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| 1 | The calcium sensing receptor: from calcium sensing to signaling显示文摘The Ca2+-sensing receptor(the Ca SR),a G-protein-coupled receptor,regulates Ca2+ homeostasis in the body by monitoring extracellular levels of Ca2+([Ca2+]o) and responding to a diverse array of stimuli.Mutations in the Ca2+-sensing receptor result in hypercalcemic or hypocalcemic disorders,such as familial hypocalciuric hypercalcemia,neonatal severe primary hyperparathyroidism,and autosomal dominant hypocalcemic hypercalciuria.Compelling evidence suggests that the Ca SR plays multiple roles extending well beyond not only regulating the level of extracellular Ca2+ in the human body,but also controlling a diverse range of biological processes.In this review,we focus on the structural biology of the Ca SR,the ligand interaction sites as well as their relevance to the disease associated mutations.This systematic summary will provide a comprehensive exploration of how the Ca SR integrates extracellular Ca2+ into intracellular Ca2+ signaling. | ZHANG Chen MILLER Cassandra Lynn BROWN Edward M YANG Jenny J. | 2015 | Science China(Life Sciences)2015，58，1： | 14 |
| 2 | 卒中一级预防指南 美国心脏协会/美国卒中协会为医疗卫生专业人员制定的指南美国神经病学学会肯定本指南作为神经科医生继续教育工具的价值显示文摘背景和目的本指南对各种已确定和新出现的卒中危险因素的证据进行概述,以提供降低首次卒中风险的循证推荐。方法写作组成员由委员会主席根据每位成员先前在相关课题领域中的工作提名,并经美国心脏协会(American HeartAssociation,AHA)卒中委员会科学声明监督委员会批准。写作组采用系统文献回顾的方法(涵盖时间为2006年上一次回顾发表到2009年4月),参考先前已发表的指南、个人文件和专家意见来总结现有证据,并指出现有知识的差距;如果合适,则根据标准的AHA标准做出推荐。写作组全体成员均有机会对推荐进行评论并审核这份声明的最终文本。在AHA科学咨询和协调委员会考察和批准之前,本指南已南卒中委员会领导层和AIIA科学声明督察委员会进行过广泛的同行评议。结果对评价个体首次卒巾风险的流程图进行了评价。根据干预的町能性(不可于预、可于预或潜在可干预)和证据的强度(证据充分或证据不太充分),对首次卒中的危险因素或风险标记物进行分类。不可干预危险因素包括年龄、性别、低出生体质量、人种/种族和遗传倾向。证据充分的叮干预危险因素包括高血压、吸烟、糖尿病、心房颤动和某些其他心脏病、血脂异常、颈动脉狭窄、镰状细胞病、绝经后激素治疗、不良饮食习惯、体力活动过少以及肥胖和体脂分布。证据不太充分或潜在的可干预危险因素包括代谢综合征、酗酒、药物滥用、口服避孕药、睡眠呼吸障碍、偏头痛、高同型半胱氨酸血症、脂蛋白(a)升高、高凝状态、炎症和感染。对用阿司匹林进行卒中一级预防的资料进行了回顾。结论多方面的证据可用于确定能增高首次卒中风险的多种具体因素并提供降低这种风险的策略。 | Larry B. Goldstein Cheryl D. Bushnell Robert J. Adams Lawrence J. Appel Lynne T. Braun Seemant Chaturvedi Mark A. Creager Antonio Culebras Robert H. Eckel Robert G. Hart Judith A. Hinchey Virginia J. Howard Edward C. Jauch Steven R. Levine James F. Meschia Wesley S. Moore J.V. (Ian) Nixon Thomas A. Pearson 张霞(译) 尤寿江(译) 陈孝东(译) 卢涛声(译) 石际俊(译) 曹勇军(译) 徐兴顺(译) | 2010 | 国际脑血管病杂志2010，18，12： | 12 |
| 3 | Guidelines for the Primary Prevention of Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Larry B. Goldstein Cheryl D. Bushnell Robert J. Adams Lawrence J. Appel Lynne T. Braun Seemant Chaturvedi Mark A. Creager Antonio Culebras Robert H. Eckel Robert G. Hart Judith A. Hinchey Virginia J. Howard Edward C. Jauch Steven R. Levine James F. Meschi | 2011 | Stroke2011，，2： | 6 |
| 4 | 卒中一级预防指南美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘这份更新版指南旨在为既往无卒中或短暂性脑缺血发作史的人群提供适时的综合性卒中预防循证建议,包括危险因素控制、头颈部动脉粥样硬化性疾病的干预方法以及预防血栓形成和血栓栓塞性卒中的抗栓治疗。此外,本指南还提供了针对遗传和药理学检测以及在其他特殊情况下(包括镰状细胞疾病和卵圆孔未闭)进行卒中预防的建议。 | James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager Robert H. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B Goldstein Steven M. Greenberg Susanna E. Horvath Costantino Iadecola Edward C. Jauch Wesley S. Moore John A. Wilson 李迪 高一鹭 陈政弘 霍晓川 孙海欣 孙冬玲 茹小娟 江滨 | 2015 | 国际脑血管病杂志2015，23，6： | 4 |
| 5 | Improvement After Constraint Induced Movement Therapy Is Independent of Infarct Location in Chronic Stroke Patients显示文摘 | Gauthier Lynne V MA Taub Edward PhD | 2009 | Stroke2009，40，7： | 1 |
| 6 | Homocysteine stimulates the expression of monocyte chemoattractant protein-1 in endothelial cells leading to enhanced monocyte chemotaxis显示文摘 | Fion L. Sung Yaw L. Siow Guoping Wang Edward G. Lynn O Karmin | 2001 | Molecular and Cellular Biochemistry (-)2001，，1： | 1 |
| 7 | Learning to See in Classroom: What Are Student Teachers Learning a- bout Teaching and Learning While Learning to Teach in Schools? 显示文摘 | Anne Edwards and Lynn Protheroe | 2003 | British Educational Research Journal2003，29，2： | 1 |
| 8 | Is There a Latent Period for the Surgical Treatment of Children With Dense Bilateral Congenital Cataracts?显示文摘 | Scott R. Lambert Michael J. Lynn Rachel Reeves David A. Plager Edward G. Buckley M. Edward Wilson | 2006 | Journal of AAPOS2006，，1： | 1 |
