 | Genetic diversity analyses of class 1 integrons and their associated antimicrobial re- sistance genes in Enterobacteriaceae strains recovered from aquatic habitats in China 显示文摘 | GUO X XIA R HAN N | 2011 | Lett Appl Microbiol2011，52，6： | 1 |
| 17 | Market Orientation and Organizational Performance:Is Innovation a Missing Link? 显示文摘 | Han J K Kim N Srivastava R K | 1998 | Journal of Marketing1998，62，4： | 1 |
| 18 | The stability of the plasma sheath with secondary emission显示文摘 | Franklin R N Han W E | 1988 | Plasma Physics and Controlled Fusion1988，30，6： | 1 |
| 19 | Glycoalkaloids and metabolites inhibit the'growth of human colon (HT29) and liver(HepG2) cancer cells显示文摘 | Lee K R Kozukue N Han J S | 2004 | J Agric Food Chem2004，52，10： | 1 |
| 20 | Cathodic electrodeposition mixed oxide thin films 显示文摘 | PAUPORTE T GOUX A KAHN-HARARI A TACCONI N HAN C R | 2003 | Journal of Physics and Chemistry Solids2003，64，17： | 1 |
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