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| 1 | B-doped and La_(4)NiLiO_(8)-coated Ni-rich cathode with enhanced structural and interfacial stability for lithium-ion batteries显示文摘Ni-rich layered oxides are considered promising cathodes for advanced lithium-ion batteries(LIBs)in the future,owing to their high capacity and low cost.However,the issues on structural and interfacial stability of Ni-rich cathodes still pose substantial obstacles in the practical application of advanced LIBs.Here,we employ a one-step method to synthesize a B-doped and La_(4)NiLiO_(8)-coated LiNi_(0.82)5Co_(0.115)Mn_(0.06)O_(2)(BL-1)cathode with reliable structure and interface,for the first time.The La_(4)NiLiO_(8)coating layer can prevent cathodes from electrolyte assault and facilitate Li+diffusion kinetics.Moreover,B-doping can effectively restrain the pernicious H_(2)-H_(3) phase transition and adjust the orientation of primary particles to a radial alignment,which is obstructive to the arise of microcracks induced by the change of anisotropic volume.Specifically,when tested in pouch cells,the BL-1 cathode exhibits outstanding capacity retention of 93.49%after 500 cycles at 1 C.This dual-modification strategy dramatically enhances the stability of the structure and interface for Ni-rich cathode materials,consequently accelerating the commercialization process of high-energy–density LIBs. | Lingjun Li Lizhi Fu Miao Li Chu Wang Zixiang Zhao Shangchen Xie Haichen Lin Xianwen Wu Haodong Liu Li Zhang Qiaobao Zhang Lei Tan | 2022 | Journal of Energy Chemistry2022，31，8： | 10 |
| 2 | Atg5 regulates late endosome and lysosome biogenesis显示文摘Autophagy is an evolutionarily conserved lysosome-based degradation process.Atg5 plays a very important role in autophagosome formation.Here we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autophagy-independent manner.In Atg5 cells,but not in other essential autophagy genes defecting cells,recycling and retrieval of late endosomal components from hybrid organelles are impaired,causing persistent hybrid organelles and defective formation of late endosomes and lysosomes.Defective retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid organelles.Lowering the intracellular pH restores late endosome/lysosome biogenesis in Atg5 cells.Our data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis. | PENG JunYa ZHANG Ran CUI YiTong LIU HaoDong ZHAO XiaoXin HUANG Lei HU MingXu YUAN XiaoXi MA BenYu MA XiaoWei TAKASHI Ueno MASAAKI Komatsu LIANG XingJie YU Li | 2014 | Science China(Life Sciences)2014，57，1： | 6 |
| 3 | Screen efficiency comparisons of decision tree and neural network algorithms in machine learning assisted drug design显示文摘In view of huge search space in drug design, machine learning has become a powerful method to predict the affinity between small molecular drug and targeting protein with the development of artificial intelligence technology. However, various machine learning algorithms including massive different parameters make the prediction framework choice to be quite difficult. In this work, we took a recent drug design competition(from XtalPi company on the DataCastle platform) as the typical case to find the optimized parameters for different machines learning algorithms and the most effective algorithm. After the parameter optimizations, we compared the typical machine learning methods as decision tree(XGBoost, LightGBM) and artificial neural network(MLP, CNN) with root-mean-square error(RMSE) and coefficient of determination(R^2) evaluation. As a result, decision tree is more effective than the neural network as LightGBM>XGBoost>CNN>MLP in the affinity prediction of the specific drug design problem with ~160000 samples. For a much larger screening task in a more complicated drug design study, the sophisticated neural network model may go beyond the decision tree algorithm after generalization enhancing and overfitting reducing. The advanced machine learning methods could extract more information of protein-ligand bindings than traditional ones and improve the screen efficiency of drug design up to 200–1000 times. | Qiumei Pu Yinghao Li Hong Zhang Haodong Yao Bo Zhang Bingji Hou Lin Li Yuliang Zhao Lina Zhao | 2019 | Science China Chemistry2019，62，4： | 5 |
