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| 1 | Overcoming HBV immune tolerance to eliminate HBsAg-positive hepatocytes via pre-administration of GM-CSF as a novel adjuvant for a hepatitis B vaccine in HBV transgenic mice显示文摘尽管有矛盾的结果, Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 从动物和人的研究被知道是一个潜在的疫苗的助手。差异可能由于被使用的 GM-CSF 的不同剂量和政体,给那成熟或不成熟的树枝状的房间(DC ) 能在不同条件下面被导致。为了测试假设,那 GM-CSF 能为一个肝炎 B 病毒(HBV ) 被用作一个新奇助手治疗学的疫苗,我们与 recombinant HBV 疫苗(rHBVvac ) 在种痘以前每天管理了 GM-CSF 一次三天在老鼠。我们在作为与白天 1 每日的 GM-CSF 管理或白天 2 相比的白天 3 点在这些预先对待的动物观察了更大的 DC 成熟。这策略进一步为它打破在肝炎 B 表面建立的有免疫力的忍耐的能力被调查抗原转基因(HBsAg-Tg ) 动物。我们发现导致的 anti-HBsAg 抗体的层次在在第三免疫以后在 rHBV 种痘前跟随三天 GM-CSF 预告的处理的动物是显著地更高的。除了 anti-HBsAg 抗体层次的增加,调停房间的 anti-HBsAg 回答包括延期类型超敏性, T 房间增长, interferon-γ生产,和细胞毒素的 T 淋巴细胞,戏剧性地在三天的 GM-CSF 被提高预先对待的组。在从使免疫的动物的 CD8 + T 房间的采纳转移以后,抗原特定的 CD8 + T 房间在接受者 HBsAg-Tg 动物的肝被观察。而且,有在 rHBVvac 种痘以前的 GM-CSF 的三天的预告的处理能显著地消除 HBsAg 积极的 hepatocytes,建议有益的治疗学的效果。因此,与 rHBVvac 疫苗在联合作为一个助手利用 GM-CSF 的这个协议有潜力为长期的肝炎 B 病人成为新奇免疫疗法。 | Xianzheng Wang Aihua Dong Jingjing Xiao Xingjun Zhou Haili Mi Hanqian Xu Jiming Zhang Bin Wang | 2016 | Cellular & Molecular Immunology2016，13，6： | 11 |
| 2 | LORELEI-LIKE GPI-ANCHORED PROTEINS 2/3 Regulate Pollen Tube Growth as Chaperones and Coreceptors for ANXUR/BUPS Receptor Kinases in Arabidopsis显示文摘Pollen tube growth is crucial for successful fertilization.In Arabidopsis thaliana,the ANXUR(ANX)/BUPS receptor kinase complex controls and maintains pollen tube growth in response to autocrine rapid alkalin-ization factor 4/19(RALF4/19)signaling;however,the molecular and cellular mechanisms underlying the ANX/BUPS-mediated regulation of pollen tube growth remain unclear.In this study,we found that pollen-specific LORELEI-like GPI-anchored proteins 2 and 3(LLG2/3)promote pollen tube growth in vitro and in vivo.LLG2/3 interacte with ANX/BUPS in a RALF4-concentration-dependent manner,suggesting that ANX/BUPS and LLG2/3 might form a receptor-coreceptor complex for perceiving RALF peptide signals.Disruption of the ANX/BUPS-LLG2/3 interaction led to the cytoplasmic retention of ANX1/2,in either llg2/3 knockdown mutants or in anx1/2 mutants lacking the J region,which mediates the ANX/BUPS-LLG2/3 interaction.Moreover,we found that RALF4 induced the production of reactive oxygen species(ROS),which stimulate pollen tube growth and reduce pollen burst rate.ROS levels are reduced in the pollen tubes of LLG2/3 RNAi lines,and application of exogenous H2O2 could partially rescue the defective pollen tube growth of LLG2/3 RNAi lines.Taken together,our study identifies LLG2/3 as novel regulatory components of pollen tube growth,and shows that they chaperone ANX/BUPS for secretion to the apical plasma membrane of pollen tube and act as coreceptors of ANX/BUPS in the acti-vation of ROS production for promoting pollen tube growth. | Hanqian Feng Chen Liu Rong Fu Minmin Zhang Hui Li Lianping Shen Qiqi Wei Xiang Sun Lin Xu Bin Ni Chao Li | 2019 | Molecular Plant2019，12，12： | 10 |
| 3 | Development of SA-533 Type B CL. 1+SA-240 Type 304L roll-bonded clad steel plate for safety injection tank of CAP1400 nuclear power plant显示文摘Aiming to meet the demand of the country's nuclear demonstration project on the CAP1400 nuclear power plant,Baosteel uses the roll-bonding technology and develops the SA-533 Type B CL. 1+SA-240 Type 304L high-strength and high-toughness clad steel plate with a shear strength of over 310 MPa for the nuclear power plant's safety injection tank. The properties of the quenched and tempered and the simulated post-weld heat treatment states are systematically studied herein through a comprehensive inspection and evaluation of the composition,microstructure,and properties of the clad