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| 1 | Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase Ⅱ study显示文摘AIM To evaluate the efficacy and tolerability of neoadjuvant hyperfractionated accelerated radiotherapy(HART)and concurrent chemotherapy in patients with locally advanced infraperitoneal rectal cancer. METHODS A total of 30 patients with histopathologically confirmed T2-3/N0+ infraperitoneal adenocarcinoma of rectum cancer patients received preoperative 42 Gy/1.5 Gy/18 days/bid radiotherapy and continuous infusion of 5-fluorouracil(325 mg/m^2). All patients were operated 4-8 wk after neoadjuvant concomitant therapy. RESULTS In the early phase of treatment, 6 patients had grade Ⅲ-Ⅳ gastrointestinal toxicity, 2 patients had grade Ⅲ-Ⅳ hematologic toxicity, and 1 patient had grade Ⅴ toxicity due to postoperative sepsis during chemotherapy. Only 1 patient had radiotherapy-related late side effects, i.e., grade Ⅳ tenesmus. Complete pathological response was achieved in 6 patients(21%), while near-complete pathological response was obtained in 9(31%). After a median follow-up period of 60 mo, the local tumor control rate was 96.6%. In 13 patients, distant metastasis occurred. Disease-free survival rates at 2 and 5 years were 63.3% and 53%, and corresponding overall survival rates were 70% and 53.1%, respectively.CONCLUSION Although it has excellent local control and complete pathological response rates, neoadjuvant HART concurrent chemotherapy appears to not be a feasible treatment regimen in locally advanced rectal cancer, having high perioperative complication and intolerable side effects. Effects of reduced 5-fluorouracil dose or omission of chemotherapy with the aim of reducing toxicity may be examined in further studies. | Zeynep Gural Sezer Saglam Serap Yucel Esra Kaytan-Saglam Oktar Asoglu Cetin Ordu Hediye Acun Rasul Sharifov Semen Onder Ahmet Kizir Ethem N Oral | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 3 |
| 2 | Elongator is a histone H3and H4acetyltransferase important for normal histone acetyla-tion levels in vivo显示文摘 | Winker S G Kristjuhan A Hediye E B | 2002 | Proc Natl Acad Sci USA2002，99，6： | 1 |
| 3 | Differential responses of antioxidative enzymes and lipid peroxidation to salt stress in salt-tolerant Plantago maritime and salt-sensitive Plantago media显示文摘 | Hediye S Ismail T Susumu T | 2007 | Physiologia Plantarum2007，131，： | 1 |
| 4 | Differential responses of antioxidative enzymes and lipid peroxidation to salt stress in salt-tolerant Plantago maritime and salt-sensitive Plantago media显示文摘 | HEDIYE SEKMENA ISMAIL TURKANA SUSUMU TAKIO | | 0，，03： | 1 |
| 5 | Hematopoiesis controlled by distinct TIF1 γ and smad4 branches of the TGFβpath- way显示文摘 | WEI H DAVID C D HEDIYE E B | 2006 | Cell2006，125，： | 1 |
| 6 | Histone H3 and H4 Ubiquitylation by the CUL4-DDB-ROC1 Ubiquitin Ligase Facilitates Cellular Response to DNA Damage显示文摘 | Hengbin Wang Ling Zhai Jun Xu Heui-Yun Joo Sarah Jackson Hediye Erdjument-Bromage Paul Tempst Yue Xiong Yi Zhang | 2006 | Molecular Cell2006，，3： | 1 |
| 7 | Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases显示文摘 | Adolfo Saiardi Hediye Erdjument-Bromage Adele M. Snowman Paul Tempst Solomon H. Snyder | 1999 | Current Biology1999，，： | 1 |
