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| 1 | Conversion between polarization states based on a metasurface显示文摘Transmission of an anisotropic metasurface is analyzed in a polar base relying on the Jones calculus, and polarization conversion from the spatial uniform polarization to the spatial nonuniform polarization is explored.Simple and compact polarization converters based on rectangular holes or cross holes etched in silver film are designed, and polarization conversions from the linear and circular polarization to the radial and azimuthal polarization are realized. Numerical simulations of three designed polarization converters consisting of rectangular holes equivalent to polarizers and quarter-and half-wave plates, exhibit the perfect polarization conversion.The experiment results consistent with the simulations verify theoretic predictions. This study is helpful for designing metasurface polarization converters and expanding the application of a metasurface in polarization manipulations. | SHUYUN TENG QI ZHANG HAN WANG LIXIA LIU HAORAN LV | 2019 | Photonics Research2019，7，3： | 7 |
| 2 | Infrared spectroscopic study on chemical and phase equilibrium in triethylammonium acetate显示文摘Protic ionic liquid (PIL) triethylammonium acetate was prepared by mixing equimolar amounts of acetic acid and triethylamine, and then studied using the combination of the Attenuated Total Reflection Fourier Transform Infrared spectroscopy, in-situ infrared spectroscopy, pH, and conductivity titration measurements. It was found that the equimolar synthesized triethylammonium acetate was separated into two layers, which suggesting that there were both chemical and phase equilibrium in this solution. Molecular species could be directly observed in the IR spectra over the range of 1200-1800 cm-1 and also checked by 1H NMR. Based on analysis, the upper layer was rich in amine with little acid and PIL, and the down layer was rich in PIL with residual acetic acid and amine. And single PIL-rich layer could be separated into two layers again when the mole ratio of newly added triethyamine to the theoretical produced triethylammonium acetate reached 0.12. | LV YiQi GUO Yan LUO XiaoYan LI HaoRan | 2012 | Science China Chemistry2012，55，8： | 2 |
| 3 | Genome-wide analysis of NDR1/HIN1-like genes in pepper(Capsicum annuum L.)and functional characterization of CaNHL4 under biotic and abiotic stresses显示文摘Plant NDR1/HIN1-like(NHL)genes play an important role in triggering plant defenses in response to biotic stresses.In this study,we performed a genome-wide identification of the NHL genes in pepper(Capsicum annuum L.)and characterized the functional roles of these CaNHL genes in response to abiotic stresses and infection by different pathogens.Phylogenetic analysis revealed that CaNHLs can be classified into five distinct subgroups,with each group containing generic and specific motifs.Regulatory element analysis showed that the majority of the promoter regions of the identified CaNHLs contain jasmonic acid(JA)-responsive and salicylic acid(SA)-responsive elements,and transcriptomic analysis revealed that CaNHL genes are expressed in all the examined tissues of pepper.The CaNHL1,CaNHL4,CaNHL6,CaNHL10,CaNHL11,and CaNHL12 genes were significantly upregulated under abiotic stress as well as in response to different pathogens,such as TMV,Phytophthora capsici and Pseudomonas syringae.In addition,we found that CaNHL4 localizes to the plasma membrane.CaNHL4-silenced pepper plants display significantly increased susceptibility to TMV,Phytophthora capsici and Pseudomonas syringae,exhibiting reduced expression of JA-related and SA-related genes and reduced ROS production.However,transient overexpression of CaNHL4 in pepper increases the expression of JArelated and SA-related genes,enhances the accumulation of ROS,and inhibits the infection of these three pathogens.Collectively,for the first time,we identified the NHL genes in pepper and demonstrated that CaNHL4 is involved in the production of ROS and that it also regulates the expression of JA-related and SA-related genes in response to different pathogens,suggesting that members of the CaNHL family play an essential role in the disease resistance of pepper. | Changyun Liu Haoran Peng Xinyu Li Chaolong Liu Xing Lv Xuefeng Wei Aihong Zou Jian Zhang Guangjin Fan Guanhua Ma Lisong Ma Xianchao Sun | 2020 | Horticulture Research2020，7，1： | 2 |
| 4 | NG2 expression in rats with acute T_(10) spinal cord injury显示文摘Rat models of T10 spinal cord injury were established with a clamp method.NG2 expression was detected with immunohistochemical staining and western blot.Ten days after spinal cord injury,the number of NG2-positive cells in the damaged areas and NG2 absorbance were both significantly increased.The findings indicate that acute T10 spinal cord injury in rats can lead to upregulation of NG2 protein expression in damaged areas. | Haoran Lv Jinshun Yang Zhuangwen Liao Yu Zhao Yan Huang | 2012 | Neural Regeneration Research2012，7，5： | 1 |
