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| 1 | Delivery of dsRNA for RNAi in insects: an overview and future directions显示文摘抽象 RNA 干扰(RNAi ) 指外长的双 stranded RNA (dsRNA ) silencing 的过程互补内长的送信人 RNA。RNAi 广泛地在昆虫学的研究被使用了因为主要因为它的高特性,在为基于 RNAi 的害虫控制的许多昆虫和它的潜力的功能的 genomics 逐渐地被强调了。这评论集中于介绍 dsRNA 进昆虫房间或昆虫身体导致有效 RNAi 的途径。三个很普通的交货方法,也就是 microinjection,摄取,并且浸泡,在细节和他们的优点被说明,限制为可行 RNAi 研究的目的被总结。在这评论,我们简短也在昆虫学介绍二可能的 dsRNA 举起机械,另外的 dsRNA 交货方法和 RNAi 的历史。在 RNAi 研究影响象 transfection 试剂, dsRNA 区域的选择,长度,和 dsRNA 的稳定性那样的 RNAi 的特性和效率的因素为进一步的研究被讨论。 | Na yu Olivier Christiaens Jisheng Liu Jinzhi Niu Kaat Cappelle Silvia Caccia Hanneke Huvenne Guy Smagghe | 2013 | Insect Science2013，20，1： | 15 |
| 2 | Four cancer cases after esophageal atresia repair: Time to start screening the upper gastrointestinal tract显示文摘Esophageal atresia(EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities after EA repair are dysphagia(72%) and gastroesophageal reflux(GER)(67%). Chronic GER after EA repair might lead to mucosal damage, esophageal stricturing, Barrett's esophagus and eventually esophageal adenocarcinoma. Several long-term follow-up studies found an increased risk of Barrett's esophagus and esophageal carcinoma in EA patients, both at a relatively young age. Given these findings, the recent ESPGHAN-NASPGHAN guideline recommends routine endoscopy in adults born with EA. We report a series of four EA patients who developed a carcinoma of the gastrointestinal tract: three esophageal carcinoma and one colorectal carcinoma in a colonic interposition. These cases emphasize the importance of lifelong screening of the upper gastrointestinal tract in EA patients. | Floor WT Vergouwe Madeleine Gottrand Bas PL Wijnhoven Hanneke IJsselstijn Guillaume Piessen Marco J Bruno René MH Wijnen Manon CW Spaander | 2018 | World Journal of Gastroenterology2018，24，9： | 3 |
| 3 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 4 | Mechanisms of integrin activation and trafficking显示文摘 | Coert Margadant Hanneke N Monsuur Jim C Norman Arnoud Sonnenberg | 2011 | Current Opinion in Cell Biology2011，，5： | 2 |
| 5 | Rates of convergence in active learning 显示文摘 | Hanneke S | 2011 | The Annals of Statistics2011，39，1： | 1 |
| 6 | determinants of different di-mensions of disease severity in asthma and COPD显示文摘 | Hanneke AH Wijnbren MLE Didi M | 2001 | COPDhest2001，199，： | 1 |
| 7 | Facilitation of antibody forming responses to viral vaccine antigens in young cats by recombinant baculovirus-expressed feline IFN-γ显示文摘 | VIRGIL E J NICOLETTE C HANNEKE I | 2002 | Vaccine2002，20，1314： | 1 |
| 8 | Supplemental oxy- gen prevents exercise-induced oxidative stress in muscle-wast- ed patients with chronic obstructive pulmonary disease 显示文摘 | Hanneke AC Yvonne FH Leo MA | 2006 | Am J Respir Crit Care Med2006，173，10： | 1 |
| 9 | Relationship between graft-versus-host disease and graft-versus-leukemia in partial T cell-depleted bone marrow transplantation 显示文摘 | Hanneke M van der Straaten Rob F | 2001 | Br J Heamotol2001，114，： | 1 |
| 10 | Determination of different dimensions of disease severity in asthma and COPD显示文摘 | Hanneke AH Wijnboven Msc Didi M | 2001 | Chest2001，199，： | 1 |
| 11 | Which chronic conditions are associated with better or poorer quality of life?显示文摘 | Mirjam A.G. Sprangers Ellen B. de Regt Frank Andries Heleen M.E. van Agt Rob V. Bijl Josien B. de Boer Marleen Foets Nancy Hoeymans Annelies E. Jacobs Gertrudis I.J.M. Kempen Harold S. Miedema Marja A.R. Tijhuis Hanneke C.J.M. de Haes | 2000 | Journal of Clinical Epidemiology2000，，9： | 1 |
| 12 | Perceived need to take medication is associated with medication non- adherence in patients with rheumatoid arthritis 显示文摘 | HANNEKE E ZWIKKER SANDRA VAN DULMEN AA DEN BROEDER | 2014 | Patient Preference and Adherence2014，，8： | 1 |
| 13 | Influence of folic acid on postprandial endothelial dysfunction显示文摘 | Hanneke WW Erik SG Willew DE | 2000 | Atherosclerosis and Lipoproteins2000，20，： | 1 |
| 14 | Development of highly polymorphic SNP markers from the complexity reduced portion of maize [Zea mays L.] genome for use in marker-assisted breeding显示文摘 | Jafar A. Mammadov Wei Chen Ruihua Ren Reetal Pai Wesley Marchione Feyruz Yal?in Hanneke Witsenboer Thomas W. Greene Steven A. Thompson Siva P. Kumpatla | 2010 | Theoretical and Applied Genetics2010，，3： | 1 |
| 15 | Bevacizumab reduces tumor targeting of antiepidermal growth factor and anti‐insulin‐like growth factor 1 receptor antibodies显示文摘 | Sandra Heskamp Otto C. Boerman Janneke D.M. Molkenboer‐Kuenen Wim J.G. Oyen Winette T.A. Graaf Hanneke W.M. Laarhoven | 2013 | Cancer2013，，2： | 1 |
| 16 | Predictors of health care utilization in patients with inflammatory bowel disease: a longitudinal study显示文摘 | Angela G.E.M. de Boer Mirjam A.G. Sprangers Joep F.W. Bartelsman Hanneke C.J.M. de Haes | 1998 | European Journal of Gastroenterology & Hepatology1998，，9： | 1 |
| 17 | Influence of folic acid on postprandial endothelial dysfunction显示文摘 | Hanneke WW Erik SG Willew DE | 2000 | Artherioscler Thromb2000，20，1： | 1 |
| 18 | Diffusion-weighted MR imaging in liver metastases of colorectal cancer: reproducibility and biological validation显示文摘 | Linda Heijmen Edwin E. G. W. Voert Iris D. Nagtegaal Paul Span Johan Bussink Cornelis J. A. Punt Johannes H. W. Wilt Fred C. G. J. Sweep Arend Heerschap Hanneke W. M. Laarhoven | 2013 | European Radiology2013，，3： | 1 |
| 19 | Does COPD Global Initiative for Chronic Obstructive Lung Disease Stage Matter? 显示文摘 | Jorien D C Hannink Hanneke A C | 2010 | CHEST2010，137，5： | 1 |
| 20 | Effect of peri-operative chemotherapy on the quality of life of patients with early breast cancer 显示文摘 | KIEBERT G M HANNEKE J DE HAES C J | 1990 | Eur J Cancer1990，26，： | 1 |
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