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| 1 | Significance of Axial Length Monitoring in Children with Congenital Cataract and Update of Measurement Methods显示文摘Congenital cataract is the main cause of blindness in children, with significantly varying treatment effects. The development of axial length is an important factor that affects the prognosis of these children.However,when compared with the eyes of normal children,the mechanism of growth of the axial length is so complicated that the reported findings differ significantly in terms of the measuring apparatus,assessment methods,and statistical outcome,making the rule of axial length development still unclear. In this paper, we first review the process of axial length development in normal healthy children and compare different hypotheses about certain factors that could affect the development of axial length. The results of some current research about the characteristics of axial length development in congenital cataract children are then reviewed. Lastly, the advantages and disadvantages of current axial length measurements methods are compared and analyzed.The purpose of this review is to improve our understanding of the complexity and importance of axial length development and to suggest better use of axial length monitoring measurements in congenital cataract children for pediatric ophthalmologists,with the hope of offering assistance that will enhance long-term therapeutic effects for these children. | Jiao Zhan Haotian Lin Xinyu Zhang Weirong Chen Yizhi Liu | 2013 | Eye Science2013，28，2： | 11 |
| 2 | A pre-generated matrix-based method for real-time robotic drilling chatter monitoring显示文摘Currently, due to the detrimental effects on surface finish and machining system, chatter has been one crucial factor restricting robotic drilling operations, which improve both quality and efficiency of aviation manufacturing. Based on the matrix notch filter and fast wavelet packet decomposition, this paper presents a novel pre-generated matrix-based real-time chatter monitoring method for robotic drilling. Taking vibration characteristics of robotic drilling into account, the matrix notch filter is designed to eliminate the interference of spindle-related components on the measured vibration signal. Then, the fast wavelet packet decomposition is presented to decompose the filtered signal into several equidistant frequency bands, and the energy of each sub-band is obtained. Finally, the energy entropy which characterizes inhomogeneity of energy distribution is utilized as the feature to recognize chatter on-line, and the effectiveness of the presented algorithm is validated by extensive experimental data. The results show that the proposed algorithm can effectively detect chatter before it is fully developed. Moreover, since both filtering and decomposition of signal are implemented by the pre-generated matrices, calculation for an energy entropy of vibration signal with 512 samples takes only about 0.690 ms. Consequently, the proposed method achieves real-time chatter monitoring for robotic drilling, which is essential for subsequent chatter suppression. | Jianfeng TAO Chengjin QIN Dengyu XIAO Haotian SHI Chengliang LIU | 2019 | Chinese Journal of Aeronautics2019，32，12： | 9 |
| 3 | Soil water repellency and influencing factors of Nitraria tangutorun nebkhas at different succession stages显示文摘Soil water repellency(WR) is an important physical characteristic of soil surface. It is capable of largely influencing the hydrological and geomorphological processes of soil, as well as affecting the ecological processes of plants, such as growth and seed germination, and has thus been a hot topic in recent research around the world. In this paper, the capillary rise method was used to study the soil WR characteristics of Nitraria tangutorun nebkhas. Soil water repellencies at different succession stages of Nitraria tangutorun were investigated, and the relationships between soil WR and soil organic matter, total N, and total P, soil texture, pH, and concentrations of CO3 2-, HCO3-, Cl-, SO4 2-, Na+, K+, Ca2+and Mg2+were discussed. Soil WR may be demonstrated