steel plate. The results show that the bonding interface has high shear strength and that the base metal has high strength and good toughness at low temperatures. Hence,the performance fully meets the technical requirements of the CAP1400 nuclear power plant's safety injection tank in the country's nuclear demonstration project. The roll-bonded clad steel plate can be used to manufacture the safety injection tank of the CAP1400 nuclear power plant. | HOU Hong ZHANG Hanqian YUAN Xiangqian DING Jianhua | 2017 | Baosteel Technical Research2017，11，1： | 2 |
| 4 | Microstructure and properties of S30403+Q345R roll-bonded clad steel plate for pressure vessels显示文摘To meet the demand of the domestic pressure vessel industry for roll-bonded clad steel plates,Baosteel has developed an S30403+Q345R roll-bonded clad steel plate. Comprehensive inspections of the composition,microstructure,and properties are made to systematically evaluate the steel plate in the normalized and normalized +stress relieved states. The results show the cladding interface of the S30403+Q345R roll-bonded clad steel plate has high shear strength,the base metal has good properties,and the mechanical properties of the steel plate head and tail are uniform. The performance is fully consistent with the technical requirements of the roll-bonded clad steel plate for pressure vessels. | HOU Hong ZHANG Hanqian JIAO Sihai | 2017 | Baosteel Technical Research2017，11，1： | 2 |
| 5 | Production of a monoclonal antibody specific for high molecular weight glutenin subunits (HMW-GS) in wheat and its antigenic determinant显示文摘Wheat high molecular weight glutenin subunits (HMW-GS) 1Bx14 and 1By15 isolated by preparative SDS-PAGE are used as antigen to immunize BALB/c mice. Subcutaneous inoculation of the antigen is performed. The intra-peritoneal injection is completed 3 days before fusion with myeloma cell (SP2/0) via PEG-1500. The fusion cells are selected by indirect enzyme-linked immuno-sorbent assay (ELISA). Positive hybrid cells are further verified three times by limit dilution of the culture cells. A hybridoma cell line is successfully obtained. The monoclonal antibody belongs to IgG1 subclass. In immunoblotting, the antibody binds to all HMW-GS of T.aestivum cultivars, but does not bind to other storage proteins in seeds of wheat. This result is consisting with the high homology in amino acid sequences among the HMW glutenin subunits in wheat. The antibody also binds to HMW-GS storage proteins in Aegilops squarrosa and T. durum (durum wheat). Furthermore, it also binds to HMW storage proteins in Secale cereale (rye),Hordeum vulgare (barley). However, it never binds seed storage proteins in other cereals such as maize, oat, rice, foxtail millet, sorghum etc. The antigen determinant recognized by the antibody has been located within hexapeptide [PGQGQQ] or / and nonapeptide [GYYPTSPQQ] in the central repetitive region of HMW-GS. | WANG Hanqian ZHANG Xueyong WANG Hongmei PANG Binshuang | 2005 | Science China(Life Sciences)2005，48，1： | 1 |
| 6 | New methods of predicting dissimilar steel weld metal microstructures by Schaeffler Diagram显示文摘NewmethodsofpredictingdissimilarsteelweldmetalmicrostructuresbySchaefflerDiagramZHANGHanqian;WANGBaoandZHANGWenyue(TheResearc... | ZHANG Hanqian WANG Bao and ZHANG Wenyue(The Research Institute of Welding Materials. Taiyuan University of Technology.Taiyuan. 030024. Prof. ZHANG Wenyue. Welding Department. Tianjin University. Tianjin. 300072) | 1996 | China Welding1996，5，1： | 1 |
