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| 1 | Structure and function of aggrecan显示文摘Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan. | CHRIS KIANI, LIWEN CHEN, YAO JIONG WU, ALBERT J YEE, BURTON B YANG, Sunnybrook and Women’s College Health Sciences Centre and Department of Laboratory Medicine and Patobiology, 2 Department of Surgeny, Faculty of Medicine, University of Toronto, Canada | 2002 | Cell Research2002，12，1： | 27 |
| 2 | 澳大利亚人乳头状瘤病毒疫苗计划实施5年对年轻人群生殖器疣患病情况的影响:国家调查数据分析显示文摘目的评估2007年中开始的澳大利亚人乳头状瘤病毒(HPV)疫苗计划对生殖器疣患病情况的影响。设计国家调查数据趋势分析。数据来源数据收集于2004--2011年度澳大利亚8所性健康服务机构;其中2所最大的临床中心收集了自我报告的本中心2009年度HPV疫苗现状。研究对象2004--2011年度首次就诊的85770名澳大利亚出生的国民;其中7686(9.0%)名患生殖器疣。主要结局测量比较前疫苗时期(2004—2007年中)和疫苗时期(2007年中-2001年末)不同人群生殖器疣新发病率变化趋势。结果疫苗时期21岁以下和21~30岁女性诊断患有生殖器疣的比例明显下降,发病率分别从2007年度的11.5%和11.3%下降至2011年度的0.85%和3.1%,P均〈0.001。在30岁以上的女性中未发现发病率的明显下降。在21岁以下和21~30岁异性恋男性人群中疫苗时期生殖器疣的发病率较前疫苗时期明显下降,分别由2007年度12.1%和18.2%下降至2011年度2.2%和8.9%,P均〈0.001。30岁以上的异性恋男性人群中发病率无明显下降。2011年235名21岁以下女性在使用HPV疫苗后无新发生殖器疣病例。结论年轻女性生殖器疣发病率的显著下降和2011年度部分年轻女性使用疫苗后的零发病率,说明HPV疫苗获得实验室外的良好功效。异性恋男性生殖器疣发病率的显著下降可能是由于群体免疫所致。 | Hammad Ali,lecturer Basil Donovan, professor HandanWand,senior lecturer Tim R H Read, sexual health physician David G Regan,senior lecturer Andrew E Grulich, professor Christopher K FaMey, professor Rebecca J Guy, associate professor 尹婕(译) 潘凌亚(校) | 2013 | 英国医学杂志中文版2013，16，4： | 4 |
| 3 | Does social media im- prove communication?Evaluating the NIOSH science blog显示文摘 | V Sublet C Spring J Howard National Institute of Oc- cupational Safety and Health | 2011 | Am J Ind Med2011，54，5： | 1 |
| 4 | Treatment of mutidrug-resistant tuberculosis: evident and controversies 显示文摘 | CAMINERO J A World Health Organization American Thoracic Society | 2006 | Int J Tuberc Lung Dis2006，10，6： | 1 |
| 5 | Does social media improve communication? Evaluating the NIOSH sci- ence blog显示文摘 | V Sublet C Spring J Howard National Institute of Occupational Safety and Health | 2011 | AmJ lnd Med2011，54，5： | 1 |
| 6 | 2003 World Health Organization(WHO)/International Society of Hypertension (ISH) statementon management of hypertension 显示文摘 | Whitworth J A World Health Organization International Societyof Hypertension Writing Group | 2003 | J Hypertens2003，21，11： | 1 |
| 7 | 查看详情显示文摘 | Kroto H W Health J R O'Brien S C Curl R F Smalley R E | | 0，，： | 1 |
| 8 | Performance and heterosis in fanned and wild chinook salmon ( Oncorhynchus tstaurytscha) hybrid and purebred crosses 显示文摘 | Bryden C A Heath J W Health D D | 2004 | Aquaculture2004，235，： | 1 |
| 9 | C60:buckminsterfullerene显示文摘 | Kroto H W Health J R Curl R R | 1985 | Nature1985，318，： | 1 |
| 10 | 2003 World Health Organization(WHO)/International Society of Hypertension(ISH)statement on management of hypertension显示文摘 | Whitworth J A World Health Organization International Society of Hypertension Writing Group | 2003 | J Hy- pertens2003，21，11： | 1 |
| 11 | Emergency medicine the critical role of emergency departments in US public health显示文摘 | HIRSHON J M MORRIS and the health of the public: D M | 2006 | Emerg Med Clin North Am2006，24，4： | 1 |
| 12 | C60 : Buck-ministerfullerene显示文摘 | Kroto H W Health J R Smalley R E | 1985 | Nature1985，，： | 1 |
| 13 | Risks and benefits of estrogen plus progestin in healthy postmenopausal women:principal results From the Women's Health Initiative randomized controlled trial显示文摘 | Rossouw JE Anderson GL Prentice RL LaCroix AZ Kooperberg C Stefanick ML Jackson RD Beresford SA Howard BV Johnson KC Kotchen JM Ockene J Writing Group for the Women's Health Initiative Investigators | | 0，，： | 1 |
| 14 | The 2008 revision of the Organization (WHO) classification of myeloid acute leukemia: rationale and important changes 显示文摘 | Vardiman JW World Health neoplasms and Blood 2009 Thiele J Arber DA | 2009 | 114 (5): 937-9512009，114，5： | 1 |
| 15 | Lanthanum complexes of spheroidal carbon shells显示文摘 | Health J R Curl R F Smalley R E | 1985 | J Am Chem Soc1985，107，25： | 1 |
| 16 | Cross-national consistency in relationship between bullying behaviors and psychosocial adjustment显示文摘 | Nansel T Craig WM Overpeck M Saluja G Ruan J and the Health Behavior in School-aged Children Bullying Analyses Working Group | | 0，，： | 1 |
| 17 | Coherent measures of risk显示文摘 | Artzner P Delbaen F Eber J M Health D | 1999 | Mathematical Finance1999，9，： | 1 |
| 18 | Coordination of Zn( Ⅱ ),Cd( Ⅱ ),ng( Ⅱ )and Ag(Ⅰ) by Bis(benzimid- azole) Ligands 显示文摘 | Matthews C J Health S L Martin N C etc | 1998 | Inorg Chem1998，37，： | 1 |
| 19 | Recommendations on screening for cervical cancer显示文摘 | Canadian Task Force on Preventive Health Care Dickinson J Tsakonas E | 2013 | CMAJ2013，185，1： | 1 |
| 20 | Allergic rhinitis and its impact on asth- ma显示文摘 | BOUSQUET J VAN CAUWENBERGE P KHAL-TAEV N Aria Workshop Group World Health Organization | 2001 | :J Allergy Clin Immunol2001，108，： | 1 |
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