at the following nebkhas dune evolvement stages: extremely degraded>degraded>stabilized>well developed>newly developed>quick sand. Apart from some soil at the bottom, the WR of other soils(crest and slope of dune) was found to be largest at the topsoil, and decreased as the soil depth increased. The results showed that multiple factors affected soil WR characteristics, e.g. WR increased significantly as the contents of soil organic matter and total N increased, but did not change as the total P content increased. Soil texture was a key factor affecting soil WR; soil WR increased significantly as clay content increased, and decreased significantly as sand content increased. Low pH was shown to be more suitable for the occurrence of soil WR. Four cations(Ca2+, Mg2+, K+and Na+) and two anions(Cl-and SO4 2-) enhanced soil WR, while CO3 2-decreased it. HCO3-did not show any observable effect. Finally, we established a best-fit general linear model(GLM) between soil-air-water contact angle(CA) and influencing factors(CA=5.606 sand+6.496(clay and silt)–2.353 pH+470.089 CO3 2-+11.346 Na+–407.707 Cl-–14.245 SO4 2-+0.734 total N–519.521). It was concluded that all soils contain subcritical WR(0° | HaoTian YANG XinRong LI LiChao LIU YanHong GAO Gang LI RongLiang JIA | 2014 | Journal of Arid Land2014，6，3： | 9 |
| 4 | Notch signaling pathway mediates the immunomodulatory mechanism of Yangfei Huoxue decoction alleviating bleomycin-induced pulmonary fibrosis in rats显示文摘OBJECTIVE: To investigate the immunomodulatory mechanism by which Yangfei Huoxue decoction(YHD) alleviates bleomycin(BLM)-induced pulmonary fibrosis(PF) in rats.METHODS: Rats were randomly divided into two time-point groups(day 14 and 28), and each timepoint group comprised the following six subgroups: control, BLM, dexamethasone(DXM), YHD high dose(YHD-H), YHD middle dose(YHD-M), and YHD low dose(YHD-L). Haematoxylin and eosin and Masson staining, flow cytometry, enzymelinked immunosorbent assay, Western blotting and UPLC-QT of analyses were examined.RESULTS: The results showed that YHD reduced the degree of alveolar inflammation and fibrosis;downregulated the expression of CD28, CD80,CD86, Delta-like 1, Notch2, and Notch3;and upregulated the proportions of Th1/Th2 and Tc1/Tc2. The seven components of YHD were detected.CONCLUSION: The current study indicates that YHD mainly functions by regulating the immune system and that the molecular mechanism may be related to the regulation of the Notch signaling pathway. | Chen Hui Liu Xiao Su Yinxu Chang Ke Wu Haotian Su Guangbao Gong Jiening | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 7 |
| 5 | Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy显示文摘Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE-1) are also overexpressing in the reticuloendothelial system(RES). Therefore,polyethylene glycol(PEG) modification of HA-based DDS is necessary to reduce RES capture.Unfortunately, pegylation remarkably inhibits tumor cellular uptake and endosomal escapement,significantly compromising the in vivo antitumor efficacy. Herein, we developed a Dox-loaded HA-based transformable supramolecular nanoplatform(Dox/HCVBP) to overcome this dilemma. Dox/HCVBP contains a tumor extracellular acidity-sensitive detachable PEG shell achieved by a benzoic imine linkage.The in vitro and in vivo investigations further demonstrated that Dox/HCVBP could be in a 'stealth' state at blood stream for a long circulation time due to the buried HA ligands and the minimized nonspecific interaction by PEG shell. However, it could transform into a 'recognition' state under the tumor acidic microenvironment for efficient tumor cellular uptake due to the direct exposure of active targeting ligand HA following PEG shell detachment. Such a transformative concept provides a promising strategy to resolve the dilemma of natural ligand-based DDS with conflicting two processes of tumor cellular uptake and in vivo nonspecific biodistribution. | Lu Zhong Lu Xu Yanying Liu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Yongjun Wang Jin Sun Zhonggui He | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 6 | Engineering the surface of LiCoO2 electrodes using atomic layer deposition for stable high-voltage lithium ion batteries显示文摘 | Jin Xie Jie Zhao Yayuan Liu Haotian Wang Chong Liu Tong Wu Po-Chun Hsu Dingchang Lin Yang Jin Yi Cui | 2017 | Nano Research2017，10，11： | 6 |
