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| 1 | 【特刊综述】迟发型性腺功能减退症:发病机制、诊断、和治疗的现有概念以及争议显示文摘尽管血清睾酮(T)受抑制在中老年男性中常见,但仅有一小部分人发展成伴有弥漫性(如勃起功能障碍),生理性(如缺乏活力和虚弱)以及心理性(如抑郁)症状的真正的低雄激素综合征。这种综合征有多种称法,包括男性更年期或更年期,男人更年期和中老年男性部分雄激素缺乏。迟发型性腺功能减退症(LoH)最恰当地描述了这类综合征因而被普遍接受。在LOH中睾酮的降低是轻微的,因此性腺功能减退症可由原发性睾丸衰竭造成(睾酮水平低,黄体生成素水平高),也可继发于下丘脑.垂体轴功能障碍(睾酮水平低,黄体生成素水平低或不正常)。后一种形式更常见,而且经常与超重/肥胖或慢性疾病相关(如2型糖尿病、代谢综合征、心脏病以及慢性阻塞性肺病、虚弱)。LOH诊断的问题是症状(在20%-40%随机男性中)和低水平的循环睾酮(占70岁以上的男性的20%)不相符。欧洲男性增龄研究(EMAs)近期为LOH定义了严格的诊断标准,包括同时存在可再生的低水平血清睾酮(总睾酮〈11nmol l-1且游离睾酮〈220pmol l-1),以及性功能方面的三个症状(勃起功能障碍,性幻想和晨勃频次的减少)。以这个标准来看,仅有2%的40~80岁男性患有LOH。比之生理年龄本身,低水平睾酮的原因更常见的是肥胖,尤其是总体健康受损的那种。关于LOH是否需要治疗以及如何治疗的循证资料是非常稀缺的。最合理的方法是改变生活方式,降低体重以及对合并疾病进行有效治疗。雄激素替代治疗被广泛应用,但该法的真正疗效以及短期和长期的风险尚缺乏循证资料的支持。在这篇综述中,我们将总结迟发型性腺功能减退症的发病机制、诊断、和治疗的现有概念以及存在的争议。 | Ilpo Huhtaniemi | 2014 | Asian Journal of Andrology2014，16，2： | 39 |
| 2 | Exponential Polynomials as Solutions of Certain Nonlinear Difference Equations显示文摘Recently, C.-C. Yang and I. Laine have investigated finite order entire solutions f of nonlinear differential-difference equations of the form fn + L(z, f ) = h, where n ≥ 2 is an integer. In particular, it is known that the equation f(z)2 + q(z)f (z + 1) = p(z), where p(z), q(z) are polynomials, has no transcendental entire solutions of finite order. Assuming that Q(z) is also a polynomial and c ∈ C, equations of the form f(z)n + q(z)e Q(z) f(z + c) = p(z) do posses finite order entire solutions. A classification of these solutions in terms of growth and zero distribution will be given. In particular, it is shown that any exponential polynomial solution must reduce to a rather specific form. This reasoning relies on an earlier paper due to N. Steinmetz. | Zhi Tao WEN Janne HEITTOKANGAS Ilpo LAINE | 2012 | Acta Mathematica Sinica,English Series2012，28，7： | 9 |
| 3 | Low circulating levels of gastrin-17 in patients with Barrett's esophagus显示文摘AIM: To examine whether the fasting levels of serum gastrin-17 (G-17) are lower in Barrett's esophagus (BE)patients than in non-Barrett controls.METHODS: Nineteen patients with BE (presenting with a tubular segment ≥2 cm long in lower esophagus and intestinal metaplasia of incomplete type ('specialized columnar epithelium') in endoscopic biopsies from the tubular segment below the squamocolumnar junction were collected prospectively from outpatients referred to diagnostic gastroscopy. The controls comprised 199 prospectively collected dyspeptic outpatients without BE or any endoscopically visible lesions in the upper GI tract.Fasting levels of serum G-17 (G-17fast) were assayed with an EIA test using a Mab highly specific to amidated G-17. None of the patients and controls received therapy with PPIs or other antisecretory agents.RESULTS: The mean and median levels of G-17fast in serum were significantly lower (P = 0.001) in BE patients than in controls. The positive likelihood ratios (LR+) of low G-17fast to predict BE in the whole study population