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| 1 | USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors显示文摘(K63 ) 离氨酸 63 连接了 RIG-I 戏的 ubiquitination 在类型的激活的一个关键角色我干扰素小径,然而,为它的 deubiquitination 负责的分子的机制仍然糟糕被理解。这里,我们报导 deubiquitination 酶 ubiquitin 特定的朊酶(USP3 ) 3 否定地调整类型的激活我干扰素由指向 RIG-I 发信号。USP3 击倒 RIG-I 的明确地提高的连接 K63 的 ubiquitination, upregulated IRF3 的 phosphorylation 并且扩充了类型的生产我干扰素 cytokines 和抗病毒的免疫。我们进一步证明在 unstimulated 或 uninfected 房间在 USP3 和 RIG-I-like 受体( RLR )之间没有相互作用,但是在病毒的感染或 ligand 刺激之上, USP3 绑在 RLR 的 caspase 激活招募领域然后通过它的锌手指的合作劈开 polyubiquitin 链Ub有约束力的领域和 USP 催化领域。变化分析表明到 RIG-I 上的 polyubiquitin 链的 USP3 的那绑定是为它 polyubiquitin 链的劈开的前提步。我们的调查结果在 RIG-I 激活识别 USP3 的一个以前未被认出的角色并且提供卓见进 USP3 由禁止 RIG-I 发信号和抗病毒的免疫的机制。 | Jun Cui Yanxia Song Yinyin Li Qingyuan Zhu Peng Tan Yunfei Qin Helen Y Wang Rong-Fu Wang | 2014 | Cell Research2014，24，4： | 20 |
| 2 | Immune targets and neoantigens for cancer immunotherapy and precision medicine显示文摘利用免疫系统根除恶意的房间正在成为一条很强大的新途径到癌症治疗。基于免疫疗法的药的食物及药品管理局赞同, sipuleucel-T ( Provenge ), ipilimumab ( Yervoy , anti-CTLA-4 ),并且更最近,规划房间死亡( PD ) -1 抗体( pembrolizumab , Keytruda ),因为癌症的多重类型的治疗极大地在癌症免疫疗法的领域里推进了研究和临床的研究。而且,用 NY-ESO-1-specific T 房间受体(TCR ) 或 CD19 妄想的抗原受体(汽车) ,最近的临床的试用与变形癌症为病人显示出有希望的临床的结果。癌症免疫疗法的当前的成功在癌症抗原和 20 年以前识别的 co 禁止的发信号分子的工作之上被造。在大量目标抗原之中, CD19 是为为血癌症的汽车 T 房间治疗的最好的目标,但是设计汽车的 T 房间免疫疗法还没在固体做工作癌症。NY-ESO-1 是为在稳固的癌症的基于 TCR 的免疫疗法的最好的目标之一。尽管有检查点封锁治疗的大成功,超过 50% 癌症病人没能反应封锁治疗。象下一代的定序那样的新技术的来临提高了我们的能力在 onco 免疫学寻找新有免疫力的目标并且与癌症病人的潜在地更宽广的范围加速了免疫疗法的发展。在这评论,我们将为癌症免疫疗法和 immunoprecision 药在新有免疫力的目标和导出变化的抗原(neoantigens ) 的鉴定讨论癌症免疫疗法和新奇策略的最近的进步。 | Rong-Fu Wang Helen Y Wang | 2017 | Cell Research2017，27，1： | 19 |
| 3 | Enhanced TLR-induced NF-KB signaling and type I interferon responses in NLRC5 deficient mice显示文摘 | Yanzheng Tong Jun Cui Qingtian Li Jia Zou Helen Y Wang Rong-Fu Wang | 2012 | Cell Research2012，22，5： | 14 |
| 4 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 5 | Immunostimulatory DNA sequences necessary for effective intraderlmal gene immunization显示文摘 | Snato Y Mark R Helen T | 1996 | Science1996，273，： | 1 |
| 6 | Studies of microstructural and mechanical properties of Nylon/glass composite显示文摘 | Cartledge Caroline A B | 1999 | Journal of Materials Science1999，34，： | 1 |
| 7 | Multiphase hydrodynamics and solid-liquid mass transport in an external-loop airlift reactor-a comparative study显示文摘 | Mao Helen H H Chisti Y Moo-Young M | 1992 | Chem Eng Commun1992，113，： | 1 |
| 8 | Removal of NO by reversible adsorption on Fe-Mn based transition metal oxides显示文摘 | Huang Helen Y Yang Ralph T | 2001 | Langmuir2001，16，17： | 1 |
| 9 | Cotton (Gossypium hirsutum) MatP6 and MatP7 Oleosin Genes 显示文摘 | D Wayne Hughes Helen Y C Wang Clenn A Calau | 1993 | Plant Physiology1993，101，： | 1 |
| 10 | Correction of lung boundary using t he gradient and intensity distribution显示文摘 | Yeny Y Helen H Joon B S | | 0，，3： | 1 |
| 11 | NLRX1 negatively reg- ulates TLR-induced NFkappaB signaling by targeting TRAF6 and IKK显示文摘 | Xia Xiaojun Cui Jun Helen Y | 2011 | Immunity2011，34，6： | 1 |
| 12 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 13 | Support vector ma- chines with adaptive Lq penalties 显示文摘 | LIU Y HELEN ZHANG H PARK C | 2007 | Computational Statistics & Data Analysis2007，51，12： | 1 |
| 14 | Immunostimulatory DNA sequences necessary for effective intraderimal gene immunization显示文摘 | Santo Y Mark R Helen T | 1996 | Science1996，272，： | 1 |
| 15 | A dual frequency ultrasonic transducer based on BNBT-6/epoxy 1-3 composite 显示文摘 | WANG D Y CHAN HELEN L W | 2003 | Materials Science and Engineering B2003，99，： | 1 |
| 16 | Effect of various polyols and polyol contents on physical and mechanical properties of potato starch-based films显示文摘 | Talja R A Helen H Roos Y H | 2007 | Carbohydrate Polymers2007，67，3： | 1 |
| 17 | An audit of transfusion of red blood cell units inpediatric anesthesia 显示文摘 | Charlotte Y Katherine R Helen F | 2009 | Pediat Anesth2009，19，2： | 1 |
| 18 | Extraction and analysis of soil organic acids 显示文摘 | Wang T S C Cheng S Y Helen Tung | 1967 | Soil Science1967，103，5： | 1 |
| 19 | Determination of Elemental Sulfur in Environmental Samples by Gas Chromatography-Mass Spectrometry显示文摘 | Chen Y W Helen A J Nelson B | 1997 | Chemical Geology1997，137，： | 1 |
| 20 | Prevalence of deliberate self harmand attempted suicide within contemporary Goth youth subculture:longitudi原nal cohort study显示文摘 | ROBERT Y HELEN S PATRICK W | 2006 | BMJ2006，332，7549： | 1 |
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