| 7 | Information theory of metasurfaces显示文摘We propose a theory to characterize the information and information processing abilities of metasurfaces,and demonstrate the relation between the information of the metasurface and its radiation pattern in the far-field region.By incorporating a general aperturemodel with uncertainty relation in L2-space,we propose a theory to predict the upper bound of information contained in the radiation pattern of a metasurface,and reveal the theoretical upper limit of orthogonal radiation states.Theproposed theory also provides guidance for inverse design of the metasurface with respect to given functionalities.Through investigation of the information of disordered-phase modulated metasurfaces,we find the information invariance(1?γ,whereγis Euler’s constant)of chaotic radiation patterns.That is to say,the information of the disordered-phase modulated radiation patterns is always equal to 1?γ,regardless of variations in size,the number of elements and the phase pattern of metasurface.This value might be the lower bound of radiation-pattern information of the metasurface,which can provide a theoretical limit for information modulation applications,including computational imaging,stealth technologies and wireless communications. | Haotian Wu Guo Dong Bai Shuo Liu Lianlin Li Xiang Wan Qiang Cheng Tie Jun Cui | 2020 | National Science Review2020，7，3： | 5 |
| 8 | Phosphate removal by a La(OH)_(3) loaded magnetic MAPTAC-based cationic hydrogel:Enhanced surface charge density and Donnan membrane effect显示文摘Cationic hydrogels have received great attention to control eutrophication and recycle phosphate.In this study,a type of La(OH)_(3) loaded magnetic MAPTAC-based cationic hydrogel(La(OH)_(3)@MMCH)was developed as a potential adsorbent for enhanced phosphate removal from aqueous environment.La(OH)_(3)@MMCH exhibited high adsorption capacity of 105.72±5.99 mg P/g,and reached equilibrium within 2 hr.La(OH)_(3)@MMCH could perform effectively in a wide pH range from 3.0 to 9.0 and in the presence of coexisting ions(including SO_(4)^(2-),Cl^(-),NO_(3)^(-),HCO_(3)^(-),SiO_(4)^(4-) and HA).The adsorption-desorption experiment indicated that La(OH)_(3)@MMCH could be easily regenerated by using NaOH-NaCl as the desorption agent,and 73.3%adsorption capacity remained after five cycles.Moreover,La(OH)_(3)@MMCH was employed to treat surface water with phosphate concentration of 1.90 mg/L and showed great removal efficiency of 95.21%.Actually,MMCH showed high surface charge density of 34.38-59.38 meq/kg in the pH range from 3.0 to 11.0 and great swelling ratio of 3014.57%within 24 h,indicating that MMCH could produce the enhanced Donnan membrane effect to pre-permeate phosphate.Furthermore,the bifunctional structure of La(OH)_(3)@MMCH enabled it to capture phosphate through electrostatic attraction and ligand exchange.All the results prove that La(OH)_(3)@MMCH is a promising adsorbent for eutrophication control and phosphate recovery. | Yanqing Zhou Yili Wang Shuoxun Dong Haotian Hao Junyi Li Chenyang Liu Xiaolin Li Yao Tong | 2022 | Journal of Environmental Sciences2022，34，3： | 4 |
| 9 | Homogeneous label-free fluorescent assay of small molecule-protein interactions using protein binding-inhibited transcription nanomachine显示文摘Quantitative analysis of interactions between small molecules and proteins is a central challenge in chemical genetics, molecular diagnostics and drug developments. Here, we developed a RNA transcription nanomachine by assembling T7 RNA polymerase on a small molecule-labeled DNA heteroduplex. The nanomachine, of which the RNA transcription activity can be quantitatively inhibited by protein binding, showed a great potential for small molecule-protein interaction assay. This finding enabled us to develop a novel homogeneous label-free strategy for assays of interactions between small molecules and their protein receptors. Three small molecule