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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver显示文摘AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat liver.METHODS After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by intravenousroute.At different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and immunohistochemistry.RESULTS The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three weeks.Both liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the liver.CONCLUSION G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver. | Yang, CQ Wang, JY He, BM Liu, JJ Guo, JS | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 3 | Translocation of Single-Stran- ded DNA through Single-Walled Carbon nanotubes显示文摘 | Liu HT He J Jy T | 2010 | Science2010，327，2： | 1 |
| 4 | Assessing the effect of land use/ land cover change on the change of urban heat island intensity显示文摘 | JF He JY Liu DF Zhang | 2007 | Theor Appl Climatol2007，，： | 1 |
| 5 | Serotonin receptors expressed by myelinating Schwann cells in rat sciatic nerve 显示文摘 | Elizabeth JY Hadassah T Mark HE | 1997 | Brain Research1997，753，2： | 1 |
| 6 | In-vitro antitumor activity evaluation of hyperforin derivatives显示文摘 | Sun F Liu JY He F Liu Z Wang R Wang DM | 2011 | J Asian Nat Prod Res2011，13，8： | 1 |
| 7 | Finite element analysis of antiimpact loading of wrist protectors显示文摘 | Dong XP Wang DM He JY | 2011 | J Clin Rehab Tiss Eng Res2011，15，30： | 1 |
| 8 | Formaldehyde strees 显示文摘 | He RQ Lu J Miao JY | 2010 | Sci China Life Sci2010，，12： | 1 |
| 9 | Carbonate apatite coating on titanium induced rapidly by precalcification显示文摘 | FENG B CHEN JY QI S K HE L ZHAO J Z ZHANG X D | 2002 | Biomaterials2002，23，1： | 1 |
| 10 | Tamoxifen inhibits Na^+ and K^+ currents in rat ventricular myocytes 显示文摘 | He JY Kargacin ME Kargacin GJ | 2003 | Am J Physiol Heart Circ Physiol2003，285，： | 1 |
| 11 | Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyoc-yte contractile dysfunction during ischemia显示文摘 | Zhao P Wang JY He LL | 2009 | J Cell Mol Med2009，13，8： | 1 |
| 12 | Three-dimensional microchannels in biodegradable polymeric films for control orientation and phenotype of vascular smooth muscle cells 显示文摘 | Shen JY Chan-Park MB He B | 2006 | Tissue Eng2006，12，8： | 1 |
| 13 | Invariant surfaceEMG feature against varying contraction level formyoelectric control based on muscle coordination显示文摘 | He JY Zhang DG Sheng XJ | 2015 | IEEE Journal of Biomedical and HealthInformatics2015，19，3： | 1 |
| 14 | Pharmacokinetics,tissue distribution and photodynamic therapy efficacy of liposomal-delivered hypocrenin A, a potential photo- sensitizer for tumor therapy 显示文摘 | Wang 72 He YY Huang CG Huang JS Huang YC An JY | 1999 | Photochem Photobiol1999，70，5： | 1 |
| 15 | RNA interference-mediated FANCF silencing sensitizes 0VCAR3 ovarian cancer cells to adriamycin through increased adriamycin-induced apoptosis dependent on JNK activation显示文摘 | He M Sun HG Hao JY | 2013 | Oncol Rep2013，29，5： | 1 |
| 16 | Adhesion of uropathogenic Escherichia coli to human renal pelvis epithelial primary cells显示文摘 | Gu C Chen JY Hou M He JD | 2006 | Chin J Microbiol Immunol2006，4，： | 1 |
| 17 | Fluoxetine inhibits transient global is- chemia- induced hippocampal neuronal death and memory impair- ment by preventing blood -brain barrier disruption显示文摘 | Lee JY Lee HE Kang SR | 2014 | Neuropharma- cology2014，79，： | 1 |
| 18 | miRNAs expression profiling to distinguish lung squamous-cell carcinoma from adenocarcinoma subtypes显示文摘 | Zhang YK Zhu WY He JY | 2012 | J Cancer Res Clin Oncol2012，138，10： | 1 |
| 19 | Tissue microarray analysis of multiple gene expression in intestinal metaplasia,dysplasia and carcinoma of the stomach显示文摘 | Sun Y Li JY He JS | 2005 | Histopathology2005，46，5： | 1 |
| 20 | The flavonoid quercetin inhibits dimethylnltrosamine-indueed liver damage in rats显示文摘 | Lee ES Lee HE Shin JY | 2003 | J Pharm Pharmaeol2003，55，8： | 1 |
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