| 4 | Advances in 3D bioprinting technology for cardiac tissue engineering and regeneration显示文摘Cardiovascular disease is still one of the leading causes of death in the world,and heart transplantation is the current major treatment for end-stage cardiovascular diseases.However,because of the shortage of heart donors,new sources of cardiac regenerative medicine are greatly needed.The prominent development of tissue engineering using bioactive materials has creatively laid a direct promising foundation.Whereas,how to precisely pattern a cardiac structure with complete biological function still requires technological breakthroughs.Recently,the emerging three-dimensional(3D)bioprinting technology for tissue engineering has shown great advantages in generating micro-scale cardiac tissues,which has established its impressive potential as a novel foundation for cardiovascular regeneration.Whether 3D bioprinted hearts can replace traditional heart transplantation as a novel strategy for treating cardiovascular diseases in the future is a frontier issue.In this review article,we emphasize the current knowledge and future perspectives regarding available bioinks,bioprinting strategies and the latest outcome progress in cardiac 3D bioprinting to move this promising medical approach towards potential clinical implementation. | Nanbo Liu Xing Ye Bin Yao Mingyi Zhao Peng Wu Guihuan Liu Donglin Zhuang Haodong Jiang Xiaowei Chen Yinru He Sha Huang Ping Zhu | 2021 | Bioactive Materials2021，6，5： | 4 |
| 5 | Room-temperature ligancy engineering of perovskite electrocatalyst for enhanced electrochemical water oxidation显示文摘Perovskite oxides are significant candidates to develop electrochemical catalysts for water oxidation in consideration of their high catalysis capacity,low costing and excellent stability.Rational design of coordination structure and overcoming poor electronic transport are regarded as critical factors for outstanding perovskite-based oxygen evolution reaction (OER) catalysts.Herein,we report a mild chemical oxidation method to realize ligancy engineering from strongly-correlated brownmillerite Sr2Co2O5 to perovskite phase Sr2Co2O5.5,along with abundant oxygen vacancies formation and greatly boosted electric conductivity,which helps to form the active species of Co hydroxide/oxide on the surface of catalysts.The coupling effect of catalytic kinetics and unimpeded electronic movement brings high OER activities in Sr2Co2O5.5 with a low onset potential and a small Tafel slope.Our work not only displays in-depth understanding into the relationship among catalysis performance and multiple physical degrees of freedom,but also paves a new path to develop high-efficient electrochemical catalysts. | Junchi Wu Yuqiao Guo Haifeng Liu Jiyin Zhao Haodong Zhou Wangsheng Chu Changzheng Wu | 2019 | Nano Research2019，12，9： | 4 |
| 6 | Reductive immobilization and long-term remobilization of radioactive pertechnetate using bio-macromolecules stabilized zero valent iron nanoparticles显示文摘Reductive immobilization of radioactive pertechnetate(99TcO4^-) in simulated groundwater was studied by prepared carboxymethyl cellulose(CMC) and starch stabilized zero valent iron nanoparticles(nZVI),and long-term remobilization of reduced Tc was also evaluated under anoxic and oxic conditions.The stabilized nZVI can effectively reduce soluble 99Tc(Ⅶ) to insoluble 99 Tc(Ⅳ),and they can be easily delivered into a contaminated groundwater zone and facilitate in situ remediation.In this study,CMCstabilized nZVI showed higher reactivity than that using starch as the stabilizer.Batch experiments indicated that more than 99% of 99 Tc(Ⅶ)(CO=12 mg/mL) was reduced and removed from groundwater by CMC-stabilized nZVI with a CMC content of 0.2%(w/w) at a broad pH of 5-8.X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS) analyses further confirmed that 99Tc(Ⅶ)O4^-transformed into 99Tc(Ⅳ)O2(s).The presence of bicarbonate exhibited insignificant effect on Tc immobilization,while humic acid(HA) inhibited reaction mainly due to retardation on electron transfer and formation of Tc(IV)-HA complexes.More interesting,the immobilized Tc(Ⅳ) remained insoluble even after 120 d under anoxic condition,while only^21 % was remobilized when exposed to air.Therefore,biomacromolecules stabilized nZVI nanoparticles could be a viable alternative for in situ remediation of radioactive contamination in groundwater. | Haodong Ji Yangmo Zhu Jun Duan Wen Liu Dongye Zhao | 2019 | Chinese Chemical Letters2019，30，12： | 3 |
