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| 1 | Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy显示文摘Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE-1) are also overexpressing in the reticuloendothelial system(RES). Therefore,polyethylene glycol(PEG) modification of HA-based DDS is necessary to reduce RES capture.Unfortunately, pegylation remarkably inhibits tumor cellular uptake and endosomal escapement,significantly compromising the in vivo antitumor efficacy. Herein, we developed a Dox-loaded HA-based transformable supramolecular nanoplatform(Dox/HCVBP) to overcome this dilemma. Dox/HCVBP contains a tumor extracellular acidity-sensitive detachable PEG shell achieved by a benzoic imine linkage.The in vitro and in vivo investigations further demonstrated that Dox/HCVBP could be in a 'stealth' state at blood stream for a long circulation time due to the buried HA ligands and the minimized nonspecific interaction by PEG shell. However, it could transform into a 'recognition' state under the tumor acidic microenvironment for efficient tumor cellular uptake due to the direct exposure of active targeting ligand HA following PEG shell detachment. Such a transformative concept provides a promising strategy to resolve the dilemma of natural ligand-based DDS with conflicting two processes of tumor cellular uptake and in vivo nonspecific biodistribution. | Lu Zhong Lu Xu Yanying Liu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Yongjun Wang Jin Sun Zhonggui He | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 2 | Decoding Cortical Glial Cell Development显示文摘Mouse cortical radial glial cells(RGCs)are primary neural stem cells that give rise to cortical oligodendrocytes,astrocytes,and olfactory bulb(OB)GABAergic interneurons in late embryogenesis.There are fundamental gaps in understanding how these diverse cell subtypes are generated.Here,by combining single-cell RNA-Seq with intersectional lineage analyses,we show that beginning at around E16.5,neocortical RGCs start to generate ASCL1^(+)EGFR^(+)apical multipotent intermediate progenitors(MIPCs),which then differentiate into basal MIPCs that express ASCL1,EGFR,OLIG2,and MKI67.These basal MIPCs undergo several rounds of divisions to generate most of the cortical oligodendrocytes and astrocytes and a subpopulation of OB interneurons.Finally,single-cell ATAC-Seq supported our model for the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons.Taken together,this work reveals the process of cortical radial glial cell lineage progression and the developmental origins of cortical astrocytes and oligodendrocytes. | Xiaosu Li Guoping Liu Lin Yang Zhenmeiyu Li Zhuangzhi Zhang Zhejun Xu Yuqun Cai Heng Du Zihao Su Ziwu Wang Yangyang Duan Haotian Chen Zicong Shang Yan You Qi Zhang Miao He Bin Chen Zhengang Yang | 2021 | Neuroscience Bulletin2021，37，4： | 2 |
| 3 | A multipurpose image watermarking method for copyright notification and pro-tection 显示文摘 | Lu Zheming Wu Haotian Xu Dianguo | 2003 | IEICE Transactions on Information and Systems2003，86，9： | 1 |
| 4 | Fructus ligustri lucidi Ethanol Extract Improves Bone Mineral Density and Properties Through Modulating Calcium Absorption-Related Gene Expression in Kidney and Duodenum of Growing Rats显示文摘 | Xin Feng Ying Lyu Zhenghao Wu Yuehui Fang Hao Xu Pengling Zhao Yajun Xu Haotian Feng | 2014 | Calcified Tissue International2014，，4： | 1 |
| 5 | Experimental study on the shear performance of quasi-NPR steel bolted rock joints显示文摘Quasi-NPR(negative Poisson’s ratio)steel is a new type of super bolt material with high strength,high ductility,and a micro-negative Poisson’s effect.This material overcomes the contrasting characteristics of the high strength and high ductility of steel and it has significant energy-absorbing characteristics,which is of high value in deep rock and soil support engineering.However,research on the shear resistance of quasi-NPR steel has not been carried out.To study the shear performance of quasi-NPR steel bolted rock joints,indoor shear tests of bolted rock joints under different normal stress conditions were carried out.Q235 steel and#45 steel,two representative ordinary bolt steels,were set up as a control group for comparative tests to compare and analyze the shear strength,deformation and instability mode,shear energy absorption characteristics,and bolting contribution of different types of bolts.The results show that the jointed rock masses without bolt reinforcement undergo brittle failure under shear load,while the bolted jointed rock masses show obvious ductile failure characteristics.The shear deformation ca-pacity of quasi-NPR steel is more than 3.5 times that of Q235 steel and#45 steel.No fracture occurs in the quasi-NPR steel during large shear deformation and it can provide stable shear resistance.However,the other two types of control bolts become fractured under the same conditions.Quasi-NPR steel has significant energy-absorbing characteristics under shear load and has obvious advantages in terms of absorbing the energy released by shear deformation of jointed rock masses as compared with ordinary steel.In particular,the shear force plays a major role in resisting the shear deformation of Q235 steel and#45 steel,therefore,fracture failure occurs under small bolt deformation.However,the axial force of quasi-NPR steel can be fully exerted when resisting joint shear deformation;the steel itself does not break when large shear deformation occurs,and the supporting effect of the jointed rock mass is effectively guaranteed. | Manchao He Shulin Ren Haotian Xu Senlin Luo Zhigang Tao Chun Zhu | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，2： | 1 |