| 7 | First Report of Phomopsis Leaf Spot on Patchouli [Pogostemon cablin( Blanco) Benth. ]Caused by Diaporthe arecae in China显示文摘A severe leaf spot disease on patchouli,was observed in Guangdong,China.Early symptom appeared as circular or irregularly shaped and dark brown spots along the leaf margins and tips.As the disease progressed,the spots enlarged and with masses black,sessile conidiomata were observed in lesions.The results of morphology,molecular biology and pathogenicity test indicate that the causal agent of leaf disease of patchouli is Diaporthe arecae. | Qingqian ZENG Hanqian HUANG Zhouxi LEI Yicheng HUANG Yong HUANG Huiyun FAN | 2020 | Agricultural Biotechnology2020，9，2： | 1 |
| 8 | The effect of M 23 C 6 on the high-temperature tensile strength of two austenitic heat-resistant steels: 22Cr–25Ni–Mo–Nb–N and 25Cr–20Ni–Nb–N显示文摘 | Bicao Peng Hongxiang Zhang Jie Hong Jiaqiang Gao Hanqian Zhang Qijiang Wang Jinfu Li | 2011 | Materials Science & Engineering A2011，，10： | 1 |
| 9 | NEW VIEW OF CHARACTERISTIC ZONE CLASSIFICATION OF FUSION WELDING JOINT显示文摘NEWVIEWOFCHARACTERISTICZONECLASSIFICATIONOFFUSIONWELDINGJOINTNEWVIEWOFCHARACTERISTICZONECLASSIFICATIONOFFUSIONWELDINGJOINTZha... | Zhang Hanqian Wang Bao Wu Yu Lu Wenxiong (Taiyuan University of Technology) | 1995 | Chinese Journal of Mechanical Engineering1995，8，4： | 1 |
| 10 | Microstructural evolution of 9Cr-1Mo deposited metal subjected to weld heating 显示文摘 | Wang Honghong Zhang Hanqian Li Jinfu | 2009 | Journal of Materials Processing Technology2009，209，6： | 1 |
| 11 | Development of S11306+SA516Gr70 roll-bonded clad steel plate for pressure vessels显示文摘To meet the demand of the pressure vessel industry,Baosteel has developed an S11306+SA516Gr70 roll-bonded clad steel plate. Comprehensive inspections of the composition,microstructure,and properties are performed to systematically evaluate the steel plate in normalized state and normalized+stress relieved state. The results show the cladding interface of the S11306+SA516Gr70 roll-bonded clad steel plate has high shear strength,and the base metal has good mechanical properties. The performance is fully consistent with the technical requirements of the roll-bonded clad steel plate for pressure vessels. | HOU Hong ZHANG Hanqian ZHANG Aiwen | 2017 | Baosteel Technical Research2017，11，2： | 1 |
| 12 | Activation of the Melanocortin-4 receptor signaling byα-MSH stimulates nervedependent mouse digit regeneration显示文摘Background:Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and regeneration.However,the expression and function of Mc4r in the mouse limb and digit has not been fully investigated.Our previous work showed that Mc4r−/−mice fail to regenerate the digit,but whether activation of MC4R signaling could rescue digit regeneration,or stimulate proximal digit regeneration is not clear.Results:We analyzed the expression dynamics of Mc4r in the embryonic and postnatal mouse limb and digit using the Mc4r-gfp mice.We found that Mc4r-GFP is mainly expressed in the limb nerves,and in the limb muscles that are undergoing secondary myogenesis.Expression of Mc4r-GFP in the adult mouse digit is restricted to the nail matrix.We also examined the effect ofα-MSH on mouse digit regeneration.We found that administration ofα-MSH in the Mc4r+/−mice rescue the delayed regeneration of distal digit tip.α-MSH could rescue distal digit regeneration in denervated hindlimbs.In addition,α-MSH could stimulate regeneration of the proximally amputated digit,which is non-regenerative.Conclusions:Mc4r expression in the mouse limb and digit is closely related to nerve tissues,andα-MSH/MC4R signaling has a neurotrophic role in mouse digit tip regeneration. | Hanqian Xu Hailin Zhang Yanqing Fang Huiran Yang Ying Chen Chao Zhang Gufa Lin | 2021 | Cell Regeneration2021，10，1： | 1 |
