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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 3 | Antioxidant activity of( + )-bergenin-a phytoconstituent isolated from the bark of Sacoglottis uchi Huber ( Humi- reaceae) 显示文摘 | Heitor A De Abreu Izandina Aparecida dos S Lago Gilmar P Souza | 2008 | Organ Biomol Chem2008，6，： | 1 |
| 4 | Data Mining With an Ant Colony Optimization Algorithm 显示文摘 | Rafael S ParpineUi Heitor S Lopes Alex A Freitas | 2002 | IEEE Transactions on Evolutionary Computing2002，6，4： | 1 |
| 5 | The cash flow sensitivity of cash显示文摘 | Almeida Heitor Murillo Campello Michael S Weisbach | 2004 | Journal of Finance2004，59，： | 1 |
| 6 | Atmospheric total suspended particulate trace element identification by XRF at IlhaGrande,State of Rio De Janeiro,Brazil显示文摘 | FERNANDA S REMI L HEITOR E | 2011 | Water Air Soil Pollution2011，214，52： | 1 |
| 7 | Physical Exercise and Clinically Depressed Patients: A Systematic Review and Meta-Analysis 显示文摘 | Heitor S Helena M Natacha E | 2013 | Neuropsychobiology2013，，2： | 1 |
| 8 | Corporate Financial and Investment Policies When Future Financing is Not Frictionless显示文摘 | Almeida Heitor Murillo Campello Weisbach M S | 2011 | Journal of Corporate Finance2011，17，： | 1 |
| 9 | A reactive role assignment for data routing in event-based wireless sensor networks显示文摘 | Eduardo F Nakamura Heitor S Ramos Leandro A Villas | 2009 | Computer Networks2009，53，12： | 1 |
| 10 | Liquid film break-up in a model of a prefilming airblast nozzle 显示文摘 | Carvalho I S Heitor M V | 1998 | Exp Fluids1998，24，56： | 1 |
| 11 | Egipays:an enhanced gene expression programming approach for symbolic regression problems显示文摘 | LOPES HEITOR S WEINERT WAGNER R | 2004 | Intemational Joumal of Applied Mathematics and Computr Science(S1641-876X)2004，14，3： | 1 |
| 12 | Visualization of vortex breakdown in turbulent unconfined jet flows显示文摘 | Carvalho I S Heitor M V | 1996 | Journal Optical Diagnostics in Engineering1996，1，2： | 1 |
| 13 | Data mining with a ant colony optimization algorithm显示文摘 | Rafael S Parpinelli Heitor S Lopes Alex A Freitas | 2002 | IEEE Trans On Evolution Computing2002，6，4： | 1 |
| 14 | Data mining with an ant colony optimization algorithm 显示文摘 | RaVel S P Heitor S L Alex A F | 2002 | IEEE Transactions on Evo- lutionary Computing2002，6，4： | 1 |
| 15 | Data mining with a ant colony optimization algorithm 显示文摘 | Rafael S Parpinelli Heitor S Lopes Alex A Freitas | 2002 | IEEE Trans On Evolution Computing2002，6，4： | 1 |
| 16 | Exercise and Mental Health: Many Reasons to Move显示文摘 | Deslandes Andréa Moraes Helena Ferreira Camila Veiga Heloisa Silveira Heitor Mouta Raphael Pompeu Fernando A M S Coutinho Evandro Silva Freire Laks Jerson | 2009 | Neuropsychobiology2009，，： | 1 |
| 17 | Data Mining With an Ant Colony Optimization Algorithm 显示文摘 | Rafael S Parpinelli Heitor S Lopes Alex A Freitas | 2004 | IEEE transactions on evolutionary computing2004，6，4： | 1 |
| 18 | Data Mining with an Ant Colony Optimization Algorithm 显示文摘 | Rafael S Parpinelli Heitor S Lopes Alex A Freitas | 2002 | IEEE Trans on Evolutionary Computing2002，6，4： | 1 |
| 19 | Weisbach,The Cash Flow Sensitivity of Cash显示文摘 | Heitor Almeida Murillo Campello Michael S | 2004 | Journal of Finance2004，59，： | 1 |
| 20 | The cash flow sensitivity of cash 显示文摘 | Heitor Almeida Murillo eampello Michael S Weisbach | 2004 | Journal of Finance2004，59，4： | 1 |
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