| 5 | The rice histone methylation regulates hub species of the root microbiota显示文摘Plants have a close relationship with their root microbiota,which comprises a complex microbial network.Histone methylation is an important epigenetic modification influencing multiple plant traits;however,little is known about the role of plant histone methylation in the assembly and network structure of the root microbiota.In this study,we established that the rice(Oryza sativa)histone methylation regulates the structure and composition of the root microbiota,especially the hub species in the microbial network.DJjmj703(defective in histone H3K4 demethylation)and ZH11-sdg714(defective in H3K9 methylation)showed significant different root microbiota compared with the corresponding wild types at the phylum and family levels,with a consistent increase in the abundance of Betaproteobacteria and a decrease in the Firmicutes.In the root microbial network,35 of 44 hub species in the top 10 modules in the tested field were regulated by at least one histone methylation-related gene.These observations establish that the rice histone methylation plays a pivotal role in regulating the assembly of the root microbiota,providing insights into the links between plant epigenetic regulation and root microbiota. | Zhiyao Lv Rui Dai Haoran Xu Yongxin Liu Bo Bai Ying Meng Haiyan Li Xiaofeng Cao Yang Bai Xianwei Song Jingying Zhang | 2021 | Journal of Genetics and Genomics2021，48，9： | 1 |
| 6 | Genetic diversity of RNA viruses infecting invertebrate pests of rice显示文摘Invertebrate species are a natural reservoir of viral genetic diversity,and invertebrate pests are widely distributed in crop fields.However,information on viruses infecting invertebrate pests of crops is limited.In this report,we describe the deep metatranscriptomic sequencing of 88 invertebrate samples covering all major invertebrate pests in rice fields.We identified 296 new RNA viruses and 13 known RNA viruses.These viruses clustered within 31 families,with many highly divergent viruses constituting potentially new families and genera.Of the identified viruses,13 RNA viruses clustered within the Fiersviridae family of bacteriophages,and 48 RNA viruses clustered within families and genera of mycoviruses.We detected known rice viruses in novel invertebrate hosts at high abundances.Furthermore,some novel RNA viruses have genome structures closely matching to known plant viruses and clustered within genera of several plant virus species.Fortyfive potential insect pathogenic RNA viruses were detected in invertebrate species.Our analysis revealed that host taxonomy plays a major role and geographical location plays an important role in structuring viral diversity.Cross-species transmission of RNA viruses was detected between invertebrate hosts.Newly identified viral genomes showed extensive variation for invertebrate viral families or genera.Together,the large-scale metatranscriptomic analysis greatly expands our understanding of RNA viruses in rice invertebrate species,the results provide valuable information for developing efficient strategies to manage insect pests and virus-mediated crop diseases. | Haoran Wang Shufen Chao Qing Yan Shu Zhang Guoqing Chen Chonghui Mao Yang Hu Fengquan Yu Shuo Wang Liang Lv Baojun Yang Jiachun He Songbai Zhang Liangsheng Zhang Peter Simmonds Guozhong Feng | 2024 | Science China(Life Sciences)2024，67，1： | 0 |
| 7 | Structural insight into EV-A713A protein and its interaction with a peptide inhibitor显示文摘Dear Editor,Hand,foot,and mouth disease(HFMD)is a common illness among children that is usually mild and self-limiting.However,in some severe cases,patients may rapidly develop neurological and systemic complications that can be fatal(Ooi et al.,2010).HFMD is caused by a few serotypes of human enterovirus A(HEV-A)species(Yu and Cowling,2019),with enterovirus A71(EV-A71)and coxsackievirus A16(CV-A16)being the most typical causative agents(Yu and Cowling,2019).Furthermore,severe neurological sequelae are more common in cases with EV-A71 serotype infection than other serotypes(Ooi et al.,2010;Yu and Cowling,2019).There has been a significant increase in EV-A71 epidemic activity throughout the Asia–Pacific region(McMinn,2002)since EV-A71 was first isolated from a patient with central nervous system(CNS)disease in 1969(Schmidt et al.,1974).EV-A71 is a small non-enveloped virus belonging to HEV-A species of the genus Enterovirus in the family Picornaviridae(Nasri et al.,2007).Its genome is a single-stranded positive-sense RNA of approximately 7400 bp in length and contains only one complete open reading frame(ORF),which encodes a large polyprotein(Solomon et al.,2010). | Yahui Liu Panjing Lv Wei Wang Jiahai Zhang Xi Zhou Yang Qiu Kun Cai Haoran Zhang Yuan Fang Yan Li | 2023 | Virologica Sinica2023，38，6： | 0 |