| 6 | Impinging Cooling with a Crescent Surface Inspired by Barchan Dunes in a Simplified Gas Turbine Transition Section显示文摘For the enhancement of heat transfer efficiency,a novel turbulator inspired by the morphology of barchan dunes,called the mimetic barchan dune(MBD)turbulator,is designed and evaluated in the simplified gas turbine transition section.By using computational fluid dynamics(CFD),the numerical simulations for comparison have been carried out,concluding the smooth thermal surface,a thermal surface with riblet-shaped turbulator and a thermal surface with MBD turbulator.Then,two indicators are investigated for evaluating the coolant performance which are the heat transfer efficiency(η)on the outlet and the pressure loss(ΔP)in the coolant chamber.The numerical results show that the coolant has the best heat transfer efficiency with less pressure loss in the coolant chamber with the MBD turbulator.Then,the effect of the MBD turbulator sizes on heat transfer efficiency is investigated.When the height of the MBD turbulator(h)is set at 8 mm,the maximum amount of heat that could be transfered by the coolant is up to566.2 K and the corresponding heat transfer efficiency is 26.62%.The detail flows have been shown to elucidate the function of the MBD surface which may greatly arouse more design for solving harsh circumstance. | GUO Haotian XU Tao LIANG Xiao YU Zhenglei XING Genyuan GUO Huan | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，5： | 1 |
| 7 | Elec- trochemical tuning of vertically aligned MoS2 nanofilms and its application in improving hydrogen evolution re- action显示文摘 | WANG Haotian LU Zhiyi XU Shicheng | 2013 | PANS2013，110，19： | 1 |
| 8 | Petrogenesis and Tectonic Implications of Jurassic Granites in the Xingcheng Area,Northeastern North China Craton显示文摘New integrated geochemical studies are reported for Jurassic granites of the Xingcheng area in the northeastern North China Craton.U-Pb zircon data indicate that the Huashan and Taili monzogranites were emplaced during the Early(189±2 Ma)and Late(155±1 Ma)Jurassic,respectively.They are typical of high-K calc-alkaline series rocks and I-type granites,according to our whole-rock geochemical researches.Both Early and Late Jurassic monzogranites show adakitic rock characteristics because of their high Sr contents(221-347 ppm)and Sr/Y ratios(28.7-37.5),and low Y contents(7.83-14.7 ppm).The Early Jurassic monzogranite samples have an(^(87)Sr/^(86)Sr)i ratio of 0.7046,ε_(Nd)(t)values of -11.62 to -11.51,and ε_(Hf)(t)values of -13.6 to-6.4,whereas the Late Jurassic monzogranites have higher(87Sr/86Sr)i ratios of 0.7069-0.7071and lower ε_(Nd)(t)(-20.65 to-20.46)and ε_(Hf)(t)(-27.6 to-20.0)values.We suggest that the Early Jurassic adakitic rocks were derived from partial melting of thickened lower crust contaminated with mantle-derived materials,related to subduction of the Paleo-Pacific Plate.The Late Jurassic adakitic rocks were derived from partial melting of thickened lower crust in an extensional tectonic setting associated with an active continental margin. | MU Maosong YANG Debin XU Wenliang QUAN Yikang HAO Leran YANG Haotian WANG Anqi | 2021 | Acta Geologica Sinica(English Edition)2021，95，5： | 1 |
| 9 | Exploring the relationship of hyaluronic acid molecular weight and active targeting efficiency for designing hyaluronic acid-modified nanoparticles显示文摘Although it is reported that the targeting ability of hyaluronic acid(HA)-based nanoparticles(NPs) is molecular weight(MW) dependent,the influence of HA MW on targeting efficiency of HA-functionalized NPs and the underlying mechanism remain elusive. In this study,we constituted three HA-functionalized Dox-loaded NPs(Dox/HCVs) different HA MWs(7,63,and 102 k Da) and attempted to illustrate the effects of HA MW on the targeting efficiency.The three Dox/HCVs had similar physiochemical and pharmaceutical characteristics,but showed different affinity to CD44 receptor. Furthermore,Dox/HCV-63 exerted the best targeting effect and the highest cytotoxicity compared with Dox/HCV-7 and Dox/HCV-102. It was interesting to found that both the HA-CD44 binding affinity and induced CD44 clustering by HA-based NPs were HA MW-dependent,the two of which determine the apparent targeting efficacy of Dox/HCV NPs in the conflicting directions. Those results laid a good foundation for rationally designing HA-based NPs in cancer therapy. | Lu Zhong Yanying Liu Lu Xu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Jin Sun Zhonggui He | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 1 |
