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| 1 | Painful intervertebral disc degeneration and inflammation:from laboratory evidence to clinical interventions显示文摘Low back pain(LBP),as a leading cause of disability,is a common musculoskeletal disorder that results in major social and economic burdens.Recent research has identified inflammation and related signaling pathways as important factors in the onset and progression of disc degeneration,a significant contributor to LBP.Inflammatory mediators also play an indispensable role in discogenic LBP.The suppression of LBP is a primary goal of clinical practice but has not received enough attention in disc research studies.Here,an overview of the advances in inflammation-related pain in disc degeneration is provided,with a discussion on the role of inflammation in IVD degeneration and pain induction.Puncture models,mechanical models,and spontaneous models as the main animal models to study painful disc degeneration are discussed,and the underlying signaling pathways are summarized.Furthermore,potential drug candidates,either under laboratory investigation or undergoing clinical trials,to suppress discogenic LBP by eliminating inflammation are explored.We hope to attract more research interest to address inflammation and pain in IDD and contribute to promoting more translational research. | Feng-Juan Lyu Haowen Cui Hehai Pan Kenneth MC Cheung Xu Cao James C.Iatridis Zhaomin Zheng | 2021 | Bone Research2021，9，1： | 24 |
| 2 | Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop显示文摘The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin(IL)-1β, and is one of the main causes of intervertebral disc degeneration(IVDD). NLR pyrin domain containing 3(NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its roles in IVDD are still not well understood and require more examination. First, we demonstrated that melatonin delayed the progression of IVDD and relieved IVDD-related low back pain in a rat needle puncture IVDD model;moreover, NLRP3 inflammasome activation(NLRP3, p20, and IL-1β levels) was significantly upregulated in severely degenerated human discs and a rat IVDD model. Subsequently, an IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop was found in nucleus pulposus(NP) cells that were treated with IL-1β. In these cells, expression of NLRP3 and p20 was significantly increased, NF-κB signaling was involved in this regulation, and mitochondrial reactive oxygen species(mt ROS)production increased. Furthermore, we found that melatonin disrupted the IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop in vitro and in vivo. Melatonin treatment decreased NLRP3, p20, and IL-1β levels by inhibiting NF-κB signaling and downregulating mt ROS production. Finally, we showed that melatonin mediated the disruption of the positive feedback loop of IL-1β in vivo. In this study, we showed for the first time that IL-1β promotes its own expression by upregulating NLRP3 inflammasome activation. Furthermore, melatonin disrupts the IL-1β positive feedback loop and may be a potential therapeutic agent for IVDD. | Fan Chen Guowei Jiang Hui Liu Zemin Li Yuxin Pei Hua Wang Hehai Pan Haowen Cui Jun Long Jianru Wang Zhaomin Zheng | 2020 | Bone Research2020，8，2： | 18 |
| 3 | Hybrid heterojunctions based on 2D materials and 3D thin-films for high-performance photodetectors显示文摘Photodetectors,converting optical signals to electrical signals,play a significant role in our daily life.Two-dimensional(2D)materials,such as graphene and transition metal dichalcogenides(TMDs),have displayed excellent mechanical,optical,electric,thermal properties and have been proved to be appealing building blocks for optoelectronic applications.However,for the 2D material-based photodetectors,their responsivity,response speed,and detectivity,which | HeHai Fang WeiDa Hu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，2： | 2 |
