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| 1 | Structure and deformation around the Gyirong basin, north Himalaya, and onset of the south Tibetan detachment system显示文摘Gyirong basin and its adjacent area are located at a special position in the Himalayan orogen, where the south Tibetan detachment system (STDS) and N-S trending rift converged. The north Himalayan orogen here can be divided into five petrologic-tectonic units successively from south to north: 1) the Greater Himalayan crystalline complex (GHC); 2) the STDS shear zone; 3) the Tethyan Himalayan sedimentary sequence (THS); 4) the late Cenozoic sedimentary basins, such as Gyirong and Oma basins; and 5) the Malashan gneiss dome. Structural studies show that this area experienced four stages of deformation: 1) the earlier south-directed thrusting, preserved both in the GHC and THS; 2) top-down-to-north slip along the STDS, normal faults related to this slip formed the early controlling structures of the Cenozoic basins,and the tilted pattern of the blocks between the basins indicated a north-directed slip; 3) east-west extension, the resultant N-S trending normal fault formed the eastern boundary of the basins; and 4) late gravitational collapse. Zircon SHRIMP U-Pb dating on the syn-deformational (leuco-) granite along the STDS indicates that the major activity of the STDS occurred at ca. 26 Ma, but its onset may have begun as early as ca. 36 Ma. | YANG XiongYing ZHANG JinJiang QI GuoWei WANG DeChao GUO Lei LI PengYuan LIU Jiang | 2009 | Science China Earth Sciences2009，52，8： | 33 |
| 2 | Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop显示文摘The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin(IL)-1β, and is one of the main causes of intervertebral disc degeneration(IVDD). NLR pyrin domain containing 3(NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its roles in IVDD are still not well understood and require more examination. First, we demonstrated that melatonin delayed the progression of IVDD and relieved IVDD-related low back pain in a rat needle puncture IVDD model;moreover, NLRP3 inflammasome activation(NLRP3, p20, and IL-1β levels) was significantly upregulated in severely degenerated human discs and a rat IVDD model. Subsequently, an IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop was found in nucleus pulposus(NP) cells that were treated with IL-1β. In these cells, expression of NLRP3 and p20 was significantly increased, NF-κB signaling was involved in this regulation, and mitochondrial reactive oxygen species(mt ROS)production increased. Furthermore, we found that melatonin disrupted the IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop in vitro and in vivo. Melatonin treatment decreased NLRP3, p20, and IL-1β levels by inhibiting NF-κB signaling and downregulating mt ROS production. Finally, we showed that melatonin mediated the disruption of the positive feedback loop of IL-1β in vivo. In this study, we showed for the first time that IL-1β promotes its own expression by upregulating NLRP3 inflammasome activation. Furthermore, melatonin disrupts the IL-1β positive feedback loop and may be a potential therapeutic agent for IVDD. | Fan Chen Guowei Jiang Hui Liu Zemin Li Yuxin Pei Hua Wang Hehai Pan Haowen Cui Jun Long Jianru Wang Zhaomin Zheng | 2020 | Bone Research2020，8，2： | 18 |
| 3 | Petrogenesis and tectonic implications of Indosinian granitoids from Western Qinling Orogen,China:Products of magma-mixing and fractionation显示文摘The Western Qinling Orogen(WQO) is characterized by voluminous distribution of Indosinian granitoids,the formation of which provides an important window to unravel the geochemical and geodynamic evolution and associated metallogeny.Here we investigate a group of intrusions termed 'Five Golden Flowers' based on petrological,geochemical,zircon U-Pb geochronological and Lu-Hf isotopic studies on the granitoids and their mafic microgranular enclaves(MMEs).Our results show that these intrusions are genetically divided into two types,namely,magma-mixing and highly fractionated.The Jiaochangba,Lujing,Zhongchuan,and Luchuba granitoids are biotite monzogranites(220±0.8 Ma to 217±2.6 Ma) with abundant coeval MMEs(220±.1 Ma to 217±2.7 Ma).The rocks contain moderate to high SiO2,high MgO,Rb,Sr,Ba,and Th contents,but low TiO2,P2 