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| 1 | Flavonoids from Leaves of Heritiera littoralis D.显示文摘The mangrove plant Heritiera littoralis D. (Sterculi-aceae) is widely distributed in southeastern Asia and traditionally used as a fish, arrowhead, and spearhead poison. It has also been used as a folk medicine to treat hematuria and diarrhea for a long history in China. Past investigations on the chemical constituents of this plant have yielded four triterpenes, five sesquiterpenes, a | TIANYan WUJun ZHANGSi | 2004 | Journal of Chinese Pharmaceutical Sciences2004，13，3： | 17 |
| 2 | Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome显示文摘BACKGROUND Polycystic ovary disease(PCOS)may be a risk factor for nonalcoholic fatty liver disease(NAFLD)due to common pathogenetic pathways,including insulin resistance and obesity.Both PCOS and NAFLD are more severe in South Asian women.Data on NAFLD in South Asian women with PCOS are lacking.AIM To investigate prevalence and predictors of NAFLD and liver fibrosis in PCOS patients from South Asia.METHODS We conducted an observational routine screening program by means of transient elastography(TE)with associated controlled attenuation parameter(CAP).NAFLD was defined as CAP≥288 decibels per meter.Significant liver fibrosis(stage 2 and higher out of 4)was defined as TE measurement≥8.0 kilopascals.Elevated alanine aminotransferase(ALT)was defined as ALT>24 IU/L,as per upper limit of normal reported in South Asian women.Biochemical hyperandrogenism was defined as free androgen index>5.Predictors of NAFLD were determined by logistic regression analysis.RESULTS 101 PCOS patients(mean age 36.3 years)with no significant alcohol intake or viral hepatitis were included.Prevalence of NAFLD and significant liver fibrosis was 39.6% and 6.9%,respectively.Elevated ALT was observed in 40%and 11.5%of patients with and without NAFLD,respectively.After adjusting for duration of PCOS and insulin resistance measured by homeostasis model for assessment of insulin resistance,independent predictors of NAFLD were higher body mass index[adjusted odds ratio(aOR)1.30,95% confidence interval(CI):1.13-1.52],hyperandrogenism(aOR:5.32,95%CI:1.56-18.17)and elevated ALT(aOR:3.54,95%CI:1.10-11.47).Lifetime cardiovascular risk was higher in patients with NAFLD compared to those without NAFLD(0.31±0.11 vs 0.26±0.13).CONCLUSION Despite their young age,NAFLD diagnosed by TE with CAP is a frequent comorbidity in South Asian women with PCOS and is strongly associated with higher body mass index and hyperandrogenism.Non-invasive screening strategies could help early diagnosis and initiation of interventions,including counselling on weight loss,cardiovascular risk stratification and linkage to hepatology care where appropriate. | Mohamed Shengir Srinivasan Krishnamurthy Peter Ghali Marc Deschenes Philip Wong Tianyan Chen Giada Sebastiani | 2020 | World Journal of Gastroenterology2020，26，44： | 11 |
| 3 | Statistical Distributions of Partial Discharges in Oil-paper Insulation Under AC-DC Combined Voltages显示文摘 | LI Jian JIANG Tianyan HE Zhiman CHENG Changkui BAO Lianwei | 2012 | 高电压技术2012，38，8： | 5 |
| 4 | A water-evaporation-induced self-charging hybrid power unit for application in the Internet of Things显示文摘A self-charging hybrid power unit has been developed by integrating a water-evaporation-induced nano- generator with a flexible nano-patterned supercapacitor. The nanogenerator can harvest environmental thermal energy and mechanical energy through the water evaporation process, and the supercapacitor can be charged simultaneously. The former offers stable electrical power as output, whereas the Ppy- based supercapacitor shows a capacitance of 12.497 m F/cm^2 with 96.42% retention after 4,000 cycles. After filling the power unit with water as the fuel, it can be fully charged in about 20 min. The power unit can be flexibly integrated with electronic devices such as sensor nodes and wireless transmitters employ- ing the Internet of Things. This new approach can offer new possibilities in continuous future operation of randomly distributed electronic devices incorporated in the Internet of Things. | Haoxuan He Tianming Zhao Hongye Guan Tianyan Zhong Hui Zeng Lili Xing Yan Zhang Xinyu Xue | 2019 | Science Bulletin2019，64，19： | 5 |