| 13 | Microstructural evolution of 9Cr-IMo deposited metal subjected to weld heating 显示文摘 | Wang Honghong Zhang Hanqian Li Jinfu | 2009 | Journal of Materials Processing Technology2009，209，6： | 1 |
| 14 | 黑皮质素受体4信号通路调控脊椎动物肢体再生显示文摘文章简介在该研究中,研究人员首先发现爪蛙蝌蚪下丘脑损伤会导致断肢再生障碍。下丘脑黑皮质素系统主要调控动物的进食行为及能量平衡。黑皮质素受体(MCRs)在不同组织中存在不同的生理学功能,在能量平衡调控中起作用的主要是黑皮质素受体-3(Mc3r)及黑皮质素受体-4(Mc4r)。 | Mengshi Zhang Youwei Chen Hanqian Xu Li Yang Feng Yuan Lei Li Ying Xu Ying Chen 张超 林古法 | 2019 | 科学新闻2019，0，2： | 0 |
| 15 | Polyphenol components in black chokeberry(Aronia melanocarpa)as clinically proven diseases control factors——an overview显示文摘The black chokeberry is rich in polyphenols,including flavonoids with anthocyanins,flavanols and lavonols as the main components and a variety of phenolic acids represented by chlorogenic acid.Because of these polyphenols,black chokeberry has the effect of preventing and adjuvant therapy diseases.This study summarized the current research results on the types and contents of functional components in black chokeberry,and analyzed their digestion,absorption and metabolism in human body.On this basis,the disease control functions that have been proved effective in clinical research were reviewed and analyzed.These studies showed that black chokeberry have good prevention and adjuvant therapy effects on hyperlipidemia,hypertension,diabetes and inflammation.Because there are different functional components in black chokeberry,its prevention and treatment of the same disease can come from multiple pathways,which provides a more reliable effectiveness for the disease control of different populations. | Ningxuan Gao Chi Shu Yuehua Wang Jinlong Tian Yuxi Lang Chenyu Jin Xingyue Cui Hanqian Jiang Shi’an Liu Zhiying Li Wei Chen Hao Xu Bin Li | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
| 16 | Preventive effect of kiwi berry(Actinidia arguta)on loperamide-induced constipation显示文摘Constipation is a common intestinal disease.Kiwi berries can effectively prevent constipation.However,studies have yet to be done to determine how kiwi berries prevent constipation.For two weeks,mice in this study were continually orally gavaged with kiwi berry,loperamide,or a combination of the 2.This study found that the kiwi group's feces had more water than the constipated mice.In addition,kiwi berries can speed up gastrointestinal transit(GI),shorten the time it takes to pass the first dark stool,and dramatically enhance body weight gain.In the interstitial cells of Caj al(ICC)cells and colon tissues,alterations in the protein expression of vasoactive intestinal peptide(VIP),cyclic adenosine monophosphate(cAMP),protein kinase A(PKA),and aquapcrin-3(AQP3)were found.At 3,6,and 12 h of ICC cells and mouse colon,the kiwi group's VIP,cAMP,PKA,and AQP3 protein expression levels were lower than those of the constipated mice.The kiwi berry can decrease the Firmicutes to Bacteroidetes ratio and boost the diversity and quantity of gut microbiota.By influencing the gut microbiota and VIP-cAMP-PKA-AQP3 signaling pathway,kiwi berries prevent constipation. | Jiyue Zhang Bin Li Ningxuan Gao Haikun Li Xingyue Cui Hanqian Jiang Siyi Tang Chenyu Jin Jinlong Tian | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
| 17 | The effect of kiwi berry(Actinidia arguta)on preventing and alleviating loperamide-induced constipation显示文摘This research aimed to study the preventive and relieving outcomes of kiwi berry on constipation.The administration of kiwi berries to mice resulted in a significant increase in body weight gain of 148.2%compared to mice that were constipated.The number of stools and the water content of stools both increased by 138.5%and 106.5%,respectively.The gastrointestinal transit rate increased by 45.3%,and the time it took for the first dark stool to form decreased by 