O5,and Sc values,A/CNK of <1.1,and a range of εHf(t) values of-11.7 to +2.23 with corresponding TDM2values of 1967-1228 Ma.The MMEs possess K-feldspar megacrysts,abundant acicular apatites,and show lopsided textures.They have lower SiO2,Al2 O3,and Th contents,but higher MgO,TiO2,and Sc,with εHf(t) values of-18.0 to +3.18 and TDM1 of 849-720 Ma.The data indicate that the MMEs were derived from a magma sourced from the enriched lithospheric mantle.We suggest that these host granitoids were produced by partial melting of latePaleoproterozoic to early-Mesoproterozoic lower crust with the involvement of Neoproterozoic SCLM-derived mafic magmas.The Baijiazhuang pluton is dominantly composed of leucogranite(muscovite granite and twomica monzogranite,216±1.5 Ma) without MMEs.The rocks are peraluminous with high A/CNK(1.06-1.27).Compared with the other four granitoids,the Baijiazhuang leucogranite shows higher SiO2 content,markedly lower concentrations of TiO2,MgO,Al2 O3,CaO,and Fe2 O3T,and lower LREE/HREE and(La/Yb)N values.These leucogranites are also rich in Rb,Th,and U,and display marked depletions in Ba,Sr,Ti,and Eu,indicating that they experienced significant fractionation.Zircon εHf(t) values(-10.2 to-3.27) and TDM2(1868-1424 Ma),as well as the Nb/Ta and K2 O/Na2 O values are similar to the other four granitoids,indicating that they are likely to have been derived from a similar source;with sediments playing only a minor role in the magma generation.The low contents of Yb and Y suggest that their partial melting was controlled by garnets and micrographic texture of K-feldspar reflects high-temperature melting through undercooling.Based on the above features,we infer that the Baijiazhuang leucogranite likely represents the product of high degree fractionation of the I-type biotite monzogranite magma which generated the other four granitoids at relatively high temperatures,within magma chambers at mid-crust depths.We propose that the granitoid suite was formed in the transitional setting from synto post-collision during the collisional orogeny between the SCB and NCB,following break-off of the subducted South China Block lithosphere during 220-216 Ma. | Xiao Xiong Laimin Zhu Guowei Zhang M.Santosh Hang Jiang Jun Zheng Anlin Guo Lele Ding | 2020 | Geoscience Frontiers2020，11，4： | 6 |
| 4 | Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity显示文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research. | Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang Zhihui Zhong Hongxia Li Guowei Che Kai Xiao | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 5 | Zircon U-Pb Geochronology and Geochemical Characteristics of the Volcanic Host Rocks from the Tongyu VHMS Copper Deposit in the Western North Qinling Orogen and Their Geological Significance显示文摘Precise in situ zircon U-Pb dating and Lu–Hf isotopic measurement using an LA-ICP-MS system, whole-rock major and trace element geochemistry and Sr–Nd isotope geochemistry were conducted on the volcanic host rocks of the Tongyu copper deposit on the basis of further understanding of its geological characteristics. Three zircon samples from the volcanic host rocks yielded 206Pb/238 U weighted average ages ranging from 436±4 Ma to 440±5 Ma, which are statistically indistinguishable and coeval with the ca. 440 Ma northward subduction event of the Paleo-Qinling oceanic slab. The volcanic host rocks were products of magmatic differentiation that evolved from basalt to andesite to dacite to rhyolite, forming an integrated tholeiitic island arc volcanic rock suite. The primitive mantle-normalized trace element patterns for most samples show characteristics of island arc volcanic rocks, such as relative enrichment of LILE(e.g. Th, U, Pb and La) and depletion of HFSE(e.g. Nb, Ta, Ti, Zr and Hf). Discrimination diagrams of Ta/Yb vs Th/Yb, Ta vs Th, Yb vs Th/Ta, Ta/Hf vs Th/Hf, Hf/3 vs Th vs Nb/16, La vs La/Nb and Nb vs Nb/Th all suggest that both the volcanic host rocks from the Tongyu copper deposit and the volcanic rocks from the regional Xieyuguan Group were formed in an island arc environment related to subduction of an oceanic slab. Values of ISr(0.703457 to 0.708218) and εNd(t)(-2 to 5.8) indicate that the source materials of volcanic rocks from the Tongyu copper deposit and the Xieyuguan Group