at G-17fast levels <0.5, <1, or <1.5 pmol/L were 3.5, 3.0,and 2.8, respectively. Among patients and controls with healthy stomach mucosa, the LR+ were 5.6, 3.8, and 2.6,respectively. In the whole study population, serum G-17 was below 2 pmol/L in 15 of 19 BE patients (79%). The corresponding prevalence was 66 of 199 (33%) in controls (P<0.001). The G-17fast was 5 pmol/L or more in only one of the 19 BE patients (5%). In controls, 76 of the 199 patients (38%) had such high serum G-17fast levels (P<0.01).CONCLUSION: Serum levels of G-17fast tend to be lower in native patients with BE than in healthy controls. | Pentti Sipponen Matti Vauhkonen Timo Helske Ilpo Kriinen Matti Hrknen | 2005 | World Journal of Gastroenterology2005，11，38： | 6 |
| 4 | Zika virus infection—do they also endanger male fertility?显示文摘Zika virus(ZIKV)is a mosquito-borne flavivirus,first discovered in the 1940s.ZIKV was originally limited to sporadic cases in Africa and Asia,until the Brazil ZIKV incidences in 2015,when it rapidly spread throughout the Americas.Usually ZIKV infections are subclinical or characterized by mild febrile illness,but they may also induce neurological complications,including the rare Guillain-Barrésyndrome in adults,and congenital anomalies, | Nafis A.Rahman Ilpo Huhtaniemi | 2017 | Science China(Life Sciences)2017，60，3： | 2 |
| 5 | Inverse Correlation between Serum Testosterone and Leptin in Men显示文摘 | Virve Luukkaa Ullamari Pesonen Ilpo Huhtaniemi | 1998 | The Journal of Clinical Endocrinology & Metabolism1998，83，9： | 1 |
| 6 | Immortalization by large T-antigen of the adult epididymal duct epithelium显示文摘 | Christiane K Yoshihiko A Ilpo H | 2004 | Mol Cell Endosc2004，216，1： | 1 |
| 7 | Are gonadotrophins tumorigenic—A critical review of clinical and experimental data显示文摘 | Ilpo Huhtaniemi | 2010 | Molecular and Cellular Endocrinology2010，，1： | 1 |
| 8 | Performance of immunoassays in screening for opiates, cannabinoids and amphetamines in post mortem blood 显示文摘 | Yukiko Hino Ilkka Ojanpera Ilpo Rasanen | 2003 | Forensic Sci-ence International2003，131，23： | 1 |
| 9 | Novel nanostructured PCC fillers显示文摘 | Kimmo Koivunen Ilpo Niskanen Kai-Erik Peiponen | 2009 | Sringer Science2009，44，： | 1 |
| 10 | Effect of 12‐month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations显示文摘 | Tommi Vasankari Markku Ahotupa Jorma Viikari Ilpo Nuotio Timo Strandberg Hannu Vanhanen Helena Gylling Tatu Miettinen Matti J Tikkanen | 2004 | Annals of Medicine2004，，： | 1 |
| 11 | The effect of preoperative fasting on postoperative pain, nausea and vomiting in pediatric ambulatory tonsillectomy 显示文摘 | Seija K Ilpo K Tarja S | 2009 | Int J Ped orl2009，73，2： | 1 |
| 12 | Co-experience: user experience as interaction 显示文摘 | KATJA B ILPO K | 2005 | CoDesign: International Journal of CoCre- ation in Design and the Arts2005，1，1： | 1 |
