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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | Hepatic encephalopathy before and neurological complications after liver transplantation have no impact on the employment status 1 year after transplantation显示文摘AIM To investigate the impact of hepatic encephalopathybefore orthotopic liver transplantation(OLT) and neurological complications after OLT on employment after OLT.METHODS One hundred and fourteen patients with chronic liver disease aged 18-60 years underwent neurological examination to identify neurological complications, neuropsychological tests comprising the PSE-SyndromeTest yielding the psychometric hepatic encephalopathy score, the critical flicker frequency and the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS), completed a questionnaire concerning their occupation and filled in the short form 36(SF-36) to assess health-related quality of life before OLT and 12 mo after OLT, if possible. Sixty-eight(59.6%) patients were recruited before OLT, while on the waiting list for OLT at Hannover Medical School [age: 48.7 ± 10.2 years, 45(66.2%) male], and 46(40.4%) patients were included directly after OLT. RESULTS Before OLT 43.0% of the patients were employed. The patients not employed before OLT were more often non-academics(employed: Academic/non-academic 16(34.0%)/31 vs not employed 10(17.6%)/52, P = 0.04), had more frequently a history of hepatic encephalopathy(HE)(yes/no; employed 15(30.6%)/34 vs not employed 32(49.2%)/33, P = 0.05) and achieved worse results in psychometric tests(RBANS sum score mean ± SD employed 472.1 ± 44.5 vs not employed 443.1 ± 56.7, P = 0.04) than those employed. Ten patients(18.2%), who were not employed before OLT, resumed work afterwards. The patients employed after OLT were younger [age median(range, min-max) employed 47(42, 18-60) vs not employed 50(31, 29-60), P = 0.01], achieved better results in the psychometric tests(RBANS sum score mean ± SD employed 490.7 ± 48.2 vs not employed 461.0 ± 54.5, P = 0.02) and had a higher health-related quality of life(SF 36 sum score mean ± SD employed 627.0 ± 138.1 vs not employed 433.7 ± 160.8; P < 0.001) compared to patients not employed after OLT. Employment before OLT(P < 0.001), age(P < 0.01) and SF-36 sum score 12 mo after OLT(P < 0.01) but not HE before OLT or neurological complications after OLT were independent predictors of the employment status after OLT.CONCLUSION HE before and neurological complications after OLT have no impact on the employment status 12 mo after OLT. Instead younger age and employment before OLT predict employment one year after OLT. | Henning Pflugrad Anita B Tryc Annemarie Goldbecker Christian P Strassburg Hannelore Barg-Hock Jürgen Klempnauer Karin Weissenborn | 2017 | World Journal of Hepatology2017，9，10： | 3 |
| 3 | Effect of GABA analogues on blood pressure and central GABA metabolism in the rat显示文摘 | PERSSON B HENNING M | 1980 | Acta Pharma- col Toxicol ( Copenh)1980，47，2： | 1 |
| 4 | Predictive valueof the balloon expulsion test for excluding the diagno - sis of pelvic floor dyssynergia in constipation显示文摘 | Minguez M Hen'eros B Sanchiz V | 2004 | DisColon Rectum2004，35，11： | 1 |
| 5 | Formation mechanism of policyclic aromatic hydrocarbons and fullerenes in premixed benzene flames显示文摘 | HENNING R WILLIAM J G JACK B H | 1999 | Combus Flame1999，119，12： | 1 |
| 6 | Temporal and mechanistic tracking of cellular uptake dynamics with novel surface fluorophore-bound nanodiamonds 显示文摘 | Schrand A M Lin J B Hens S C | 2011 | Nanoscale2011，3，2： | 1 |
| 7 | Physiological decre- ments during sustained military operational stress显示文摘 | Henning P C Park B S Kim J S | 2011 | Mil Med2011，176，9： | 1 |
| 8 | Fatty acid-mediated activation of vascular endothelial cells显示文摘 | Henning B Meerarani P Ramadass P | 2000 | Metabolism2000，49，： | 1 |
| 9 | Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation显示文摘 | Henning R H Ke L | 2006 | J Mol Cell Cardiol2006，41，3： | 1 |
| 10 | Contemporary diagnosis of retrocaval ureter显示文摘 | Pienkny A J Hens B Streem S B | 1999 | J Endourol1999，13，10： | 1 |
| 11 | Radar imaging mechanism of the sea bed:resuh of the C-STAR experiment in 1996 with special emphasis on the relaxation rate of short waves due to current variations显示文摘 | Hennings I Lurin B Didden N | 2001 | Journal of Physical Oceanography2001，31，： | 1 |
| 12 | UVA-induced DNA double-strand breaks result from the repair of clustered oxida tire DNA damages 显示文摘 | Greinert R Volkmer B Henning S | 2012 | Nucleic Acids Res2012，40，10： | 1 |
| 13 | Distribution of races of head smut (Sporisorium reilianum) in the northeast and southwest areasof Mexico显示文摘 | Hen'era J A Vallejo A B | 1986 | Sorghum Newsletter1986，29，： | 1 |
| 14 | Management of heartburn in a large randomized community-based study:Comparison of fouRtherapeutic strategies显示文摘 | Howden C W Henning J M Huang B | 2001 | Am J Gastroenterol2001，96，： | 1 |
| 15 | Fattyacidmediated activation endothelial cells 显示文摘 | Henning B Meerarani P Ramadass P | 2000 | Metabolism2000，49，10： | 1 |
| 16 | The Treacher Collins syndrome (TCOF1) gene product is involved in pre - rRNA methylation 显示文摘 | Gonzales B Henning D So RB | 2005 | Hum Mol Genet2005，14，14： | 1 |
| 17 | Solid-phase microextraction (SPME) as a tool to predict the bioavailability and toxicity ofpyrene to the spring- tail, Folsomia candida, under various soil conditions 显示文摘 | Styrishave B Mortensen M Henning Krogh P | 2008 | Environmental Science & Technology2008，42，4： | 1 |
| 18 | Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation : differential regulation of protein and mRNA levels for K + channels 显示文摘 | Brundel B J Van Gelder IC Henning RH | 2001 | J Am Coll Cardiol2001，37，3： | 1 |
| 19 | Substantially reduced risk of cancer of aerodigestive tract in subjects with variant-463A of the myeloperoxidase gene显示文摘 | Cascorbi I Henning S B rockmoller J | 2000 | Cancer Res2000，60，3： | 1 |
| 20 | Tumor necrosis factor alpha-induced pulmanary vascular endothelial injury显示文摘 | Goldblum SE Henning B Jay M | 1989 | Infect Immun1989，57，4： | 1 |
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