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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Physical Exercise and Clinically Depressed Patients: A Systematic Review and Meta-Analysis 显示文摘 | Heitor S Helena M Natacha E | 2013 | Neuropsychobiology2013，，2： | 1 |
| 3 | Defining scale in fisheries: Small versus large-scale fishing operations in the Azores 显示文摘 | NATACHA C GARETH E J EDUARDO I | 2011 | Fisheries Research2011，109，： | 1 |
| 4 | Selection of large quantities of embryogenic calli from indca rice seeds for production of fertile plants using the biolistic method显示文摘 | Sivamani E Ping S Natacha O | 1996 | Plant Cell Reports1996，15，： | 1 |
| 5 | The North Sea:source or sink for nitrogen and phosphorus to the Atlantic Ocean?显示文摘 | BRION Natacha BAEYENS Willy GALAN Sander D E | 2004 | Biogeochemistry2004，68，3： | 1 |
| 6 | Isotope ratio mass spectrometry as a tool for source inference in forensic science:acritical review显示文摘 | Natacha G Rolf TW S Pierre E | 2015 | Forensic Science International2015，251，： | 1 |
| 7 | Update on Fe-dependent oxidative metabolism in vivo:An integrative view显示文摘Fe is essential for human life because it constitutes the required cofactor for proteins of diverse biological functions.However,the development of oxidative stress by exposure to excessive Fe,share signaling pathways with other treatments including activation of redox-sensitive factors.This study was focused on the comparison on the effects of Fe in the brain and other organs in vivo.The oxidative effects triggered by Fe overload strongly depend not only on the administration protocol,but also on the Fe-compound used,and the studied organ.In both the liver and the brain,Fe content drastically increased after Fe-dextran administration.However,the comparatively low lipid peroxidation in the brain as compared to the liver,suggested that Fe-dependent oxidative stress might involve mechanisms of different nature.In the brain,acute and subchronic administration of Fe-dextran triggered signaling processes that lead to the prevention of injury by the participation of catalase activity as an antioxidant protection.This brief summary opens a huge range of possible points of risk,as well as opportunities,to encounter situations in which the appropriate election of the Fe management protocol could be able of allow oxidative stress to exert beneficial effects. | NATACHA E PILONI ELIZABETH ROBELLO JULIAN G BONETTO SUSANA PUNTARULO | 2016 | BIOCELL2016，40，1： | 0 |
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