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您的检索式：作者名="Harald Becker"
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| 1 | Antioxidants,inflammation and cardiovascular disease显示文摘Multiple factors are involved in the etiology of cardiovascular disease(CVD). Pathological changes occur in a variety of cell types long before symptoms become apparent and diagnosis is made. Dysregulation of physiological functions are associated with the activation of immune cells,leading to local and finally systemic inflammation that is characterized by production of high levels of reactive oxygen species(ROS). Patients suffering from inflammatory diseases often present with diminished levels of antioxidants either due to insufficient dietary intake or,and even more likely,due to increased demand in situations of overwhelming ROS production by activated immune effector cells like macrophages. Antioxidants are suggested to beneficially interfere with diseases-related oxidative stress,however the interplay of endogenous and exogenous antioxidants with the overall redox system is complex. Moreover,molecular mechanisms underlying oxidative stress in CVD are not fully elucidated. Metabolic dybalances are suggested to play a major role in disease onset and progression. Several central signalingpathways involved in the regulation of immunological,metabolic and endothelial function are regulated in a redox-sensitive manner. During cellular immune response,interferon γ-dependent pathways are activated such as tryptophan breakdown by the enzyme indoleamine 2,3-dioxygenase(IDO) in monocyte-derived macrophages,fibroblasts,endothelial and epithelial cells. Neopterin,a marker of oxidative stress and immune activation is produced by GTP-cyclohydrolase Ⅰ in macrophages and dendritic cells. Nitric oxide synthase(NOS) is induced in several cell types to generate nitric oxide(NO). NO,despite its low reactivity,is a potent antioxidant involved in the regulation of the vasomotor tone and of immunomodulatory signaling pathways. NO inhibits the expression and function of IDO. Function of NOS requires the cofactor tetrahydrobiopterin(BH4),which is produced in humans primarily by fibroblasts and endothelial cells. Highly toxic peroxynitrite(ONOO-) is formed solely in the presence of superoxide anion(O2-). Neopterin and kynurenine to tryptophan ratio(Kyn/Trp),as an estimate of IDO enzyme activity,are robust markers of immune activation in vitro and in vivo. Both these diagnostic parameters are able to predict cardiovascular and overall mortality in patients at risk. Likewise,a significant association exists between increase of neopterin concentrations and Kyn/Trp ratio values and the lowering of plasma levels of vitamin-C,-E and-B. Vitamin-B deficiency is usually accompanied by increased plasma homoycsteine. Additional determination of NO metabolites,BH4 and plasma antioxidants in patients with CVD and related clinical settings can be helpful to improve the understanding of redox-regulation in health and disease and might provide a rationale for potential antioxidant therapies in CVD. | Harald Mangge Kathrin Becker Dietmar Fuchs Johanna M Gostner | 2014 | World Journal of Cardiology2014，6，6： | 25 |
| 2 | 节能性与结构耐久性俱佳的新型暖边系统—Kodispace 4SG显示文摘本文介绍了一项创新性反应型丁基隔条技术。这项技术使采用结构装配的建筑外立面中的中空玻璃单元具备国际先进的暖边性能与优越的气密性。在极端的环境条件下,中空玻璃单元中的二道密封胶能够承受由于风荷载和极端温度而产生的高应力。为了适应上述应力,科技人员设计了一套反应型丁基系统,该系统融合了隔条、干燥剂与丁基密封胶的各项功能。相比于刚性隔条,这套隔条系统利用中空玻璃单元的整个内部空间来吸收由于环境应力引起的形变。该隔条与玻璃和第二道硅酮密封胶的化学粘合保证了封边条卓越的耐久性。由于在产品应用中采用电脑控制,再加上隔条的极低的渗透性,在正常大规模生产条件下,中空玻璃单元也能达到EN 1279-3(气密性)标准的要求。这就使三玻两腔的中空玻璃的制作变得尤为简单,更易于制作高精度的大板结构中空玻璃,造型设计也更加自由。创新的反应型隔条系统已成为中空玻璃单元技术领域的里程碑,为建筑外立面带来了卓越的耐久性和节能效果,使建筑外立面的能源可持续性迈出了辉煌的一步。 | Christian Scherer Ernst Semar Harald Becker Wolfgang Wittwer Jens Wolthaus Thomas Scherer 李晶 | 2018 | 建设科技2018，，17： | 0 |
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