|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Current practices and future prospects for the management of gallbladder polyps: A topical review显示文摘A gallbladder polyp is an elevation of the gallbladder mucosa that protrudes into the gallbladder lumen. Gallbladder polyps have an estimated prevalence in adults of between 0.3%-12.3%. However, only 5% of polyps are considered to be 'true' gallbladder polyps, meaning that they are malignant or have malignant potential. The main radiological modality used for diagnosing and surveilling gallbladder polyps is transabdominal ultrasonography. However, evidence shows that other modalities such as endoscopic ultrasound may improve diagnostic accuracy. These are discussed in turn during the course of this review. Current guidelines recommend cholecystectomy for gallbladder polyps sized 10 mm and greater, although this threshold is lowered when other risk factors are identified. The evidence behind this practice is relatively low quality. This review identifies current gaps in the available evidence and highlights the necessity for further research to enable better decision making regarding which patients should undergo cholecystectomy, and/or radiological follow-up. | R Stephen McCain Anna Diamond Claire Jones Helen G Coleman | 2018 | World Journal of Gastroenterology2018，24，26： | 25 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 5 | 英国私营企业的可持续供应链管理显示文摘目前,私营企业越来越关注购买和供应产品和服务时的可持续性,也即称为'可持续供应链管理',利用采购活动来减少对环境、经济和社会的负面影响。但是言辞和现实之间经常会有差距,企业经常因标榜绿色耍嘴皮子而受到指责。该研究将探讨可持续供应链在7个处于各自行业领先地位的企业的实施情况,并探究影响可持续供应链的因素及将来会有哪些变化。 | Helen Walker Neil Jones 李玉荣 | 2015 | 世界农业2015，，1： | 2 |
| 6 | Enterprise logic and small finns: a model of authentic entrepreneurial leadership 显示文摘 | Oswald Jones Helen Crompton | 2009 | Journal of Strategy and Management2009，，4： | 1 |
| 7 | Promotion physical activity in women: evaluation of a 2-year community-based intervention in Sydney, Australia 显示文摘 | Li Ming Wen Margaret Thomas Helen Jones | 2002 | Health Promotion International2002，17，2： | 1 |
| 8 | Ciliated hepatic foregut cyst显示文摘 | Mark D. Stringer Matthew O. Jones Helen Woodley Judy Wyatt | 2006 | Journal of Pediatric Surgery2006，，6： | 1 |
| 9 | More than A to B: the role of free bus travel for the mobility and wellbeing of older citizens in London显示文摘 | JUDITH GREEN ALASDAIR JONES HELEN ROBERTS | 2012 | Ageing and Society2012，，3： | 1 |
| 10 | Flow-Mediated Dilation and Cardiovascular Event Prediction: Does Nitric Oxide Matter?显示文摘 | Daniel J. Green Helen Jones Dick Thijssen N.T. Cable Greg Atkinson | 2011 | Hypertension2011，，： | 1 |
| 11 | Recent developments in the MOCVD and ALD of rare earth oxides and silicates显示文摘 | Anthony C. Jones Helen C. Aspinall Paul R. Chalker Richard J. Potter Kaupo Kukli Antti Rahtu Mikko Ritala Markku Leskel? | 2005 | Materials Science & Engineering B2005，，1： | 1 |
| 12 | Outcome of a Workshop on Applications of Protein Models in Biomedical Research显示文摘 | Torsten Schwede Andrej Sali Barry Honig Michael Levitt Helen M. Berman David Jones Steven E. Brenner Stephen K. Burley Rhiju Das Nikolay V. Dokholyan Roland L. Dunbrack Krzysztof Fidelis Andras Fiser Adam Godzik Yuanpeng Janet Huang Christine Humblet Matt | 2009 | Structure2009，，2： | 1 |
| 13 | Heparin binding domain in vitronectin is required for oligomerization and thus enhances integrin mediated cell adhesion and spreading显示文摘 | Chandramouli R Chillakuri Céline Jones Helen J Mardon | 2010 | FEBS Letters2010，，15： | 1 |
| 14 | Clinical outcomes after insulin initiation in patients with type 2 diabetes: 6-month data from the INSTIGATE observational study in five European countries显示文摘 | Andreas Liebl Stephen Jones Marian Benroubi Conxa Castell Albert Goday Marie Aline Charles Helen T. Smith Claudia Nicolay Alexander Simpson | 2011 | Current Medical Research & Opinion2011，，5： | 1 |
| 15 | Diversity of Kenyan soda lake alkaliphiles assessed by molecular methods显示文摘 | Helen C. Rees William D. Grant Brian E. Jones Shaun Heaphy | 2004 | Extremophiles2004，，1： | 1 |
| 16 | Changes in Diabetes Self-Care Behaviors Make a Difference in Glycemic Control 显示文摘 | Helen Jones Lynn Edwards Michael VaUis | 2003 | Diabetes Care2003，26，3： | 1 |
| 17 | Changes in Diabetes Self-Care Behaviors Make a Difference in Glycemic Control 显示文摘 | Helen Jones Lynn Edwards Michael Vallis | 2003 | Diabetes Care2003，26，3： | 1 |
| 18 | Promotion physical activity in women:evaluation of a 2-year community-based intervention in Sydney,Australia显示文摘 | Li Ming-wen Margaret Thomas Helen Jones | 2002 | Health Promotion International2002，17，7： | 1 |
| 19 | Cyclic stretch-induced TGFβ1/Smad signaling inhibits adipogenesis in umbilical cord progenitor cells显示文摘 | Neill J. Turner Helen S. Jones John E. Davies Ann E. Canfield | 2008 | Biochemical and Biophysical Research Communications2008，，4： | 1 |
| 20 | Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease显示文摘 | Helen E. Smith J.P. Jones Thomas F. Kalhorn Federico M. Farin Patricia L. Stapleton Connie L. Davis James D. Perkins David K. Blough Mary F. Hebert Kenneth E. Thummel Rheem A. Totah | 2008 | Pharmacogenetics and Genomics2008，，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员