| 8 | Nanophotonic catalytic combustion enlightens mid-infrared light source显示文摘The tunable mid-infrared source in a broad-spectrum heralds great scientific implications and remains a challenge.Nanolocalized catalytic combustion facilitates access to customizable infrared light sources.Here,we report on fabricating platinumalumina bilayer nano-cylinder arrays for methanol catalytic combustion,which enables them to act as an array of infrared point light sources,with wavelength tunable by controlling the flow rate of methanol/air mixture.We then propose a technique of integrating nanophotonic structures with catalytic combustion to engineer infrared light emission.We demonstrate a prototype of a topological photonic crystal catalyst array in which infrared emission can be enhanced significantly with highly vertical emission.This work establishes a framework of nanophotonic catalytic combustion for infrared light sources. | Zhenhua Wu Zhimao Wu Haoran Lv Wenbin Zhang Zekun Liu Shuai Zhang Erzhen Mu Hengxin Lin Qing Zhang Daxiang Cui Thomas Thundat Zhiyu Hu | 2023 | Nano Research2023，16，9： | 0 |
| 9 | Tellurium-driven maple leaf-shaped manganese nanotherapeutics reshape tumor microenvironment via chemical transition in situ to achieve highly efficient radioimmunotherapy of triple negative breast cancer显示文摘The therapeutic efficacy of radioimmunotherapy against triple negative breast cancer(TNBC)is largely limited by the complicated tumor microenvironment(TME)and its immunosuppressive state.Thus developing a strategy to reshape TME is expected to achieve highly efficient radioimmunotherapy.Therefore,we designed and synthesized a tellurium(Te)-driven maple leaf manganese carbonate nanotherapeutics(MnCO3@Te)by gas diffusion method,but also provided a chemical catalytic strategy in situ to augment ROS level and activate immune cells for improving cancer radioimmunotherapy.As expected,with the help of H2O2 in TEM,MnCO3@Te heterostructure with reversible Mn3+/Mn2+transition could catalyze the intracellular ROS overproduction to amplify radiotherapy.In addition,by virtue of the ability to scavenge H+in TME by carbonate group,MnCO3@Te directly promote the maturation of dendritic cells and macrophage M1 repolarization by stimulator of interferon genes(STING)pathway activation,resulting in remodeling immuno-microenvironment.As a result,MnCO3@Te synergized with radiotherapy and immune checkpoint blockade therapy effectively inhibited the breast cancer growth and lung metastasis in vivo.Collectively,these findings indicate that MnCO3@Te as an agonist,successfully overcome radioresistance and awaken immune systems,showing promising potential for solid tumor radioimmunotherapy. | Wei Huang Sujiang Shi Haoran Lv Zhenyu Ju Qinghua Liu Tianfeng Chen | 2023 | Bioactive Materials2023，，9： | 0 |
| 10 | Elucidating cellular interactome of chikungunya virus identifies host dependency factors显示文摘Chikungunya virus(CHIKV)is a re-emerging mosquito-transmitted RNA virus causing joint and muscle pain.To better understand how CHIKV rewires the host cell and usurps host cell functions,we generated a systematic CHIKV-human protein-protein interaction map and revealed several novel connections that will inform further mechanistic studies.One of these novel interactions,between the viral protein E1 and STIP1 homology and U-box containing protein 1(STUB1),was found to mediate ubiquitination of E1 and degrade E1 through the proteasome.Capsid associated with G3BP1,G3BP2 and AAAþATPase valosin-containing protein(VCP).Furthermore,VCP inhibitors blocked CHIKV infection,suggesting VCP could serve as a therapeutic target.Further work is required to fully understand the functional consequences of these interactions.Given that CHIKV proteins are conserved across alphaviruses,many virus-host protein-protein interactions identified in this study might also exist in other alphaviruses.Construction of interactome of CHIKV provides the basis for further studying the function of alphavirus biology. | Peiqi Yin Xia Jian Yihan Liu Yuwen Liu Lu Lv Haoran Cui Leiliang Zhang | 2023 | Virologica Sinica2023，38，4： | 0 |
| 11 | Enhanced mixing efficiency for a novel 3D Tesla micromixer for Newtonian and non-Newtonian fluids显示文摘The fabrication of constructs with gradients for chemical,mechanical,or electrical composition is becoming critical to achieving more complex structures,particularly in 3D printing and biofabrication.This need is underscored by the complexity of in vivo tissues,which exhibit heterogeneous structures comprised of diverse cells and matrices.Drawing inspiration from the classical Tesla valve,our study introduces a new concept of micromixers to address this complexity.The innovative micromixer design is tailored to enhance the re-creation of in vivo tissue structures and demonstrates an advanced capability to efficiently mix both Newtonian and non-Newtonian fluids.Notably,our 3D Tesla valve micromixer achieves higher mixing efficiency with fewer cycles,which represents a significant improvement over the traditional mixing method.This advance is pivotal for the field of 3D printing and bioprinting,and offers a robust tool that could facilitate the development of gradient hydrogel-based constructs that could also accurately mimic the intricate heterogeneity of natural tissues. | Abdellah AAZMI Zixian GUO Haoran YU Weikang LV Zengchen JI Huayong YANG Liang MA | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，12： | 0 |
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