| 7 | Reliability and global sensitivity analysis for an airplane slat mechanism considering wear degradation显示文摘This paper focuses on the issue of reliability and global sensitivity analysis for an airplane slat mechanism considering the uncertainties in the wear process of mechanical components.First,the multi-body kinematic model of the slat mechanism is built in the ADAMS software.The geometrical sizes of the roller wheels after wear degradation are considered as input variables and the angle the slat should turn is considered as the output response.To accurately identify the influential roller wheels to the reliability and robustness of the slat mechanism,the failure probability based sensitivity and variance-based sensitivity indices are introduced.Comprehensive analysis of the results have shown that the reliability analysis and global sensitivity theory can help engineers find significant parts by their contributions,thus provide guidance for mechanical design and maintenance. | Changcong ZHOU Haodong ZHAO Qi CHANG Mengyao JI Chen LI | 2021 | Chinese Journal of Aeronautics2021，34，1： | 2 |
| 8 | Efficient activation of peroxymonosulfate by hollow cobalt hydroxide for degradation of ibuprofen and theoretical study显示文摘Hollow microsphere structure cobalt hydroxide(h-Co(OH)2) was synthesized via an optimized solvothermal-hydrothermal process and applied to activate peroxymonosulfate(PMS) for degradation of a typical pharmaceutically active compound,ibuprofen(IBP).The material characterizations confirmed the presence of the microscale hollow spheres with thin nanosheets shell in h-Co(OH)2,and the crystalline phase was assigned to a-Co(OH)2.h-Co(OH)2 could efficiently activate PMS for radicals production,and 98.6% of IBP was degraded at 10 min.The activation of PMS by h-Co(OH)2 was a pHindependent process,and pH 7 was the optimum condition for the activation-degradation system.Scavenger quenching test indicated that the sulfate radical(SO4^·-) was the primary reactive oxygen species for IBP degradation,which contributed to 75.7%.Fukui index(f^-) based on density functional theory(DFT) calculation predicted the active sites of IBP molecule for SO4^·- attack,and then IBP degradation pathway was proposed by means of intermediates identification and theoretical calculation.The developed hollow Co(OH)2 used to efficiently activate PMS is promising and innovative alternative for organic contaminants removal from water and wastewater. | Mingfeng Ma Long Chen Jingzhu Zhao Wen Liu Haodong Ji | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 9 | Inhibition of immune checkpoints prevents injury-induced heterotopic ossification显示文摘Heterotopic ossification(HO),true bone formation in soft tissue,is closely associated with abnormal injury/immune responses.We hypothesized that a key underlying mechanism of HO might be injury-induced dysregulation of immune checkpoint proteins(ICs).We found that the earliest stages of HO are characterized by enhanced infiltration of polarized macrophages into sites of minor injuries in an animal model of HO.The non-specific immune suppressants,Rapamycin and Ebselen,prevented HO providing evidence of the central role of the immune responses.We examined the expression pattern of ICs and found that they are dysregulated in HO lesions.More importantly,loss of function of inhibitory ICs(including PD1,PD-L1,and CD152)markedly inhibited HO,whereas loss of function of stimulatory ICs(including CD40L and OX-40L)facilitated HO.These findings suggest that IC inhibitors may provide a therapeutic approach to prevent or limit the extent of HO. | Chen Kan Jiazhao Yang Ding Na Yuanhong Xu Baixia Yang Haodong Zhao Huadong Lu Yuyun Li Keqin Zhang Tammy LMcGuire John AKessler Lixin Kan | 2019 | Bone Research2019，7，4： | 1 |
| 10 | Fabrication and in vivo osteogenesis of biomimetic pnly( propylene carbonate) scaffold with nanofibrous chitosan network in maeropores for bone tissue engineering 显示文摘 | Zhao Jianhao Hart Wanqing Chen Haodong | 2011 | J Mater Sci Mater Med2011，23，2： | 1 |
| 11 | Disc cam in indexing mechanism with continuous acceleration behavior and computer aided NC programming显示文摘 | ZHAO Haodong LI Taoyuan GUO Peiquan | 2010 | Journal of Harbin Institute of Technology2010，17，1： | 1 |
