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您的检索式：作者名="Haoqing Yang"
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| 1 | Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis显示文摘Periodontitis is an inflammatory autoimmune disease. Treatment should alleviate inflammation, regulate the immune reaction and promote periodontal tissue regeneration. Icariin is the main active ingredient of Epimedii Folium, and it is a promising compound for the enhancement of mesenchymal stem cell function, promotion of bone formation, inhibition of bone resorption, alleviation of inflammation and regulation of immunity. The study investigated the effect of icariin on periodontal tissue regeneration in a minipig model of periodontitis. The minipig model of periodontitis was established. Icariin was injected locally. The periodontal clinical assessment index, a computed tomography(CT) scan, histopathology and enzyme-linked immune sorbent assay(ELISA)were used to evaluate the effects of icariin. Quantitative analysis results 12 weeks post-injection demonstrated that probing depth,gingival recession, attachment loss and alveolar bone regeneration values were(3.72 ± 1.18) mm vs.(6.56 ± 1.47) mm,(1.67 ± 0.59)mm vs.(2.38 ± 0.61) mm,(5.56 ± 1.29) mm vs.(8.61 ± 1.72) mm, and(25.65 ± 5.13) mm3 vs.(9.48 ± 1.78) mm3 in the icariin group and0.9% NaCl group, respectively. The clinical assessment, CT scan, and histopathology results demonstrated significant enhancement of periodontal tissue regeneration in the icariin group compared to the 0.9% NaCl group. The ELISA results suggested that the concentration of interleukin-1 beta(IL-1β) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis. Local injection of icariin promoted periodontal tissue regeneration and exerted anti-inflammatory and immunomodulatory function. These results support the application of icariin for the clinical treatment of periodontitis. | Xiuli Zhang Nannan Han Guoqing Li Haoqing Yang Yangyang Cao Zhipeng Fan Fengqiu Zhang | 2018 | International Journal of Oral Science2018，10，3： | 9 |
| 2 | miR-4651 inhibits cell proliferation of gingival mesenchymal stem cells by inhibiting HMGA2 under nifedipine treatment显示文摘Drug-induced gingival overgrowth(DIGO) is recognized as a side effect of nifedipine(NIF);however, the underlying molecular mechanisms remain unknown. In this study, we found that overexpressed mi R-4651 inhibits cell proliferation and induces G0/G1-phase arrest in gingival mesenchymal stem cells(GMSCs) with or without NIF treatment. Furthermore, sequential window acquisition of all theoretical mass spectra(SWATH-MS) analysis, bioinformatics analysis, and dual-luciferase report assay results confirmed that high-mobility group AT-hook 2(HMGA2) is the downstream target gene of mi R-4651. Overexpression of HMGA2 enhanced GMSC proliferation and accelerated the cell cycle with or without NIF treatment. The present study demonstrates that mi R-4651 inhibits the proliferation of GMSCs and arrests the cell cycle at the G0/G1 phase by upregulating cyclin D and CDK2 while downregulating cyclin E through inhibition of HMGA2 under NIF stimulation. These findings reveal a novel mechanism regulating DIGO progression and suggest the potential of mi R-4651 and HMGA2 as therapeutic targets. | Xiao Han Ruzhuang Yang Haoqing Yang Yangyang Cao Nannan Han Chen Zhang Ruitang Shi Zhengting Zhang Zhipeng Fan | 2020 | International Journal of Oral Science2020，12，2： | 2 |
| 3 | Structural and electrochemical properties of disordered carbon prepared by the pyrolysis of poly( p -phenylene) below 1000°C for the anode of a lithium-ion battery显示文摘 | Jinbao Gong Haoqing Wu Qinghe Yang | 1999 | Carbon1999，，9： | 1 |
| 4 | Nonenzymatic glucose sensor based on renewable electrospun Ni nanoparticle-loaded carbon nanofiber paste electrode显示文摘 | Yang Liu Hong Teng Haoqing Hou Tianyan You | 2009 | Biosensors and Bioelectronics2009，，11： | 1 |
| 5 | 的研究显示文摘 | Wu Xiaomei * Yang Qinghe Jin Zhongkao Wu Haoqing Zong Xiangfu (Inst. of Material Sci. Fudan Univ. Shanghai China 200433) | 1998 | 电化学1998，，04： | 1 |
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