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| 1 | Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis显示文摘瞄准:调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra, IL-10, IL-6 和 IL-18 的传播层次之间的关系。方法:IL-1ra, IL-10, IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量,吝啬的蔡是 11.1,从 5-25 ;并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果:我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827, P <
0.001 ) , IL-6 (r = 0.785, P <
0.001 ) 并且 IL-18 (r = 0.791, P <
0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗, 31 个病人中的 24 个完成了宽恕,所有 4 cytokines 的层次掉在健康控制里到层次。进一步, IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。 | Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe | 2006 | World Journal of Gastroenterology2006，12，21： | 8 |
| 2 | Decrease of reactive-oxygen-producing granulocytes and release of IL-10 into the peripheral blood following leukocytapheresis in patients with active ulcerative colitis显示文摘AIM: To investigate the clinical efficacy of leukocytapheresis (LCAP) in patients with active ulcerative colitis (UC), and to elucidate the mechanisms by determining the changes in the cytokine levels in the peripheral blood and of the functions of the peripheral blood leukocytes in these patients.METHODS: The subjects were 19 patients with active UC, with a mean clinical activity index (CAI) of 9.2. The LCAP was conducted using Cellsorba E. In each session of LCAP, 2-3 L of blood at the flow rate of 30-50 mL/min was processed. The treatment was carried out in approximately 1-h sessions, once a week, for 5-10 wk. Blood samples for determination of the cytokine levels were collected from the inflow side of the column (site of dehematization; at the start of LCAP) and outflow side of the column (at the end of LCAP). Blood samples for the determination of reactive-oxygen-producing cells were collected from the peripheral blood before and after LCAP.RESULTS: LCAP resulted in clinical improvement in all the 19 patients of UC recruited for this study. Remission (CAI: ≤4) was noted in 15 (79%) of the 19 patients. The blood level of the pro-inflammatory cytoline IL-6 was found to be decreased following treatment by LCAP, and the level of the anti-inflammatory cytokine IL-10 at the outflow side of the LCAP column was found to be significantly elevated as compared to that at the inflow side of the column. The reactive-oxygen-producing granulocytes in the peripheral blood of UC patients was increased as compared to that in healthy persons and the increase was found to be decreased following treatment by LCAP.CONCLUSION: LCAP exerted a high therapeutic efficacy in patients with active UC. Our findings suggest that LCAP is associated with enhanced production of the inhibitory cytokine IL-10 to indirectly inhibit the functions of the inflammatory leukocytes, and that inflammation is also considerably attenuated by the direct removal of reactiveoxygen-producing neutrophils from the peripheral blood. | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Masataka Kikuyama Tatsuo Tanaka Kenji Kondo Kou Tanaka Kenji Takai | 2005 | World Journal of Gastroenterology2005，11，20： | 7 |
| 3 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial显示文摘 | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Akira Andoh Tomoyuki Tsujikawa Yosihihide Fujiyama Keiichi Mitsuyama Michio Sata Masami Yamada Yasushi Iwaoka Kazunari Kanke Hideyuki Hiraishi Kazuhisa Hirayama Hajime Arai Shi | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 2 |
| 4 | Factors Associated with the Clinical Impact of Capsule Endoscopy in Patients with Overt Obscure Gastrointestinal Bleeding显示文摘 | Motohiro Esaki Takayuki Matsumoto Shinichiro Yada Ritsuko Yanaru-Fujisawa Tetsuji Kudo Shunichi Yanai Shotaro Nakamura Mitsuo Iida | 2010 | Digestive Diseases and Sciences2010，，8： | 2 |
| 5 | Mucosal vascular pattern in ulcerative colitis: observations using narrow band imaging colonoscopy with special reference to histologic inflammation显示文摘 | Tetsuji Kudo Takayuki Matsumoto Motohiro Esaki Takashi Yao Mitsuo Iida | 2009 | International Journal of Colorectal Disease2009，，5： | 2 |
