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| 1 | Chondrogenesis of periodontal ligament stem cells by transforming growth factor-β3 and bone morphogenetic protein-6 in a normal healthy impacted third molar显示文摘The periodontal ligament-derived mesenchymal stem cell is regarded as a source of adult stem cells due to its multipotency. However, the proof of chondrogenic potential of the cells is scarce. Therefore, we investigated the chondrogenic differentiation capacity of periodontal ligament derived mesenchymal stem cells induced by transforming growth factor (TGF)-β3 and bone morphogenetic protein (BMP)-6. After isolation of periodontal ligament stem cells (PDLSCs) from human periodontal ligament, the cells were cultured in Dulbecco's modified Eagle's medium (DMEM) with 20% fetal bovine serum (FBS). A mechanical force initiated chondrogenic differentiation of the cells. For chondrogenic differentiation, 10 μg ·L-1 TGF-β3 or 100 μg ·L-1 BMP-6 and the combination treating group for synergistic effect of the growth factors. We analyzed the PDLSCs by fluorescence-activated cell sorting and chondrogenesis were evaluated by glycosaminoglycans assay, histology, immunohistochemistry and genetic analysis. PDLSCs showed mesenchymal stem cell properties proved by FACS analysis. Glycosaminoglycans contents were increased 217% by TGF-β3 and 220% by BMP-6. The synergetic effect of TGF-β3 and BMP-6 were shown up to 281% compared to control. The combination treatment increased Sox9, aggrecan and collagen II expression compared with not only controls, but also TGF-β3 or BMP-6 single treatment dramatically. The histological analysis also indicated the chondrogenic differentiation of PDLSCs in our conditions. The results of the present study demonstrate the potential of the dental stem cell as a valuable cell source for chondrogenesis, which may be applicable for regeneration of cartilage and bone fracture in the field of cell therapy. | Sunyoung Choi Tae-Jun Cho Soon-Keun Kwon Gene Lee Jaejin Cho | 2013 | International Journal of Oral Science2013，5，1： | 5 |
| 2 | MicroRNA maturation: stepwise processing and subcellular localization显示文摘 | Yoontae Lee Kipyoung Jeon Jun‐Tae Lee Sunyoung Kim V. Narry Kim | 2002 | The EMBO Journal2002，，： | 2 |
| 3 | Radiotherapy-induced secondary cancer risk for breast cancer:3D conformal therapy versus IMRT versus VMAT显示文摘 | Boram Lee Sunyoung Lee Jiwon Sung | 2014 | Journal of radiological protection:Official journal of the Society for Radiological Protection2014，34，2： | 1 |
| 4 | Overexpres- sion of IL-32ctincreases natural killer cell-mediated killing through up-regulation of Fas and UL16-binding protein 2 (ULBP2) Ex- pression in Human Chronic Myeloid Leukemia Cells 显示文摘 | Soyoung Cheon Ji Hyung Lee Sunyoung Park | 2011 | The Journal of Biological Chemistry2011，286，12： | 1 |
| 5 | Quantitative detection of porcine torque teno virus in porcine circovirus-2-negative and porcine circovirus-associated disease-affected pigs显示文摘 | Lee S S Sunyoung S Jung H | 2010 | J Vet Diagn Invest2010，22，2： | 1 |
| 6 | Failure analysis of a planetary gear carrier of 1200HP transmission显示文摘 | Sunyoung Park Jongmin Lee Uijun Moon Deugjo Kim | 2009 | Engineering Failure Analysis2009，，2： | 1 |
| 7 | Germination inhibitory constituents from Erigeron annuus显示文摘 | Hyuncheol Oh Sunyoung Lee Ho-Sub Lee | 2002 | Phytochemistry2002，61，： | 1 |
| 8 | Efficacy of chlorine dioxide gas against Alicyclobacillus restris spores on apple surfaces显示文摘 | Lee Sunyoung Dance GI Chang Susen | 2006 | International Journal of Food Microbiology2006，108，3： | 1 |
| 9 | Prevalence of type-specific oncogenic human papillomavirus infection assessed by HPV E6/E7 mRNA among women with high-grade cervical lesions显示文摘 | Hye-young Wang Sunyoung Park Dongsup Lee Sunghyun Kim Geehyuk Kim Kwang Hwa Park Hyeyoung Lee | 2015 | International Journal of Infectious Diseases2015，，： | 1 |
| 10 | Pain relief by cyberknife radiosurgery for spinal metastasis显示文摘 | Sunyoung Lee Mison Chun | 2012 | Tumori2012，98，2： | 1 |