compounds and their protein receptors have been used to demonstrate the developed strategy. The results revealed that the protein-small molecule interaction assay strategy shows dynamic responses in the concentration range from 0.5 to 64 nM with a detection limit of 0.2 nM. Due to its label-free, homogeneous, and fluorescence-based detection format, besides its desirable sensitivity this technique could be greatly robust, cost-efficient and readily automated, implying that the developed small molecule-protein interaction assay strategy might create a new methodology for developing intrinsically robust, sensitive and selective platforms for homogeneous protein detection. | ZHOU DianMing, WU YiDan, LIU Pei, BAI HaoTian, TANG LiJuan, YU RuQin & JIANG JianHui State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China | 2011 | Science China Chemistry2011，54，8： | 4 |
| 10 | Switching Power System Stabilizer and Its Coordination for Enhancement of Multi-machine Power System Stability显示文摘This paper proposes a coordinated switching power system stabilizer(SPSS)to enhance the stability of multimachine power systems.The SPSS switches between a bang-bang power system stabilizer(BPSS)and a conventional power system stabilizer(CPSS)based on a state-dependent switching strategy.The BPSS is designed as a bang-bang constant funnel controller(BCFC).It is able to provide fast damping of rotor speed oscillations in a bang-bang manner.The closed-loop stability of the power system controlled by the SPSSs and the CPSSs is analyzed.To verify the control performance of the SPSS,simulation studies are carried out in a 4-generator 11-bus power system and the IEEE 16-generator 68-bus power system.The damping ability of the SPSS is evaluated in aspects of small-signal oscillation damping and transient stability enhancement,respectively.Meanwhile,the coordination between different SPSSs and the coordination between the SPSS and the CPSS are investigated therein. | Yang Liu Qinghua Wu Haotian Kang Xiaoxin Zhou | 2016 | CSEE Journal of Power and Energy Systems2016，2，2： | 4 |
| 11 | SF_(6)decomposition and insulation condition monitoring of GIE:A review显示文摘The statistics of the Conference International des Grands Reseaux Electriques(CIGRE)indicate that the operational reliability of SF6 gas‐insulated equipment(GIE)is very high;however,the failure rate of the GIE in operation is much higher than that of the IEC standard,and the fault occurs frequently in the GIE at a high voltage level.The reason is due to the complex and strong on‐site electromagnetic interference environment and fully enclosed structure of GIE.The key method and technology for effective on‐line monitoring and fault diagnosis of GIE are still lacking.Given the partial strong electromagnetic energy and high temperature induced by early latent insulation faults in the equipment,SF6 gas insulation presents different degrees of decomposition.The decomposition products mainly include SO_(2)F_(2),SOF_(2),SO_(2),HF,and H2S.The decomposition characteristics of SF6 are closely related to the property of insulation faults.At present,this area is attracting attention from the power industry and research institutes.This study summarises the current research on SF_(6)decomposition component analysis(DCA).The content mainly includes the latest progress of SF_(6)decomposition characteristics and mechanism under fault conditions,and fault diagnosis methods based on decomposition components. | Fuping Zeng Haotian Li Hongtu Cheng Ju Tang Yilu Liu | 2021 | High Voltage2021，6，6： | 3 |