| 4 | Chronological dating and tectonic implications of late Cenozoic volcanic rocks and lacustrine sequence in Oiyug Basin of southern Tibet显示文摘Reconstruction of uplift history of the Tibetan Plateau is crucial for understanding its environmental impacts. The Oiyug Basin in southern Tibet contains multiple periods of sedimentary sequences and volcanic rocks that span much of the Cenozoic and has great potential for further studying this issue. However, these strata were poorly dated. This paper presents a chronological study of the 145 m thick and horizontally-distributed lacustrine sequence using paleomagnetic method as well as a K-Ar dating of the underlying volcanic rocks. Based on these dating results, a chronostratigraphic framework and the basin-developmental history have been established for the past 15 Ma, during which three tectonic stages are identified. The period of 15-8.1 Ma is characterized by intense volcanic activities involving at least three major eruptions. Subsequently, the basin came into a tectonically quiescent period and a lacustrine sedimentary sequence was developed. Around 2.5 Ma, an N-S fault occurred across the southern margin of the basin, leading to the disappearance of the lake environment and the development of the Oiyug River. The Gyirong basin on northern slope of the Himalayas shows a similar basin developmental history and thus there is a good agreement in tectonic activities between the Himalayan and Gangdise orogenic belts. Therefore, the tectonic evolution stages experienced by the Oiyug Basin during the past 15 Ma could have a regional significance for southern Tibet. The chronological data obtained from this study may provide some constraints for further studies with regard to the tectonic processes and environmental changes in southern Tibetan Plateau. | CHEN HeHai HAN JingTai DING ZhongLi SUN HuiGuo GUO ZhengFu | 2008 | Science China Earth Sciences2008，51，2： | 2 |
| 5 | The effect of anaesthesia and surgery on plasma cytokine production显示文摘 | Hehay S A Wahby M A El-Nawaway M | 1999 | Anaethesia1999，54，8： | 1 |
| 6 | Learningfromimbalanceddata显示文摘 | HEHaibo GARCIAEA | 2009 | IEEETransonKnowledgeandDataEngineering2009，21，9： | 1 |
| 7 | The effect of anaesthesia and surgery on plasma cytokine production显示文摘 | Hehay S A Wahby M A El-Nawaway M | 1999 | Anaethesia1999，54，8： | 1 |
| 8 | Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4^+ and CD8^+ subsets 显示文摘 | Wack A Cossarizza A Hehai S | 1998 | Int Immunol1998，10，9： | 1 |
| 9 | Chronic infections and his- tamine, CRP and IL - 6 levels after percutaneous trans luminal cor- onary angiop lasty显示文摘 | Petrovay F Hehai K Kis Z | 2007 | Inflamm Res2007，56，9： | 1 |
| 10 | V delta 1 + gamma/deha T lymphocytes infiltrating human lung cancer express the CD8 alpha/alpha homodimer 显示文摘 | Ferrarini M Hehai S Chiesa G | 1994 | Scand J Immunol1994，40，3： | 1 |
| 11 | Chronic infections and histamine, CRP and IL-6 levels after percutaneous transluminal coronary angio-plasty 显示文摘 | Petovay F Hehai K Kis Z | 2007 | Inflamm Res2007，56，9： | 1 |
| 12 | Principle and Method of Automated Generalization of Relief Forms 显示文摘 | WU Hehai | 1982 | Bulletin of Surveying and Mapping1982，85，： | 1 |
| 13 | LIM mineralization protein‐1 suppresses TNF‐α induced intervertebral disc degeneration by maintaining nucleus pulposus extracellular matrix production and inhibiting matrix metalloproteinases expression显示文摘 | Hui Liu Hehai Pan Hao Yang Jianru Wang Kuibo Zhang Xiang Li Hua Wang Wenbin Ding Bingxue Li Zhaomin Zheng | 2015 | J. Orthop. Res2015，，： | 1 |
| 14 | Principle, Method of Object-Relation Hypermedia Data Model and Its Application in the Multimedia Spatial Data Management显示文摘In this paper, a new multimedia data model, namely object-relation hypermedia data model (O-RHDM) which is an advanced and effective multimedia data model is proposed and designed based on the extension and integration of non first normal form (NF^2) multimedia data model. Its principle, mathematical description, algebra operation, organization method and store model are also discussed. And its specific application example in the multimedia spatial data management is given combining with the Hainan multimedia touring information system. | Wang, Jianhua Guo, Jingjun Zhu, Guorui Wu, Hehai | 2000 | Journal of Systems Engineering and Electronics2000，11，1： | 0 |
| 15 | Mathematical Foundation of Visual Query Languageon Spatial Information显示文摘Visual Query Language on Spatial Information (SIVQL) is one kind of visual query language based on the extension of Query by Example (QBE). It is a visual operation based on graphics or media object, such as point, line and area elements. In this paper, the relation calculation and query function of SIVQL have been studied and discussed by using set theory and relation algebra. The theory foundation of SIVQL has been investigated by the mathematical method. Finally, its application examples are also given with the specific information system. | Wang Jianhua Guo Jingjun Yan Huiwu Zhu Guorui Wu Hehai | 2000 | Journal of Systems Engineering and Electronics2000，11，4： | 0 |
