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| 1 | Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids显示文摘AIM:To investigate the ability of curcumin to counteract the impact of bile acids on gene expression of esophageal epithelial cells.METHODS:An esophageal epithelial cell line(HET1A)was treated with curcumin in the presence of deoxycholic acid.Cell proliferation and viability assays were used to establish an appropriate dose range for curcumin.The combined and individual effects of curcumin and bile acid on cyclooxygenase-2(COX-2)and superoxide dismutase(SOD-1 and SOD-2)gene expression were also assessed.RESULTS:Curcumin in a dose range of 10-100μmol/L displayed minimal inhibition of HET-1A cell viability.Deoxycholic acid at a concentration of 200μmol/L caused a 2.4-fold increase in COX-2 gene expression compared to vehicle control.The increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin,and curcumin reduced COX-2 expression 3.3-to 1.3-fold.HET-1A cells exposed to bile acid yielded reduced expression of SOD-1 and SOD-2 genes with the exception that high dose deoxycholic acid at 200μmol/L led to a 3-fold increase in SOD-2 expression.The addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin tested.CONCLUSION:Curcumin reverses bile acid suppression of gene expression of SOD-1.Curcumin is also able to inhibit bile acid induction of COX-2 gene expression. | Matthew R Bower Harini S Aiyer Robert CG Martin Yan Li | 2010 | World Journal of Gastroenterology2010，16，33： | 10 |
| 2 | Her-2/neu overex- pression due to polysomy 17 in breast cancer: molecular testing to guide therapeutic options显示文摘 | Sahoo R Babu VC Harini VV | 2011 | Onkologie2011，34，7： | 1 |
| 3 | Identification of bac- teria in culture negative and polymerase chain reaction (PCR) Positive intraocular specimen from patients with infectious en dopthalmitis显示文摘 | Aarthi P Harini R Sowmiya M | 2011 | Journal of Microbiological Methods2011，85，1： | 1 |
| 4 | Induction of osteoblast differentiation in human adipose derived stem cells by lanthanum ions显示文摘Adipose derived stem cells represent a readily available source of adult stem cells for various biomedical applications. In this study, the proliferation and osteogenic differentiation potential of lanthanum nitrate(La3+) on human adipose derived mesenchymal stem cells(hADSCs) were investigated for the first time and compared with that of dexamethasone(Dex). Our results provided evidence that La3+ at 50 μmol/L concentration promoted proliferation of hADSCs upto 2.4 fold when treated for 21 d in DMEM medium. Treatment of hADSCs with La3+ containing osteogenic induction medium(α-MEM with ascorbic acid and β-glycerophosphate) for 7 d resulted in higher calcium deposition than that in the presence of Dex(0.1 μmol/L) as shown by Alizarin red S and von Kossa staining. Scanning electron micrographs also showed more extracellular matrix mineralization in the presence of La3+. After 7 d of treatment with La3+(10 μmol/L) the expression of RunX2, osteopontin(OP) and osteocalcin(OC) increased 3.4, 5.5 and 2.7 fold respectively. Our results provided evidence that in the presence of La3+ osteogenic differentiation occurred earlier than that in the presence of Dex. | Harini D Indra R Rajaram A Rama Rajaram | 2014 | Journal of Rare Earths2014，32，11： | 1 |
| 5 | Antihyperglycemic effect of biochanin A, a soy isoflavone, on streptozotocin-diabetic rats 显示文摘 | Harini R Ezhumalai M Pugalendi KV | 2012 | Eur J Pharmacol2012，676，13： | 1 |
| 6 | Screening for EGFR mutations in lung cancer, a report from India显示文摘 | Sahoo R Harini VV Babu VC | 2011 | Lung Cancer2011，73，3： | 1 |
| 7 | Antihyperglyce- mic effect of biochanin A, a soy isoflavone, on streptozo- tocin-diabetic rats 显示文摘 | Harini R Ezhumalai M Pugalendi K V | 2012 | Eur J Pharmacol2012，676，13： | 1 |
| 8 | Screening for EGFR muta-tions in lung cancer, a report from India显示文摘 | Sahoo R* Harini VV Babu VC | 2011 | Lung Cancer2011，73，3： | 1 |
| 9 | Ursolic acid and rosiglitazone combination alleviates metabolic syndrome in high fat diet fed C57BL/6J mice 显示文摘 | Sundaresan A Harini R Pugalendi KV | 2012 | Gen Physiol Biophys2012，31，3： | 1 |
| 10 | On dual-slope linear cyclic hardening of Hastelloy X显示文摘 | PRASAD REDDY G V HARINI P SANDHY R | 2010 | Materials Science and Engineering(A)2010，527，： | 1 |
| 11 | Performance evaluation of a multi-robot search & retrieval system:Experiences with mindart显示文摘 | Paul E R Amy L Harini V | 2008 | Journal of Intelligent and Robotic Systems2008，52，4： | 1 |
| 12 | Screening for EGFR mutations in lung cancer, a report from India显示文摘 | Sahoo R Harini VV Babu VC | 2011 | Lung Cancer2011，73，3： | 1 |
| 13 | Advancing genetic testing for deafness with genomic technology显示文摘 | A Eliot Shearer E Ann Black-Ziegelbein Michael S Hildebrand Robert W Eppsteiner Harini Ravi Swati Joshi Angelica C Guiffre Christina M Sloan Scott Happe Susanna D Howard Barbara Novak Adam P DeLuca Kyle R Taylor Todd E Scheetz Terry A Braun Thomas L Casav | 2013 | Journal of Medical Genetics2013，，9： | 1 |
| 14 | Performance evaluation of a multi-robot search and retrieval system:Experiences with MinDART显示文摘 | Paul E R Amy L Harini V | 2008 | J of Intelligent and Robotic Systems2008，52，34： | 1 |
| 15 | On dual-slope linear cyclic hardening of Hastelloy X 显示文摘 | PRASAD REDDY G V HARINI P SANDHY R | 2010 | Materials Science and Engineering (A)2010，527，： | 1 |
| 16 | Performance evaluation of a multi-robot search & retrieval system : experiences with MinDART 显示文摘 | PAUL E R AMY L HARINI V MONICA L MARIA G | 2008 | Journal of Intelligent and Robotic Systems2008，52，34： | 1 |
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