| 9 | Neutral chloroacetamide herbicide degradates and related compounds in Midwestern United States drinking water sources显示文摘 | Miehelle H L Edward B J Lynn R A | 2008 | Science of the Total Environment2008，390，1： | 1 |
| 10 | Changes in Diabetes Self-Care Behaviors Make a Difference in Glycemic Control 显示文摘 | Helen Jones Lynn Edwards Michael VaUis | 2003 | Diabetes Care2003，26，3： | 1 |
| 11 | Derivation and Prospective Validation of a Simple Index for Prediction of Cardiac Risk of Major Noncardiac Surgery显示文摘 | Thomas H. Lee Edward R. Marcantonio Carol M. Mangione Eric J. Thomas Carisi A. Polanczyk E. Francis Cook David J. Sugarbaker Magruder C. Donaldson Robert Poss Kalon K.L. Ho Lynn E. Ludwig Alex Pedan Lee Goldman | 1999 | Circulation1999，，10： | 1 |
| 12 | Effects of Sofosbuvir-based Treatment, With and Without Interferon, on Outcome and Productivity of Patients With Chronic Hepatitis C显示文摘 | Zobair M. Younossi Maria Stepanova Linda Henry Edward Gane Ira M. Jacobson Eric Lawitz David Nelson Lynn Gerber Fatema Nader Sharon Hunt | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 13 | Changes in Diabetes Self-Care Behaviors Make a Difference in Glycemic Control 显示文摘 | Helen Jones Lynn Edwards Michael Vallis | 2003 | Diabetes Care2003，26，3： | 1 |
| 14 | Combination Antiretroviral Strategies for the Treatment of Pregnant HIV-1-Infected Women and Prevention of Perinatal HIV-1 Transmission显示文摘 | Ellen R. Cooper Manhattan Charurat Lynne Mofenson Celine I. Hanson Jane Pitt Clemente Diaz Karen Hayani Edward Handelsman Vincent Smeriglio Rodney Hoff William Blattner | 2002 | JAIDS Journal of Acquired Immune Deficiency Syndromes2002，，5： | 1 |
| 15 | Guidelines for the Primary Prevention of Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Larry B. Goldstein Cheryl D. Bushnell Robert J. Adams Lawrence J. Appel Lynne T. Braun Seemant Chaturvedi Mark A. Creager Antonio Culebras Robert H. Eckel Robert G. Hart Judith A. Hinchey Virginia J. Howard Edward C. Jauch Steven R. Levine James F. Meschi | 2011 | Stroke2011，，2： | 1 |
| 16 | Perceived Ethical Values and Small Busi ness Problems in Poland 显示文摘 | SeanValentine Lynn Godkin Edward Cyrson andGary Fleischman | 2006 | Business Ethics: A Euro pean Review2006，，1： | 1 |
| 17 | Current Challenges in Bioequivalence, Quality, and Novel Assessment Technologies for Topical Products显示文摘 | Avraham Yacobi Vinod P. Shah Edward D. Bashaw Eva Benfeldt Barbara Davit Derek Ganes Tapash Ghosh Isadore Kanfer Gerald B. Kasting Lindsey Katz Robert Lionberger Guang Wei Lu Howard I. Maibach Lynn K. Pershing Russell J. Rackley Andre Raw Chinmay G. Shukl | 2014 | Pharmaceutical Research2014，，4： | 1 |
| 18 | Transcriptional changes induced by the tumor dormancy-associated microRNA-190显示文摘 | Nava Almog Christine Briggs Afshin Beheshti Lili Ma Kathleen P. Wilkie Edward Rietman Lynn Hlatky | 2013 | Transcription2013，，： | 1 |
| 19 | Hyperthermic intraperitoneal chemotherapy in conjunction with surgery for the treatment of recurrent ovarian carcinoma显示文摘 | C. William Helm Leslie Randall-Whitis Robert S. Martin Daniel S. Metzinger Mary E. Gordinier Lynn P. Parker Robert P. Edwards | 2006 | Gynecologic Oncology2006，，1： | 1 |
| 20 | Identification of new genetic risk factors for prostate cancer显示文摘有证据,到前列腺癌症(PCa ) 的基因倾向的实质的部分可能由于被染色体宽的协会研究发现的更低的外显率基因。我们最近进行了如此的研究,染色体的七个新区域连接了到 PCa 风险被识别了。三这些 loci 包含候选人危险性基因:MSMB, LMTK2 和 KLK2/3。MSMB 和 KLK2/3 基因可能为 PCa 屏蔽,和 LMTK2 基因是有用的可能提供一个潜在的治疗学的目标。和从另外的组的结果,现在有 23 germline 被报导了的基因变体。这些结果有潜力被发展进基因测试。然而,我们认为测试出售到公众是早熟的,当 PCa 风险不能在这个阶段和要发展的适当屏蔽协议需要充分被评估。后续确认学习,以及学习探索基因侧面测试的心理含意,将重要在以前推出进保健。 | Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O'Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons' Section of Oncology and The UK ProtecT Study Collaborators Alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse Alan Thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles | 2009 | Asian Journal of Andrology2009，11，1： | 1 |
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