| 5 | Decomposition of acid dissolved titanium slag from Australia by sodium hydroxide显示文摘The kinetics of the decomposition of acid dissolved titanium slag with a sodium hydroxide system under atmospheric pressure was studied. The effect of reaction temperature, particle size and NaOH-to-slag mass ratio on titanium extraction was investigated. The results show that temperature and particle size have significant influence on titanium extraction. The experimental data of titanium extraction show that the shrinking core model with chemical reaction controlled process is most applicable for the decomposition of slag, with an apparent activation energy of 62.4 kJ·mol-1. Approximately 85 wt.%-90 wt.% of the titanium can be extracted from the slag under the optimal conditions. In addition, the purity of titanium dioxide obtained in the product is up to 98.5 wt.%. | FENG Yang WANG Jinggang WANG Lina QI Tao XUE Tianyan CHU Jinglong | 2009 | Rare Metals2009，28，6： | 5 |
| 6 | Wearable Battery-Free Perspiration Analyzing Sites Based on Sweat Flowing on ZnO Nanoarrays显示文摘We fabricated wearable perspiration analyzing sites for actively monitoring physiological status during exercises without any batteries or other power supply.The device mainly consists of ZnO nanowire(NW)arrays and flexible polydimethylsiloxane substrate.Sweat on the skin can flow into the flow channels of the device through capillary action and flow along the channels to ZnO NWs.The sweat flowing on the NWs(with lactate oxidase modification)can output a DC electrical signal,and the outputting voltage is dependent on the lactate concentration in the sweat as the biosensing signal.ZnO NWs generate electric double layer(EDL)in sweat,which causes a potential difference between the upper and lower ends(hydrovoltaic effect).The product of the enzymatic reaction can adjust the EDL and influence the output.This device can be integrated with wireless transmitter and may have potential application in constructing sports big data.This work promotes the development of next generation of biosensors and expands the scope of self-powered physiological monitoring system. | Wanglinhan Zhang Hongye Guan Tianyan Zhong Tianming Zhao Lili Xing Xinyu Xue | 2020 | Nano-Micro Letters2020，12，8： | 5 |
| 7 | Isozyme Analysis on the Populations of Ruditapes philippinarum显示文摘水平淀粉胶化电气泳动被用来在中国的海岸调查 Ruditapes philippinarum 的六张人口的基因结构。七酶揭示了十一通常认为的 loci,并且他们中的七个是多态的, PGM~* , MDH-1~* , MDH-3~* , LAP-1~* , LAP-2~* , MPI-1~* 并且 MPI-2~* 。R 的多态的 loci 的比例。philippinarum 人口变化了从 0.454 5 ~ 0.636 4。观察并且期望的杂合现象的价值从 0.0394 ~ 0.154 5 并且从 0.1111 ~ 0.238 5 分别地。Nei “基因距离从 0.003 3to 改变了的 s 0.025 3 与一般水准 0.013 5。R.philippinarum 的基因差异高,这被建议。 | REN Yiping GAO Tianxiang YANG Tianyan | 2006 | Journal of Ocean University of China2006，5，1： | 4 |
| 8 | SRSF1 plays a critical role in invariant natural killer T cell development and function显示文摘Invariant natural killer T(iNKT)cells are highly conserved innate-like T lymphocytes that originate from CD4^(+)CD8^(+)double-positive(DP)thymocytes.Here,we report that serine/arginine splicing factor 1(SRSF1)intrinsically regulates iNKT cell development by directly targeting Myb and balancing the abundance of short and long isoforms.Conditional ablation of SRSF1 in DP cells led to a substantially diminished iNKT cell pool due to defects in proliferation,survival,and TCRαrearrangement.The transition from stage 0 to stage 1 of iNKT cells was substantially blocked,and the iNKT2 subset was notably diminished in SRSF1-deficient mice.SRSF1 deficiency resulted in aberrant expression of a series of regulators that are tightly correlated with iNKT cell development and iNKT2 differentiation,including Myb,PLZF,Gata3,ICOS,and CD5.In particular,we found that SRSF1 directly binds and regulates pre-mRNA alternative splicing of Myb and that the expression of the short isoform of Myb is substantially reduced in SRSF1-deficient DP and iNKT cells.Strikingly,ectopic expression of the Myb short isoform partially rectified the defects caused by ablation of SRSF1.Furthermore,we confirmed that the SRSF1-deficient mice exhibited resistance to acute liver injury uponα-GalCer and Con A induction.Our findings thus uncovered a previously unknown role of SRSF1 as an essential post-transcriptional regulator in iNKT cell development and functional differentiation,providing new clinical insights into iNKT-correlated disease. | Jingjing Liu Menghao You Yingpeng Yao Ce Ji Zhao Wang Fang Wang Di Wang Zhihong Qi Guotao Yu Zhen Sun Wenhui Guo Juanjuan Liu Shumin Li Yipeng Jin Tianyan Zhao Hai-Hui Xue Yuanchao Xue Shuyang Yu | 2021 | Cellular & Molecular Immunology2021，18，11： | 3 |