| 12 | M3SC:A Generic Dataset for Mixed Multi-Modal(MMM)Sensing and Communication Integration显示文摘The sixth generation(6G)of mobile communication system is witnessing a new paradigm shift,i.e.,integrated sensing-communication system.A comprehensive dataset is a prerequisite for 6G integrated sensing-communication research.This paper develops a novel simulation dataset,named M3SC,for mixed multi-modal(MMM)sensing-communication integration,and the generation framework of the M3SC dataset is further given.To obtain multimodal sensory data in physical space and communication data in electromagnetic space,we utilize Air-Sim and WaveFarer to collect multi-modal sensory data and exploit Wireless InSite to collect communication data.Furthermore,the in-depth integration and precise alignment of AirSim,WaveFarer,andWireless InSite are achieved.The M3SC dataset covers various weather conditions,multiplex frequency bands,and different times of the day.Currently,the M3SC dataset contains 1500 snapshots,including 80 RGB images,160 depth maps,80 LiDAR point clouds,256 sets of mmWave waveforms with 8 radar point clouds,and 72 channel impulse response(CIR)matrices per snapshot,thus totaling 120,000 RGB images,240,000 depth maps,120,000 LiDAR point clouds,384,000 sets of mmWave waveforms with 12,000 radar point clouds,and 108,000 CIR matrices.The data processing result presents the multi-modal sensory information and communication channel statistical properties.Finally,the MMM sensing-communication application,which can be supported by the M3SC dataset,is discussed. | Xiang Cheng Ziwei Huang Lu Bai Haotian Zhang Mingran Sun Boxun Liu Sijiang Li Jianan Zhang Minson Lee | 2023 | China Communications2023，20，11： | 3 |
| 13 | Characteristics of soil water repellency after sand dune stabilization in the Tengger Desert显示文摘Soil water repellency (SWR) is one of the most important physical properties of soils found all over the world, and it may have significant effects on the eco-hydrological processes of land ecosystems. In this study, the Capillary Rise Method was used to measure the SWR in the artificial vegetation area in Shapotou, located in the southeast area of the Tengger Desert, Ningxia Province of western China. The variation of the soil water repellency among different minor topographies, different depths and different particle sizes was analyzed. The results of the study indicate that the SWR shows distinct changes with vegetation restoration, and it increases with an increase in the period of dune stabilization. In the same vegetation area, the SWR of soils in inter-dune depressions or windward slopes is slightly greater than that in crest or leeward slopes. The SWR of 0-3 cm topsoil is significantly greater than that in the 3-6 cm soil layer. The SWR decreases with an increase in grain size and the differences among the SWRs of different sieved soil fractions are found to be significant. There is also a significantly positive correlation between the SWR and the proportion of soils with grain sizes of 0-0.05, 0.05-0.01 and 0.01-0.15 mm, and a significantly negative correlation between the SWR and the propotion of soils with grain sizes exceeding 0.15 mm. The increase of SWR in revegetation areas may depend on the continuous depositing of atmospheric dust on the stabilized dune surface as well as the formation of biological soil crusts, especially on the formation of algal and lichen crusts. Enhanced SWR influences the effectiveness of water use of sand plants inhabiting the sand dunes. | HaoTian Yang LiChao Liu XinRong Li YongPing Wei YanHong Gao XiaoJun Li RongLiang Jia Lei Huang | 2012 | Research in Cold and Arid Regions2012，4，5： | 2 |
| 14 | Whole-process design and experimental validation of landing gear lower drag stay with global/local linked driven optimization strategy显示文摘Landing gear lower drag stay is a key component which connects fuselage and landing gear and directly effects the safety and performance of aircraft takeoff and landing. To effectively design the lower drag stay and reduce the weight of landing gear, Global/local Linked Driven Optimization Strategy(GLDOS) was developed to conduct the overall process design of lower drag stay in respect of optimization thought. The whole-process optimization involves two stages of structural conceptual design and detailed design. In the structural conceptual design, the landing gear lower drag stay was globally topologically optimized by adopting multiple starting points algorithm. In the detailed design, the local size and shape of landing gear lower drag stay were globally optimized by the gradient optimization strategy. The GLDOS method adopts different optimization strategies for different optimization stages to acquire the optimum design effect. Through the