originated from the metasomatised mantle wedge with possible crustal material assimilation. Most of the volcanic rock samples show good agreement with the values of typical island arc volcanic rocks in the ISr-εNd(t) diagram. The involvement of crustal-derived material in the magma of the volcanic rocks from the Tongyu copper deposit was also reflected in the zircon εHf(t) values, which range from-3.08 to 10.7, and the existence of inherited ancient xenocrystic zircon cores(2616±39 Ma and 1297±22 Ma). The mineralization of the Tongyu copper deposit shows syn-volcanic characteristics such as layered orebodies interbedded with the volcanic rock strata, thus, the zircon U-Pb age of the volcanic host rocks can approximately represent the mineralization age of the Tongyu copper deposit. Both the Meigou pluton and the volcanic host rocks were formed during the ca. 440 Ma northward subduction of the Paleo-Qinling Ocean when high oxygen fugacity aqueous hydrothermal fluid released by dehydration of the slab and the overlying sediments fluxed into the mantle wedge, triggered partial melting of the mantle wedge, and activated and extracted Cu and other ore-forming elements. The magma and ore-bearing fluid upwelled and erupted, and consequently formed the island arc volcanic rock suite and the Tongyu VHMS-type copper deposit. | XIONG Xiao ZHU Laimin LI Ben ZHANG Guowei GONG Hujun ZHENG Jun JIANG Hang | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 5 |
| 6 | Geochemistry of the Paleocene Clastic Rocks in Lishui Sag, East China Sea Shelf Basin: Implications for Tectonic Background and Provenance显示文摘The Lishui Sag,in the East China Sea Shelf Basin,is rich in hydrocarbons,with the major hydrocarbon-bearing layers being the Paleocene Mingyuefeng clastic rocks.Analysis of the implicit geologic background information of these Paleocene clastic rocks using petrological and geochemical methods has significant practical importance.These Paleocene sandstones are mainly lithic arenite,lithic arkose and greywacke,composed of K-feldspar,plagioclase,authigenic clays,silica and carbonates.As continental deposits,Yueguifeng clastic rocks have high aluminosilicate and mafic detritus contents,while the Lingfeng and Mingyuefeng Formations are rich in silica due to an oscillating coastal marine depositional environment The major element contents of these Paleocene sandstones are low and have a concentrated distribution,indicating that the geochemical composition is non-epigenetic,transformed by sedimentary processes and diagenesis.The Yueguifeng detritus comprises recycled sediments,controlled by moderate weathering and erosion,while the Lingfeng and Mingyuefeng detritus is interpreted as primarily first-cycle materials due to low chemical weathering.In the Late Cretaceous to Early Paleocene,the Pacific Plate began subducting under the Eurasian Plate,causing an orogeny by plate collision and magma eruption due to the melting of subducted oceanic crust.This resulted in the dual tectonic settings of'active margin'and'continental island arc'in the East China Sea Shelf Basin.During the Late Paleocene,the Pacific Plate margin migrated eastward along with development of the Philippine Ocean Plate,and the tectonic setting of the Lishui Sag gradually turned into a passive continental margin.Detrital sources included both orogenic continental blocks and continental island arcs,and the parent rocks are primarily felsic volcanic rocks and granites. | LI Deyong JIANG Xiaodian XU Fa LIU Jinshui HOU Guowei | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 4 |
| 7 | Response of coralline algae Porolithon onkodes to elevated seawater temperature and reduced pH显示文摘Coralline algae(CA),a type of primary calcifying producer presented in coastal ecosystems,are considered one of the highly sensitive organisms to marine environmental change.However,experimental studies on coralline algae responses to elevated seawater temperature and reduced pH have documented either contradictory or opposite results.In this study,we analysed the growth and physiological responses of coralline algae Porolithon onkodes to the elevated temperature(30.8°C)and reduced pH(7.8).The aim of this analysis was to observe the direct and combined effects,while elucidating the growth and photosynthesis in this response.It