| 10 | Moving target defense of routing randomization with deep reinforcement learning against eavesdropping attack显示文摘Eavesdropping attacks have become one of the most common attacks on networks because of their easy implementation. Eavesdropping attacks not only lead to transmission data leakage but also develop into other more harmful attacks. Routing randomization is a relevant research direction for moving target defense, which has been proven to be an effective method to resist eavesdropping attacks. To counter eavesdropping attacks, in this study, we analyzed the existing routing randomization methods and found that their security and usability need to be further improved. According to the characteristics of eavesdropping attacks, which are “latent and transferable”, a routing randomization defense method based on deep reinforcement learning is proposed. The proposed method realizes routing randomization on packet-level granularity using programmable switches. To improve the security and quality of service of legitimate services in networks, we use the deep deterministic policy gradient to generate random routing schemes with support from powerful network state awareness. In-band network telemetry provides real-time, accurate, and comprehensive network state awareness for the proposed method. Various experiments show that compared with other typical routing randomization defense methods, the proposed method has obvious advantages in security and usability against eavesdropping attacks. | Xiaoyu Xu Hao Hu Yuling Liu Jinglei Tan Hongqi Zhang Haotian Song | 2022 | Digital Communications and Networks2022，8，3： | 1 |
| 11 | Unbiased transcriptomic analyses reveal distinet effects of immune deficiency in CNS function with and without injury显示文摘The mammalian central nervous system (CNS) is considered an immune privileged system as it is separated from the periphery by the blood brain barrier (BBB). Yet, immune functions have been postulated to heavily influence the functional state of the CNS, especially after injury or during neurodegeneration. There is controversy regarding whether adaptive immune responses are beneficial or detrimental to CNS injury repair. In this study, we utilized immunocompromised SCID mice and subjected them to spinal cord injury (SCI). We analyzed motor function, electrophysiology, histochemistry, and performed unbiased RNA-sequencing. SCID mice displayed improved CNS functional recovery compared to WT mice after SCI. Weighted gene-coexpression network analysis (WGCNA) of spinal cord transcriptomes revealed that SCID mice had reduced expression of immune function-related genes and heightened expression of neural transmission-related genes after SCI, which was confirmed by immunohistochemical analysis and was consistent with better functional recovery. Transcriptomic analyses also indicated heightened expression of neurotransmission-related genes before injury in SCID mice, suggesting that a steady state of immune-deficiency potentially led to CNS hyper-connectivity. Consequently, SCID mice without injury demonstrated worse performance in Morris water maze test. Taken together, not only reduced inflammation after injury but also dampened steady-state immune function without injury heightened the neurotransmission program, resulting in better or worse behavioral outcomes respectively. This study revealed the intricate relationship between immune and nervous systems, raising the possibility for therapeutic manipulation of neural function via immune modulation. | Dandan Luo Weihong Ge Xiao Hu Chen Li Chia-Ming Lee Liqiang Zhou Zhourui Wu Juehua Yu Sheng Lin Jing Yu Wei Xu Lei Chen Chong Zhang Kun Jiang Xingfei Zhu Haotian Li Xinpei Gao Yanan Geng Bo Jing Zhen Wang Changhong Zheng Rongrong Zhu Qiao Yan Quan Lin Keqiang Ye Yi E. Sun Liming Cheng | 2019 | Protein & Cell2019，10，8： | 1 |
| 12 | Development of Super-Synchronization Speed Control Assembly in Two 80 MVA Motor Generators of HL-2A Tokamak显示文摘 | LI Huajun DU Chang XUAN Weimin PEN Jianfei HU Haotian LIU Lin KANG Li XU Lirong HUANG Zhaorong WANG Fen WANG Xiaoping WANG Haibing | 2005 | Southwestern Institute of Physics Annual Report2005，，1： | 0 |