experimental validation, the weight of the optimized lower dray stay with the developed GLDOS is reduced by 16.79% while keeping enough strength and stiffness, which satisfies the requirements of engineering design under the typical loading conditions. The proposed GLDOS is validated to be accurate and efficient in optimization scheme and design cycles. The efforts of this paper provide a whole-process optimization approach regarding different optimization technologies in different design phases, which is significant in reducing structural weight and enhance design tp wid 1 precision for complex structures in aircrafts. | Chengwei FEI Haotian LIU Zhengzheng ZHU Liqiang AN Shaolin LI Cheng LU | 2021 | Chinese Journal of Aeronautics2021，34，2： | 2 |
| 15 | The Enlightenment on Urban Ecological Construction by Research Progress of Sponge City in China Based on Literature Analysis显示文摘To quantitatively analyze main figure,field,agency and level of sponge city research in China,and clear research focus and hot spot in each year,by using the Full Text Database of Chinese Sci-tech Periodicals and other retrieval tools,the statistics and analysis of 3152 research literatures on sponge city published in domestic academic journals of 2004-2016 are conducted based on bibliometrics. It is found that since the concept of ' sponge city' was firstly proposed in 2012,development research of sponge city involves 40 subject fields and is mainly published in 32 kinds of journals,which is dominated by natural science research( 1427 literatures). Researchers are mainly from each college and university,some design institutes and Chinese Academy of Sciences. The research could play certain guidance significance for further research and construction of ecological city construction in China. | Jinzhu HUA Zebin CHEN Haotian WANG Zhiwei ZHENG Jingxiang HU Liyuan YAO Jiani LIU Yuyu ZHANG Lifang YIN Chunxu CHEN | 2017 | Asian Agricultural Research2017，9，5： | 2 |
| 16 | Switching Excitation Controller for Enhancement of Transient Stability of Multi-machine Power Systems显示文摘This paper proposes a switching structure excitation controller(SSEC)to enhance the transient stability of multimachine power systems.The SSEC switches between a bangbang funnel excitation controller(BFEC)and a conventional excitation controller(CEC),based on an appropriately designed state-dependent switching strategy.Only the tracking error of rotor angle is required to realize the BFEC in a bang-bang manner with two control values.If the feasibility assumptions of the BFEC are satisfied,the tracking error of rotor angle can be regulated within the predefined error funnels.The power system having the SSEC installed can achieve faster convergence performance compared to that having the CEC implemented only.Simulation studies are carried out in the New England 10-generator 39-bus power system.The control performance of the SSEC is evaluated in the cases that three-phase-to-ground fault and transmission line outage occur in the power system,respectively. | Haotian Kang Yang Liu Qinghua Wu Xiaoxin Zhou | 2015 | CSEE Journal of Power and Energy Systems2015，1，3： | 2 |
| 17 | Demonstration of epitaxial growth of strain-relaxed GaN films on graphene/SiC substrates for long wavelength light-emitting diodes显示文摘Strain modulation is crucial for heteroepitaxy such as GaN on foreign substrates.Here,the epitaxy of strain-relaxed GaN films on graphene/SiC substrates by metal-organic chemical vapor deposition is demonstrated.Graphene was directly prepared on SiC substrates by thermal decomposition.Its pre-treatment with nitrogen-plasma can introduce C–N dangling bonds,which provides nucleation sites for subsequent epitaxial growth.The scanning transmission electron microscopy measurements confirm that part of graphene surface was etched by nitrogen-plasma.We study the growth behavior on different areas of graphene surface after pre-treatment,and propose a growth model to explain the epitaxial growth mechanism of GaN films on graphene.Significantly,graphene is found to be effective to reduce the biaxial stress in GaN films and the strain relaxation improves indium-atom incorporation in InGaN/GaN multiple quantum wells(MQWs)active region,which results in the obvious red-shift of light-emitting wavelength of InGaN/GaN MQWs.This work opens up a new way for the fabrication of GaN-based long wavelength light-emitting diodes. | Ye Yu Tao Wang Xiufang Chen Lidong Zhang Yang Wang Yunfei Niu Jiaqi Yu Haotian Ma Xiaomeng Li Fang Liu Gaoqiang Deng Zhifeng Shi Baolin Zhang Xinqiang Wang Yuantao Zhang | 2021 | Light(Science & Applications)2021，10，7： | 2 |