| 11 | Radiotherapy-induced sec- ondary cancer risk for breast cancer: 3D conformal therapy versus 显示文摘 | Borarn Lee Sunyoung Lee Jiwon Sung | 2014 | J Radiol Protect: Official journal of the Society for Radiologicai Protection2014，34，2： | 1 |
| 12 | Germination inhibitory constituents from Erigeron annuus显示文摘 | Hyuncheol Oh Sunyoung Lee Ho-Sub Lee | 2002 | Phytochemistry2002，61，1： | 1 |
| 13 | Identi?cation and quanti?cation of S-allyl-L-cysteine in heated garlic juice by HPLC with ultraviolet and mass spectrometry detection显示文摘 | Sanghee Lee Miyoung Yoo Sunyoung Kim | 2014 | LWT-Food Science and Technology2014，57，2： | 1 |
| 14 | Estimated prevalence and trends in smoking among adolescents in South Korea,2005-2021:a nationwide serial study显示文摘Background Although smoking is classified as a risk factor for severe COVID-19 outcomes,there is a scarcity of studies on prevalence of smoking during the COVID-19 pandemic.Thus,this study aims to analyze the trends of prevalence of smoking in adolescents over the COVID-19 pandemic period.Methods The present study used data from middle to high school adolescents between 2005 and 2021 who participated in the Korea Youth Risk Behavior Web-based Survey(KYRBS).We evaluated the smoking prevalence(ever or daily)by year groups and estimated the slope in smoking prevalence before and during the pandemic.Results A total of 1,137,823 adolescents participated in the study[mean age,15.04 years[95%confidence interval(CI)15.03-15.06];and male,52.4%(95%CI 51.7-53.1)].The prevalence of ever smokers was 27.7%(95%CI 27.3-28.1)between 2005 and 2008 but decreased to 9.8%(95%CI 9.3-10.3)in 2021.A consistent trend was found in daily smokers,as the estimates decreased from 5.4%(95%CI 5.2-5.6)between 2005 and 2008 to 2.3%(95%CI 2.1-2.5)in 2021.However,the downward slope in the overall prevalence of ever smokers and daily smokers became less pronounced in the COVID-19 pandemic period than in the pre-pandemic period.In the subgroup with substance use,the decreasing slope in daily smokers was significantly more pronounced during the pandemic than during the pre-pandemic period.Conclusions The proportion of ever smokers and daily smokers showed a less pronounced decreasing trend during the pandemic.The findings of our study provide an overall understanding of the pandemic's impact on smoking prevalence in adolescents. | Hyoin Shin Sangil Park Hyunju Yon Chae Yeon Ban Stephen Turner Seong Ho Cho Youn Ho Shin Jung U.Shin Ai Koyanagi Louis Jacob Lee Smith Chanyang Min Young Joo Lee So Young Kim Jinseok Lee Rosie Kwon Min Ji Koo Guillaume Fond Laurent Boyer Jong Woo Hahn Namwoo Kim Sang Youl Rhee Jae Il Shin Ho Geol Woo Hyeowon Park Hyeon Jin Kim Yoonsung Lee Man S.Kim Eléa Lefkir Vlasta Hadalin Jungwoo Choi Seung Won Lee Dong Keon Yon Sunyoung Kim | 2023 | World Journal of Pediatrics2023，19，4： | 1 |
| 15 | Anti-complement activity of onstituents from the stem-bark of Juglans mandshurica显示文摘 | MIN BYUNGSUN LEE SUNYOUNG KIM JUNGHEE | 2003 | Biological & Pharmaceutical Bulletin2003，26，7： | 1 |
| 16 | Early stature prediction method using stature growth parameters显示文摘 | Shin-jae lee Hongseok an Sug-joon ahn Young ho kim Sunyoung pak Jae won lee | | 0，，： | 1 |
| 17 | Preparation and characterization of metal-doped carbon aerogel for supercapaeitor 显示文摘 | Yoon Jae Lee Ji Chul Jung Sunyoung Park | 2010 | Current Applied Physies2010，10，3： | 1 |
| 18 | Quantitative detection ofporcine torque teno virus in porcine circovirus-2-negative and porcine circovirus-associated disease-affected pigs显示文摘 | Lee S S Sunyoung S Jung H | 2010 | J Vet Diagn Invest2010，22，2： | 1 |
| 19 | Germi nation inhibitory constituents from Erigeron annuus 显示文摘 | HyuncheolOh Sunyoung Lee Ho-Sub Lee | 2002 | Phytochemistry2002，61，： | 1 |
| 20 | Direct synthesis of hydrogen peroxide from hydrogen and oxygen over palladium-exchanged insoluble heteropolyacid catalysts显示文摘 | Park Sunyoung Lee Sang Hee Song Sun Ho | 2009 | Catalysis Communications2009，10，4： | 1 |
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