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| 1 | Comethylation of p16 and MGMT genes in colorectal carcinoma:Correlation with clinicopathological features and prognostic value显示文摘AIM: To investigate the significance of p16 and O6- methylguanine-DNA methyltransferase (MGMT) genes promoter hypermethylation and K-ras mutations on colorectal tumorigenesis and progression. METHODS: p16 and MGMT methylation status was examined on 47 tumor samples, and K-ras mutational status was examined on 85 tumor samples. For methylation analysis, a methylation specific PCR (MS-PCR) method was used. RESULTS: p16 and MGMT promoter methylation was found in 51% (24/47) and 43% (20/47) of CRCs, respectively, and the K-ras mutation was found in 44% (37/85) of CRCs. Comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease within a two-year period of observation. Only 27% of patients with simultaneous p 16 and MGMT methylation showed the detectible occurrence of metastasis and/or death, compared to 67% of patients without double methylation or with no methylation (3/11 vs 22/33, P < 0.05, χ2-test). In addition, p16 and MGMT comethylation showed a trend toward an association with longer survival in patients with CRCs (35.5 ± 6.0 mo vs 23.1 ± 3.2 mo, P = 0.072, Log-rank test). Progression of the disease within a two-year period was observed in 66% of patients carrying the K-ras mutation, compared to only 19% of patients with wild type K-ras (29/44 vs 7/37, P < 0.001, χ2-test). The presence of the K-ras mutation significantly correlated to shortened overall survival (20.0 ± 1.9 mo vs 37.0 ± 1.8 mo, P < 0.001, Log-rank test). The comethylation of p16 and MGMT genes was significantly associated with lower aggressiveness of the disease even when K-ras mutations were included in the analysis as an independent variable. CONCLUSION: Our data suggest that comethylation of promoters of p 16 and MGMT genes could have a prognostic value in patients with CRC. Specifically, concurrent methylation of both genes correlates with better prognosis. | Koviljka Krtolica Milena Krajnovic Slavica Usaj-Knezevic Dragan Babic Dusan Jovanovic Bogomir Dimitrijevic | 2007 | World Journal of Gastroenterology2007，13，8： | 10 |
| 2 | Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease显示文摘AIM: To investigate autonomic nervous function in patients with a diagnosis of gastroesophageal reflux disease(GERD).METHODS: The investigation was performed on 29patients(14 men), aged 18-80 years(51.14 ± 18.34),who were referred to our Neurocardiology Laboratory at the Clinical and Hospital Center 'Bezanijska Kosa'with a diagnosis of GERD. One hundred sixteen healthy volunteers matched in age and sex with the examinees served as the control group. The study protocol included the evaluation of autonomic function and hemodynamic status, short-term heart rate variability(HRV) analysis, 24 h ambulatory ECG monitoring with long-term HRV analysis and 24 h ambulatory blood pressure monitoring.RESULTS: Pathologic results of cardiovascular reflex test were more common among patients with reflux compared to the control group. Severe autonomic dysfunction was detected in 44.4% of patients and in7.9% of controls(P < 0.001). Parameters of short-term analysis of RR variability, which are the indicators ofvagal activity, had lower values in patients with GERD than in the control group. Long-term