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| 1 | 松花粉抗氧化性的体外实验研究显示文摘目的:通过体外试验对马尾松花粉的消炎、抗氧化性能进行评价。方法:四个模拟人类疾病过程中的生化反应系统为(1)MPO/H2O2系统主要模拟炎症反应,使中性粒细胞活化产生次氯酸;(2)Xan-XOD系统:模拟缺血再灌注,主要产生过氧化氢,超氧自由基和羟自由基;(3)Fenton系统,模拟体内炎性反应,从转铁蛋白或铁蛋白中释放出铁而产生羟自由基;(4)ABTS系统,用于总抗氧化能力的评估。结果:松花粉对以上反应系统所产生的过氧化氢、超氧自由基、羟自由基和次氯酸等活性氧系具有较好的清除作用,以浓度依赖关系抑制反应的发生并发挥抗氧化作用,对涉及炎症反应的MPO酶活性有一定的抑制作用。 | 鲍善芬 丛涛 J Illig H Schempp E F Elstner | 2005 | 营养学报2005，27，6： | 21 |
| 2 | 松花粉和松针提取物在亲脂性体外模型系统中抗氧化能力和机制的研究显示文摘目的:对松花粉和松针提取物在亲脂性抗氧化模型系统中的抗氧化能力和机制进行研究。方法:采用铜诱导的LDL氧化反应模型和Rose Bengal反应模型分别进行评价。结果:松花粉乙醇提取液具有较好的自由基链式反应阻断剂的作用,有效地推迟人血浆中低密度脂蛋白(LDL)氧化生成共轭二烯。松针乙醇提取液对LDL的保护作用优于松花粉。在Rose Bengal系统中,松花粉以清除自由基和螯合铜的两种机制抑制脂质过氧化反应的发生,而松针主要作为自由基清除剂发挥抗氧化作用。结论:松花粉和松针在两个亲脂性体外模型中均发挥很好的抗氧化能力,而抗氧化机制不尽相同。 | 鲍善芬 丛涛 Illig J Schempp H Elstner EF | 2006 | 军医进修学院学报2006，27，5： | 7 |
| 3 | Differential role of Hedgehog signaling in human pancreatic(patho-)physiology:An up to date review显示文摘Since the discovery of the Hedgehog(Hh)pathway in drosophila melanogaster,our knowledge of the role of Hh in embryonic development,inflammation,and cancerogenesis in humans has dramatically increased over the last decades.This is the case especially concerning the pancreas,however,real therapeutic breakthroughs are missing until now.In general,Hh signaling is essential for pancreatic organogenesis,development,and tissue maturation.In the case of acute pancreatitis,Hh has a protective role,whereas in chronic pancreatitis,Hh interacts with pancreatic stellate cells,leading to destructive parenchym fibrosis and atrophy,as well as to irregular tissue remodeling with potency of initiating cancerogenesis.In vitro and in situ analysis of Hh in pancreatic cancer revealed that the Hh pathway participates in the development of pancreatic precursor lesions and ductal adenocarcinoma including critical interactions with the tumor microenvironment.The application of specific inhibitors of components of the Hh pathway is currently subject of ongoing clinical trials(phases 1 and 2).Furthermore,a combination of Hh pathway inhibitors and established chemotherapeutic drugs could also represent a promising therapeutic approach.In this review,we give a structured survey of the role of the Hh pathway in pancreatic development,pancreatitis,pancreatic carcinogenesis and pancreatic cancer as well as an overview of current clinical trials concerning Hh pathway inhibitors and pancreas cancer. | Eckhard Klieser Stefan Swierczynski Christian Mayr Tarkan Jager Johanna Schmidt Daniel Neureiter Tobias Kiesslich Romana Illig | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 5 |
| 4 | GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers?显示文摘 | Romana Illig Eckhard Klieser Tobias Kiesslich Daniel Neureiter P. Marco Fisichella | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 5 | Combined transmandibular-zygomatic approach and infratemporal craniotomy for intracrnial skull base tumors 显示文摘 | Donovan MG Ondra S Illig JJ | 1993 | J Oral Maxillofac Surg1993，51，： | 1 |
| 6 | Genetics of type 2 diabetes: impact of interleukin-6 gene variants显示文摘 | Illig T Bongardt F Schopfer-Wendels A | 2005 | Gesundheitswesen2005，67，： | 1 |
| 7 | An implantable carotid sinus stimulator for drug-resistant hypertension: surgical technique and short-term outcome from the muhicenter phase II Rheos feasibility trial显示文摘 | Illig KA Levy M Sanchez L | 2006 | J Vasc Surg2006，44，6： | 1 |
| 8 | Rickets following bone tumor 显示文摘 | Prader A Illig R Uehlinger E | 1959 | Helv Paediatr Acta1959，14，： | 1 |
| 9 | Transforming growth factor-beta stimulates the expression of desmosomal proteins in bron- chial epithelial cells显示文摘 | Yoshida M Romberger D J Illig MG | 1992 | Am J Respir Cell Mol Biol1992，6，4： | 1 |
| 10 | Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors显示文摘 | Wilson K J Illig C R Subasinghe N | 2011 | J Bioorg Med Chem Lett2011，11，： | 1 |
| 11 | Association of the interleukin-1 receptor antagonist gene with asthma显示文摘 | Gohlke H Illig T Bahnweg M | 2004 | Am J Respir Crit Care Mcd2004，169，11： | 1 |
| 12 | STAT6 as an asthma candidate gene:polymorphism-screening,association and haplotype analysis in a Caucasian sib-pair study 显示文摘 | Illig T Loesgen S | 2002 | Hum Mol Genet2002，11，6： | 1 |
| 13 | Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants显示文摘 | Hinney A Nguyen T T Scherag A Friedel S Bronner G Muller T D Grallert H Illig T Wichmann H E Rief W Schafer H and Hebebrand J | | 0，，12： | 1 |
| 14 | Single nucleotide polymor- phism screening and association analysis exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q)as candidate genes for asthma 显示文摘 | Vollmert C Illig T Altmttller J | 2004 | Clin Exp Allergy2004，34，12： | 1 |
| 15 | Genes and lifestyle factors in obesity:Results from 12462 subjects from MONICA/KORA显示文摘 | Holzapfel C Grallert H Huth C Wahl S Fischer B Doring A Ruckert I M Hinney A Hebebrand J Wichmann H E Hauner H Illig T and Heid I M | | 0，，10： | 1 |
| 16 | Financial impact of endoscopic vein harvest for infrainguinal bypass 显示文摘 | Illig KA Rhodes JM Sternbach Y | 2003 | J Vasc Surg2003，37，： | 1 |
| 17 | Congenital cataract and macular hypoplasia in humans associated with a de novo mutation in CRYAA and compound heterozygous mutations in P显示文摘 | Graw J Klopp N Illig T | | 0，，08： | 1 |
| 18 | IL-2 in combination with IFN-alpha and 5-FU verse tamoxifen in metastatic renal cell carcinoma:long-term results of a radomixed clinical trial显示文摘 | Atzpodien J Kirchner H Illiger H J | 2001 | Br J Cancer2001，85，： | 1 |
| 19 | STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sibpair study 显示文摘 | Gabriele Duetsch Thomas Illig Sabine Loesgen | 2002 | Human Molecular Genetics2002，11，6： | 1 |
| 20 | Assessment of a dental anxiety scale 显示文摘 | Corah N L Gale E N Illig S J | 1978 | J Am Dent Assoe1978，97，5： | 1 |
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