| 12 | Highly efficient metal-free catalyst from cellulose for hydrogen peroxide photoproduction instructed by machine learning and transient photovoltage technology显示文摘Great attention has been paid to green procedures and technologies for the design of environmental catalytic systems.Biomassderived catalysts represent one of the greener alternatives for green catalysis.Photocatalytic production of hydrogen peroxide(H_(2)O_(2))from O_(2) and H_(2)O is an ideal green way and has attracted widespread attention.Here,we show a metal-free photocatalyst from cellulose,which has a high photocatalytic activity for the photoproduction of H_(2)O_(2) with the reaction rate up to 2,093μmol/(h·g)and the apparent quantum efficiency of 2.33%.Importantly,a machine learning model was constructed to guide the synthesis of this metal-free photocatalyst.With the help of transient photovoltage(TPV)tests,we optimized their fabrication and catalytic activity,and clearly showed that the formation of carbon dots(CDs)facilitates the generation,separation,and transfer of photo-induced charges on the catalyst surface.This work provides a green way for the highly efficient metal-free photocatalyst design and study from biomass materials with the machine learning and TPV technology. | Yan Liu Xiao Wang Yajie Zhao Qingyao Wu Haodong Nie Honglin Si Hui Huang Yang Liu Mingwang Shao Zhenhui Kang | 2022 | Nano Research2022，15，5： | 1 |
| 13 | Disc cam in indexing mechanism with continuous acceleration behavior and computer aided NC programming 显示文摘 | ZHAO Haodong LI Taoyuan GUO Peiquan | 2010 | Journal of Harbin Institute of Technology2010，17，1： | 1 |
| 14 | A facile synthesis of non-aqueous LiPO_(2)F_(2) solution as the electrolyte additive for high performance lithium ion batteries显示文摘Constructing a reliable and favorable electrode-electrolyte interface is crucial to utilize the exceptional energy storage capability in commercial lithium-ion batteries.Here,we report a facile synthesis approach for the lithium difluorophosphate(LiPO_(2)F_(2))solution as an effective film-forming additive via direct adding the Li_(2)CO_(3) into LiPF6 solution at 45℃.Benefiting from the significantly reduced interface resistance(RSEI)and charge transfer impedance(Rct)of both the cathode and anode by adding the prepared LiPO_(2)F_(2)solution into a baseline electrolyte,the cycling performance of the graphite||LiNi_(0.5)Mn_(0.3)Co_(0.2)O_(2) pouch cell is remarkably improved under all-climate condition. | Weimin Zhao Fucheng Ren Qizhang Yan Haodong Liu Yong Yang | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 15 | China's policy framework for carbon capture,utilization and storage:Review,analysis,and outlook显示文摘Carbon capture,utilization,and storage(CCUS)is estimated to contribute substantial CO_(2)emission reduction to carbon neutrality in China.There is yet a large gap between such enormous demand and the current capacity,and thus a sound enabling environment with sufficient policy support is imperative for CCUS development.This study reviewed 59 CCUS-related policy documents issued by the Chinese government as of July 2022,and found that a supporting policy framework for CCUS is taking embryonic form in China.More than ten departments of the central government have involved CCUS in their policies,of which the State Council,the National Development and Reform Commission(NDRC),the Ministry of Science and Technology(MOST),and the Ministry of Ecological Environment(MEE)have given the greatest attention with different focuses.Specific policy terms are further analyzed following the method of content analysis and categorized into supply-,environment-and demand-type policies.The results indicate that supply-type policies are unbalanced in policy objectives,as policy terms on technology research and demonstration greatly outnumber those on other objectives,and the attention to weak links and industrial sectors is far from sufficient.Environment-type policies,especially legislations,standards,and incentives,are inadequate in pertinence and operability.Demand-type policies are absent in the current policy system but is essential to drive the demand for the CCUS technology in domestic and foreign markets.To meet the reduction demand of China's carbon neutral goal,policies need to be tailored according to needs of each specific technology and implemented in an orderly manner with well-balanced use on multiple objectives. | Qiao MA Shan WANG Yan FU Wenlong ZHOU Mingwei SHI Xueting PENG Haodong LV Weichen ZHAO Xian ZHANG | 2023 | Frontiers in Energy2023，17，3： | 1 |