HRV analysis of time-domain parameters indicated lower values in patients with reflux disease when compared to the control group. Power spectral analysis of long-term HRV revealed lower low- and high-frequency values.Detailed 24 h ambulatory blood pressure analysis showed significantly higher values of systolic blood pressure and pulse pressure in the reflux group than in the control group.CONCLUSION: Patients with GERD have distortion of sympathetic and parasympathetic components of the autonomic nervous system, but impaired parasympathetic function appears more congruent to GERD. | Branislav Milovanovic Branka Filipovic Slavica Mutavdzin Marija Zdravkovic Tatjana Gligorijevic Jovana Paunovic Marina Arsic | 2015 | World Journal of Gastroenterology2015，21，22： | 4 |
| 3 | Co-expression of the proteinase inhibitors oryzacystatin I and oryzacystatin II in transgenic potato alters Colorado potato beetle larval development显示文摘科罗拉多土豆甲壳虫(CPB;Leptinotarsa decemlineata 说,翘目:Chrysomelidae ) 显示出显著适应性到许多控制措施。尽管 oryzacystatin 我和 II (OCI 和 OCII ) 在控制为食物消化使用半胱氨酸朊酶的害虫有潜力,在土豆的单个 OC 基因的表示展出了一最小或 CPB 健康特点上的没有效果。这研究的目的是在土豆(茄属 tuberosum L.) 检验 coexpressed OCI 和 OCII 的效果 CPB 幼虫上的栽培变种 Desiree, Dragaevka 和 Jelica。CPB 幼虫的朊酶的生长参数,消费率和食物利用,以及活动是 assayed。第二和第三个中间形态幼虫在更高相对的生长和消费比在 nontransformed 叶子喂的幼虫评估的更早、有的转变叶子 molted 上喂了,当食物利用的效率是未受影响的时。相反,消费的叶子的第四中间形态最大值重量获得和数量是大约 20% 为在转基因的土豆上喂的幼虫更低。第三个中间形态幼虫的全部的朊酶活动的分析在 azocasein 水解作用测量的全面解朊的活动揭示了减小,在土豆的摄取离开以后,与半胱氨酸朊酶活动 24 h 的抑制伴随了表示 OCI 和 OCII。然而,在在转变叶子的长期的喂以后,幼虫的解朊的活动变得类似于控制。尽管在 OCI/OCII 叶子喂没影响幼虫的幸存, OC 基因的 coexpression 减少了发展时间并且显著地因此减少了 CPB 幼虫引起的植物损坏。 | Aleksandar Cingel Jelena Savic Jelica Lazarevic Tatjana Cosic Martin Raspor Ann Smigocki Slavica Ninkovic | 2017 | Insect Science2017，24，5： | 3 |
| 4 | The role of remote ischemic preconditioning in organ protection after cardiac surgery: a meta-analysis显示文摘 | Nur A.B. Haji Mohd Yasin Peter Herbison Pankaj Saxena Slavica Praporski Igor E. Konstantinov | 2014 | Journal of Surgical Research2014，，1： | 2 |
| 5 | 通过轧制纯铝箔和阳极铝箔制备多层铝基复合材料(英文)显示文摘介绍了一种以商业纯铝箔为基体的多层复合材料的加工过程、组织结构和力学性能。采用热轧制交替排布的纯铝和阳极铝箔制备多层复合材料;此外,采用同样的工艺制备纯铝箔多层复合材料。在这两种情况下,均得到紧实致密的多层复合材料。为了研究复合材料的微观组织演变和力学性能,分别进行了光学和扫描电镜(SEM)、能谱(EDS)、X射线衍射(XRD)分析以及硬度、拉伸和三点弯曲试验。微观组织表征显示,阳极铝复合材料铝基体中平行分布着棒状Al_2O_3颗粒,而且铝箔界面间生成少量粗大颗粒。两种复合材料的硬度、强度、弹性模量和抗弯强度均高于纯铝材料的,而延展性明显降低。与纯铝箔多层复合材料相比,阳极铝箔多层复合材料具有较高的强度和弹性模量以及较低的延展性。材料的断裂失效方式与延展性的变化一致。 | Milan T.JOVANOVI? Nenad ILI? Ivana CVIJOVI?-ALAGI? Vesna MAKSIMOVI? Slavica ZEC | 2017 | Transactions of Nonferrous Metals Society of China2017，27，9： | 2 |
| 6 | Is excess folic acid supplementation a risk factor for autism?显示文摘 | C. Mary Beard Laurel A. Panser Slavica K. Katusic | 2011 | Medical Hypotheses2011，，1： | 1 |
| 7 | Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation显示文摘 | Slavica Pavlovic-Djuranovic Jürgen F.J. Kun Joachim E. Schultz Eric Beitz | 2005 | BBA - Biomembranes2005，，8： | 1 |
| 8 | Epithelial ovarian cancer with CD117 phenotype is highly aggressive and resistant to chemotherapy显示文摘 | Irena Conic Zorica Stanojevic Ljubinka Jankovic Velickovic Slavica Stojnev Ana Ristic Petrovic Miljan Krstic Marko Stanojevic Dragan Bogdanovi? Vladisav Stefanovic | 2015 | J. Obstet. Gynaecol. Res2015，，10： | 1 |
| 9 | A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins 1 1 Nucleotide sequence data are available in the DDBJ/EMBL/GenBank databases under accession number AJ581909 .显示文摘 | Slavica Pavlovic-Djuranovic Joachim E. Schultz Eric Beitz | 2003 | FEBS Letters2003，，3： | 1 |