was demonstrated that the algae thallus growth rate and photosynthesis under elevated temperature were depressed by 21.5%and 14.9%respectively.High pCO2 enhanced the growth and photosynthesis of the thallus at ambient temperature,while they were deceased when both temperature and pCO2 were elevated.CA is among the most sensitive organisms to ocean acidification(OA)because of their precipitate high Mg-calcite.We hypothesize that coralline algae could increase their calcification rate in order to counteract the effects of moderate acidification,but offset by the effect of elevated temperature.Accordingly,our results also support the conclusion that global warming(GW)is a stronger threat to algal performance than OA.Our findings are also proposed that coralline algae may be more resilient under OA than GW. | Xinming Lei Lei Jiang Yuyang Zhang Guowei Zhou Jiansheng Lian Hui Huang | 2020 | Acta Oceanologica Sinica2020，39，2： | 2 |
| 8 | Proximally Based Conjoined Tendon Transfer for Coracoclavieular Reconstruction in the Treatment of Acromioclavicular Dislocation 显示文摘 | CHUNYAN JIANG MANYI WANG GUOWEI RONG | 2007 | J Bone Joint Surg(Am)2007，89，： | 1 |
| 9 | Effect of extract from Yiyuan Yiliu Tang(益元抑瘤汤)on human lung adenocarcinoma and human hepatoma cell lines显示文摘OBJECTIVE:To investigate the efficacy of the extract from Yiyuan Yiliu Tang(益元抑瘤汤,YYYLT)on human lung adenocarcinoma cells A549 and human hepatoma cells Bel7402.METHODS:The cancer cell lines were treated with various concentrations(0,100,200,300,and400μg/m L)of the crude water extract of YYYLT and then cell viability,toxicity,cytokine secretion,and cell cycle/apoptosis were determined by MTT assay,LDH assay,and flow cytometry,respectively.RESULTS:The extract from YYYLT significantly suppressed the proliferation of the cancer cell lines and the release of interleukin-2 and tumor necrosis factor-αin a dose-dependent manner.The extract also promoted apoptosis,caused cell cycle arrest at G0/G1 phase,and increased the expression of caspase-3,B-cell lymphoma-2(Bcl-2),and Bcl-2-associated X proteins.CONCLUSION:The extract from YYYLT might be a potential treatment for human lung and liver cancers. | Yl Qingqing CHANG Qing LIANG Dongyu CAI Weiwei QIU Liying YANG Rong JIANG Guowei | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 1 |
| 10 | Synthetic of hydroxyapatite films on porous Al2O3 substrate for hard tissue prosthetics显示文摘 | Shi Donglu Jiang Guowei | 1998 | Materials Science and Engineering C1998，6，23： | 1 |
| 11 | A Multicenter Retrospective Analysis of Survival Outcome Following Postoperative Chemoradiotherapy in Non–Small-Cell Lung Cancer Patients With N2 Nodal Disease显示文摘 | Bingwen Zou Yong Xu Tao Li Wenhui Li Bangxian Tang Lin Zhou Lu Li Yongmei Liu Jiang Zhu Meijuan Huang Jin Wang Li Ren Youlin Gong Guowei Che Lunxu Liu Mei Hou You Lu | 2010 | International Journal of Radiation Oncology Biology Physics2010，，2： | 1 |
| 12 | 显示文摘 | Wu Cuicui Zhou Guowei Jiang Xiaojie | 2012 | Process Bio-chemistry2012，47，6： | 1 |
| 13 | Effect of Sand Body Enrichment Under the Restriction of a Tectonic Transfer Zone: A Case Study on the Pinghu Formation in the Kongqueting Region on the Pinghu Slope显示文摘Results of long-term explorations in the Kongqueting region,located in an East China Sea depression,suggest that the strong fault activity during the sedimentary period of the Pinghu formation significantly influenced the development of the sedimentary system.However,the aggregation and enrichment of the sand body under a tectonic background has become a problem that requires an immediate solution.Considering research outcomes of previous studies,this study used three-dimensional seismic and logging data to identify Y-or H-type and the en echelon distribution patterns of the fault plane,as well as identify the locations wherein the fault growth index value is greater than 1 in the study region,indicating the tectonic background of the fault transfer zone in the region.Second,the development type of the fault transfer zone was studied,and the sand body enrichment site was identified based on seismic inversion data and the development position of the fault transfer point.This helps clarify the evolution of sedimentary facies of the Pinghu formation combined with the sedimentary environment of the braided-river delta.Finally,after summarizing the coupling relationship between the synsedimentary fault systems and the sand body enrichment patterns,three sand-control models were determined,namely,the flexural-parallel,the en echelon collinear,and the torsional-reformed superimposed transfer zones.The findings of this study lay a foundation for the subsequent search of tectonic lithologic oil and gas reservoirs. | LI Junjie HOU Guowei QIN Lanzhi XIE Jingjing JIANG Xue | 2021 | Journal of Ocean University of China2021，20，4： | 1 |
