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| 1 | Tumor-associated macrophages in osteosarcoma显示文摘Osteosarcoma(OS)is the most common primary bone tumor in children and adolescents.It is an aggressive tumor with a tendency to spread to the lung,which is the most common site of metastasis.Patients with advanced OS with metastases have poor prognoses despite the application of chemotherapy,thus highlighting the need for novel therapeutic targets.The tumor microenvironment(TME)of OS is confirmed to be essential for and supportive of tumor growth and dissemination.The immune component of the OS microenvironment is mainly composed of tumor-associated macrophages(TAMs).In OS,TAMs promote tumor growth and angiogenesis and upregulate the cancer stem cell-like phenotype.However,TAMs inhibit the metastasis of OS.Therefore,much attention has been paid to investigating the mechanism of TAMs in OS development and the progression of immunotherapy for OS.In this article,we aim to summarize the roles of TAMs in OS and the major findings on the application of TAMs in OS treatment. | Yi ZHAO Benzheng ZHANG Qianqian ZHANG Xiaowei MA Helin FENG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 1 |
| 2 | Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13显示文摘 | Junli Liu Hongguang Xia Minsu Kim Lihua Xu Ying Li Lihong Zhang Yu Cai Helin Vakifahmetoglu Norberg Tao Zhang Tsuyoshi Furuya Minzhi Jin Zhimin Zhu Huanchen Wang Jia Yu Yanxia Li Yan Hao Augustine Choi Hengming Ke Dawei Ma Junying Yuan | 2011 | Cell2011，，1： | 1 |
| 3 | Mo-based perpendicularly magnetized thin films with low damping for fast and low-power consumption magnetic memory显示文摘Perpendicular magnetic anisotropy-based magnetic tunnel junctions(p-MTJs) with low Gilbert damping constant(α) are of particular interest for fast and low-power consumption magnetic random-access memory(MRAM). However, obtaining a faster switching speed and lower power consumption is still a big challenge. Herein, we report a Mo-based perpendicular double free layer structure with a low Gilbert damping constant of 0.02 relative to W-based films, as measured by time-resolved magnetooptical Kerr effect equipment. To show the influence of different film structures on the Gilbert damping constant, we measured the Mo-based single free layer. Thereafter, we deposited the full stacks with the Mo-based double free layer and obtained a high tunneling magnetoresistance of 136.3% and high thermal stability. The results of high-resolution transmission electron microscopy(HR-TEM) and energy-dispersive X-ray spectroscopy(EDS) showed that the Mo-based films had better crystallinity,sharper interfaces, and weaker diffusion than the W-based films and thus produced a weaker external contribution of the Gilbert damping constant. As a result of the weak spin-orbit coupling in the Mo-based structure, the intrinsic contribution of the Gilbert damping constant was also weak, thereby leading to the small Gilbert damping constant of the Mo-based stacks. In addition, the macro-spin simulation results demonstrated that the magnetization switching by the spin transfer torque of the Mo-based MTJs was faster than that of the W-based MTJs. These findings help to understand the mechanism behind the good performance of Mo-based p-MTJ films and show the great promise of these structures in low-power consumption MRAM or other spintronic devices. | Houyi Cheng Boyu Zhang Yong Xu Shiyang Lu Yuxuan Yao Rui Xiao Kaihua Cao Yongshan Liu Zilu Wang Renyou Xu Danrong Xiong Yan Wang Helin Ma Sylvain Eimer Chao Zhao Weisheng Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 0 |
| 4 | Affinity-Engineered Flexible Scaffold toward Energy-Dense, Highly Reversible Na Metal Batteries显示文摘The practical deployment of metallic anodes in the energy-dense batteries is impeded by the thermodynamically unstable interphase in contact with the aprotic electrolyte,structural collapse of the substrates as well as their insufficient affinity toward the metallic deposits.Herein,the mechanical flexible,lightweight(1.2 mg cm^(−2))carbon nanofiber scaffold with the monodispersed,ultrafine Sn_(4)P_(3) nanoparticles encapsulation(Sn_(4)P_(3)NPs@CNF)is proposed as the deposition substrate toward the high-areal-capacity sodium loadings up to 4 mAh cm^(−2).First-principles calculations manifest that the alloy intermediates,namely the Na_(15)Sn_(4) and Na_(3)P matrix,exhibit