| 13 | Framework and Key Technologies of Human-machine Hybrid-augmented Intelligence System for Large-scale Power Grid Dispatching and Control显示文摘With integration of large-scale renewable energy,new controllable devices,and required reinforcement of power grids,modern power systems have typical characteristics such as uncertainty,vulnerability and openness,which makes operation and control of power grids face severe security challenges.Application of artificial intelligence(AI)technologies represented by machine learning in power grid regulation is limited by reliability,interpretability and generalization ability of complex modeling.Mode of hybrid-augmented intelligence(HAI)based on human-machine collaboration(HMC)is a pivotal direction for future development of AI technology in this field.Based on characteristics of applications in power grid regulation,this paper discusses system architecture and key technologies of human-machine hybrid-augmented intelligence(HHI)system for large-scale power grid dispatching and control(PGDC).First,theory and application scenarios of HHI are introduced and analyzed;then physical and functional architectures of HHI system and human-machine collaborative regulation process are proposed.Key technologies are discussed to achieve a thorough integration of human/machine intelligence.Finally,state-of-theart and future development of HHI in power grid regulation are summarized,aiming to efficiently improve the intelligent level of power grid regulation in a human-machine interactive and collaborative way. | Shixiong Fan Jianbo Guo Shicong Ma Lixin Li Guozheng Wang Haotian Xu Jin Yang Zening Zhao | 2024 | CSEE Journal of Power and Energy Systems2024，10，1： | 0 |
| 14 | Achieving Fuzzy Matching Data Sharing for Secure Cloud-Edge Communication显示文摘In this paper,we propose a novel fuzzy matching data sharing scheme named FADS for cloudedge communications.FADS allows users to specify their access policies,and enables receivers to obtain the data transmitted by the senders if and only if the two sides meet their defined certain policies simultaneously.Specifically,we first formalize the definition and security models of fuzzy matching data sharing in cloud-edge environments.Then,we construct a concrete instantiation by pairing-based cryptosystem and the privacy-preserving set intersection on attribute sets from both sides to construct a concurrent matching over the policies.If the matching succeeds,the data can be decrypted.Otherwise,nothing will be revealed.In addition,FADS allows users to dynamically specify the policy for each time,which is an urgent demand in practice.A thorough security analysis demonstrates that FADS is of provable security under indistinguishable chosen ciphertext attack(IND-CCA)in random oracle model against probabilistic polynomial-time(PPT)adversary,and the desirable security properties of privacy and authenticity are achieved.Extensive experiments provide evidence that FADS is with acceptable efficiency. | Chuan Zhang Mingyang Zhao Yuhua Xu Tong Wu Yanwei Li Liehuang Zhu Haotian Wang | 2022 | China Communications2022，19，7： | 0 |
| 15 | Coordinated Development of Population, Economy and Environment System and Diagnosis of Its Obstacle Factors in Nanjing显示文摘Promoting the coordinated development of regional population,economy and environment is beneficial to the realization of sustainable development.Based on the construction of evaluation index system of coordinated development of systems,the entropy weight-TOPSIS method and coupling coordination model,the coordinated development degree of population,economy and environment system in Nanjing was measured,and the temporal variation characteristics of each subsystem and their coordinated development degree form 1997 to 2016 were analyzed.The results showed that the development of population,economy system and environment system in Nanjing was generally in a continuous upward trend.Among them,the economy system developed fastest.The coordinated development degree of population,economy system and environment system in Nanjing was constantly increasing but still at a low level;the degree was only in the primary coordination phase,and its type was environment lagging.The economy subsystem and environment subsystem were important factors restricting the development of population,economy and environment in Nanjing,and the main obstacle factor was the production of industrial solid waste.The results above can provide a scientific basis for promoting the coordinated development of population,economy and environment system in Nanjing and achieving regional sustainable development. | Liu Binglin Jiang Shengnan Xu Minghui Xing Yun Wu Haotian Li Lu | 2019 | Meteorological and Environmental Research2019，10，5： | 0 |