| 16 | Carbon dots/Bi_(2)WO_(6) composite with compensatory photo-electronic effect for overall water photo-splitting at normal pressure显示文摘Overall water photo-splitting is a prospective ideal pathway to produce ultra-clean H_(2) energy by semiconductors.However,the band structure of many semiconductors cannot satisfy the requirement of H_(2) and O_(2) production at the same time.Herein,we illustrate that carbon dots(CDs)/Bi_(2)WO_(6) photocatalyst with compensatory photo-electronic effect has enhanced activity for overall water photo-splitting without any sacrificial agent.In this complex photocatalytic system,the photo-potential provided by CDs makes the CDs/Bi2WO6(C-BWO)composite could satisfy the band structure conditions for overall water photo-splitting.The C-BWO composite(3 wt%CDs content)exhibits optimized hydrogen evolution(oxygen evolution)of 0.28μmol/h(0.12μmol/h)with an approximate 2:1(H_(2):O_(2))stoichiometry at normal pressure.We further employed the in-situ transient photovoltage(TPV)technique to study the photoelectron extraction and the interface charge transfer kinetics of this composite catalyst. | Haodong Nie Kaiqiang Wei Yi Li Yan Liu Yajie Zhao Hui Huang Mingwang Shao Yang Liu Zhenhui Kang | 2021 | Chinese Chemical Letters2021，32，7： | 0 |
| 17 | Description and surgical management of epiretinal membrane due to combined hamartoma of the retina and retinal pigment epithelium显示文摘Purpose:To outline the characteristics of Combined Hamartoma of the Retina and Retinal Pigmentation Epithelium(CHRRPE)and provide a comprehensive overview of surgical management of epiretinal membrane(ERM)caused by CHRRPE.Main text:CHRRPE is a rare ocular tumor.It clinically mimics other diseases such as retinoblastoma and choroidal melanoma.The present study reviewed the multimodal imaging of CHRRPE,highlighted the multimodal imaging modalities which are useful for revealing the unique features of CHRRPE and hence allowing physicians to confirm the diagnosis.Although most of CHRRPEs are benign harmatoma,progressive visual loss may occur because of the traction of the tumor and other complications.It is treated through surgical removal of the ERM caused by CHRRPE to free retina from the traction.Currently,there is no consensus on the surgical management of CHRRPE.Therefore,the current review was designed to explore the surgical management of ERM caused by CHRRPE and hence provide updated data on this subject.Conclusions:Multimodal imaging technologies,especially optical coherence tomography(OCT),significantly contributes to the diagnosis of CHRRPE and visual prognosis.Surgical management of CHRRPE through removal of ERM is beneficial in patients with worsening VA which is secondary to ERM which is associated with CHRRPE.However,the strategy is limited to patients with long-standing poor vision.However,earlier surgical therapy and subsequent postoperative amblyopia therapy can be explored for children of amblyogenic age. | Xuerui Zhang Yuan Yang Yanjun Wen Haodong Xiao Jie Peng Peiquan Zhao | 2023 | Advances in Ophthalmology Practice and Research2023，3，1： | 0 |
| 18 | Broken electron transfer pathway in enzyme:Gold clusters inhibiting TrxR1/Trx via cell studies and theory simulations显示文摘Thioredoxin reductase 1(TrxR1)is over activity in tumor cell to maintain their redox balance.Although gold clusters have great potential in antitumor drug as they could well inhibit TrxR1,the molecular mechanism has not been disclosed yet.In this work,we revealed gold clusters can well inhibit the activity of TrxR1 in lung tumor cells and further disclosed the inhibition mechanism by using computational simulation methods.We firstly inferred the binding sites of gold in the hydrophobic cavities on TrxR1.The simulation results show that the gold ion(released from Au cluster)interact with–SH of Cys189 in TrxR1,this greatly increase the distance between the C-terminal redox center of TrxR1 and the Trx redox center,thereby destroy the electron transfer pathway between them.Our electron transfer destroying mechanism is different from the previous hypothesis that gold binds to the Sec498 of TrxR1 which has never been proved by experimental and theory studies.This work provides a new understanding of the gold clusters to inhibit TrxR1 activity. | Wenchao Niu Zhongying Du Chunyu Zhang Deting Xu Jiaojiao Li Minghui Sun Liyuan Wu Haodong Yao Lina Zhao Xueyun Gao | 2022 | Chinese Chemical Letters2022，33，7： | 0 |
