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| 1 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 2 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 3 | The cortical morphogenetic cycle associated with cell division in Diophrys Dujardin,1848 (Ciliophora Hypotrichida)显示文摘 | Hill B F | 1981 | Protozool1981，28，2： | 2 |
| 4 | Nitrification of ammonical fertilizers in some California soils显示文摘 | Broadbent F E Tyler K B Hill G N | 1957 | Hilgardia1957，27，： | 1 |
| 5 | Progesterone represses interleukin-8 and cyclo-oxygenase-2 in human lower segment fibroblast cells and amnion epithelial cells 显示文摘 | Loudon JA Elliott CL Hills F | 2003 | Biol Reprod2003，69，1： | 1 |
| 6 | New design concept for a narrow band wavelength-selective optical tap and combiner显示文摘 | JOHNSON D C HILL K O BILODEAU F | 1987 | Electron Lett1987，23，： | 1 |
| 7 | Molecular and func- tional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells显示文摘 | De Bosscher K Hill C S Nicola's F J | 2004 | Biochem2004，379，： | 1 |
| 8 | Treatment ex- haustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdom: multicentre cohort study 显示文摘 | Sabin CA Hill T Lampe F | 2005 | Br Med J2005，300，7493： | 1 |
| 9 | Birefriengent photosensitivity in monomode optical fiber:application to external writing of rocking filters显示文摘 | Hill K O Bilodeau F Malo B | 1991 | Elec Lett1991，27，17： | 1 |
| 10 | Composite membranes for fuel cell applications 显示文摘 | Verbrugge Mark W Hill Robert F Schneider Eric W | 1992 | AICHE Journal1992，38，1： | 1 |
| 11 | Effects of milk replacer composition on growth, body composition, and nutrient excretion in preweaned holstein heifers显示文摘 | Hill S R Knowlton K F Daniels K M | 2008 | J Dairy Sci2008，91，： | 1 |
| 12 | Crystal structure of a biliverdin Ⅸalpha reductase enzyme-cofactor complex显示文摘 | WHITBY F G PHILLIPS J D HILL C P | 2002 | J Mol Biol2002，319，5： | 1 |
| 13 | Steriod nuclear dehydrogenation and colon csncer显示文摘 | M F Hill | 1974 | Am J Clin Nutr1974，27，： | 1 |
| 14 | Detection of individual gas molecules absorbed on graphene 显示文摘 | Schedin F Geim A K Hill E W | 2007 | Nature Materials2007，，6： | 1 |
| 15 | Recreation Demand Equation: Functional Form and Consumer Surplus 显示文摘 | Ziemer R F Musser WN Hill R C | 1980 | American Journal of Agricultural Economics1980，62，： | 1 |
| 16 | Tolerability of beta-blockers in elderly patients with chronic heart failure:the COLA II study显示文摘 | Krum H Hill J Fruhwald F | 2006 | Eur J Heart Fail2006，8，3： | 1 |
| 17 | Diamondoid hydrocarbons as a molecular proxy for thermal maturity and oil cracking: Geochemical models from hydrous pyrolysis显示文摘 | Wei Z B Moldowan J M Zhang S C Hill R Jarvie D M Wang H T Song F Q Fago F | 2007 | Org Geochem2007，38，2： | 1 |
| 18 | Turning on gibberellin and abscisic acid signaling 显示文摘 | Razerm F A Baron K Hill R D | 2006 | Curr Opin Plant Biol2006，9，5： | 1 |
| 19 | Properties of hydrophobically associating polyacrylamides: influence of the method of synthesis 显示文摘 | Hill A Candau F Selb J | 1993 | Macromolecules1993，26，17： | 1 |
| 20 | The utilization of contingent work, knowledge creation, and competitive advan- tage显示文摘 | Matusik S F Hill C L | 1998 | Academy of Management Review1998，23，4： | 1 |
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