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| 1 | Treating inflammatory bowel disease by adsorptive leucocytapheresis:A desire to treat without drugs显示文摘Ulcerative colitis and Crohn’s disease are the major phenotypes of the idiopathic inflammatory bowel disease(IBD),which afflicts millions of individuals throughout the world with debilitating symptoms,impairing function and quality of life.Current medications are aimed at reducing the symptoms or suppressing exacerbations.However,patients require life-long medications,and this can lead to drug dependency,loss of response together with adverse side effects.Indeed,drug side effects become additional morbidity factor in many patients on long-term medications.Nonetheless,the efficacy of anti-tumour necrosis factors(TNF)-αbiologics has validated the role of inflammatory cytokines notably TNF-αin the exacerbation of IBD.However,inflammatory cytokines are released by patients’own cellular elements including myeloid lineage leucocytes,which in patients with IBD are elevated with activation behaviour and prolonged survival.Accordingly,these leucocytes appear logical targets of therapy and can be depleted by adsorptive granulocyte/monocyte apheresis(GMA)with an Adacolumn.Based on this background,recently GMA has been applied to treat patients with IBD in Japan and in the European Union countries.Efficacy rates have been impressive as well as disappointing.In fact the clinical response to GMA seems to define the patients’disease course,response to medications,duration of active disease,and severity at entry.The best responders have been first episode cases(up to 100%)followed by steroid nave and patients with a short duration of active disease prior to GMA.Patients with deep ulcers together with extensive loss of the mucosal tissue and cases with a long duration of IBD refractory to existing medications are not likely to benefit from GMA.It is clinically interesting that patients who respond to GMA have a good long-term disease course by avoiding drugs including corticosteroids in the early stage of their IBD.Additionally,GMA is very much favoured by patients for its good safety profile.GMA in 21st century reminds us of phlebotomy as a major medical practice at the time of Hippocrates.However,in patients with IBD,there is a scope for removing from the body the sources of proinflammatory cytokines and achieve disease remission.The bottom line is that by introducing GMA at an early stage following the onset of IBD or before patients develop extensive mucosal damage and become refractory to medications,many patients should respond to GMA and avoid pharmacologics.This should fulfill the desire to treat without drugs. | Abbi R Saniabadi Tomotaka Tanaka Toshihide Ohmori Koji Sawada Takayuki Yamamoto Hiroyuki Hanai | 2014 | World Journal of Gastroenterology2014，20，29： | 11 |
| 2 | Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis显示文摘瞄准:调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra, IL-10, IL-6 和 IL-18 的传播层次之间的关系。方法:IL-1ra, IL-10, IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量,吝啬的蔡是 11.1,从 5-25 ;并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果:我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827, P <
0.001 ) , IL-6 (r = 0.785, P <
0.001 ) 并且 IL-18 (r = 0.791, P <
0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗, 31 个病人中的 24 个完成了宽恕,所有 4 cytokines 的层次掉在健康控制里到层次。进一步, IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。 | Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe | 2006 | World Journal of Gastroenterology2006，12，21： | 8 |
| 3 | Discrepancies in cytogenetic results between amniocytes and postnatally obtained blood :trisomy 9 mosaicism显示文摘 | Kosaki R Hanai S Kakishima H | 2006 | Congenit Anom (Kyoto)2006，46，： | 1 |
| 4 | KL-6 as a potential new marker for amiodarone-induced puhnonary toxicity 显示文摘 | Endoh Y Hanai R Uto K | 2000 | Am J Cardiol2000，86，2： | 1 |
| 5 | Flexural strengthening of reinforcement concrete beams using high performance fiber reinforcement cement-based composite (HPFRCC) and carbon fiber reinforced polymers (CFRP)显示文摘 | Ferrari V J De Hanai J B De Souza R A | 2013 | Construction and Building Materials2013，48，： | 1 |
| 6 | Environmental effects on a grid connected 900 W photovoltaic thin-film amorphous silicon system 显示文摘 | Hanai T A Hashim R B Chaar L E Lamont L A | 2011 | Renewable Energy2011，36，： | 1 |
| 7 | Aspects of cationic dye molecule adsorption to palygorskite 显示文摘 | A1 - Futaisi A Jamrah A Ai - Hanai R | 2007 | Desalination2007，214，13： | 1 |
| 8 | Development,characterization,and comparative analysis of polymorphism at common bean SSR loci isolated from genic and genomic sources显示文摘 | Hanai L R Campos T Camargo L E | 2007 | Genome2007，50，3： | 1 |
| 9 | Environ- mental effects on a grid connected 900 W photovoltaic tliin -film amorphous silicon system 显示文摘 | HANAI T A HASHIM R B CHAAR L E | 2011 | Renewable Energy2011，36，10： | 1 |
| 10 | Development, characterization, and comparative analysis of polymorphism at common bean SSR loci isolated from genie and genomie sources 显示文摘 | HANAI L R DE CAMPOS T CAMARGO L E | 2007 | Genome2007，50，3： | 1 |
| 11 | Discrepancies in cytogenet- ic results between amni~cytes and postnatally obtained blood: trisomy 9 mosaicism 显示文摘 | Kosaki R Hanai S Kakishima H | 2006 | Congenit Anom (Kyoto)2006，46，： | 1 |
| 12 | Genistein,a new cosmetic ingredient derived from soy: application in postmenpausal skin problems,skin aging and cellulite显示文摘 | Schmid D Hanay Chr Muggli R | 2001 | SOFW J2001，127，1： | 1 |
| 13 | Study of ion-ion interaction for protein-durg binding using a newly developed guanid-bonded phase in liquid-chromatography显示文摘 | MIYAKAKI R HANAI T SUZUKI J | 1998 | J Liq Chromatogr1998，21，： | 1 |
| 14 | An experience of indwelling of a urethral stent (Urolume Wallstent) for urethral stricture accompanying pelvic fracture in a young man显示文摘 | Hanai T Katoh Y Miyatake R | 1999 | Hinyokika Kiyo1999，45，11： | 1 |
| 15 | The effects of guanine and cytosine variation on dinucleofide frequency and amino acid composition in the human genome 显示文摘 | HANAI R WADA A | 1988 | Mol Evol1988，27，： | 1 |
| 16 | Preloaded RC Columns Strengthened with High-Strength Concrete Jackets Under Uniaxial Compression 显示文摘 | TAKEUTI A R HANAI J B D MIRMIRAN A | 2008 | Materials & Structures2008，41，7： | 1 |
| 17 | Extension of the core map of common bean with EST-SSR, RGA, AFLP, and putative functional markers显示文摘 | Hanai L R Santini L Camargo L E | 2010 | Mol Breed2010，25，1： | 1 |
| 18 | Development,characterization and comparative analysis of pol- ymorphism at common bean SSR loci isolated from genie and genomie sources 显示文摘 | Hanai L R Campos T Camargo L E | 2007 | Genome2007，50，3： | 1 |
| 19 | Discrepancies in cytogenetic results between amniocytes and postnatally obtained blood: trisomy 9 mosaieism显示文摘 | Kosaki R Hanai S Kakishima H | 2006 | Congenit Anom(Kyoto)2006，46，： | 1 |
| 20 | An experience of indwelling of a urethral stent ( Urolume Wallstent) for urethral stricture accompanying pelvic fracture in a young man 显示文摘 | Hanai T Miyatake R Katoh Y | 1999 | Hinyokika Kiyo1999，45，11： | 1 |
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