| 14 | Developing super-hydrophobic and corrosion-resistant coating on magnesium-lithium alloy via one-step hydrothermal processing显示文摘Formation of super-hydrophobic and corrosion-resistant coatings can provide significant corrosion protection to magnesium alloys.However,it remains a grand challenge to produce such coatings for magnesium-lithium alloys due to their high chemical reactivity.Herein,a one-step hydrothermal processing was developed using a stearic-acid-based precursor medium,which enables the hydrothermal conversion and the formation of low surface energy materials concurrently to produce the super-hydrophobic and corrosion-resistant coating.The multiscale microstructures with nanoscale stacks and microscale spheres on the surface,as well as the through-thickness stearates,lead to the super-hydrophobicity and excellent corrosion resistance of the obtained coating. | Guowei Wang Dan Song Yanxin Qiao Jiangbo Cheng Huan Liu Jinghua Jiang Aibin Ma Xiaolong Ma | 2023 | Journal of Magnesium and Alloys2023，11，4： | 1 |
| 15 | Microstruc- ture and mechanical properties of 6063 aluminum alloy brazed joints with A1-Si-Cu-Ni-RE filler metal 显示文摘 | Zhang Guowei Bao Yefeng Jiang Yongfeng | 2011 | Journal of Materials Engineering and Performance2011，20，8： | 1 |
| 16 | Study on Properties of Composite OxidesTiO2/SiO2显示文摘 | Zhou Yasong Jiang Guowei | | 0，，03： | 1 |
| 17 | Bi-layer collagen/microporous electrospun nanofiber scaffold improves the osteochondral regeneration显示文摘 | Shufang Zhang Longkun Chen Yangzi Jiang Youzhi Cai Guowei Xu Tong Tong Wei Zhang Linlin Wang Junfeng Ji Peihua Shi Hong Wei Ouyang | 2013 | Acta Biomaterialia2013，，7： | 1 |
| 18 | Preparation and Properties of Polyether Pentaerythritol Monomaleate Grafted Linear Low Density Polyethylene by Reactive Extrusion 显示文摘 | Yao Zhanhai Yin Jinghua Jiang Guowei | 2008 | Journal of Macromolecular Sciencew PartA: Pure and Applied Chemistry2008，45，5： | 1 |
| 19 | Proximally based conjoined tendon transfer for coracoclavicular reconstruction in the treatment of acromioclavicular dislocation显示文摘 | Jiang Chunyan Wang Manyi Rong Guowei | 2007 | Bone Joint Surg Am2007，89，11： | 1 |
| 20 | Unravelling the precipitation evolutions of AZ80 magnesium alloy during non-isothermal and isothermal processes显示文摘The precipitation evolutions of Mg-Al-Zn alloys play essential roles in their mechanical properties,corrosion performance,formability,plastic deformation mechanisms and texture development.In the present work,the precipitation evolutions of AZ80 magnesium alloy during both non-isothermal and isothermal processes were unraveled by utilizing in situ electrical resistivity monitoring,hardness testing,differential scanning calorimetry and microstructural characterization.The results showed that discontinuous precipitation(DP)and continuous precipitation(CP)occurred competitively during non-isothermal and isothermal processes.The precipitation of dominantβ-Mg17 Al12 phase during non-isothermal processes was highly dependent on the thermal history.During isothermal processes,the precipitation behavior of AZ80 magnesium alloy could be considered as the functions of holding temperature and time.At lower temperatures,massive DP and CP were gradually formed to equally strengthen the alloy.At higher temperatures,the Ostwald coarsening was characterized in the later stages and indicated to slightly soften the alloy.Isothermal time-temperature-precipitation curves and quantitative precipitate evolution were estimated to unravel precipitation characteristics and their strengthening functions. | Longqing Tang Guowei Bo Fulin Jiang Shiwei Xu Jie Teng Dingfa Fu Hui Zhang | 2021 | Journal of Materials Science & Technology2021，，16： | 1 |
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