| 18 | Ultrasmall Nanoparticle ROS Scavengers Based on Polyhedral Oligomeric Silsesquioxanes显示文摘Although tremendous efforts have been devoted to the structural and functional tailoring of natural polyphenol-functionalized nan oparticles,preparing ultrasmall sized(<6 nm)particles with precisely-defined structures has remained a grand challenge.In this work,we reported the preparation of ultra-small and precisely structured polyhedral oligomeric silsesquioxanes(POSS)-based polyphenol nanopartides(T8^-,T10^-,and T12^-GAPOSS)by accurately functionalizing the POSS surface with plant polyphenol gallic acid units via thiol-Michael'click'reactions.Those polyphenol nanoparticles exhibited strong free radical scavenging capacity,good biocompatibility and ability to resist cell oxidative damage,which dem on strated great potentials in inhibiting oxidative stress in duced pathologies. | Zhan Li Haotian Li Jianhua Zhang Xianhu Liu Zhipeng Gu Yiwen Li | 2020 | Chinese Journal of Polymer Science2020，38，11： | 2 |
| 19 | Microstructure evolution and deformation mechanism of amorphous/crystalline high-entropy-alloy composites显示文摘High-entropy amorphous alloys present high hardness,but low tensile ductility.Here,deformation behavior of the amorphous/crystalline Fe Co Cr Ni high-entropy alloy(HEA)composite prepared by the previous experiment is investigated using atomic simulations.The result shows the partial dislocations in the crystal HEA layer,and the formation of shear bands in the amorphous HEA layer occurs after yielding.The strength of the amorphous/crystalline HEA composite reduces with increasing the thickness of the amorphous layer,agreeing with the previous experiments.The coupled interaction between the crystal plasticity and amorphous plasticity in amorphous/crystalline HEA composites results in a more homogeneous redistribution of plastic deformation to cause interface hardening,due to the complex stress field in the amorphous layer.The current findings provide the insight into the deformation behavior of the amorphous/crystalline HEA composite at the nanoscale,which are useful for optimizing the structure of the HEA composite with high strength and good plasticity. | Jia Li Haotian Chen Hui Feng Qihong Fang Yong Liu Feng Liu Hong Wu Peter K Liaw | 2020 | Journal of Materials Science & Technology2020，54，19： | 2 |
| 20 | Decoding Cortical Glial Cell Development显示文摘Mouse cortical radial glial cells(RGCs)are primary neural stem cells that give rise to cortical oligodendrocytes,astrocytes,and olfactory bulb(OB)GABAergic interneurons in late embryogenesis.There are fundamental gaps in understanding how these diverse cell subtypes are generated.Here,by combining single-cell RNA-Seq with intersectional lineage analyses,we show that beginning at around E16.5,neocortical RGCs start to generate ASCL1^(+)EGFR^(+)apical multipotent intermediate progenitors(MIPCs),which then differentiate into basal MIPCs that express ASCL1,EGFR,OLIG2,and MKI67.These basal MIPCs undergo several rounds of divisions to generate most of the cortical oligodendrocytes and astrocytes and a subpopulation of OB interneurons.Finally,single-cell ATAC-Seq supported our model for the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons.Taken together,this work reveals the process of cortical radial glial cell lineage progression and the developmental origins of cortical astrocytes and oligodendrocytes. | Xiaosu Li Guoping Liu Lin Yang Zhenmeiyu Li Zhuangzhi Zhang Zhejun Xu Yuqun Cai Heng Du Zihao Su Ziwu Wang Yangyang Duan Haotian Chen Zicong Shang Yan You Qi Zhang Miao He Bin Chen Zhengang Yang | 2021 | Neuroscience Bulletin2021，37，4： | 2 |
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