| 8 | Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton显示文摘 | Dos D. Sarbassov Siraj M Ali Do-Hyung Kim David A Guertin Robert R Latek Hediye Erdjument-Bromage Paul Tempst David M Sabatini | 2004 | Current Biology2004，，14： | 1 |
| 9 | Cloning of p27kip1, a cyclin-dependent kinase inhibitor and a potential medictor of extracellular antimitogenic signals显示文摘 | Mong-Hong L Hediye EB | 1994 | Cell1994，78，1： | 1 |
| 10 | Identification of vertical total electron content by time series analysis 显示文摘 | Hediye E Niyazi A | 2009 | Digital Signal Process- ing2009，19，4： | 1 |
| 11 | Adsorption of some cationic and anionic dyes on magnetite nanoparticles-modified activated carbon from aqueous solutions:equilibrium and kinetics study显示文摘 | Tayyebeh Madrakian Abbas Afkhami Hediye MahmoodKashani | 2013 | Journal of the Iranian Chemical Society2013，，6： | 1 |
| 12 | An Iron Delivery Pathway Mediated by a Lipocalin显示文摘 | Jun Yang David Goetz Jau-Yi Li Wenge Wang Kiyoshi Mori Daria Setlik Tonggong Du Hediye Erdjument-Bromage Paul Tempst Roland Strong Jonathan Barasch | 2002 | Molecular Cell2002，，5： | 1 |
| 13 | Different antioxidant defense responses to salt stress during germination and vegetative stages of endemic halophyte Gypsophila oblanceolata Bark.显示文摘 | Askim Hediye Sekmen Ismail Turkan Zehra Ozgecan Tanyolac Ceyda Ozfidan Ahmet Dinc | 2011 | Environmental and Experimental Botany2011，，： | 1 |
| 14 | Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetyla- tion levels in vivo显示文摘 | Winker S G Kristjuhan A Hediye E B | 2002 | Proc Natl Acad Sci USA2002，99，6： | 1 |
| 15 | A CK2-Dependent Mechanism for Degradation of the PML Tumor Suppressor显示文摘 | Pier Paolo Scaglioni Thomas M. Yung Lu Fan Cai Hediye Erdjument-Bromage Andrew J. Kaufman Bhuvanesh Singh Julie Teruya-Feldstein Paul Tempst Pier Paolo Pandolfi | 2006 | Cell2006，，2： | 1 |
| 16 | USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing显示文摘 | Zhuo Zhang Amanda Jones Heui-Yun Joo Dewang Zhou Ying Cao Shaoxia Chen Hediye Erdjument-Bromage Matthew Renfrow Hang He Paul Tempst Tim M. Townes Keith E. Giles Ligeng Ma Hengbin Wang | 2013 | Genes & Development2013，，14： | 1 |
| 17 | Siah2 Regulates Stability of Prolyl-Hydroxylases, Controls HIF1α Abundance, and Modulates Physiological Responses to Hypoxia显示文摘 | Koh Nakayama Ian J Frew Mette Hagensen Marianne Skals Hasem Habelhah Anindita Bhoumik Takayuki Kadoya Hediye Erdjument-Bromage Paul Tempst Peter B Frappell David D Bowtell Ze’ev Ronai | 2004 | Cell2004，，： | 1 |
| 18 | Superparamagnetic surface molecularly imprinted nanoparticles for sensitive solid-phase extraction of tramadol from urine samples显示文摘 | Tayyebeh Madrakian Abbas Afkhami Hediye Mahmood-Kashani Mazaher Ahmadi | 2012 | Talanta2012，，： | 1 |
| 19 | Functional Regeneration after Laser Axotomy 显示文摘 | MEHMET FATIH YANIK HULUSI CINAR HEDIYE NESE CINAR | 2004 | Nature2004，432，： | 1 |
| 20 | Differential responses of antioxida- tive enzymes and lipid peroxidation to salt stress in salt-tolerant Plan- tago maritime and salt-sensitive Plantago media 显示文摘 | Hediye S Ismail T Susumu T | 2007 | Physiologia Plantarum2007，131，3： | 1 |
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