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| 1 | Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection显示文摘Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields. | Andrew E Becker Yasmin G Hernandez Harold Frucht Aimee L Lucas | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 2 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 3 | MicroRNA in pancreatic ductal adenocarcinoma and its precursor lesions显示文摘Pancreatic ductal adenocarcinoma(PDAC) is the 4^(th) deadliest cancer in the United States, due to its aggressive nature, late detection, and resistance to chemotherapy. The majority of PDAC develops from 3 precursor lesions, pancreatic intraepithelial lesions(PanIN), intraductual papillary mucinous neoplasm(IPMN), and mucinous cystic neoplasm. Early detection and surgical resection can increase PDAC 5-year survival rate from 6% for Stage Ⅳ to 50% for Stage Ⅰ. To date, there are no reliable biomarkers that can detect PDAC. MicroRNAs(miRNA) are small noncoding RNAs(18-25 nucleotides) that regulate gene expression by affecting translation of messenger RNA(mRNA). A large body of evidence suggests that miRNAs are dysregulated in various types of cancers. MiRNA has been profiled as a potential biomarker in pancreatic tumor tissue, blood, cyst fluid, stool, and saliva. Four mi RNA biomarkers(miR-21, miR-155, miR-196, and miR-210) have been consistently dysregulated in PDAC. MiR-21, miR-155, and miR-196 have also been dysregulated in IPMN and PanIN lesions suggesting their use as early biomarkers of this disease. In this review, we explore current knowledge of miRNA sampling, miR NA dysregulation in PDAC and its precursor lesions, and advances that have been made in using miRNA as a biomarker for PDAC and its precursor lesions. | yasmin g hernandez aimee l lucas | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 6 |
| 4 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 5 | Cytotoxic effect of Spirulina platensis extracts on human acute leukemia Kasumi-1 and chronic myelogenous leukemia K-562 cell lines显示文摘Objective: To evaluate the cytotoxic effects of Spirulina platensis extracts on acute leukemia Kasumi-1 and chronic leukemia K-562 cancer cell lines.Methods: Various concentrations of Spirulina platensis extracts(0.25–50.00 mg/m L)obtained with different solvents were used to treat cell lines for 72 h. For cytotoxic effect studies, cell viability test with trypan blue solution, MTT assay and microscopic cytomorphological assessment were done.Results: Spirulina extract obtained with 70% ethanol showed significant cytotoxicity in K562 and Kasumi-1 cell lines. With trypan blue solution, IC_(50) values were found to be4.64 mg/m L for K-562 and 3.68 mg/m L for Kusumi-1 cell lines. Spirulina aqueous extract also showed cytotoxicity with trypan blue method, at a slightly higher dose; where IC_(50) values were 12.68 mg/m L for K-562 and 2.13 mg/m L for Kusumi-1 cell lines. The IC_(50) values were found 0.40 mg/m L for K-562 and 0.31 mg/m L for Kusumi-1 cell lines for the 70% ethanol extract according to the MTT assay. Spirulina extract obtained with water also showed cytotoxicity but the dose was a little higher where IC_(50) values were15.77 mg/m L for K-562 and 9.44 mg/m L for Kusumi-1 cell lines. The effect of cytotoxicity with ethanol extract is quite comparable with that observed for cyclophosphamide, which is a chemical used as anticancer agent.Conclusions: The cytotoxicity exhibited by Spirulina extract to cancer cell lines might be due to the presence of phytopigments(carotenoids, chlorophyll, phycocyanin) as well as polysaccharides that were reported previously as constituents of the extract. So crude extracts of Spirulina can be used as a source to develop anticancer drugs. | Flor Yohana Flores Hernandez Sanghamitra Khandual Inocencia Guadalupe Ramírez López | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，1： | 4 |
| 6 | Toxicity of Benzotriazole and Benzotriazole Derivatives to Three Aquatic Species显示文摘 | David A Pillard Jeffrey S Cornell Doree L DuFresne Mark T Hernandez | 2000 | Water Research2000，，2： | 2 |
| 7 | Distribution of cadmium in shoot and root tissues of maize and pea plants:physiological disturbances显示文摘 | Lozano E Hernandez L E Bonay P | 1997 | Journal of Experimental Botany1997，48，1： | 1 |
| 8 | Cell motility and cytoskeletal regulation in invasion and me- tastasis显示文摘 | Kedrin D Van Rheenen J Hernandez L | 2007 | Mammary Gland Biol Neoplasia2007，12，23： | 1 |
| 9 | Risk of uncomplicated peptic ulcer among users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs 显示文摘 | Garcia Rodriguez L A Hernandez Diaz S | 2004 | Am J Epidemiol2004，159，1： | 1 |
| 10 | The effect of sample size and species characteristics on performance of different species distribution modeling methods 显示文摘 | Hernandez P A Graham C H Master L L | 2006 | Ecography2006，29，5： | 1 |
| 11 | Dopa- mine abnormalities in the neocortex of patients with temporal lobe epi- lepsy 显示文摘 | Rocha L Alonso- Vanegas M Villeda- Hernandez J | 2012 | Neurobiol Dis2012，45，1： | 1 |
| 12 | Charaeterisation of three hydrophobic porous membranes used in membrane distillation: modelling and evaluation of their water vapour permeabilities显示文摘 | MARTINEZ L FLORIDO-DIAZ F J HERNANDEZ A | 2002 | Journal of Membrane Science2002，203，12： | 1 |
| 13 | Modeling and optimization of low pass continuous time Sigma-Delta modulators for clock jitter noise reduction显示文摘 | HERNANDEZ L WIESBAUER A PATON S | 2004 | IEEE ISCAS2004，，： | 1 |
| 14 | Injectable acrylic bone cements for vertebroplasty based on a radiopaque hydroxyapatite : formulation and rheological behaviour 显示文摘 | Hernandez L Gurruchaga M Goni I | 2009 | Mater Sci: Mater Med2009，20，1： | 1 |
| 15 | Preconditioning limits mitochondrial Ca2+ during ischemia in rat hearts:role of K(ATP) channels显示文摘 | Wang L Cherednichenko G Hernandez L | 2001 | Am J Physiol2001，280，： | 1 |
| 16 | Enhanced resistance to Botrytis cinerea mediated by the transgenic expression of the chitinase gene ch5B in strawberry显示文摘 | VELLICCE G R RICCI J C HERNANDEZ L CASTAGNARO A P | 2006 | Transgenic Res2006，15，1： | 1 |
| 17 | Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases in Spain 显示文摘 | Hernandez JR Martinez-Martinez L Canton R | 2005 | Antimicrob Agents Chemother2005，49，5： | 1 |
| 18 | ElectronTransport and Swarm Parameters in CO2 and Its Mixtureswith SF6显示文摘 | Hernandez J L Avila Basurto E Urquijo J D | 2001 | Physics D:Applied Physics2001，35，18： | 1 |
| 19 | Nodal status and clinical outcomes in a large cohort of patients with triple-negative breast cancer显示文摘 | Hernandez Aya L F Chavez Macgegor M Lei X | | 0，，19： | 1 |
| 20 | Liver transplanta- tion for malignant tumors in children显示文摘 | Avila L F Luis A L Hernandez F | 2006 | Eur J Pediatr Surg2006，16，： | 1 |
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