| 6 | Magnifying colonoscopy with narrow band imaging system for the diagnosis of dysplasia in ulcerative colitis: a pilot study显示文摘 | Takayuki Matsumoto Tetsuji Kudo Yukihiko Jo Motohiro Esaki Takashi Yao Mitsuo Iida | 2007 | Gastrointestinal Endoscopy2007，，： | 1 |
| 7 | GI involvement in Henoch-Sch?nlein purpura显示文摘 | Motohiro Esaki Takayuki Matsumoto Shotaro Nakamura Masumi Kawasaki Keiichiro Iwai Katsuya Hirakawa Ken-ichi Tarumi Takashi Yao Mitsuo Iida | 2002 | Gastrointestinal Endoscopy2002，，6： | 1 |
| 8 | Mesenteric Phlebosclerosis显示文摘 | Akinori Iwashita M.D. Ph.D. Tsuneyoshi Yao M.D. Ph.D. Ronald J. Schlemper M.D. Ph.D. Yasuyuki Kuwano M.D. Takashi Yao M.D. Ph.D. Mitsuo Iida M.D. Ph.D. Takayuki Matsumoto M.D. Ph.D. Masahiro Kikuchi M.D. Ph.D | 2003 | Diseases of the Colon & Rectum2003，，2： | 1 |
| 9 | Ultrasound-guided superior laryngeal nerve block and translaryngeal block for awake tracheal intubation in a patient with laryngeal abscess显示文摘 | Takafumi Iida Akihiro Suzuki Takayuki Kunisawa | 2013 | J Anesth2013，27，： | 1 |
| 10 | Probe EUS for the diagnosis of invasion depth in superficial esophageal cancer: a comparison between a jelly-filled method and a water-filled balloon method显示文摘 | Motohiro Esaki Takayuki Matsumoto Tomohiko Moriyama Kazuoki Hizawa Yutaka Ohji Shotaro Nakamura Katsuya Hirakawa Minako Hirahashi Takashi Yao Mitsuo Iida | 2006 | Gastrointestinal Endoscopy2006，，3： | 1 |
| 11 | GI involvement in Henoch-Sch?nlein purpura显示文摘 | Motohiro Esaki Takayuki Matsumoto Shotaro Nakamura Masumi Kawasaki Keiichiro Iwai Katsuya Hirakawa Ken-ichi Tarumi Takashi Yao Mitsuo Iida | 2002 | Gastrointestinal Endoscopy2002，，6： | 1 |
| 12 | Chromoscopy might improve diagnostic accuracy in cancer surveillance for ulcerative colitis显示文摘 | Takayuki Matsumoto Shotaro Nakamura Yukihiko Jo Takashi Yao Mitsuo Iida | 2003 | The American Journal of Gastroenterology2003，，8： | 1 |
| 13 | Significance of appendiceal involvement in patients with ulcerative colitis显示文摘 | Takayuki Matsumoto Shotaro Nakamura Michio Shimizu Mitsuo Iida | 2002 | Gastrointestinal Endoscopy2002，，2： | 1 |
| 14 | Recombinant human granulocyte colony-stimulating factor reduces colonic epithelial cell apoptosis and ameliorates murine dextran sulfate sodium-induced colitis显示文摘 | Tetsuji Kudo Takayuki Matsumoto Ikuo Nakamichi Shinichiro Yada Motohiro Esaki Yukihiko Jo Yutaka Ohji Takashi Yao Mitsuo Iida | 2008 | Scandinavian Journal of Gastroenterology2008，，6： | 1 |
| 15 | Mucin core protein expression in serrated polyps of the large intestine显示文摘 | Kohei Fujita Minako Hirahashi Hidetaka Yamamoto Takayuki Matsumoto Masaki Gushima Yoshinao Oda Junji Kishimoto Takashi Yao Mitsuo Iida Masazumi Tsuneyoshi | 2010 | Virchows Archiv2010，，4： | 1 |
| 16 | Hyperglycemia Increases Risk of Gastric Cancer Posed by Helicobacter pylori Infection: A Population-Based Cohort Study显示文摘 | Fumie Ikeda Yasufumi Doi Koji Yonemoto Toshiharu Ninomiya Michiaki Kubo Kentaro Shikata Jun Hata Yumihiro Tanizaki Takayuki Matsumoto Mitsuo Iida Yutaka Kiyohara | 2009 | Gastroenterology2009，，4： | 1 |
| 17 | Comparison of EUS and magnifying colonoscopy for assessment of small colorectal cancers显示文摘 | Takayuki Matsumoto Kazuoki Hizawa Motohiro Esaki Koichi Kurahara Mitsuru Mizuno Katsuya Hirakawa Takashi Yao Mitsuo Iida | 2002 | Gastrointestinal Endoscopy2002，，3： | 1 |
| 18 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial显示文摘 | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Akira Andoh Tomoyuki Tsujikawa Yosihihide Fujiyama Keiichi Mitsuyama Michio Sata Masami Yamada Yasushi Iwaoka Kazunari Kanke Hideyuki Hiraishi Kazuhisa Hirayama Hajime Arai Shi | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 1 |
| 19 | An improved synthesis of taurine- and glycine-conjugated bile acids 显示文摘 | Toshiaki Momose Takayuki Tsubaki Takashi Iida | 1997 | Lipids1997，32，7： | 1 |
| 20 | Factors Associated with the Clinical Impact of Capsule Endoscopy in Patients with Overt Obscure Gastrointestinal Bleeding显示文摘 | Motohiro Esaki Takayuki Matsumoto Shinichiro Yada Ritsuko Yanaru-Fujisawa Tetsuji Kudo Shunichi Yanai Shotaro Nakamura Mitsuo Iida | 2010 | Digestive Diseases and Sciences2010，，8： | 1 |
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