57.5%.The levels of the excitability neurotransmitters were found to be higher in the group that had been given kiwi berries in comparison to the group that had been given loperamide.The opposite results were produced by vasoactive intestinal peptide(VIP)and aquaporin-3(AQP3).In addition,kiwi berry consumption may lessen epithelial cell apoptosis and promote colon health.All the results point to kiwi berries as an extremely promising food supplement for the prevention and relief of constipation in the future since they successfully prevent and alleviate constipation brought on by loperamide. | Jiyue Zhang Dongnan Li Qilin Tian Yumeng Ding Hanqian Jiang Guang Xin Shunchang Cheng Siyi Tang Chenyu Jin Jinlong Tian Bin Li | 2023 | Food Innovation and Advances2023，2，1： | 0 |
| 18 | Fracture toughness of 12Cr2Mo1R steel at elevated temperature显示文摘The microstructure,tensile properties,and fracture toughness of 12Cr2Mo1R steel were studied. The results indicate that this steel is characterized by a bainite microstructure,in which several types of carbides precipitate along the ferrite laths. As the temperature increases from room temperature to 375 ℃,the strength of the steel increases slightly and the fracture toughness clearly decreases. However,when the temperature continues to increase up to 500 ℃,the strength decreases and the fracture toughness increases. At all the temperatures investigated,the strength and toughness of the developed 12Cr2Mo1R steel were capable of meeting the design requirements of a high-temperature gas-cooled reactor. The fracture of 12Cr2Mo1R steel at high temperature typically occurs in the ductile mode. | LIU Huibin ZHANG Hanqian | 2015 | Baosteel Technical Research2015，9，2： | 0 |
| 19 | The effect of different cooling and tempering conditions on the strength and toughness of SA533B steel显示文摘The microstructure and mechanical properties of SA533B low-alloy steel were investigated under different cooling and tempering conditions. Steel plates cooled at 40℃ /s and 25℃ /min,exibited microstructures of auto-tempered martensite and bainite,respectively. During tempering,the strength of steels quenched at the two different cooling rates decreased continuously with an increase in the tempering parameter,which is defined by T(20 +log t),where T is the temperature and t is the holding time.However,the rate of change of the strength scales with the degree to which the virgin microstructure deviates from equilibrium. The strength of the martensitic steel decreased faster and finally obtained a value close to that of the bainitic steel. The ductility and toughness gradually improved during tempering,passed through a maximum value,and finally diminished. The level of maximum toughness was also found to depend on the cooling rates of SA533B steel. The high cooling rate with a microstructure of auto-tempered martensite exhibited a larger toughness and a lower ductile-brittle transition temperature than the low cooling rate with a microstructure of bainite,because the former had finer precipitated cementite particles at quenching and a slower coarsing rate during tempering. | LIU Huibin ZHANG Hanqian | 2014 | Baosteel Technical Research2014，8，2： | 0 |
| 20 | Present Status and Future Development of HL-2A Data Acquisition System显示文摘HL-2A data acquisition system (DAS) was developed and used in engineering tests last year. The main parts of the system include the experiment network, the data acquisition and processing mechanisms, and the graph and character display equipments. | CHENLiaoyuan LUOCuiwen PANLi YANGYang XUZhengyu HANQian | 2002 | Southwestern Institute of Physics Annual Report2002，，1： | 0 |
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