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| 1 | Endoscopic ultrasound-guided drainage of the biliary system:Techniques,indications and future perspectives显示文摘Over the last decade, endoscopic ultrasound-guided biliary drainage(EUS-BD)has evolved into a widely accepted alternative to the percutaneous approach in cases of biliary obstruction with failed endoscopic retrograde cholangiopancreaticography(ERCP). The available evidence suggests that, in experienced hands, EUS-BD might even replace ERCP as the first-line procedure in specific situations such as malignant distal bile duct obstruction. The aim of this review is to summarize the available data on EUS-BD and propose an evidence-based algorithm clarifies the role of the different EUS-BD techniques in the management of benign and malignant biliary obstructive disease. | Pieter Hindryckx Helena Degroote David J Tate Pierre H Deprez | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，2： | 4 |
| 2 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 3 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
| 4 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 5 | Empirical Analysis of Business Growth Factors Using Swedish Data显示文摘 | Per Davidsson Bruce Kirehhojf Abdulnasser Hatemi- J Helena Gustavsson | 2002 | Journal of Small Business Management2002，40，4： | 1 |
| 6 | Social capital,knowledge acquisition,and knowledge exploitation in young technology‐based firms显示文摘 | RENKO Yli Helena AUTIO Erkko SAPIENZA J Harry | 2001 | Strategic management journal2001，22，67： | 1 |
| 7 | Pine wood modification by heat treatment in air 显示文摘 | Bruno M Esteves Idalina J Domingos Helena M Pereira | 2008 | BioResources2008，3，1： | 1 |
| 8 | Active genes are tri-methylated at K4 of histone H3显示文摘 | Helena Santos-Rosa Robert Schneider Andrew J Bannister | 2002 | Nature2002，419，： | 1 |
| 9 | Structural and functional consequences of methionine oxidation in thrombomodulin 显示文摘 | Wood M J Helena Prieto J Komives EA | 2005 | Biochim Biophys Acta2005，1703，2： | 1 |
| 10 | Very high plant stanol intake and serum plant stanols and non-cholesterol sterols显示文摘 | Helena G Maarit H Markku J | 2010 | Eur J Nutr2010，49，： | 1 |
| 11 | Rapid resolution of diabetes after gastric bypass显示文摘 | LIMA J HELENA L OLIVERIA S | 2005 | Obes Surg2005，15，3： | 1 |
| 12 | Partially esterified sucrose derivatives:Synthesis of 6-acetyl -2,3,4-tri-O- sucrose,a naturally occurring flavour precursor of tobacco显示文摘 | Garegg P J Stefan Oscarson Helena Ritzen | 1988 | Carbohy drate Research1988，，181： | 1 |
| 13 | Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding 显示文摘 | Helena J Maier Takahito Kashiwagi Koyu Hara | 2008 | Virology2008，370，1： | 1 |
| 14 | Empirical Analysis of Business Growth Factors Using Swedish Data显示文摘 | Per Davidsson Bruce Kirchhoff Abdulnasser Hatemi -J and Helena Gustavsson | 2002 | Journal of Small Business Management2002，40，4： | 1 |
| 15 | Rapid resolution of diabetes after gastric bypass 显示文摘 | Lima J Helena L Oliveira S | 2005 | Obes Surg2005，15，3： | 1 |
| 16 | Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation 显示文摘 | Steven J Helena J Sunil A | 1997 | Cancer Res1997，57，19： | 1 |
| 17 | Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning显示文摘 | Lars-Inge Larsson Ole D. Madsen Palle Serup J?rgen Jonsson Helena Edlund | 1996 | Mechanisms of Development1996，，2： | 1 |
| 18 | Spontaneous Coronary Artery Dissection with Clinical Presentation of Acute Myocardial Infarction显示文摘 | Taísa Godoy Guzzela Luciano de Siqueira Bracci Júnior Mauro Rogério de Barros Wanderley Júnior Sandra Helena Gonsalves de Andrade Mauro Cosme Gomes de Andrade Raony Previtali Paniquar Izabela Guimaraes Falcao Alves Nayrelle de Alencar Ferreira Gomes Jandir Ferreira Gomes Júnior Marcela Lopes Muniz de Andrade Renata London Rodrigues Diego Silveira da Costa Lucila Buriasco de Oliveira Amanda Ribeiro Letícia Trad Martins Costa Diego Braga Filartiga Reiby Caetano Mustafá | 2018 | Journal of Pharmacy and Pharmacology2018，6，7： | 1 |
| 19 | Seroprevalence of Toxoplasma gondii and Encephalitozoon cuniculi in rabbits from different farming systems显示文摘 | Helena N Jana J Edita J | 2014 | Vet Parasitol2014，204，： | 1 |
| 20 | Effect of 12‐month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations显示文摘 | Tommi Vasankari Markku Ahotupa Jorma Viikari Ilpo Nuotio Timo Strandberg Hannu Vanhanen Helena Gylling Tatu Miettinen Matti J Tikkanen | 2004 | Annals of Medicine2004，，： | 1 |
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