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| 1 | Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties显示文摘 | Monica Bostad Kristian Berg Anders H?gset Ellen Skarpen Harald Stenmark P?l K. Selbo | 2013 | Journal of Controlled Release2013，，3： | 4 |
| 2 | Emerging role of bioflavonoids in gastroenterology:Especially their effects on intestinal neoplasia显示文摘Flavonoids,secondary plant products which could be essential for normal physiology in humans and animals,may be the vitamins of the next century.Flavonoids belong to the polyphenols and possess antioxidative,anti-inflammatory,antimutagenic and anticarcinogenic properties.Among the various flavonoid species,tea flavonoids such as apigenin (from camomile) and epigallocatechin gallate (EGCG from green tea) can be used for the prevention of intestinal neoplasia,especially for adenoma and cancer prevention in the gastrointestinal tract.Numerous experimental studies with molecular and biological end points support the therapeutic efficacy of bioflavonoids.Clinical studies with cohorts and case-control trials suggest that flavonoids are effective in tertiary bioprevention but,as yet,there are no controlled randomized clinical trials.Flavonoids can inhibit inflammatory pathways and could be useful for chronic inflammatory bowel diseases.Flavonoid deficiency syndromes could be therapeutic targets in the future. | Harald P Hoensch Reinhard Oertel | 2011 | World Journal of Gastrointestinal Oncology2011，3，5： | 3 |
| 3 | Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas显示文摘AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds.METHODS:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal cancer.Biopsies were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)reasons.After storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as substrates.RESULTS:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by histopathology.Enzyme activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the UGT.Analysis of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer patients.The means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for carcinomas.CONCLUSION:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range. | Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 4 | New insights into the management of acne: An update from the Global Alliance to Improve Outcomes in Acne Group显示文摘 | Diane Thiboutot Harald Gollnick Vincenzo Bettoli Brigitte Dréno Sewon Kang James J. Leyden Alan R. Shalita Vicente Torres Lozada Diane Berson Andrew Finlay Chee Leok Goh María Isabel Herane Ana Kaminsky Raj Kubba Alison Layton Yoshiki Miyachi Montserrat P | 2009 | Journal of the American Academy of Dermatology2009，，5： | 2 |
| 5 | The Swiss lithoclast:a new device for endoscopic stone disintegration显示文摘 | Harald S Gerald H Marco P | 1993 | J urol1993，149，3： | 1 |
| 6 | Fast HPLC determination of serum free fatty acids in the picomole range显示文摘 | Micharel P Harald K Elke Von O | 1993 | Clin Chem1993，39，5： | 1 |
| 7 | Effective prophylaxis against rotavirus diarrhea using a combination of Lactobacillus rhamnosus GG and antibodies显示文摘 | Neha P Harold M Harald B | 2007 | BMC Microbiol2007，7，1： | 1 |
| 8 | Human capital heterogeneity,collaborative relationships,and publication patterns in a multidisciplinary scientific alliance:a comparative case study of two scientific teams显示文摘 | JOSEPH F P JAMES B W HARALD M F | 2004 | Research Policy2004，，33： | 1 |
| 9 | The swiss lithoclast:a new device for endoscopic stone disintegration显示文摘 | Harald S Garald H Marco P | 1993 | J Urol1993，149，1： | 1 |
| 10 | Classification of Coronary Atherosclerotic Plaques Ex Vivo With T1, T2, and Ultrashort Echo Time CMR显示文摘 | Mihály Károlyi Harald Seifarth Gary Liew Christopher L. Schlett Pál Maurovich-Horvat Paul Stolzmann Guangping Dai Shuning Huang Craig J. Goergen Masataka Nakano Fumiyuki Otsuka Renu Virmani Udo Hoffmann David E. Sosnovik | 2013 | JACC: Cardiovascular Imaging2013，，4： | 1 |
| 11 | The Napkin-Ring Sign Indicates Advanced Atherosclerotic Lesions in Coronary CT Angiography显示文摘 | Pál Maurovich-Horvat Christopher L. Schlett Hatem Alkadhi Masataka Nakano Fumiyuki Otsuka Paul Stolzmann Hans Scheffel Maros Ferencik Matthias F. Kriegel Harald Seifarth Renu Virmani Udo Hoffmann | 2012 | JACC: Cardiovascular Imaging2012，，12： | 1 |
| 12 | Folding in vitro of light-harvesting chlorophyll a/b protein is coupled with pigment binding 显示文摘 | Ruth H and Harald P | 2002 | Journal of Molecular Biology2002，318，： | 1 |
| 13 | The Swiss lithoclast: a new device for endoscopic stone disintegration显示文摘 | Harald S Gerald H Marco P | 1993 | J Urol1993，149，1： | 1 |
| 14 | N-Methyl-D-aspartate receptor antibodies in herpes simplex encephalitis 显示文摘 | Harald P Carsten F Markus H | 2012 | Ann Neurol2012，72，6： | 1 |
| 15 | The Swiss lithoclast:a new device for endoscopic stone disintegration显示文摘 | Harald S Gerald H Marco P | 2011 | J Urol2011，149，1： | 1 |
| 16 | The swiss lithoclast: a new device for endoscopic stone disintegration显示文摘 | Harald S Garald H Marco P | 1993 | J Urol1993，149，： | 1 |
| 17 | Preparation of phenol-urea-formaldehyde eopolymer adhesives under heterogeneous catalysis 显示文摘 | Kerstin S Dirk G Harald P | 2006 | Journal of Applied Polymer Science2006，102，5： | 1 |
| 18 | Peak Performance and Higher States of Consciousness: A Study of World - Class Performers 显示文摘 | Harald S H Dennis P H William W G | 1996 | Journal of Manage- rial Psychology1996，11，4： | 1 |
| 19 | Wavelet-based method for burst detection 显示文摘 | HARALD KALPERSEN J KROGSTAD P | 2001 | Fluid Dynamics Research2001，28，： | 1 |
| 20 | Immunochemical characterization of the MPB70/80 and MPB83 proteins of mycobacterium boris显示文摘 | Harald G Wiker Konstantin P | 1998 | Infect Immun Apr1998，，： | 1 |
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