| 16 | Qualitative and quantitative evaluation of Flos Puerariae by using chemical fingerprint in combination with chemometrics method显示文摘In order to better control the quality of Flos Puerariae(FP),qualitative and quantitative analyses were initially performed by using chemical fingerprint and chemometrics methods in this study.First,the fingerprint of FP was developed by HPLC and the chemical markers were screened out by similarity analysis(SA),hierarchical clustering analysis(HCA),principal components analysis(PCA),and orthogonal partial least squares discriminant analysis(OPLS-DA).Next,the chemical constituents in FP were profiled and identified by HPLC coupled to Fourier transform ion cyclotron resonance mass spectrometry(HPLCFT-ICR MS).Then,the characteristic constituents in FP were quantitatively analyzed by HPLC.As a result,31 common peaks were assigned in the fingerprint and 6 of them were considered as qualitative markers.A total of 35 chemical constituents were detected by HPLC-FT-ICR MS and 16 of them were unambiguously identified by comparing retention time,UV absorption wavelength,accurate mass,and MS/MS data with those of reference standards.Subsequently,the contents of glycitin,genistin,tectoridin,glycitein,genistein,and tectorigenin in 13 batches of FP were detected,ranging from 0.4438 to 11.06 mg/g,0.955 to 1.726 mg/g,9.81 to 57.22 mg/g,3.349 to 41.60 mg/g,0.3576 to 0.989 mg/g,and 2.126 to 9.99 mg/g,respectively.In conclusion,fingerprint analysis in combination with chemometrics methods could discover chemical markers for improving the quality control standard of FP.It is expected that the strategy applied in this study will be valuable for further quality control of other traditional Chinese medicines. | Jing Han Ke Xu Quanxiang Yan Wenwen Sui Haotian Zhang Sijie Wang Zan Zhang Ziyun Wei Fei Han | 2022 | Journal of Pharmaceutical Analysis2022，12，3： | 0 |
| 17 | Anti-catabolic effect of caffeic acid phenethyl ester, an active component of honeybee propolis on bone loss in ovariectomized mice: a micro-computed tomography study and histological analysis显示文摘 | Duan Wangping Wang Qing Li Fang Xiang Chuan Zhou Lin Xu Jiake Feng Haotian Wei Xiaochun | 2014 | Chinese Medical Journal2014，，22： | 0 |
| 18 | Hierarchical Frequency-dependent Chance Constrained Unit Commitment for Bulk AC/DC Hybrid Power Systems with Wind Power Generation显示文摘As the steady-state frequency of an actual power system decreases from its nominal value,the composite load of the system generally responds positively to lower power consumption,and vice versa.It is believed that this load frequency damping(LFD)effect will be artificially enhanced,i.e.,sensitivities of loads with respect to operational frequency will increase,in future power systems.Thus,for wind-integrated power systems,this paper proposes a frequency-dependent chance constrained unit commitment(FDCCUC)model that employs the operational frequency as a dispatching variable so that the LFD effect-based load power can act as a supplemental reserve.Because the frequency deviation is safely restricted,this low-cost reserve can be sufficiently exerted to upgrade the wind power accommodation capability of a power system that is normally confined by an inadequate reserve to cope with uncertain wind power forecasting error.Moreover,when the FDCCUC model is applied to a bulk AC/DC hybrid power system consisting of several independently operated regional AC grids interconnected by DC tie-lines,a hierarchically implemented searching algorithm is proposed to protect private scheduling information of the regional AC grids.Simulations on a 2-area 6-bus system and a 3-area 354-bus system verify the effectiveness of the FDCCUC model and hierarchical searching algorithm. | Rui Chen Deping Ke Yuanzhang Sun C.Y.Chung Haotian Wu Siyang Liao Jian Xu Congying Wei | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，4： | 0 |
| 19 | TCP-LTE/5G Cross-layer performance analysis tool for high mobility data networking and a case study on high-speed railway显示文摘Nowadays,high mobility scenarios have become increasingly common.The widespread adoption of High-speed Rail(HSR)in China exemplifies this trend,while more promising use cases,such as vehicle-to-everything,continue to emerge.However,the Internet access provided in high mobility environments stllstruggles to achieve seamless connectivity.The next generation of wireless cellular technology 5 G further poses more requirements on the endto-end evolution to fully utilize its ultra-high band-width,while existing network diagnostic tools focus on above-IP layers or below-IP layers only.We then propose HiMoDiag,which enables flexible online analysis of the network performance in a cross-layer manner,i.e.,from the top(application layer)to the bottom(physical layer).We believe HiMoDiag could greatly simplify the process of pinpointing the deficiencies of the Internet access delivery on HSR,lead to more timely optimization and ultimately help to improve the network performance. | Ruihan Li Yueyang Pan Xiangtian Ma Haotian Xu Chenren Xu | 2023 | High-Speed Railway2023，1，2： | 0 |
| 20 | Deep insight into the B-cell associated tertiary lymphoid structure and tumor immunotherapy显示文摘Bod et al.1 recently published a study in Nature that garnered attention to B cell-associated anti-tumor immunity and immunotherapy of melanoma and other tumors1.As a promising supplemental immunotherapy to mainstream methods that target T and natural killer(NK)cells,B cell-associated anti-tumor immunotherapy is promising。 | Jilong Yang Jin Xu Haotian Liu Wanyi Xiao Gengpu Zhang | 2024 | Cancer Biology & Medicine2024，21，2： | 0 |
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