| 9 | Analysis on internal mechanism of zedoary turmeric in treatment of liver cancer based on pharmacodynamic substances and pharmacodynamic groups显示文摘Zedoary tumeric(Curcumae Rhizoma,Ezhu in Chinese)has a long history of application and has great potential in the treatment of liver cancer.The antiliver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances.In order to clarify the specific mechanism of zedoary tumeric against liver cancer,this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer,and then verifies the joint anti liver cancer mechanism of its“pharmacodynamic group”.By searching the research on the antihepatoma effect of active components of zedoary tumeric in recent years,we found that pharmacodynamic substances,including curcumol,zedoarondiol,curcumenol,curzerenone,curdione,curcumin,germacrone,β-elemene,can act on multi-target and multi-channel to play an antihepatoma role.For example,curcumin can regulate miR,GLO1,CD133,VEGF,YAP,LIN28B,GPR81,HCAR-1,P53 and PI3K/Akt/mTOR,HSP70/TLR4 and NF-κB.Wnt/TGF/EMT,Nrf2/Keap1,JAK/STAT and other pathways play an antihepatoma role.Network pharmacological analysis showed that the core targets of the“pharmacodynamic group”for anti-life cancer are AKT1,EGFR,MAPK8,etc,and the core pathways are neuroactive live receiver interaction,nitrogen metabolism,HIF-1 signaling pathway,etc.At the same time,by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and“pharmacodynamic group”,it is found that they have great reference significance in target,pathway,biological function,determination of core pharmacodynamic components,formation of core target protein interaction,in-depth research of single pharmacodynamic substance,increasing curative effect and so on.By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and“pharmacodynamic group”in the treatment of liver cancer,this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and“pharmacodynamic group”. | Zeyu Li Erwei Hao Rui Cao Si Lin Linghui Zou Tianyan Huang Zhengcai Du Xiaotao Hou Jiagang Deng | 2022 | Chinese Herbal Medicines2022，14，4： | 2 |
| 10 | Wavelet method optimised by ant colony algorithm used for extracting stable and unstable signals in intelligent substations显示文摘Partial discharge(PD)signals are an important index to evaluate the operation state of intelligent substations.The correct distinction of PD pulse and interference pulse has become a challenging task.Because of the noise and the low signal-to-noise ratio,the stable signals become non-stationary.The selection of a wavelet basis,the selection rule of thresholdλand the design of the threshold function are the key factors affecting the final denoising effect.Therefore,an enhanced ant colony optimisition wavelet(ACOW)algorithm was applied to find the global optimal threshold through the continuous derivative threshold function and the ant colony optimisation(ACO)algo-rithm.At the same time the efficiency of adaptive search calculation,was also significantly improved.The method of the ACOW algorithm was compared with the soft wavelet method,gradient-based wavelet method and the genetic optimisation wavelet(GOW)method.Using these four methods to denoise four typical signals,different mean square errors(MSE),magnitude errors(ME)and time costs were obtained.Interestingly,the results show that the ACOW method can achieve the minimum MSE and has less time cost.It generates significantly smaller waveform distortion than the other three threshold estimation methods.In addition,the high efficiency and good quality of the output signals are beneficial to the diagnosis of local discharge signals in intelligent substations. | Tianyan Jiang Xiao Yang Yuan Yang Xi Chen Maoqiang Bi Jianfei Chen | 2022 | CAAI Transactions on Intelligence Technology2022，7，2： | 2 |
| 11 | Nucleoside analogues improve the short-term and long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure显示文摘 | Tianyan Chen Yingli He Xiaojing Liu Zhi Yan Ke Wang Hongli Liu Shuling Zhang Yingren Zhao | 2012 | Clinical and Experimental Medicine2012，，3： | 2 |
| 12 | Calculation and decomposition of regional household energy consumption in China:based on perspectives of urbanization and residents' consumption显示文摘Demographic urbanization caused great changes in scale of residents' consumption and residents' lifestyle and then impacted changes of regional household energy consumption. This paper expanded Logarithmic Mean Decomposition Index method through introducing variables of urbanization and residential consumption into the model. It also analyzed the influences of six factors as energy structure, energy intensity, population scale, urbanization, residential consumption, and consumption inhibit on regional household energy consumption. Results showed that in 2003-2012, impact of urbanization on regional household energy consumption of Chinese three areas was significantly higher than population size. The 'population