| 16 | Subject,Object and Target Systems of Rural Human Resource Development显示文摘From subject,object and target subsystems,we analyze the rural human resource development system.The subject system includes government,education and training organizations,society,and rural human resource itself.Different development subject bears different responsibility.Object system includes farmers engaged in farming,farmer workers,rural unemployed people,rural students,rural left-behind people,and other people in rural areas.Different development object has different features.Development target system includes raising quality of rural human resource,keeping reasonable population size,optimizing structure of rural human resource,and improving vitality of rural human resource,etc. | SHEN Hong1,2,ZHAO Yong-le2,HUANG De-bing1 1.School of Management,Guilin University of Technology,Guilin 541004,China 2.Business School of Hehai University,Nanjing 210098,China | 2012 | Asian Agricultural Research2012，4，3： | 0 |
| 17 | Ethical Defects of the System for Ensuring the Minimum Standard of Living in China显示文摘There are many ethical defects in the Chinese system for ensuring the minimum standard of living as shown during its implementation: In terms of people eligible to receive the aid, there is discrimination: the peasants who make up two-thirds of Chinese population are not entitled to the subsistence allowance and the peasant workers in the cities also suffer from discrimination; | Wu Ling & Shi Guoqing, the School of Public Administration, Hehai University Pan Jiabin | 2006 | Social Sciences in China2006，27，1： | 0 |
| 18 | DESIGN AND REALIZATION OF MAP DIGITIZATION SYSTEM ON MICRO-COMPUTER BASED MAP GRAPHIC WORKSTATION显示文摘The main purpose to develop a Map Graphic Workstation on thewidely used micro-computer is that by it the whole processing of map data fromcapturing,managing,editing,updating to graphic outputting can be realized.Map Digitization System(MDS)is the software system to deal with the initial andalso the most important processing.In this paper,the authors introduce a MDSon a micro-computer based Map Grphic Workstation that has been qualitified forthe producation of digital map.Since the system is designed totally independentlyand in the general frame of the Map Graphic Workstation,the capturing and man-aging and other processings for map data are in an integral manner,in which theproducation of digital map can be fulfilled conveniently.At the same time,thesystem is flexible for function extension and widely applicable to the data from dif-ferent sources and with different information characterisitcs(e.g.,the processingof Chinese characters on map). | DU Qingyun WU Hehai | 1998 | Geo-Spatial Information Science1998，1，1： | 0 |
| 19 | THE ESTABLISHMENT OF A MICRO--COMPUTER BASED GEOGRAPHIC INFORMATION SYSTEM显示文摘In this paper,authors introduce the establishment of a Micro-computer Based Geographic Information System(MCGIS),which is one of the subsystems of The Loess Plateau Geographic Information System (LP-GIS) being carried out by the REIS Laboratory and several universities of China on various types and levels of computer.MCGIS is developed on the micro-computer Gteat Wall-286.Its purpose is to providean information system with powerful perforrmance,which could be afforded by thosecounty-level units or departments,so that the general guide-line of multi-function,multi-level and multi-user can come to practice. The system MCGIS is composed of the spatial database management systems and some software packages for geographic analysis and other further data processing.The spatial database management svstem is the kernel part of the MCGIS,and other function packages are babed on it.The whole system remains open, i.e.,ready to be extende in function. | Wu Hehai Li Lin Du Qingyun | 1989 | 地图1989，，2： | 0 |
| 20 | A Continuous Minimization Method for Solving Optimal Control Problem | GU Rongzhong (Management Department,Hehai University,Nanjing 210024,P.R.China) | 1994 | Systems Science and Systems Engineering1994，4，4： | 0 |
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