| 10 | The activity of antioxidant defence enzymes in the mussel Mytilus galloprovincialis from the Adriatic Sea 显示文摘 | Slavica S Borkovic Jelena S Saponjic Sladjan Z Pavlovic | 2005 | Comparative Biochemistry and Physiology Part C2005，141，4： | 1 |
| 11 | Genetic trans- formation of alfalfa somatic embryos and their clonal propagation through repetitive somatic embryogenesis显示文摘 | Slavica N Jovanka M Mirjana N | 1995 | Plant Cell Tiss Organ Cult1995，42，2： | 1 |
| 12 | Improved transformation of alfalfa somatic embryos using a superbinary vector显示文摘 | Slavica N Jovanka M Branka V | 2004 | Acta Biol Cracov Bot2004，46，1： | 1 |
| 13 | Glutamine synthetase in astrocytes from entorhinal cortex of the triple transgenic animal model of Alzheimer' s disease is not affected by pathological progression 显示文摘 | Chia-Yu Yeh Alexei Verkhratsky Slavica Terzieva | 2013 | Biogeronto- logy2013，14，6： | 1 |
| 14 | Skip Mediastinal Nodal Metastases in the IIIa/N2 Non-Small Cell Lung Cancer显示文摘 | Nenad Ilic Ante Petricevic Dragan Arar Slavica Kotarac Josip Banovic Nives Frleta Ilic Andro Tripkovic Leo Grandic | 2007 | Journal of Thoracic Oncology2007，，11： | 1 |
| 15 | Latent brain infection with Moraxella osloensis as a possible cause of cerebral gliomatosis type 2:A case report显示文摘BACKGROUND The gram-negative aerobic bacterium Moraxella osloensis is an opportunistic pathogen in brain tissues.CASE SUMMARY The gram-negative aerobic bacterium Moraxella osloensis was isolated from a patient’s brain tissue during a stereotactic biopsy.CONCLUSION This is the first report of a brain tissue infection with Moraxella osloensis possibly causing brain gliomatosis. | Tadej Strojnik Rajko Kavalar Kristina Gornik-Kramberger Maja Rupnik Slavica Lorencic Robnik MaraPopovic Tomaz Velnar | 2020 | World Journal of Clinical Oncology2020，11，12： | 1 |
| 16 | A Proteinaceous elicitor Sml from beneficial fungus Trichoderma vitens is required for induced systemic resistance in maize 显示文摘 | Slavica D Walter A Vargas M | 2007 | Plant Physiology2007，145，： | 1 |
| 17 | Utilization of baker's yesLSt(Saccharomyces cerevisiae)for the production of yeast extract 1 effects of different enzy-matic treatments on solid,protein and carbohydrate recovery显示文摘 | Tajana Vuka Sinovic Milic Marica Rakin Slavica Siler-Marin-kovic | 2007 | Journal of Serbian chemical2007，72，5： | 1 |
| 18 | Utilization of baker's yeast (Saccharomyces cerevisiae) for the production of yeast extract: effects of different enzymatic treatments on solid, protein and carbohydrate recovery显示文摘 | Tatjana vuka sinovic milic Marica rakin Slavica silermarinkovic | 2007 | Journal of Serbian chemical2007，72，5： | 1 |
| 19 | Adsorption of Pb^2+ Cd^2+ Sr^2+ ions onto natural and acid-activated sepiolites显示文摘 | Slavica L Ivona J Dusan J | 2007 | Appl Clay Sci2007，37，1： | 1 |
| 20 | Liposome-based delivery of a boron-containing cholesteryl ester for high-LET particle-induced damage of prostate cancer cells: A boron neutron capture therapy study显示文摘 | Ian Gifford Wyatt Vreeland Slavica Grdanovska Eric Burgett John Kalinich Vernieda Vergara C.-K. Chris Wang Eric Maimon Dianne Poster Mohamad Al-Sheikhly | 2014 | International Journal of Radiation Biology2014，，6： | 1 |
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