gathered in eastern region' phenomenon caused eastern region getting the largest population scale effect. Driving force of residential consumption on regional household energy consumption was much higher than the other five effects. Due to the comparative advantage of residential consumption compared with government consumption, investment, and net export, the decrease of consumption ratio promoted the growth of regional household energy consumption. Energy intensity in Chinese three regions kept reducing in 2003-2012. The progress of energy utilization technology slowed the growth of regional household energy consumption, and energy intensity effect was most significant in the central region. | Wen Guo Tianyan Zhao Hongjun Dai | 2017 | Chinese Journal of Population,Resources and Environment2017，15，2： | 2 |
| 13 | Characteristic Analysis of Partial Discharges and Dissolved Gases Generated Cavityin Oil-paper Insulation Under AC-DC Combined Voltages显示文摘 | HE Zhiman LI Jian BAO Lianwei JIANG Tianyan WANG Youyuan | 2012 | 高电压技术2012，38，8： | 2 |
| 14 | Recognition of ultra high frequency partial discharge signals using multi-scale features显示文摘 | Li Jian Jiang Tianyan Harrison R F | 2012 | IEEE Trans on Dielectrics and Electrical Insulation2012，19，4： | 1 |
| 15 | In vitro screening of reversible and time-dependent inhibition on CYP3A by TM208 and TM209 in rat liver microsomes显示文摘TM208 and TM209,dithiocarbamate derivatives with potential anti-cancer effects,were evaluated in reversible and time-dependent cytochrome P450(CYP)3A inhibition assays in rat liver microsomes using testosterone as probe substrate.Both compounds were found to be weak reversible inhibitors and moderate mechanism-based inhibitors of rat CYP3A.For reversible inhibition on rat CYP3A,the Ki values of competitive inhibition model were 12.10±1.75 and 13.94±1.31 μM,respectively.For time-dependent inhibition,the inactivation constants(K_(l))were 31.93±12.64 and 32.91±15.58 μM,respectively,and the maximum inactivation rates(kinact)were 0.0349770.0069 and 0.0725970.0172 min^(-1) respectively.These findings would provide useful in vitro information for future in vivo DDI studies on TM208 or TM209。 | Miaoran Ning Liang Li Jian Li Zaiquan Li Runtao Li Tianyan Zhou Wei Lu | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 1 |
| 16 | Sensitive and rapid detection of Shigella and enteroinvasive Escherichia coli by a loop-mediated isothermal amplification method显示文摘 | Song Tianyan Toma C Nakasone N | 2005 | FEMS Microbiology Letters2005，243，： | 1 |
| 17 | Proapoptotic IL-18 in patients with chronic hepatitis C treated with pegylated interferon-alpha 显示文摘 | YingLi H Shumei L Qian Y Tianyan C Yingren Z Wei C | 2009 | Clin Exp Med2009，9，2： | 1 |
| 18 | Variation of white water composition in a TMP and DIP newsprint paper machine显示文摘 | Thendore M G Tianyan X Keneth H B | 1997 | Tappi J1997，80，8： | 1 |
| 19 | Decomposition Kinetics of Titanium Slag in Sodium Hydroxide System显示文摘 | Xue Tianyan Wang Lina Qi Tao | 2009 | Hydrometallurgy2009，95，1： | 1 |
| 20 | A self-powered temperature-sensitive electronic-skin based on tribotronic effect of PDMS/PANI nanostructures显示文摘A new self-powered temperature-sensitive electronic-skin(e-skin) for real-time monitoring body temperature without external electricity power was fabricated from patterned polydimethylsiloxane/polyaniline(PDMS/PANI) nanostructures. The e-skin can be feasibly attached on the human body and driven by the mechanical motion energy through triboelectric effect. The outputting triboelectric impulse of the PDMS/PANI units is significantly dependent on the local surface temperature of the eskin, serving as both the power source and temperature sensing signal. The outputting current of the e-skin increases with increasing surface temperature of the device. Under applied bending deformation,the response of the e-skin is up to 63.6 for 38.6℃. The e-skin can detect minimum temperature change of 0.4℃. The working mechanism can be ascribed to the coupling effect of triboelectric and semiconductor properties(tribotronic effect). A practical application of the e-skin attaching on the human body for detecting the body temperature range of 36.5–42.0℃ has been simply demonstrated. This work provides a viable method for real-time monitoring body temperature, and can promote the development of wearable temperature sensors and self-powered multifunctional nanosystems. | Zize Liu Tianming Zhao Hongye Guan Tianyan Zhong Haoxuan He Lili Xing Xinyu Xue | 2019 | Journal of Materials Science & Technology2019，35，10： | 1 |
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