| 13 | Targeted expression of human FSH receptor Asp567Gly mutant mRNA in testis of transgenic mice: role of humanFSH receptor promoter显示文摘Aim:To specifically express the Asp567Gly human follicle-stimulating hormone receptor (FSHR) under the control of its promoter to evaluate the phenotypic consequences in the presence of normal pituitary function.Methods:We produced transgenic mice overexpressing the Asp567Gly human FSHR under the control of a 1.5kb 5’-flanking region fragment of its promoter.Results: Mice were phenotypically normal and fertile.In males,mRNA could be detected in the testis and the brain, indicating that the 1.5kb promoter fragment drives expression not only in the gonads. The testis weight/body weight ratio and the testosterone levels in transgenic and non-transgenic littermates were similar. By in situ hybridisation we found that the transgenic FSHR was highly expressed in Sertoli cells,spermatocytes and round spermatids. However, a radioligand receptor assay failed to show a significant difference in total FSHR binding sites in testis homogenates of transgenic and wild type animals, suggesting that the transgenic FSHR is probably not translated into functional receptor protein. Conclusion: A 1.5kb 5'-region of the human FSHR drives mRNA expression of the transgene in the testis but leads to ectopic expression in germ cells and in the brain. No phenotypic consequences could be documented due to the lack of protein expression. | Verena Nordhoff Jrg Gromoll Luca Foppiani C.Marc Luetjens Stefan Schlatt Elena Kostova Ilpo Huhtaniemi Eberhard Nieschlag Manuela Simoni | 2003 | Asian Journal of Andrology2003，5，4： | 1 |
| 14 | The Crystal and Molecular Structure of Atipamezole Base and Atipamezole Hydrochloride显示文摘 | Liana Orola Mikelis V. Veidis Ilpo Mutikainen Reinis Arajs | 2010 | Journal of Chemical Crystallography2010，，4： | 1 |
| 15 | On a Class of Prime Entire Functions显示文摘在这笔记,它被证明那表格的全部功能在 H 和 α
是全部功能的地方,与有至少一零的 α
, H′并且 α′不普通零并且 T (r, α
)= S (r, H ) ,在为大多数价值的全部意义是主要的一。这些函数的类被看见包含全部函数由 Noda 发现了的周期、非周期性的素数的例子, Qiao, Urabe 并且由 Singh 和 Charak。另一结果将也由于 Singh 和 Charak 被改进。 | Kuldeep Singh CHARAK Ilpo LAINE | 2009 | Acta Mathematica Sinica,English Series2009，25，10： | 1 |
| 16 | On the zeros of meromorphic solutions of second-order linear differential equations显示文摘 | Steven B. Bank Ilpo Laine | 1983 | Commentarii Mathematici Helvetici1983，，1： | 1 |
| 17 | Co-experience: user experience as interaction显示文摘 | Katja Battarbee Ilpo Koskinen | 2005 | CoDesign2005，，1： | 1 |
| 18 | Value distribution of difference polynomials显示文摘 | LAINE Ilpo YANG Chungchun | 2007 | Proceedings of the Japan Academy:SeriesA2007，83，： | 1 |
| 19 | Chapter 3 Complex differential equations显示文摘 | Ilpo Laine | 2008 | Handbook of Differential Equations: Ordinary Differential Equations2008，，： | 1 |
| 20 | 仔貂的补饲和断乳前的饲喂显示文摘拍卖水貂皮时,除了颜色和毛皮质量外,皮张的大小对其价格也有很大影响。在其他方面相同的情况下,皮张越大价格也就越高。因此,饲养场主们总是在保证质量的同时,以最小的成本生产尽可能大的皮张。虽然皮张的大小受到遗传因素的影响,但获得理想的尺寸还依赖于营养水平的高低,其中包括饲料的质量和数量。 | Ilpo Polonen 张惠丽 | 1991 | 毛皮动物饲养1991，，2： | 1 |
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