| 19 | NetBCE: An Interpretable Deep Neural Network for Accurate Prediction of Linear B-cell Epitopes显示文摘Identification of B-cell epitopes(BCEs)plays an essential role in the development of peptide vaccines and immuno-diagnostic reagents,as well as antibody design and production.In this work,we generated a large benchmark dataset comprising 124,879 experimentally supported linear epitope-containing regions in 3567 protein clusters from over 1.3 million B cell assays.Analysis of this curated dataset showed large pathogen diversity covering 176 different families.The accuracy in linear BCE prediction was found to strongly vary with different features,while all sequencederived and structural features were informative.To search more efficient and interpretive feature representations,a ten-layer deep learning framework for linear BCE prediction,namely Net BCE,was developed.Net BCE achieved high accuracy and robust performance with the average area under the curve(AUC)value of 0.8455 in five-fold cross-validation through automatically learning the informative classification features.Net BCE substantially outperformed the conventional machine learning algorithms and other tools,with more than 22.06%improvement of AUC value compared to other tools using an independent dataset.Through investigating the output of important network modules in Net BCE,epitopes and non-epitopes tended to be presented in distinct regions with efficient feature representation along the network layer hierarchy.The Net BCE is freely available at https://github.com/bsml320/Net BCE. | Haodong Xu Zhongming Zhao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，5： | 0 |
| 20 | A low-cost and high-efficiency 10-in-1 test for the PCR-based screening of SARS-CoV-2 infection in low-risk areas显示文摘To the Editor:As of August 9,2020,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected 19,432,244 people and caused 721,594 deaths globally.To timely identify the infected persons,nucleic acid detection screenings have been carried out for high-infection risk groups in areas known to have coronavirus disease 19(COVID-19)cases,such as Wuhan,Beijing,and Xinjiang.The rapid identification of infected patients and the implementation of quarantine measures play an important role in preventing the transmission of SARS-CoV-2.However,there are some issues associated with large-scale screening for this virus.The consumption of equipment and reagents for specimen collection and detection is high,resulting in elevated screening costs.Moreover,with the increase in the number of samples collected,the testing capabilities of medical institutions have reached a saturation point,hindering the speed and scope of large-scale screenings.For this reason,the mixed detection after RNA extraction(detection in a mixture of nucleic acids extracted from several patients)or before RNA extraction(detection in a mixture of pharyngeal swab transfer buffer obtained from different patients before nucleic acid extraction)has been proposed in many regions.[1]However,both the pooling of swab transfer buffer before nucleic acid extraction and pooling of RNA after nucleic acid extraction inevitably cause dilution of samples and decrease of detection sensitivity.However,there is still a lack of research on how to effectively improve the screening efficiency and control the decrease of sensitivity caused by dilution in an appropriate range.In this study,we designed a novel 10-in-1 test(ten pharyngeal swab samples from ten individuals were placed in one custom-made virus collection tube[CMT]for nucleic acid extraction and testing)by optimizing the current mixed acquisition technique,and after a promising pilot test. | Xiaosong Qin Peng Gao Zhijie Zhang Zhijian Bo Shijun Li Mei Yang Jianhua Liu Lina Wu Ting Li Zuowei Zhao Yan Li Haodong Bian Yong Liu | 2022 | Chinese Medical Journal2022，，4： | 0 |
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