the intimate Na affinity as the“sodiophilic”sites.Meanwhile,the porous CNF regulates the heterogeneous alloying process and confines the deposit propagation along the nanofiber orientation.With the precise control of pairing mode with the NaVPO4F cathode(8.7 mg cm^(−2)),the practical feasibility of the Sn_(4)P_(3) NPs@CNF anode(1^(*)Na excess)is demonstrated in 2 mAh single-layer pouch cell prototype,which achieves the 95.7%capacity retention for 150 cycles at various mechanical flexing states as well as balanced energy/power densities. | Yujie Liu Miao Bai Dou Du Xiaoyu Tang Helin Wang Min Zhang Ting Zhao Fu Liu Zhiqiao Wang Yue Ma | 2023 | Energy & Environmental Materials2023，6，2： | 0 |
| 5 | A comparative study of the electrical characteristics of positive and negative narrow bipolar events显示文摘Narrow bipolar events(NBEs)are intriguing intra-cloud discharge that have attracted enormous interest in the lightning community.They come with two polarities that dominate at different altitudes in thunderclouds.The sources of negative NBEs are usually located near the top of thunderclouds;those of positive NBEs are at the middle levels.NBEs may occur at the onset of lightning.The electrical properties of NBEs remain poorly understood.We present here the first comparative study of the electrical characteristics of negative and positive NBEs.To derive electrical parameters from the fast electric field change waveforms of 1673 positive NBEs and 364 negative NBEs recorded by the Jianghuai Area Sferic Array(JASA)in China,we use an improved method based on the transmission line model.This approach concludes that negative NBEs occurring at high altitudes tend to produce a narrower current pulse and take a shorter time to traverse the channel than their positive counterparts.Moreover,compared to positive NBEs,a larger portion of negative NBEs are associated with slightly greater peak current moments but smaller overall charge moments.The differences reported herein between electrical properties of negative and positive NBEs suggest that charge distribution in NBE-producing thunderstorms tends to vary systematically with altitude. | FeiFan Liu BaoYou Zhu HeLin Zhou GaoPeng Lu Ming Ma JiuHou Lei | 2023 | Earth and Planetary Physics2023，7，6： | 0 |
| 6 | In situ growth of NiSe_(2) nanocrystalline array on graphene for efficient hydrogen evolution reaction显示文摘Nickel selenide electrocatalysts for hydrogen evolution reaction(HER)with a high efficiency and a lowcost have a significant potential in the development of water splitting.However,the inferiority of the high overpotential and poor stability restricts their practical applications.Herein,a composite nanostructure consists of ultrasmall NiSe_(2) nanocrystals embedded on graphene by microwave reaction is reported.The prepared NiSe_(2)/reduced graphite oxide(rGO)electrocatalyst exhibited a high HER activity with an overpotential of 158 mV at a current density of 10 mA/cm^(2) and a corresponding moderate Tafel slope of 56 mV/dec in alkaline electrolyte.In addition,a high retention of electrochemical properties(approximately 100%)was demonstrated with an unchangeable microstructure after 100 h of continuous operation. | Shuai JI Changgan LAI Huan ZHOU Helin WANG Ling MA Cong WANG Keying ZHANG Fajun LI Lixu LEI | 2022 | Frontiers in Energy2022，16，4： | 0 |
| 7 | An ultra-wideband coding polarizer for beam control and RCS reduction显示文摘Pancharatnam–Berry(PB)phase metasurface,as a special class of gradient metasurfaces,has been paid much attention owing to the robust performance for phase control of circularly polarized waves.Herein,we present an element-based polarizer for the first step,which enables the incident electromagnetic waves into the cross-polarized waves with the relative bandwidth of 71%,and the polarization conversion ratio exceeds 90%at 6.9–14.5 GHz.Then an eight-elements coding polarizer based on the PB phase is presented for the applications on beam control and radar cross section reduction.The simulated values indicate that the reduction of radar cross section is more than 10 dB at 6–16 GHz.Our work reveals the availability of manipulating the waves,beamforming in communication systems and electromagnetic stealth,and so on. | Huanhuan Gao Xiaojun Huang Xiongwei Ma Xiaoyan Li Linyan Guo Helin Yang | 2023 | Frontiers of physics2023，18，4： | 0 |
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